Professor | Dianfan Li | Asia Growth Partners

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Name	Dianfan Li
Contact Information	dianfan.li@sibcb.ac.cn
Language ability	Chinese, English
Province	Shanghai

Upload Avatar (500 x 500)

Name

Dianfan Li

Contact Information

dianfan.li@sibcb.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Areas of Focus	Membrane protein structure and function
Publications	Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis, Jingjing Hong, Tingting Li, Yulin Chao, Yidan Xu, Zhini Zhu, Zixuan Zhou, Weijie Gu, Qianhui Qu, Dianfan Li, 2024 Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis, Xu, Yidan, Li, Tingting, Zhou, Zixuan, Hong, Jingjing, Chao, Yulin, Zhu, Zhini, Zhang, Ying, Qu, Qianhui, Li, Dianfan, 2023 A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy, Meng, Lu, Zha, Jialu, Zhou, Bingjie, Cao, Long, Jiang, Congli, Zhu, Yuanfei, Li, Teng, Lu, Lu, Zhang, Junqi, Yang, Heng, Feng, Jian, Gu, Zhifeng, Tang, Hong, Jiang, Lubin, Li, Dianfan, Lavillette, Dimitri, Zhang, Xiaoming, 2023 Structural Characterization of a Neutralizing Nanobody With Broad Activity Against SARS-CoV-2 Variants, Li, Tingting, Zhou, Bingjie, Luo, Zhipu, Lai, Yanling, Huang, Suqiong, Zhou, Yuanze, Li, Yaning, Gautam, Anupriya, Bourgeau, Salome, Wang, Shurui, Bao, Juan, Tan, Jingquan, Lavillette, Dimitri, Li, Dianfan, 2022 Structural insights into auxin recognition and efflux by Arabidopsis PIN1, Yang, Zhisen, Xia, Jing, Hong, Jingjing, Zhang, Chenxi, Wei, Hong, Ying, Wei, Sun, Chunqiao, Sun, Lianghanxiao, Mao, Yanbo, Gao, Yongxiang, Tan, Shutang, Friml, Jiri, Li, Dianfan, Liu, Xin, Sun, Linfeng, 2022 Selenourea for Experimental Phasing of Membrane Protein Crystals Grown in Lipid Cubic Phase, Luo, Zhipu, Gu, Weijie, Wang, Yichao, Tang, Yannan, Li, Dianfan, 2022 Isolation, characterization, and structure-based engineering of a neutralizing nanobody against SARS-CoV-2, Tingting Li, Bingjie Zhou, Yaning Li, Suqiong Huang, Zhipu Luo, Yuanze Zhou, Yanling Lai, Anupriya Gautam, Salome Bourgeau, Shurui Wang, Juan Bao, Jingquan Tan, Dimitri Lavillette, Dianfan Li, 2022 Molecular insights into biogenesis of glycosylphosphatidylinositol anchor proteins, Xu, Yidan, Jia, Guowen, Li, Tingting, Zhou, Zixuan, Luo, Yitian, Chao, Yulin, Bao, Juan, Su, Zhaoming, Qu, Qianhui, Li, Dianfan, 2022 Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae, Luo, Yitian, Wan, Guoyue, Zhang, Xiang, Zhou, Xuan, Wang, Qiuwen, Fan, Jialin, Cai, Hongmin, Ma, Liya, Wu, Hailong, Qu, Qianhui, Cong, Yao, Zhao, Yun, Li, Dianfan, 2021 A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2, Hebang Yao, Hongmin Cai, Tingting Li, Bingjie Zhou, Wenming Qin, Dimitri Lavillette, Dianfan Li, 2021 A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection, Li, Tingting, Cai, Hongmin, Yao, Hebang, Zhou, Bingjie, Zhang, Ning, van Vlissingen, Martje Fentener, Kuiken, Thijs, Han, Wenyu, GeurtsvanKessel, Corine H, Gong, Yuhuan, Zhao, Yapei, Shen, Quan, Qin, Wenming, Tian, XiaoXu, Peng, Chao, Lai, Yanling, Wang, Yanxing, Hutter, Cedric A J, Kuo, ShuMing, Bao, Juan, Liu, Caixuan, Wang, Yifan, Richard, Audrey S, Raoul, Herve, Lan, Jiaming, Seeger, Markus A, Cong, Yao, Rockx, Barry, Wong, Gary, Bi, Yuhai, Lavillette, Dimitri, Li, Dianfan, 2021 The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface, Bowei Yang, Hebang Yao, Dianfan Li, Liu, Zhenfeng, 2021 Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release, Luo, Yitian, Wan, Guoyue, Zhou, Xuan, Wang, Qiuwen, Zhang, Yunbin, Bao, Juan, Cong, Yao, Zhao, Yun, Li, Dianfan, 2021 Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody, Li, Tingting, Cai, Hongmin, Zhao, Yapei, Li, Yanfang, Lai, Yanling, Yao, Hebang, Liu, Liu Daisy, Sun, Zhou, van Vlissingen, Martje Fentener, Kuiken, Thijs, GeurtsvanKessel, Corine H, Zhang, Ning, Zhou, Bingjie, Lu, Lu, Gong, Yuhuan, Qin, Wenming, Mondal, Moumita, Duan, Bowen, Xu, Shiqi, Richard, Audrey S, Raoul, Herve, Chen, JianFeng, Xu, Chenqi, Wu, Ligang, Zhou, Haisheng, Huang, Zhong, Zhang, Xuechao, Li, Jun, Wang, Yanyan, Bi, Yuhai, Rockx, Barry, Chen, Junfang, Meng, FeiLong, Lavillette, Dimitri, Li, Dianfan, 