Professor | 刘默芳 | 数字化转型顾问

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Name	刘默芳
Contact Information	mfliu@sibcb.ac.cn
Language ability	中文, 英语
Province	上海

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Name

刘默芳

Contact Information

mfliu@sibcb.ac.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	1997-09--2000-08 博士: 中国科学院上海生物化学研究所 1991-09--1994-07 硕士: 华东理工大学 1987-09--1991-07 学士: 华东理工大学
Work Experience	2020-04~现在 - 中国科学院分子细胞科学卓越创新中心 - 教授 2006-01~2020-04 - 中国科学院上海生命科学研究院 - 教授 2004-11~2006-01 - 美国约翰霍普金斯医学院 - 研究助理 2000-09~2004-10 - 美国国家健康研究院国立癌症研究所 - 博士后 1994-07~1997-09 - 华东理工大学 - 讲师
Awards	上海市自然科学奖, 一等奖 (2023) 全国妇幼健康科学技术奖自然科学, 一等奖 (2019) 谈家桢生命科学创新奖 (2018) 国家百千万人才工程 (2017) 上海市巾帼创新奖 (2017) 中国生命科学十大进展 (2017) 上海市优秀学术带头人 (2016) 中科院优秀研究生指导教师, 一等奖 (2014)

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

1997-09--2000-08 博士: 中国科学院上海生物化学研究所
1991-09--1994-07 硕士: 华东理工大学
1987-09--1991-07 学士: 华东理工大学

Work Experience

2020-04~现在 - 中国科学院分子细胞科学卓越创新中心 - 教授
2006-01~2020-04 - 中国科学院上海生命科学研究院 - 教授
2004-11~2006-01 - 美国约翰霍普金斯医学院 - 研究助理
2000-09~2004-10 - 美国国家健康研究院国立癌症研究所 - 博士后
1994-07~1997-09 - 华东理工大学 - 讲师

Awards

上海市自然科学奖, 一等奖 (2023)
全国妇幼健康科学技术奖自然科学, 一等奖 (2019)
谈家桢生命科学创新奖 (2018)
国家百千万人才工程 (2017)
上海市巾帼创新奖 (2017)
中国生命科学十大进展 (2017)
上海市优秀学术带头人 (2016)
中科院优秀研究生指导教师, 一等奖 (2014)

Areas of Focus	非编码RNA在精子发生和男性不育中的功能机制非编码RNA在肿瘤发生中的功能机制研究
Publications	The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility, 刘默芳, 2023 Emerging roles and functional mechanisms of PIWI-interacting RNAs, 刘默芳, 2023 LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs, 刘默芳, 2022 piRNA 3′uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells, 刘默芳, 2022 Defective piRNA Processing and Azoospermia, 刘默芳, 2022 Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases, 刘默芳, 2022 The Study of MIWI/piRNA-Mediated mRNA Translational Activation during Mouse Spermiogenesis, 刘默芳, 2020 LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice, 刘默芳, 2020 piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis, 刘默芳, 2020 A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis, 刘默芳, 2019 KRAS-NFκB-YY1-miR-489 signaling axis controls pancreatic cancer metastasis, 刘默芳, 2017 MicroRNA regulation and analytical methods in cancer cell metabolism, 刘默芳, 2017 Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis, 刘默芳, 2017 miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells, 刘默芳, 2016 Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma, 刘默芳, 2015 MIWI and piRNA-Mediated Cleavage of Messenger RNAs in Mouse Testes, 刘默芳, 2015 IL-1b-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis, 刘默芳, 2014 MicroRNA-155 broadly orchestrates inflammation-induced changes of microRNA expression in breast cancer, 刘默芳, 2014 Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation, 刘默芳, 2014

Areas of Focus

非编码RNA在精子发生和男性不育中的功能机制
非编码RNA在肿瘤发生中的功能机制研究

Publications

The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility, 刘默芳, 2023
Emerging roles and functional mechanisms of PIWI-interacting RNAs, 刘默芳, 2023
LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs, 刘默芳, 2022
piRNA 3′uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells, 刘默芳, 2022
Defective piRNA Processing and Azoospermia, 刘默芳, 2022
Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases, 刘默芳, 2022
The Study of MIWI/piRNA-Mediated mRNA Translational Activation during Mouse Spermiogenesis, 刘默芳, 2020
LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice, 刘默芳, 2020
piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis, 刘默芳, 2020
A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis, 刘默芳, 2019
KRAS-NFκB-YY1-miR-489 signaling axis controls pancreatic cancer metastasis, 刘默芳, 2017
MicroRNA regulation and analytical methods in cancer cell metabolism, 刘默芳, 2017
Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis, 刘默芳, 2017
miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells, 刘默芳, 2016
Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma, 刘默芳, 2015
MIWI and piRNA-Mediated Cleavage of Messenger RNAs in Mouse Testes, 刘默芳, 2015
IL-1b-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis, 刘默芳, 2014
MicroRNA-155 broadly orchestrates inflammation-induced changes of microRNA expression in breast cancer, 刘默芳, 2014
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation, 刘默芳, 2014

非编码Rna 精子发生男性不育肿瘤发生 Piwi相互作用Rna Rna调控基因表达分子生物学细胞生物学生殖生物学

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