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刘默芳
Life Science
中国科学院大学
上海
Language: 中文, 英语
非编码Rna
精子发生
男性不育
肿瘤发生
Piwi相互作用Rna
Rna调控
基因表达
分子生物学
细胞生物学
生殖生物学
Areas of Focus
- 非编码RNA在精子发生和男性不育中的功能机制
- 非编码RNA在肿瘤发生中的功能机制研究
Work Experience
- 2020-04~现在 - 中国科学院分子细胞科学卓越创新中心 - 教授
- 2006-01~2020-04 - 中国科学院上海生命科学研究院 - 教授
- 2004-11~2006-01 - 美国约翰霍普金斯医学院 - 研究助理
- 2000-09~2004-10 - 美国国家健康研究院国立癌症研究所 - 博士后
- 1994-07~1997-09 - 华东理工大学 - 讲师
Academic Background & Achievements
- 1997-09--2000-08 博士: 中国科学院上海生物化学研究所
- 1991-09--1994-07 硕士: 华东理工大学
- 1987-09--1991-07 学士: 华东理工大学
Publications
- The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility, 刘默芳, 2023
- Emerging roles and functional mechanisms of PIWI-interacting RNAs, 刘默芳, 2023
- LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs, 刘默芳, 2022
- piRNA 3′uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells, 刘默芳, 2022
- Defective piRNA Processing and Azoospermia, 刘默芳, 2022
- Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases, 刘默芳, 2022
- The Study of MIWI/piRNA-Mediated mRNA Translational Activation during Mouse Spermiogenesis, 刘默芳, 2020
- LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice, 刘默芳, 2020
- piRNA-independent function of PIWIL1 as a co-activator for anaphase promoting complex/cyclosome to drive pancreatic cancer metastasis, 刘默芳, 2020
- A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis, 刘默芳, 2019
- KRAS-NFκB-YY1-miR-489 signaling axis controls pancreatic cancer metastasis, 刘默芳, 2017
- MicroRNA regulation and analytical methods in cancer cell metabolism, 刘默芳, 2017
- Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis, 刘默芳, 2017
- miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells, 刘默芳, 2016
- Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma, 刘默芳, 2015
- MIWI and piRNA-Mediated Cleavage of Messenger RNAs in Mouse Testes, 刘默芳, 2015
- IL-1b-Mediated Repression of microRNA-101 Is Crucial for Inflammation-Promoted Lung Tumorigenesis, 刘默芳, 2014
- MicroRNA-155 broadly orchestrates inflammation-induced changes of microRNA expression in breast cancer, 刘默芳, 2014
- Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation, 刘默芳, 2014
Awards
- 上海市自然科学奖, 一等奖 (2023)
- 全国妇幼健康科学技术奖自然科学, 一等奖 (2019)
- 谈家桢生命科学创新奖 (2018)
- 国家百千万人才工程 (2017)
- 上海市巾帼创新奖 (2017)
- 中国生命科学十大进展 (2017)
- 上海市优秀学术带头人 (2016)
- 中科院优秀研究生指导教师, 一等奖 (2014)