2021 Thermostabilization of Membrane Proteins by Consensus Mutation: A Case Study for a Fungal Δ8-7 Sterol Isomerase, Hebang Yao, Hongmin Cai, Dianfan Li, 2020 An improved fluorescent tag and its nanobodies for membrane protein expression, stability assay, and purification, Hongmin Cai, Hebang Yao, Tingting Li, Cedric A J Hutter, Yanfang Li, Yannan Tang, Markus A Seeger, Dianfan Li, 2020 Structure and Functional Characterization of Membrane Integral Proteins in the Lipid Cubic Phase, Li, Dianfan, Caffrey, Martin, 2020 Structural Characterization of the N-Terminal Domain of the Dictyostelium discoideum Mitochondrial Calcium Uniporter, Yuan, Yuan, Cao, Chan, Wen, Maorong, Li, Min, Dong, Ying, Wu, Lijie, Wu, Jian, Cui, Tanxing, Li, Dianfan, Chou, James J, OuYang, Bo, 2020 Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers, Wang Daisong, Hu Xin, Liu Chunye, Jia Yingying, Bai Yiqin, Cai Cheguo, Wang Jingqiang, Bai Lanyue, Yang Ruikai, Lin Changdong, Liu Yirong, Li Shan, Qiao Feng, Yao Ling, Chen Li, Ge Gaoxiang, Jiang Hai, Li Dianfan, Li Lin, Chen Jianfeng, Shao Zhiming, Zeng Yi Arial, 2019 High-level heterologous expression of the human transmembrane sterol Δ8,Δ7-isomerase in Pichia pastoris, Hongmin Cai, Hebang Yao, Tingting Li, Yannan Tang, Dianfan Li, 2019 Developing a High-Throughput Assay for the Integral Membrane Glycerol 3-Phosphate Acyltransferase, Tang, Yannan, Li, Dianfan, 2019 In Meso Crystallization of the Integral Membrane Glycerol 3-Phosphate Acyltransferase with Substrates, Li, Zhenjian, Tang, Yannan, Li, Dianfan, 2018 Structure and mechanism of a group-I cobalt energy coupling factor transporter, Bao, Zhihao, Qi, Xiaofeng, Hong, Sen, Xu, Ke, He, Fangyuan, Zhang, Minhua, Chen, Jiugeng, Chao, Daiyin, Zhao, Wei, Li, Dianfan, Wang, Jiawei, Zhang, Peng, 2017 Structural basis for lipopolysaccharide extraction by ABC transporter LptB(2)FG, Luo, Qingshan, Yang, Xu, Yu, Shan, Shi, Huigang, Wang, Kun, Xiao, Le, Zhu, Guangyu, Sun, Chuanqi, Li, Tingting, Li, Dianfan, Zhang, Xinzheng, Zhou, Min, Huang, Yihua, 2017 Structural insights into the committed step of bacterial phospholipid biosynthesis, Zhenjian Li, Yannan Tang, Yiran Wu, Suwen Zhao, Juan Bao, Yitian Luo, Dianfan Li, 2017 Cholesterol homeostasis: How do cells sense sterol excess?, Howe, Vicky, Sharpe, Laura J, Alexopoulos, Stephanie J, Kunze, Sarah V, Chua, Ngee Kiat, Li, Dianfan, Brown, Andrew J, 2016 DHCR7: A vital enzyme switch between cholesterol and vitamin D production, Prabhu, Anika V, Luu, Winnie, Li, Dianfan, Sharpe, Laura J, Brown, Andrew J, 2016 X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex, Zhou, X Edward, Gao, Xiang, Barty, Anton, Kang, Yanyong, He, Yuanzheng, Liu, Wei, Ishchenko, Andrii, White, Thomas A, Yefanov, Oleksandr, Han, Gye Won, Xu, Qingping, de Waal, Parker W, SuinoPowell, Kelly M, Boutet, Sebastien, Williams, Garth J, Wang, Meitian, Li, Dianfan, Caffrey, Martin, Chapman, Henry N, Spence, John C H, Fromme, Petra, Weierstall, Uwe, Stevens, Raymond C, Cherezov, Vadim, Melcher, Karsten, Xu, H Eric, 2016 Data-collection strategy for challenging native SAD phasing, Olieric, Vincent, Weinert, Tobias, Finke, Aaron D, Anders, Carolin, Li, Dianfan, Olieric, Natacha, Borca, Camelia N, Steinmetz, Michel O, Caffrey, Martin, Jinek, Martin, Wang, Meitian, 2016 Fast native-SAD phasing for routine macromolecular structure determination (vol 12, pg 131, 2015), Weinert, Tobias, Olieric, Vincent, Waltersperger, Sandro, Panepucci, Ezequiel, Chen, Lirong, Zhang, Hua, Zhou, Dayong, Rose, John, Ebihara, Akio, Kuramitsu, Seiki, Li, Dianfan, Howe, Nicole, Schnapp, Gisela, Pautsch, Alexander, Bargsten, Katja, Prota, Andrea E, Surana, Parag, Kottur, Jithesh, Nair, Deepak T, Basilico, Federica, Cecatiello, Valentina, Pasqualato, Sebastiano, Boland, Andreas, Weichenrieder, Oliver, Wang, BiCheng, Steinmetz, Michel O, Caffrey, Martin, Wang, Meitian, 2015 Ternary structure reveals mechanism of a membrane diacylglycerol kinase, Li, Dianfan, Stansfeld, Phillip J, Sansom,

