Professor | Ke Liu | Asia Growth Partners

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Name	Ke Liu
Contact Information	ke.liu@siat.ac.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Ke Liu

Contact Information

ke.liu@siat.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2009-09 to 2014-06 Ph.D. in Science: Sichuan University, State Key Laboratory of Biotherapy 2005-09 to 2009-07 Bachelor's in Science: Sichuan University, College of Life Sciences/Wu Yuzhang Honors College

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2009-09 to 2014-06 Ph.D. in Science: Sichuan University, State Key Laboratory of Biotherapy
2005-09 to 2009-07 Bachelor's in Science: Sichuan University, College of Life Sciences/Wu Yuzhang Honors College

Areas of Focus	High-throughput screening of natural peptides with anti-tumor bioactivity Identification of new anti-tumor natural peptide molecular targets Design and synthesis of biomimetic artificial peptide molecules for anti-tumor therapy
Publications	Coibamide A kills cancer cells through inhibiting autophagy, Shi, Wenli, Lu, Danyi, Wu, Chunlei, Li, Meiqing, Ding, Zhihao, Li, Yanyan, Chen, Binghua, Lin, Xian, Su, Wu, Shao, Ximing, Xia, Zhihui, Fang, Lijing, Liu, Ke, Li, Hongchang, 2021 Novel N-Methylated Cyclodepsipeptide Prodrugs for Targeted Cancer Therapy, Wu, Chunlei, Cheng, Zhehong, Lu, Danyi, Liu, Ke, Cheng, Yulian, Wang, Pengxin, Zhou, Yimin, Li, Meiqing, Shao, Ximing, Li, Hongchang, Su, Wu, Fang, Lijing, 2021 Aligned Biofunctional Electrospun PLGA-LysoGM1 Scaffold for Traumatic Brain Injury Repair, Tang, Wei, Fang, Fei, Ke, Liu, Huang, Zhi, Li, Hui, Yin, Ying, Wang, Jun, Wang, Guocheng, Wei, Liyu, Ou, Yun, Wang, Yazhou, 2020 Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2, Liu, Ke, Zou, Rongfeng, Cui, Wenqiang, Li, Meiqing, Wang, Xueying, Dong, Junlin, Li, Hongchun, Li, Hongpei, Wang, Peihui, Shao, Ximing, Su, Wu, Chan, H C Stephen, Li, Hongchang, Yuan, Shuguang, 2020 Chlorotoxin-derived bicyclic peptides for targeted imaging of glioblastomas, Li, Meiqing, Shao, Ximing, Wu, Chunlei, Lu, Danyi, Liu, Ke, Wang, Wei, Liu, Jiakai, Li, Hongchang, Su, Wu, Fang, Lijing, 2020 Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues, Yao, Guiyang, Wang, Wei, Ao, Lijiao, Cheng, Zhehong, Wu, Chunlei, Pang, Zhengyin, Liu, Ke, Li, Hongchang, Su, Wu, Fang, Lijing, 2018 Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth In Vivo, Liu, Ke, Fang, Lijing, Sun, Haiyan, Pan, Zhengyin, Zhang, Jianchao, Chen, Juntao, Shao, Ximing, Wang, Wei, Tan, Yuanyan, Ding, Zhihao, Ao, Lijiao, Wu, Chunlei, Liu, Xiaoqi, Li, Huashun, Wang, Rui, Su, Wu, Li, Hongchang, 2018 Polydopamine-Derivated Hierarchical Nanoplatforms for Efficient Dual-Modal Imaging-Guided Combination in Vivo Cancer Therapy, Ao, Lijiao, Wu, Chunlei, Liu, Ke, Wang, Wei, Fang, Lijing, Huang, Liang, Su, Wu, 2018 Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues, Yao, Guiyang, Wang, Wei, Ao, Lijiao, Cheng, Zhehong, Wu, Chunlei, Pang, Zhengyin, Liu, Ke, Li, Hongchang, Su, Wu, Fang, Lijing, 2018 Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B, Pan, Zhengyin, Wu, Chunlei, Wang, Wei, Cheng, Zhehong, Yao, Guiyang, Liu, Ke, Li, Hongchang, Fang, Lijing, Su, Wu, 2017 Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4, Shao, Ximing, Ding, Zhihao, Zhao, Ming, Liu, Ke, Sun, Haiyan, Chen, Juntao, Liu, Xianming, Zhang, Yuzhen, Hong, Yang, Li, Huashun, Li, Hongchang, 2017 Numb positively regulates autophagic flux via regulating lysosomal function, Sun, Haiyan, Liu, Yi, Zhang, Lei, Shao, Ximing, Liu, Ke, Ding, Zhihao, Liu, Xianming, Jiang, Changan, Li, Huashun, Li, Hongchang, 2017 Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4, Shao, Ximing, Ding, Zhihao, Zhao, Ming, Liu, Ke, Sun, Haiyan, Chen, Juntao, Liu, Xianming, Zhang, Yuzhen, Hong, Yang, Li, Huashun, Li, Hongchang, 2017 NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling, Zhang, Jianchao, Shao, Ximing, Sun, Haiyan, Liu, Ke, Ding, Zhihao, Chen, Juntao, Fang, Lijing, Su, Wu, Hong, Yang, Li, Huashun, Li, Hongchang, 2016 Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity, Liu, Ke, Lei, Run, Li, Qiong, Wang, XinXin, Wu, Qian, An, Peng, Zhang, Jianchao, Zhu, Minyan, Xu, Zhiheng, Hong, Yang, Wang, Fudi, Shen, Ying, Li, Hongchang, Li, Huashun, 2016 G alpha s regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression, Liu, Ke, Lin, Quan, Wei, Yanxia, He, Renbing, Shao, Ximing, Ding, Zhihao, Zhang, Jianchao, Zhu, Minyan, Weinstein, Lee S, Hong, Yang, Li, Hongchang, Li, Huashun, 2015 G alpha(s) Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity, Shao, Ximing, Liu, Ke, Fan, Yi, Ding, Zhihao, Chen, Min, Zhu, Minyan, Weinstein, Lee S, Li, Hongchang, Li, Huashun, 2015

