Professor | Xin-Yuan Liu | Asia Growth Partners

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Name	Xin-Yuan Liu
Contact Information	xyliu@sibs.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Xin-Yuan Liu

Contact Information

xyliu@sibs.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1957-09 to 1963-07: Vice Doctoral Graduate, Shanghai Institute of Biochemistry, Chinese Academy of Sciences 1948-09 to 1952-07: Nankai University, No Degree
Work Experience	2011-07 to Present: Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2001-07 to Present: Academician, Third World Academy of Sciences 2000-01 to Present: Researcher, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 1992-10 to Present: Foreign Academician, Ukrainian Academy of Sciences 1991-12 to Present: Academician, Chinese Academy of Sciences 1985-02 to 2000-01: Researcher, Shanghai Institute of Biochemistry, Chinese Academy of Sciences 1983-07 to 1984-12: Visiting Scholar, Roche Institute of Molecular Biology, USA 1979-08 to 1985-01: Associate Researcher, Shanghai Institute of Biochemistry, Chinese Academy of Sciences 1963-08 to 1979-07: Assistant Researcher, Shanghai Institute of Biochemistry, Chinese Academy of Sciences 1952-09 to 1957-08: Teaching Assistant, Hebei Medical College
Awards	2010: Scientist of the Year, Science China, National Level, 2011 2001: Ho Leung Ho Lee Award, Other Level 1997: Advanced Worker of the Chinese Academy of Sciences, Institute Level 1997: Second Prize, National Level, for the development, pilot production, and clinical application of gene-engineered human interleukin-2 1996: Second National Excellent Inventor Entrepreneur, National Level 1996: Excellent Doctoral Supervisor of the Chinese Academy of Sciences, Institute Level 1992: First Prize, Institute Level, for gene engineering research on human gamma-interferon 1991: National Level, for the development of new gene-engineered interleukin-2 (863 High-Tech Program) 1991: National Level, for gene engineering research on human gamma-interferon and interleukin (Seventh Five-Year Plan) 1987: Second Prize, Institute Level, for the discovery of 2'-5' oligoadenylate receptor (2'-5'P3A3)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1957-09 to 1963-07: Vice Doctoral Graduate, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
1948-09 to 1952-07: Nankai University, No Degree

Work Experience

2011-07 to Present: Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
2001-07 to Present: Academician, Third World Academy of Sciences
2000-01 to Present: Researcher, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
1992-10 to Present: Foreign Academician, Ukrainian Academy of Sciences
1991-12 to Present: Academician, Chinese Academy of Sciences
1985-02 to 2000-01: Researcher, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
1983-07 to 1984-12: Visiting Scholar, Roche Institute of Molecular Biology, USA
1979-08 to 1985-01: Associate Researcher, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
1963-08 to 1979-07: Assistant Researcher, Shanghai Institute of Biochemistry, Chinese Academy of Sciences
1952-09 to 1957-08: Teaching Assistant, Hebei Medical College

Awards

2010: Scientist of the Year, Science China, National Level, 2011
2001: Ho Leung Ho Lee Award, Other Level
1997: Advanced Worker of the Chinese Academy of Sciences, Institute Level
1997: Second Prize, National Level, for the development, pilot production, and clinical application of gene-engineered human interleukin-2
1996: Second National Excellent Inventor Entrepreneur, National Level
1996: Excellent Doctoral Supervisor of the Chinese Academy of Sciences, Institute Level
1992: First Prize, Institute Level, for gene engineering research on human gamma-interferon
1991: National Level, for the development of new gene-engineered interleukin-2 (863 High-Tech Program)
1991: National Level, for gene engineering research on human gamma-interferon and interleukin (Seventh Five-Year Plan)
1987: Second Prize, Institute Level, for the discovery of 2'-5' oligoadenylate receptor (2'-5'P3A3)

