Professor | Mofang Liu | Asia Growth Partners

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Name	Mofang Liu
Contact Information	mfliu@sibcb.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Mofang Liu

Contact Information

mfliu@sibcb.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1997-09--2000-08 PhD: Shanghai Institute of Biochemistry, Chinese Academy of Sciences 1991-09--1994-07 Master's: East China University of Science and Technology 1987-09--1991-07 Bachelor's: East China University of Science and Technology
Work Experience	2020-04~Present - Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science - Professor 2006-01~2020-04 - Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences - Professor 2004-11~2006-01 - Johns Hopkins University School of Medicine - Research Assistant 2000-09~2004-10 - National Cancer Institute, National Institutes of Health - Postdoctoral Fellow 1994-07~1997-09 - East China University of Science and Technology - Lecturer
Awards	Shanghai Natural Science Award, First Prize (2023) National Maternal and Child Health Science and Technology Award, First Prize (2019) Tan Jiazhen Life Science Innovation Award (2018) National Hundred, Thousand, and Ten Thousand Talent Project (2017) Shanghai Women's Innovation Award (2017) Top Ten Advances in Life Sciences in China (2017) Shanghai Outstanding Academic Leader (2016) Outstanding Graduate Advisor of the Chinese Academy of Sciences, First Prize (2014)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1997-09--2000-08 PhD: Shanghai Institute of Biochemistry, Chinese Academy of Sciences
1991-09--1994-07 Master's: East China University of Science and Technology
1987-09--1991-07 Bachelor's: East China University of Science and Technology

Work Experience

2020-04~Present - Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science - Professor
2006-01~2020-04 - Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences - Professor
2004-11~2006-01 - Johns Hopkins University School of Medicine - Research Assistant
2000-09~2004-10 - National Cancer Institute, National Institutes of Health - Postdoctoral Fellow
1994-07~1997-09 - East China University of Science and Technology - Lecturer

Awards

Shanghai Natural Science Award, First Prize (2023)
National Maternal and Child Health Science and Technology Award, First Prize (2019)
Tan Jiazhen Life Science Innovation Award (2018)
National Hundred, Thousand, and Ten Thousand Talent Project (2017)
Shanghai Women's Innovation Award (2017)
Top Ten Advances in Life Sciences in China (2017)
Shanghai Outstanding Academic Leader (2016)
Outstanding Graduate Advisor of the Chinese Academy of Sciences, First Prize (2014)

Areas of Focus	Function and Mechanism of Non-coding RNA in Spermatogenesis and Male Infertility Function and Mechanism of Non-coding RNA in Tumorigenesis
Publications	The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility, Liu, Mofang, 2023 Emerging roles and functional mechanisms of PIWI-interacting RNAs, Liu, Mofang, 2023 LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs, Liu, Mofang, 2022 piRNA 3′uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells, Liu, Mofang, 2022 Defective piRNA Processing and Azoospermia, Liu, Mofang, 2022 Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases, Liu, Mofang, 2022 The Study of MIWI/piRNA-Mediated mRNA Translational Activation during Mouse Spermiogenesis, Liu, Mofang, 2020 LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice, Liu, Mofang, 2020 piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis, Liu, Mofang, 2020 A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis, Liu, Mofang, 2019 KRAS-NFκB-YY1-miR-489 signaling axis controls pancreatic cancer metastasis, Liu, Mofang, 2017 MicroRNA regulation and analytical methods in cancer cell metabolism, Liu, Mofang, 2017 Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis, Liu, Mofang, 2017 miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells, Liu, Mofang, 2016 Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma, Liu, Mofang, 2015 MIWI and piRNA-Mediated Cleavage of Messenger RNAs in Mouse Testes, Liu, Mofang, 2015 IL-1b-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis, Liu, Mofang, 2014 MicroRNA-155 broadly orchestrates inflammation-induced changes of microRNA expression in breast cancer, Liu, Mofang, 2014 Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation, Liu, Mofang, 2014 Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis, Liu, Mofang, 2014 piRNA-Triggered MIWI Ubiquitination and Removal by APC/C in Late Spermatogenesis, Liu, Mofang, 2013 Onconase downregulates microRNA expression through targeting microRNA precursors, Liu, Mofang, 2012 A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells, Liu, Mofang, 2012 MicroRNA-155 Functions as an OncomiR in Breast Cancer by Targeting the Suppressor of Cytokine Signaling 1 Gene, Liu, Mofang, 2010 Genetic Deficiency of Mtdh Gene in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs, Liu, Mofang

Areas of Focus

Function and Mechanism of Non-coding RNA in Spermatogenesis and Male Infertility
Function and Mechanism of Non-coding RNA in Tumorigenesis

Publications

The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility, Liu, Mofang, 2023
Emerging roles and functional mechanisms of PIWI-interacting RNAs, Liu, Mofang, 2023
LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs, Liu, Mofang, 2022
piRNA 3′uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells, Liu, Mofang, 2022
Defective piRNA Processing and Azoospermia, Liu, Mofang, 2022
Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases, Liu, Mofang, 2022
The Study of MIWI/piRNA-Mediated mRNA Translational Activation during Mouse Spermiogenesis, Liu, Mofang, 2020
LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice, Liu, Mofang, 2020
piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis, Liu, Mofang, 2020
A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis, Liu, Mofang, 2019
KRAS-NFκB-YY1-miR-489 signaling axis controls pancreatic cancer metastasis, Liu, Mofang, 2017
MicroRNA regulation and analytical methods in cancer cell metabolism, Liu, Mofang, 2017
Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis, Liu, Mofang, 2017
miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells, Liu, Mofang, 2016
Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma, Liu, Mofang, 2015
MIWI and piRNA-Mediated Cleavage of Messenger RNAs in Mouse Testes, Liu, Mofang, 2015
IL-1b-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis, Liu, Mofang, 2014
MicroRNA-155 broadly orchestrates inflammation-induced changes of microRNA expression in breast cancer, Liu, Mofang, 2014
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation, Liu, Mofang, 2014
Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis, Liu, Mofang, 2014
piRNA-Triggered MIWI Ubiquitination and Removal by APC/C in Late Spermatogenesis, Liu, Mofang, 2013
Onconase downregulates microRNA expression through targeting microRNA precursors, Liu, Mofang, 2012
A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells, Liu, Mofang, 2012
MicroRNA-155 Functions as an OncomiR in Breast Cancer by Targeting the Suppressor of Cytokine Signaling 1 Gene, Liu, Mofang, 2010
Genetic Deficiency of Mtdh Gene in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs, Liu, Mofang

Non-Coding Rna Spermatogenesis Male Infertility Tumorigenesis Piwi-Interacting Rnas Rna Regulation Gene Expression Molecular Biology Cell Biology Reproductive Biology

Jing Xie - Tongji University

Jianfeng Chang - Tongji University

You Wu - Tongji University

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