Professor | Xiaoshan Shi | Asia Growth Partners

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Name	Xiaoshan Shi
Contact Information	xs.shi@siat.ac.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Xiaoshan Shi

Contact Information

xs.shi@siat.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2009-09--2015-02 PhD in Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences 2005-09--2009-07 Bachelor of Science: Shanghai Jiao Tong University
Work Experience	2021-06~Present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Researcher 2016-04~2021-03 - University of California, Berkeley - Postdoctoral Researcher 2015-03~2016-03 - Shanghai Institute of Life Sciences, Chinese Academy of Sciences - Research Assistant 2009-09~2015-02 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - PhD Student 2005-09~2009-07 - Shanghai Jiao Tong University - Bachelor Student
Awards	2020: Top Ten Advances in Life Sciences in China 2020: Important Medical Advances in China 2020: Cell Press China Annual Paper

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2009-09--2015-02 PhD in Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
2005-09--2009-07 Bachelor of Science: Shanghai Jiao Tong University

Work Experience

2021-06~Present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Researcher
2016-04~2021-03 - University of California, Berkeley - Postdoctoral Researcher
2015-03~2016-03 - Shanghai Institute of Life Sciences, Chinese Academy of Sciences - Research Assistant
2009-09~2015-02 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - PhD Student
2005-09~2009-07 - Shanghai Jiao Tong University - Bachelor Student

Awards

2020: Top Ten Advances in Life Sciences in China
2020: Important Medical Advances in China
2020: Cell Press China Annual Paper

Areas of Focus	T-cell anti-tumor immunity Development and application of new mass spectrometry technology Development of synthetic immunotherapy
Publications	Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy, SCIENCE ADVANCES, 2021 Multiple Signaling Roles of CD3 and Its Application in CAR-T Cell Therapy, Cell, 2020 ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer, JOURNAL OF CELL BIOLOGY, 2020 The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment, ELIFE, 2020 How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates, AUTOPHAGY, 2019 FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates, MOLECULAR CELL, 2019 Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017 Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor, CELL RESEARCH, 2017 Regulation of T cell signalling by membrane lipids, NATURE REVIEWS IMMUNOLOGY, 2016 Acidic phospholipids govern the enhanced activation of IgG-B cell receptor, NATURE COMMUNICATIONS, 2015 Lipid in T-cell receptor transmembrane signaling, PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2015 Regulatory Mechanism of T-Cell Receptor Complex Phosphorylation, 2014, 2014 Regulation of EGFR nanocluster formation by ionic protein-lipid interaction, CELL RESEARCH, 2014 Ionic protein-lipid interaction at the plasma membrane: what can the charge do?, TRENDS IN BIOCHEMICAL SCIENCES, 2014 Small ions, big functions, LIFE SCIENCES, 2013 Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids, NATURE, 2013 Small ions, big functions - Study on the mechanism of calcium ion regulation of T cell antigen receptor activation, CHINESE JOURNAL OF CELL BIOLOGY, 2013 Structural basis for the recognition of Asef by adenomatous polyposis coli, CELL RESEARCH, 2012 Structural and Functional Studies of T Cell Receptor, CHINESE JOURNAL OF CELL BIOLOGY, 2011 Crystal structure of the armadillo repeat domain of adenomatous polyposis coli which reveals its inherent flexibility, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011 Purification, crystallization and preliminary X-ray analysis of the DndE protein from Salmonella enterica serovar Cerro 87, which is involved in DNA phosphorothioation, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2011

Areas of Focus

T-cell anti-tumor immunity
Development and application of new mass spectrometry technology
Development of synthetic immunotherapy

Publications

Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy, SCIENCE ADVANCES, 2021
Multiple Signaling Roles of CD3 and Its Application in CAR-T Cell Therapy, Cell, 2020
ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer, JOURNAL OF CELL BIOLOGY, 2020
The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment, ELIFE, 2020
How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates, AUTOPHAGY, 2019
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates, MOLECULAR CELL, 2019
Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017
Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor, CELL RESEARCH, 2017
Regulation of T cell signalling by membrane lipids, NATURE REVIEWS IMMUNOLOGY, 2016
Acidic phospholipids govern the enhanced activation of IgG-B cell receptor, NATURE COMMUNICATIONS, 2015
Lipid in T-cell receptor transmembrane signaling, PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2015
Regulatory Mechanism of T-Cell Receptor Complex Phosphorylation, 2014, 2014
Regulation of EGFR nanocluster formation by ionic protein-lipid interaction, CELL RESEARCH, 2014
Ionic protein-lipid interaction at the plasma membrane: what can the charge do?, TRENDS IN BIOCHEMICAL SCIENCES, 2014
Small ions, big functions, LIFE SCIENCES, 2013
Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids, NATURE, 2013
Small ions, big functions - Study on the mechanism of calcium ion regulation of T cell antigen receptor activation, CHINESE JOURNAL OF CELL BIOLOGY, 2013
Structural basis for the recognition of Asef by adenomatous polyposis coli, CELL RESEARCH, 2012
Structural and Functional Studies of T Cell Receptor, CHINESE JOURNAL OF CELL BIOLOGY, 2011
Crystal structure of the armadillo repeat domain of adenomatous polyposis coli which reveals its inherent flexibility, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011
Purification, crystallization and preliminary X-ray analysis of the DndE protein from Salmonella enterica serovar Cerro 87, which is involved in DNA phosphorothioation, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2011

T-Cell Anti-Tumor Immunity Mass Spectrometry Technology Development Application Synthetic Immunotherapy Research

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Chenhui Wang - Huazhong University of Science and Technology

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