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Xin-Yuan Liu
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Cancer
Gene Therapy
Virus
Targeted Therapy
Interferon
Mechanism
Anticancer
Biochemistry
Molecular Biology
Clinical Application
Areas of Focus
- Cancer Targeted Gene-Virus Therapy
- Anticancer Mechanism of Super Interferon
Work Experience
- 2011-07 to Present: Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- 2001-07 to Present: Academician, Third World Academy of Sciences
- 2000-01 to Present: Researcher, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- 1992-10 to Present: Foreign Academician, Ukrainian Academy of Sciences
- 1991-12 to Present: Academician, Chinese Academy of Sciences
- 1985-02 to 2000-01: Researcher, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
- 1983-07 to 1984-12: Visiting Scholar, Roche Institute of Molecular Biology, USA
- 1979-08 to 1985-01: Associate Researcher, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
- 1963-08 to 1979-07: Assistant Researcher, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
- 1952-09 to 1957-08: Teaching Assistant, Hebei Medical College
Academic Background & Achievements
- 1957-09 to 1963-07: Vice Doctoral Graduate, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
- 1948-09 to 1952-07: Nankai University, No Degree
Publications
- Augmenting the antitumor effect of TRAIL by SOCS3 with double-regulated replicating oncolytic adenovirus in Hepatocellular Carcinoma, Xin-Yuan Liu, 2011
- Cancer Targeting Gene-Viro-Therapy of Liver Carcinoma by Dual-regulated Oncolytic Adenovirus Armed with TRAIL Gene, Xin-Yuan Liu, 2011
- E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFα-induced JNK activation, Xin-Yuan Liu, 2010
- VEGI-armed oncolytic adenovirus inhibits tumor neovascularization and directly induces mitochondria-mediated cancer cell apoptosis, Xin-Yuan Liu, 2010
- Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane, Xin-Yuan Liu, 2010
- ASK1–JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells, Xin-Yuan Liu, 2010
- The antitumor efficacy of IL-24 mediated by E1A and E1B triple regulated oncolytic adenovirus, Xin-Yuan Liu, 2010
- Targeting Gene-ViroTherapy for prostate cancer by DD3-driven oncolytic virus-harboring interleukin-24 gene, Xin-Yuan Liu, 2010
- Double-regulated oncolytic denovirus-mediated IL-24 overexpression exhibits potent antitumor activity on gastric adenocarcinoma, Xin-Yuan Liu, 2010
- Reexpression of Human Somatostatin Receptor Gene 2 Gene Mediated by Oncolytic Adenovirus Increases Antitumor Activity of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand against Pancreatic Cancer, Xin-Yuan Liu, 2009
- Enhanced antitumor acativity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis, Xin-Yuan Liu, 2008
- Completely Elimination of Colorectal Tumor Xenograft by Combined Manganese Superoxide Dismutase with Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Gene Therapy, Xin-Yuan Liu, 2006
- Suppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, Soluble sflt-1, Xin-Yuan Liu, 2005
- Effective Gene-Virotherapy for Complete Eradication of Tumor Mediated by the Combination of hTRAIL (TNFSF10) and Plasminogen k5, Xin-Yuan Liu, 2005
- An Oncolytic Adenovrial Vector of Smac Increases Antitumor Activity of TRAIL Against HCC in Human Cells and in Mice, Xin-Yuan Liu, 2004
- Effective gene-viral therapy for telomerase-positive cancers by selective replicative -competent adenovirus combining with endostatin gene, Xin-Yuan Liu, 2004
- An Armed Oncolytic Adenovirus system, ZD55-gene, Demonstrating Potent Antitumoral Efficacy, Xin-Yuan Liu, 2003
Awards
- 2010: Scientist of the Year, Science China, National Level, 2011
- 2001: Ho Leung Ho Lee Award, Other Level
- 1997: Advanced Worker of the Chinese Academy of Sciences, Institute Level
- 1997: Second Prize, National Level, for the development, pilot production, and clinical application of gene-engineered human interleukin-2
- 1996: Second National Excellent Inventor Entrepreneur, National Level
- 1996: Excellent Doctoral Supervisor of the Chinese Academy of Sciences, Institute Level
- 1992: First Prize, Institute Level, for gene engineering research on human gamma-interferon
- 1991: National Level, for the development of new gene-engineered interleukin-2 (863 High-Tech Program)
- 1991: National Level, for gene engineering research on human gamma-interferon and interleukin (Seventh Five-Year Plan)
- 1987: Second Prize, Institute Level, for the discovery of 2'-5' oligoadenylate receptor (2'-5'P3A3)