Areas of Focus

Membrane protein structure and function

Publications

Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis, Jingjing Hong, Tingting Li, Yulin Chao, Yidan Xu, Zhini Zhu, Zixuan Zhou, Weijie Gu, Qianhui Qu, Dianfan Li, 2024
Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis, Xu, Yidan, Li, Tingting, Zhou, Zixuan, Hong, Jingjing, Chao, Yulin, Zhu, Zhini, Zhang, Ying, Qu, Qianhui, Li, Dianfan, 2023
A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy, Meng, Lu, Zha, Jialu, Zhou, Bingjie, Cao, Long, Jiang, Congli, Zhu, Yuanfei, Li, Teng, Lu, Lu, Zhang, Junqi, Yang, Heng, Feng, Jian, Gu, Zhifeng, Tang, Hong, Jiang, Lubin, Li, Dianfan, Lavillette, Dimitri, Zhang, Xiaoming, 2023
Structural Characterization of a Neutralizing Nanobody With Broad Activity Against SARS-CoV-2 Variants, Li, Tingting, Zhou, Bingjie, Luo, Zhipu, Lai, Yanling, Huang, Suqiong, Zhou, Yuanze, Li, Yaning, Gautam, Anupriya, Bourgeau, Salome, Wang, Shurui, Bao, Juan, Tan, Jingquan, Lavillette, Dimitri, Li, Dianfan, 2022
Structural insights into auxin recognition and efflux by Arabidopsis PIN1, Yang, Zhisen, Xia, Jing, Hong, Jingjing, Zhang, Chenxi, Wei, Hong, Ying, Wei, Sun, Chunqiao, Sun, Lianghanxiao, Mao, Yanbo, Gao, Yongxiang, Tan, Shutang, Friml, Jiri, Li, Dianfan, Liu, Xin, Sun, Linfeng, 2022
Selenourea for Experimental Phasing of Membrane Protein Crystals Grown in Lipid Cubic Phase, Luo, Zhipu, Gu, Weijie, Wang, Yichao, Tang, Yannan, Li, Dianfan, 2022
Isolation, characterization, and structure-based engineering of a neutralizing nanobody against SARS-CoV-2, Tingting Li, Bingjie Zhou, Yaning Li, Suqiong Huang, Zhipu Luo, Yuanze Zhou, Yanling Lai, Anupriya Gautam, Salome Bourgeau, Shurui Wang, Juan Bao, Jingquan Tan, Dimitri Lavillette, Dianfan Li, 2022
Molecular insights into biogenesis of glycosylphosphatidylinositol anchor proteins, Xu, Yidan, Jia, Guowen, Li, Tingting, Zhou, Zixuan, Luo, Yitian, Chao, Yulin, Bao, Juan, Su, Zhaoming, Qu, Qianhui, Li, Dianfan, 2022
Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae, Luo, Yitian, Wan, Guoyue, Zhang, Xiang, Zhou, Xuan, Wang, Qiuwen, Fan, Jialin, Cai, Hongmin, Ma, Liya, Wu, Hailong, Qu, Qianhui, Cong, Yao, Zhao, Yun, Li, Dianfan, 2021
A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2, Hebang Yao, Hongmin Cai, Tingting Li, Bingjie Zhou, Wenming Qin, Dimitri Lavillette, Dianfan Li, 2021
A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection, Li, Tingting, Cai, Hongmin, Yao, Hebang, Zhou, Bingjie, Zhang, Ning, van Vlissingen, Martje Fentener, Kuiken, Thijs, Han, Wenyu, GeurtsvanKessel, Corine H, Gong, Yuhuan, Zhao, Yapei, Shen, Quan, Qin, Wenming, Tian, XiaoXu, Peng, Chao, Lai, Yanling, Wang, Yanxing, Hutter, Cedric A J, Kuo, ShuMing, Bao, Juan, Liu, Caixuan, Wang, Yifan, Richard, Audrey S, Raoul, Herve, Lan, Jiaming, Seeger, Markus A, Cong, Yao, Rockx, Barry, Wong, Gary, Bi, Yuhai, Lavillette, Dimitri, Li, Dianfan, 2021
