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Shuangjun Lin
Life Science
Shanghai Jiao Tong University
Shanghai
Language: Chinese, English
Natural Products
Bioactive
Structural Identification
Biosynthesis
Combinatorial
Enzyme-Catalyzed
Mechanism
Application
Antibiotics
Anticancer
Areas of Focus
- Discovery and structural identification of bioactive natural products
- Biosynthesis and combinatorial biosynthesis of natural products
- Mechanism and application of enzyme-catalyzed reactions
Work Experience
- 2015-present, Shanghai Jiao Tong University, Distinguished Professor, Doctoral Supervisor
- 2009-2014, Shanghai Jiao Tong University, Researcher
- 2005-2008, University of Wisconsin-Madison, Research Assistant
- 2002-2005, University of Alberta, Postdoctoral Researcher
Academic Background & Achievements
- 1999-2002, Ph.D. in Organic Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Supervisor: Professor Meixiang Wang
- 1996-1999, Master's in Organic Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Supervisor: Researcher Dayuan Zhu
- 1992-1996, Bachelor's in Organic Chemistry, Jilin University
Publications
- Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily, Zhang Y, Zou Y, Brock NL, Huang T, Lan Y, Wang X, Deng X, Tang Y, Lin S*, 2017
- Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway, Lan Y, Zou Y, Huang T, Wang X, Brock NL, Deng Z, Lin S*, 2016
- Transformation of Streptonigrin to Streptonigrone: Flavin Reductase-Mediated Flavin-Catalyzed Concomitant Oxidative Decarboxylation of Picolinic Acid Derivatives, Wo J, Kong D, Brock NL, Xu F, Zhou X, Deng Z, Lin S*, 2016
- An Acyl Transfer Reaction Catalyzed by an Epimerase MarH, Han M, Yin H, Zou Y, Brock NL, Huang T, Deng Z, Chu Y*, Lin S*, 2016
- Stereospecific biosynthesis of β-methyl tryptophan from L-tryptophan features a stereochemical switch, Zou Y, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S*, 2013
- Characterization of Streptonigrin Biosynthesis Reveals a Cryptic Carboxyl Methylation and an Unusual Oxidative Cleavage of a N-C Bond, Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S*
- Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis, Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B*, 2012
- A Free-Standing Condensation Enzyme Catalyzing Ester Bond Formation in C-1027 Biosynthesis, Lin S, Van Lanen SG and Shen B*, 2009
- Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis, Lin S, Horsman GP, Chen Y, Li W, Shen B*, 2009
- Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517, Huang T, Wang Y, Yin J, Du Y, Tao M, Xu J, Chen W, Lin S*, Deng Z, 2011
Awards
- 2018: Shanghai Jiao Tong University Postdoctoral Reward Fund Supervisor
- 2016: Shanghai Outstanding Doctoral Dissertation Supervisor
- 2014: National Science Fund for Distinguished Young Scholars
- 2014: Jiusan Youth Teacher Award
- 2012: Shanghai Jiao Tong University 'Morning Star Young Scholar Award' Category A
- 2011: Ministry of Education 'New Century Excellent Talents Support Plan'
