Upload Avatar (500 x 500)
Mofang Liu
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Non-Coding Rna
Spermatogenesis
Male Infertility
Tumorigenesis
Piwi-Interacting Rnas
Rna Regulation
Gene Expression
Molecular Biology
Cell Biology
Reproductive Biology
Areas of Focus
- Function and Mechanism of Non-coding RNA in Spermatogenesis and Male Infertility
- Function and Mechanism of Non-coding RNA in Tumorigenesis
Work Experience
- 2020-04~Present - Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science - Professor
- 2006-01~2020-04 - Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences - Professor
- 2004-11~2006-01 - Johns Hopkins University School of Medicine - Research Assistant
- 2000-09~2004-10 - National Cancer Institute, National Institutes of Health - Postdoctoral Fellow
- 1994-07~1997-09 - East China University of Science and Technology - Lecturer
Academic Background & Achievements
- 1997-09--2000-08 PhD: Shanghai Institute of Biochemistry, Chinese Academy of Sciences
- 1991-09--1994-07 Master's: East China University of Science and Technology
- 1987-09--1991-07 Bachelor's: East China University of Science and Technology
Publications
- The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility, Liu, Mofang, 2023
- Emerging roles and functional mechanisms of PIWI-interacting RNAs, Liu, Mofang, 2023
- LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs, Liu, Mofang, 2022
- piRNA 3′uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells, Liu, Mofang, 2022
- Defective piRNA Processing and Azoospermia, Liu, Mofang, 2022
- Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases, Liu, Mofang, 2022
- The Study of MIWI/piRNA-Mediated mRNA Translational Activation during Mouse Spermiogenesis, Liu, Mofang, 2020
- LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice, Liu, Mofang, 2020
- piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis, Liu, Mofang, 2020
- A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis, Liu, Mofang, 2019
- KRAS-NFκB-YY1-miR-489 signaling axis controls pancreatic cancer metastasis, Liu, Mofang, 2017
- MicroRNA regulation and analytical methods in cancer cell metabolism, Liu, Mofang, 2017
- Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis, Liu, Mofang, 2017
- miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells, Liu, Mofang, 2016
- Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma, Liu, Mofang, 2015
- MIWI and piRNA-Mediated Cleavage of Messenger RNAs in Mouse Testes, Liu, Mofang, 2015
- IL-1b-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis, Liu, Mofang, 2014
- MicroRNA-155 broadly orchestrates inflammation-induced changes of microRNA expression in breast cancer, Liu, Mofang, 2014
- Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation, Liu, Mofang, 2014
- Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis, Liu, Mofang, 2014
- piRNA-Triggered MIWI Ubiquitination and Removal by APC/C in Late Spermatogenesis, Liu, Mofang, 2013
- Onconase downregulates microRNA expression through targeting microRNA precursors, Liu, Mofang, 2012
- A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells, Liu, Mofang, 2012
- MicroRNA-155 Functions as an OncomiR in Breast Cancer by Targeting the Suppressor of Cytokine Signaling 1 Gene, Liu, Mofang, 2010
- Genetic Deficiency of Mtdh Gene in Mice Causes Male Infertility via Impaired Spermatogenesis and Alterations in the Expression of Small Non-coding RNAs, Liu, Mofang
Awards
- Shanghai Natural Science Award, First Prize (2023)
- National Maternal and Child Health Science and Technology Award, First Prize (2019)
- Tan Jiazhen Life Science Innovation Award (2018)
- National Hundred, Thousand, and Ten Thousand Talent Project (2017)
- Shanghai Women's Innovation Award (2017)
- Top Ten Advances in Life Sciences in China (2017)
- Shanghai Outstanding Academic Leader (2016)
- Outstanding Graduate Advisor of the Chinese Academy of Sciences, First Prize (2014)