The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface, Bowei Yang, Hebang Yao, Dianfan Li, Liu, Zhenfeng, 2021
Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release, Luo, Yitian, Wan, Guoyue, Zhou, Xuan, Wang, Qiuwen, Zhang, Yunbin, Bao, Juan, Cong, Yao, Zhao, Yun, Li, Dianfan, 2021
Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody, Li, Tingting, Cai, Hongmin, Zhao, Yapei, Li, Yanfang, Lai, Yanling, Yao, Hebang, Liu, Liu Daisy, Sun, Zhou, van Vlissingen, Martje Fentener, Kuiken, Thijs, GeurtsvanKessel, Corine H, Zhang, Ning, Zhou, Bingjie, Lu, Lu, Gong, Yuhuan, Qin, Wenming, Mondal, Moumita, Duan, Bowen, Xu, Shiqi, Richard, Audrey S, Raoul, Herve, Chen, JianFeng, Xu, Chenqi, Wu, Ligang, Zhou, Haisheng, Huang, Zhong, Zhang, Xuechao, Li, Jun, Wang, Yanyan, Bi, Yuhai, Rockx, Barry, Chen, Junfang, Meng, FeiLong, Lavillette, Dimitri, Li, Dianfan, 2021
Thermostabilization of Membrane Proteins by Consensus Mutation: A Case Study for a Fungal Δ8-7 Sterol Isomerase, Hebang Yao, Hongmin Cai, Dianfan Li, 2020
An improved fluorescent tag and its nanobodies for membrane protein expression, stability assay, and purification, Hongmin Cai, Hebang Yao, Tingting Li, Cedric A J Hutter, Yanfang Li, Yannan Tang, Markus A Seeger, Dianfan Li, 2020
Structure and Functional Characterization of Membrane Integral Proteins in the Lipid Cubic Phase, Li, Dianfan, Caffrey, Martin, 2020
Structural Characterization of the N-Terminal Domain of the Dictyostelium discoideum Mitochondrial Calcium Uniporter, Yuan, Yuan, Cao, Chan, Wen, Maorong, Li, Min, Dong, Ying, Wu, Lijie, Wu, Jian, Cui, Tanxing, Li, Dianfan, Chou, James J, OuYang, Bo, 2020
Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers, Wang Daisong, Hu Xin, Liu Chunye, Jia Yingying, Bai Yiqin, Cai Cheguo, Wang Jingqiang, Bai Lanyue, Yang Ruikai, Lin Changdong, Liu Yirong, Li Shan, Qiao Feng, Yao Ling, Chen Li, Ge Gaoxiang, Jiang Hai, Li Dianfan, Li Lin, Chen Jianfeng, Shao Zhiming, Zeng Yi Arial, 2019
High-level heterologous expression of the human transmembrane sterol Δ8,Δ7-isomerase in Pichia pastoris, Hongmin Cai, Hebang Yao, Tingting Li, Yannan Tang, Dianfan Li, 2019
Developing a High-Throughput Assay for the Integral Membrane Glycerol 3-Phosphate Acyltransferase, Tang, Yannan, Li, Dianfan, 2019
In Meso Crystallization of the Integral Membrane Glycerol 3-Phosphate Acyltransferase with Substrates, Li, Zhenjian, Tang, Yannan, Li, Dianfan, 2018
