Professor | Anwei Hou | Asia Growth Partners

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Name	Anwei Hou
Contact Information	anwei.hou@tib.cas.cn
Language ability	Chinese, English, German
Province	Tianjin

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Name

Anwei Hou

Contact Information

anwei.hou@tib.cas.cn

Language ability

Chinese, English, German

Province

Tianjin

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2014-09--2017-12 PhD: Wuhan University 2009-09--2012-06 Master's: Hubei University of Chinese Medicine 2005-09--2009-06 Bachelor's: Hubei University of Chinese Medicine
Work Experience	2024-03~Present - Chinese Academy of Sciences, Tianjin Institute of Industrial Biotechnology - Researcher 2022-08~2024-03 - Chinese Academy of Sciences, Tianjin Institute of Industrial Biotechnology - Associate Researcher 2018-12~2021-05 - University of Bonn - Postdoctoral Researcher 2018-02~2022-06 - Jiangxi Academy of Sciences, Institute of Microbiology - Assistant Researcher 2012-08~2014-05 - Zhejiang Yongning Pharmaceutical Co., Ltd. - Experimenter

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2014-09--2017-12 PhD: Wuhan University
2009-09--2012-06 Master's: Hubei University of Chinese Medicine
2005-09--2009-06 Bachelor's: Hubei University of Chinese Medicine

Work Experience

2024-03~Present - Chinese Academy of Sciences, Tianjin Institute of Industrial Biotechnology - Researcher
2022-08~2024-03 - Chinese Academy of Sciences, Tianjin Institute of Industrial Biotechnology - Associate Researcher
2018-12~2021-05 - University of Bonn - Postdoctoral Researcher
2018-02~2022-06 - Jiangxi Academy of Sciences, Institute of Microbiology - Assistant Researcher
2012-08~2014-05 - Zhejiang Yongning Pharmaceutical Co., Ltd. - Experimenter

Areas of Focus	Natural Product Discovery and Biosynthesis Biocatalysis
Publications	Cladosporin, A Highly Potent Antimalaria Drug?, Corresponding Author, 2023 Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides, First Author, 2023 Mechanism of the Bifunctional Multiple Product Sesterterpene Synthase AcAS from Aspergillus calidoustus, Second Author, 2022 Discovery of non-squalene triterpenes, Fifth Author, 2022 Deceptive Complexity in Formation of Cleistantha-8,12-diene, Fourth Author, 2022 The stereochemical course of 2-methylisoborneol biosynthesis, Second Author, 2022 Using Terpene Synthase Plasticity in Catalysis: On the Enzymatic Conversion of Synthetic Farnesyl Diphosphate Analogues, First Author, 2021 Rerouting and Improving Dauc-8-en-11-ol Synthase from Streptomyces venezuelae to a High Yielding Biocatalyst, Second Author, 2021 A Flavoprotein Dioxygenase Steers Bacterial Tropone Biosynthesis via Coenzyme A-Ester Oxygenolysis and Ring Epoxidation, Third Author, 2021 Functional Switch and Ethyl Group Formation in the Bacterial Polytrichastrene Synthase from Chryseobacterium polytrichastri, First Author, 2021 The EI-MS Fragmentation Mechanisms of the Bacterial Diterpenes Polytrichastrene A and Wanju-2,5-diene, First Author, 2021 Targeting active site residues and structural anchoring positions in terpene synthases, First Author, 2021 The Biosynthetic Gene Cluster for Sestermobaraenes-Discovery of a Geranylfarnesyl Diphosphate Synthase and a Multiproduct Sesterterpene Synthase fromStreptomyces mobaraensis, First Author, 2020 Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases, Sixth Author, 2020 On the mass spectrometric fragmentations of the bacterial sesterterpenes sestermobaraenes A-C, First Author, 2020 Enzymatic Synthesis of Methylated Terpene Analogues Using the Plasticity of Bacterial Terpene Synthases, First Author, 2020 Metabolic Engineering-Based Rapid Characterization of a Sesquiterpene Cyclase and the Skeletons of Fusariumdiene and Fusagramineol from Fusarium graminearum, Second Author, 2018 A Clade II-D Fungal Chimeric Diterpene Synthase from Colletotrichum gloeosporioides Produces Dolasta-1(15),8-diene, Fifth Author, 2018 Releasing the potential power of terpene synthases by a robust precursor supply platform, Third Author, 2017 Substrate screening of amino transaminase for the synthesis of a sitagliptin intermediate, First Author, 2016

Areas of Focus

Natural Product Discovery and Biosynthesis
Biocatalysis

Publications

Cladosporin, A Highly Potent Antimalaria Drug?, Corresponding Author, 2023
Labelling studies in the biosynthesis of polyketides and non-ribosomal peptides, First Author, 2023
Mechanism of the Bifunctional Multiple Product Sesterterpene Synthase AcAS from Aspergillus calidoustus, Second Author, 2022
Discovery of non-squalene triterpenes, Fifth Author, 2022
Deceptive Complexity in Formation of Cleistantha-8,12-diene, Fourth Author, 2022
The stereochemical course of 2-methylisoborneol biosynthesis, Second Author, 2022
Using Terpene Synthase Plasticity in Catalysis: On the Enzymatic Conversion of Synthetic Farnesyl Diphosphate Analogues, First Author, 2021
Rerouting and Improving Dauc-8-en-11-ol Synthase from Streptomyces venezuelae to a High Yielding Biocatalyst, Second Author, 2021
A Flavoprotein Dioxygenase Steers Bacterial Tropone Biosynthesis via Coenzyme A-Ester Oxygenolysis and Ring Epoxidation, Third Author, 2021
Functional Switch and Ethyl Group Formation in the Bacterial Polytrichastrene Synthase from Chryseobacterium polytrichastri, First Author, 2021
The EI-MS Fragmentation Mechanisms of the Bacterial Diterpenes Polytrichastrene A and Wanju-2,5-diene, First Author, 2021
Targeting active site residues and structural anchoring positions in terpene synthases, First Author, 2021
The Biosynthetic Gene Cluster for Sestermobaraenes-Discovery of a Geranylfarnesyl Diphosphate Synthase and a Multiproduct Sesterterpene Synthase fromStreptomyces mobaraensis, First Author, 2020
Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases, Sixth Author, 2020
On the mass spectrometric fragmentations of the bacterial sesterterpenes sestermobaraenes A-C, First Author, 2020
Enzymatic Synthesis of Methylated Terpene Analogues Using the Plasticity of Bacterial Terpene Synthases, First Author, 2020
Metabolic Engineering-Based Rapid Characterization of a Sesquiterpene Cyclase and the Skeletons of Fusariumdiene and Fusagramineol from Fusarium graminearum, Second Author, 2018
A Clade II-D Fungal Chimeric Diterpene Synthase from Colletotrichum gloeosporioides Produces Dolasta-1(15),8-diene, Fifth Author, 2018
Releasing the potential power of terpene synthases by a robust precursor supply platform, Third Author, 2017
Substrate screening of amino transaminase for the synthesis of a sitagliptin intermediate, First Author, 2016

Natural Products Biosynthesis Biocatalysis Enzymes Metabolic Engineering Synthetic Biology Microbial Biotechnology Drug Discovery Biochemical Pathways Genetic Engineering

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