Areas of Focus	Cancer Targeted Gene-Virus Therapy Anticancer Mechanism of Super Interferon
Publications	Augmenting the antitumor effect of TRAIL by SOCS3 with double-regulated replicating oncolytic adenovirus in Hepatocellular Carcinoma, Xin-Yuan Liu, 2011 Cancer Targeting Gene-Viro-Therapy of Liver Carcinoma by Dual-regulated Oncolytic Adenovirus Armed with TRAIL Gene, Xin-Yuan Liu, 2011 E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFα-induced JNK activation, Xin-Yuan Liu, 2010 VEGI-armed oncolytic adenovirus inhibits tumor neovascularization and directly induces mitochondria-mediated cancer cell apoptosis, Xin-Yuan Liu, 2010 Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane, Xin-Yuan Liu, 2010 ASK1–JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells, Xin-Yuan Liu, 2010 The antitumor efficacy of IL-24 mediated by E1A and E1B triple regulated oncolytic adenovirus, Xin-Yuan Liu, 2010 Targeting Gene-ViroTherapy for prostate cancer by DD3-driven oncolytic virus-harboring interleukin-24 gene, Xin-Yuan Liu, 2010 Double-regulated oncolytic denovirus-mediated IL-24 overexpression exhibits potent antitumor activity on gastric adenocarcinoma, Xin-Yuan Liu, 2010 Reexpression of Human Somatostatin Receptor Gene 2 Gene Mediated by Oncolytic Adenovirus Increases Antitumor Activity of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand against Pancreatic Cancer, Xin-Yuan Liu, 2009 Enhanced antitumor acativity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis, Xin-Yuan Liu, 2008 Completely Elimination of Colorectal Tumor Xenograft by Combined Manganese Superoxide Dismutase with Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Gene Therapy, Xin-Yuan Liu, 2006 Suppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, Soluble sflt-1, Xin-Yuan Liu, 2005 Effective Gene-Virotherapy for Complete Eradication of Tumor Mediated by the Combination of hTRAIL (TNFSF10) and Plasminogen k5, Xin-Yuan Liu, 2005 An Oncolytic Adenovrial Vector of Smac Increases Antitumor Activity of TRAIL Against HCC in Human Cells and in Mice, Xin-Yuan Liu, 2004 Effective gene-viral therapy for telomerase-positive cancers by selective replicative -competent adenovirus combining with endostatin gene, Xin-Yuan Liu, 2004 An Armed Oncolytic Adenovirus system, ZD55-gene, Demonstrating Potent Antitumoral Efficacy, Xin-Yuan Liu, 2003

Areas of Focus

Cancer Targeted Gene-Virus Therapy
Anticancer Mechanism of Super Interferon

Publications

Augmenting the antitumor effect of TRAIL by SOCS3 with double-regulated replicating oncolytic adenovirus in Hepatocellular Carcinoma, Xin-Yuan Liu, 2011
Cancer Targeting Gene-Viro-Therapy of Liver Carcinoma by Dual-regulated Oncolytic Adenovirus Armed with TRAIL Gene, Xin-Yuan Liu, 2011
E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFα-induced JNK activation, Xin-Yuan Liu, 2010
VEGI-armed oncolytic adenovirus inhibits tumor neovascularization and directly induces mitochondria-mediated cancer cell apoptosis, Xin-Yuan Liu, 2010
Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane, Xin-Yuan Liu, 2010
ASK1–JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells, Xin-Yuan Liu, 2010
The antitumor efficacy of IL-24 mediated by E1A and E1B triple regulated oncolytic adenovirus, Xin-Yuan Liu, 2010
Targeting Gene-ViroTherapy for prostate cancer by DD3-driven oncolytic virus-harboring interleukin-24 gene, Xin-Yuan Liu, 2010
Double-regulated oncolytic denovirus-mediated IL-24 overexpression exhibits potent antitumor activity on gastric adenocarcinoma, Xin-Yuan Liu, 2010
Reexpression of Human Somatostatin Receptor Gene 2 Gene Mediated by Oncolytic Adenovirus Increases Antitumor Activity of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand against Pancreatic Cancer, Xin-Yuan Liu, 2009
Enhanced antitumor acativity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis, Xin-Yuan Liu, 2008
Completely Elimination of Colorectal Tumor Xenograft by Combined Manganese Superoxide Dismutase with Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Gene Therapy, Xin-Yuan Liu, 2006
Suppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, Soluble sflt-1, Xin-Yuan Liu, 2005
Effective Gene-Virotherapy for Complete Eradication of Tumor Mediated by the Combination of hTRAIL (TNFSF10) and Plasminogen k5, Xin-Yuan Liu, 2005
An Oncolytic Adenovrial Vector of Smac Increases Antitumor Activity of TRAIL Against HCC in Human Cells and in Mice, Xin-Yuan Liu, 2004
Effective gene-viral therapy for telomerase-positive cancers by selective replicative -competent adenovirus combining with endostatin gene, Xin-Yuan Liu, 2004
An Armed Oncolytic Adenovirus system, ZD55-gene, Demonstrating Potent Antitumoral Efficacy, Xin-Yuan Liu, 2003

Cancer Gene Therapy Virus Targeted Therapy Interferon Mechanism Anticancer Biochemistry Molecular Biology Clinical Application

Geng Wu - Shanghai Jiao Tong University

Shuangjun Lin - Shanghai Jiao Tong University

Geng Wu - Shanghai Jiao Tong University

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