Professor | Shuangjun Lin | Asia Growth Partners

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Name	Shuangjun Lin
Contact Information	linsj@sjtu.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Shuangjun Lin

Contact Information

linsj@sjtu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Shanghai Jiao Tong University
Faculty	Life Sciences
Academic Background & Achievements	1999-2002, Ph.D. in Organic Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Supervisor: Professor Meixiang Wang 1996-1999, Master's in Organic Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Supervisor: Researcher Dayuan Zhu 1992-1996, Bachelor's in Organic Chemistry, Jilin University
Work Experience	2015-present, Shanghai Jiao Tong University, Distinguished Professor, Doctoral Supervisor 2009-2014, Shanghai Jiao Tong University, Researcher 2005-2008, University of Wisconsin-Madison, Research Assistant 2002-2005, University of Alberta, Postdoctoral Researcher
Awards	2018: Shanghai Jiao Tong University Postdoctoral Reward Fund Supervisor 2016: Shanghai Outstanding Doctoral Dissertation Supervisor 2014: National Science Fund for Distinguished Young Scholars 2014: Jiusan Youth Teacher Award 2012: Shanghai Jiao Tong University 'Morning Star Young Scholar Award' Category A 2011: Ministry of Education 'New Century Excellent Talents Support Plan'

University/Lab Affiliation and Title

Shanghai Jiao Tong University

Faculty

Life Sciences

Academic Background & Achievements

1999-2002, Ph.D. in Organic Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Supervisor: Professor Meixiang Wang
1996-1999, Master's in Organic Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Supervisor: Researcher Dayuan Zhu
1992-1996, Bachelor's in Organic Chemistry, Jilin University

Work Experience

2015-present, Shanghai Jiao Tong University, Distinguished Professor, Doctoral Supervisor
2009-2014, Shanghai Jiao Tong University, Researcher
2005-2008, University of Wisconsin-Madison, Research Assistant
2002-2005, University of Alberta, Postdoctoral Researcher

Awards

2018: Shanghai Jiao Tong University Postdoctoral Reward Fund Supervisor
2016: Shanghai Outstanding Doctoral Dissertation Supervisor
2014: National Science Fund for Distinguished Young Scholars
2014: Jiusan Youth Teacher Award
2012: Shanghai Jiao Tong University 'Morning Star Young Scholar Award' Category A
2011: Ministry of Education 'New Century Excellent Talents Support Plan'

Areas of Focus	Discovery and structural identification of bioactive natural products Biosynthesis and combinatorial biosynthesis of natural products Mechanism and application of enzyme-catalyzed reactions
Publications	Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily, Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng X, Tang Y, Lin S, 2017 Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway, Lan Y, Zou Y, Huang T, Wang X, Brock NL, Deng Z, Lin S, 2016 Transformation of Streptonigrin to Streptonigrone: Flavin Reductase-Mediated Flavin-Catalyzed Concomitant Oxidative Decarboxylation of Picolinic Acid Derivatives, Wo J, Kong D, Brock NL, Xu F, Zhou X, Deng Z, Lin S, 2016 An Acyl Transfer Reaction Catalyzed by an Epimerase MarH, Han M, Yin H, Zou Y, Brock NL, Huang T, Deng Z, Chu Y, Lin S, 2016 Stereospecific biosynthesis of β-methyl tryptophan from L-tryptophan features a stereochemical switch, Zou Y, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S, 2013 Characterization of Streptonigrin Biosynthesis Reveals a Cryptic Carboxyl Methylation and an Unusual Oxidative Cleavage of a N-C Bond, Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S* Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis, Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B, 2012 A Free-Standing Condensation Enzyme Catalyzing Ester Bond Formation in C-1027 Biosynthesis, Lin S, Van Lanen SG and Shen B, 2009 Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis, Lin S, Horsman GP, Chen Y, Li W, Shen B, 2009 Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517, Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S, Deng Z, 2011

Areas of Focus

Discovery and structural identification of bioactive natural products
Biosynthesis and combinatorial biosynthesis of natural products
Mechanism and application of enzyme-catalyzed reactions

Publications

Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily, Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng X, Tang Y, Lin S*, 2017
Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway, Lan Y, Zou Y, Huang T, Wang X, Brock NL, Deng Z, Lin S*, 2016
Transformation of Streptonigrin to Streptonigrone: Flavin Reductase-Mediated Flavin-Catalyzed Concomitant Oxidative Decarboxylation of Picolinic Acid Derivatives, Wo J, Kong D, Brock NL, Xu F, Zhou X, Deng Z, Lin S*, 2016
An Acyl Transfer Reaction Catalyzed by an Epimerase MarH, Han M, Yin H, Zou Y, Brock NL, Huang T, Deng Z, Chu Y*, Lin S*, 2016
Stereospecific biosynthesis of β-methyl tryptophan from L-tryptophan features a stereochemical switch, Zou Y, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S*, 2013
Characterization of Streptonigrin Biosynthesis Reveals a Cryptic Carboxyl Methylation and an Unusual Oxidative Cleavage of a N-C Bond, Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S*
Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis, Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B*, 2012
A Free-Standing Condensation Enzyme Catalyzing Ester Bond Formation in C-1027 Biosynthesis, Lin S, Van Lanen SG and Shen B*, 2009
Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis, Lin S, Horsman GP, Chen Y, Li W, Shen B*, 2009
Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517, Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S*, Deng Z, 2011

Natural Products Bioactive Structural Identification Biosynthesis Combinatorial Enzyme-Catalyzed Mechanism Application Antibiotics Anticancer

Yinhua Lu - Shanghai Normal University

Hua Yuan - Shanghai Normal University

Shuangjun Lin - Shanghai Jiao Tong University

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