Structure and mechanism of a group-I cobalt energy coupling factor transporter, Bao, Zhihao, Qi, Xiaofeng, Hong, Sen, Xu, Ke, He, Fangyuan, Zhang, Minhua, Chen, Jiugeng, Chao, Daiyin, Zhao, Wei, Li, Dianfan, Wang, Jiawei, Zhang, Peng, 2017
Structural basis for lipopolysaccharide extraction by ABC transporter LptB(2)FG, Luo, Qingshan, Yang, Xu, Yu, Shan, Shi, Huigang, Wang, Kun, Xiao, Le, Zhu, Guangyu, Sun, Chuanqi, Li, Tingting, Li, Dianfan, Zhang, Xinzheng, Zhou, Min, Huang, Yihua, 2017
Structural insights into the committed step of bacterial phospholipid biosynthesis, Zhenjian Li, Yannan Tang, Yiran Wu, Suwen Zhao, Juan Bao, Yitian Luo, Dianfan Li, 2017
Cholesterol homeostasis: How do cells sense sterol excess?, Howe, Vicky, Sharpe, Laura J, Alexopoulos, Stephanie J, Kunze, Sarah V, Chua, Ngee Kiat, Li, Dianfan, Brown, Andrew J, 2016
DHCR7: A vital enzyme switch between cholesterol and vitamin D production, Prabhu, Anika V, Luu, Winnie, Li, Dianfan, Sharpe, Laura J, Brown, Andrew J, 2016
X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex, Zhou, X Edward, Gao, Xiang, Barty, Anton, Kang, Yanyong, He, Yuanzheng, Liu, Wei, Ishchenko, Andrii, White, Thomas A, Yefanov, Oleksandr, Han, Gye Won, Xu, Qingping, de Waal, Parker W, SuinoPowell, Kelly M, Boutet, Sebastien, Williams, Garth J, Wang, Meitian, Li, Dianfan, Caffrey, Martin, Chapman, Henry N, Spence, John C H, Fromme, Petra, Weierstall, Uwe, Stevens, Raymond C, Cherezov, Vadim, Melcher, Karsten, Xu, H Eric, 2016
Data-collection strategy for challenging native SAD phasing, Olieric, Vincent, Weinert, Tobias, Finke, Aaron D, Anders, Carolin, Li, Dianfan, Olieric, Natacha, Borca, Camelia N, Steinmetz, Michel O, Caffrey, Martin, Jinek, Martin, Wang, Meitian, 2016
Fast native-SAD phasing for routine macromolecular structure determination (vol 12, pg 131, 2015), Weinert, Tobias, Olieric, Vincent, Waltersperger, Sandro, Panepucci, Ezequiel, Chen, Lirong, Zhang, Hua, Zhou, Dayong, Rose, John, Ebihara, Akio, Kuramitsu, Seiki, Li, Dianfan, Howe, Nicole, Schnapp, Gisela, Pautsch, Alexander, Bargsten, Katja, Prota, Andrea E, Surana, Parag, Kottur, Jithesh, Nair, Deepak T, Basilico, Federica, Cecatiello, Valentina, Pasqualato, Sebastiano, Boland, Andreas, Weichenrieder, Oliver, Wang, BiCheng, Steinmetz, Michel O, Caffrey, Martin, Wang, Meitian, 2015
Ternary structure reveals mechanism of a membrane diacylglycerol kinase, Li, Dianfan, Stansfeld, Phillip J, Sansom,

Membrane Protein Structure Function Lipid Metabolism Enzyme Prostaglandin E2 Synthase Pathogen Antibiotic Resistance Phospholipid Synthesis Glycerol-3-Phosphate Acyltransferase

Hua Zhang - Huazhong Agricultural University

Zhengwu Qi - Tongji University

Yan Feng - Shanghai Jiao Tong University

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