Areas of Focus

High-throughput screening of natural peptides with anti-tumor bioactivity
Identification of new anti-tumor natural peptide molecular targets
Design and synthesis of biomimetic artificial peptide molecules for anti-tumor therapy

Publications

Coibamide A kills cancer cells through inhibiting autophagy, Shi, Wenli, Lu, Danyi, Wu, Chunlei, Li, Meiqing, Ding, Zhihao, Li, Yanyan, Chen, Binghua, Lin, Xian, Su, Wu, Shao, Ximing, Xia, Zhihui, Fang, Lijing, Liu, Ke, Li, Hongchang, 2021
Novel N-Methylated Cyclodepsipeptide Prodrugs for Targeted Cancer Therapy, Wu, Chunlei, Cheng, Zhehong, Lu, Danyi, Liu, Ke, Cheng, Yulian, Wang, Pengxin, Zhou, Yimin, Li, Meiqing, Shao, Ximing, Li, Hongchang, Su, Wu, Fang, Lijing, 2021
Aligned Biofunctional Electrospun PLGA-LysoGM1 Scaffold for Traumatic Brain Injury Repair, Tang, Wei, Fang, Fei, Ke, Liu, Huang, Zhi, Li, Hui, Yin, Ying, Wang, Jun, Wang, Guocheng, Wei, Liyu, Ou, Yun, Wang, Yazhou, 2020
Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2, Liu, Ke, Zou, Rongfeng, Cui, Wenqiang, Li, Meiqing, Wang, Xueying, Dong, Junlin, Li, Hongchun, Li, Hongpei, Wang, Peihui, Shao, Ximing, Su, Wu, Chan, H C Stephen, Li, Hongchang, Yuan, Shuguang, 2020
Chlorotoxin-derived bicyclic peptides for targeted imaging of glioblastomas, Li, Meiqing, Shao, Ximing, Wu, Chunlei, Lu, Danyi, Liu, Ke, Wang, Wei, Liu, Jiakai, Li, Hongchang, Su, Wu, Fang, Lijing, 2020
Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues, Yao, Guiyang, Wang, Wei, Ao, Lijiao, Cheng, Zhehong, Wu, Chunlei, Pang, Zhengyin, Liu, Ke, Li, Hongchang, Su, Wu, Fang, Lijing, 2018
Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth In Vivo, Liu, Ke, Fang, Lijing, Sun, Haiyan, Pan, Zhengyin, Zhang, Jianchao, Chen, Juntao, Shao, Ximing, Wang, Wei, Tan, Yuanyan, Ding, Zhihao, Ao, Lijiao, Wu, Chunlei, Liu, Xiaoqi, Li, Huashun, Wang, Rui, Su, Wu, Li, Hongchang, 2018
Polydopamine-Derivated Hierarchical Nanoplatforms for Efficient Dual-Modal Imaging-Guided Combination in Vivo Cancer Therapy, Ao, Lijiao, Wu, Chunlei, Liu, Ke, Wang, Wei, Fang, Lijing, Huang, Liang, Su, Wu, 2018
Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues, Yao, Guiyang, Wang, Wei, Ao, Lijiao, Cheng, Zhehong, Wu, Chunlei, Pang, Zhengyin, Liu, Ke, Li, Hongchang, Su, Wu, Fang, Lijing, 2018
Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B, Pan, Zhengyin, Wu, Chunlei, Wang, Wei, Cheng, Zhehong, Yao, Guiyang, Liu, Ke, Li, Hongchang, Fang, Lijing, Su, Wu, 2017
Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4, Shao, Ximing, Ding, Zhihao, Zhao, Ming, Liu, Ke, Sun, Haiyan, Chen, Juntao, Liu, Xianming, Zhang, Yuzhen, Hong, Yang, Li, Huashun, Li, Hongchang, 2017
Numb positively regulates autophagic flux via regulating lysosomal function, Sun, Haiyan, Liu, Yi, Zhang, Lei, Shao, Ximing, Liu, Ke, Ding, Zhihao, Liu, Xianming, Jiang, Changan, Li, Huashun, Li, Hongchang, 2017
Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4, Shao, Ximing, Ding, Zhihao, Zhao, Ming, Liu, Ke, Sun, Haiyan, Chen, Juntao, Liu, Xianming, Zhang, Yuzhen, Hong, Yang, Li, Huashun, Li, Hongchang, 2017
NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling, Zhang, Jianchao, Shao, Ximing, Sun, Haiyan, Liu, Ke, Ding, Zhihao, Chen, Juntao, Fang, Lijing, Su, Wu, Hong, Yang, Li, Huashun, Li, Hongchang, 2016
Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity, Liu, Ke, Lei, Run, Li, Qiong, Wang, XinXin, Wu, Qian, An, Peng, Zhang, Jianchao, Zhu, Minyan, Xu, Zhiheng, Hong, Yang, Wang, Fudi, Shen, Ying, Li, Hongchang, Li, Huashun, 2016
G alpha s regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression, Liu, Ke, Lin, Quan, Wei, Yanxia, He, Renbing, Shao, Ximing, Ding, Zhihao, Zhang, Jianchao, Zhu, Minyan, Weinstein, Lee S, Hong, Yang, Li, Hongchang, Li, Huashun, 2015
G alpha(s) Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity, Shao, Ximing, Liu, Ke, Fan, Yi, Ding, Zhihao, Chen, Min, Zhu, Minyan, Weinstein, Lee S, Li, Hongchang, Li, Huashun, 2015

Natural Peptides Anti-Tumor High-Throughput Screening Bioactivity Molecular Targets Biomimetic Artificial Peptides Cancer Therapy Peptide Synthesis Tumor Targeting

Tuying Yong - Huazhong University of Science and Technology

Lanlan Liu - University of Chinese Academy of Sciences

Yanping Xu - Tongji University

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