Professor | 施小山 | 数字化转型顾问

	Upload Avatar (500 x 500)
Name	施小山
Contact Information	xs.shi@siat.ac.cn
Language ability	中文, 英语
Province	广东

Upload Avatar (500 x 500)

Name

施小山

Contact Information

xs.shi@siat.ac.cn

Language ability

中文, 英语

Province

广东

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2009-09--2015-02 理学博士: 中国科学院上海生物化学与细胞生物学研究所 2005-09--2009-07 理学学士: 上海交通大学
Work Experience	2021-06~现在 - 中国科学院深圳先进技术研究院 - 研究员 2016-04~2021-03 - 美国加州大学伯克利分校 - 博士后 2015-03~2016-03 - 中国科学院上海生命科学研究院 - 研究助理 2009-09~2015-02 - 中国科学院上海生物化学与细胞生物学研究所 - 理学博士 2005-09~2009-07 - 上海交通大学 - 理学学士
Awards	2020: 中国生命科学十大进展 2020: 中国重要医学进展 2020: 细胞出版社中国年度论文

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

2009-09--2015-02 理学博士: 中国科学院上海生物化学与细胞生物学研究所
2005-09--2009-07 理学学士: 上海交通大学

Work Experience

2021-06~现在 - 中国科学院深圳先进技术研究院 - 研究员
2016-04~2021-03 - 美国加州大学伯克利分校 - 博士后
2015-03~2016-03 - 中国科学院上海生命科学研究院 - 研究助理
2009-09~2015-02 - 中国科学院上海生物化学与细胞生物学研究所 - 理学博士
2005-09~2009-07 - 上海交通大学 - 理学学士

Awards

2020: 中国生命科学十大进展
2020: 中国重要医学进展
2020: 细胞出版社中国年度论文

Areas of Focus	T细胞抗肿瘤免疫新型质谱技术开发与应用合成免疫学疗法开发
Publications	Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy, SCIENCE ADVANCES, 2021 Multiple Signaling Roles of CD3 and Its Application in CAR-T Cell Therapy, Cell, 2020 ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer, JOURNAL OF CELL BIOLOGY, 2020 The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment, ELIFE, 2020 How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates, AUTOPHAGY, 2019 FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates, MOLECULAR CELL, 2019 Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017 Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor, CELL RESEARCH, 2017 Regulation of T cell signalling by membrane lipids, NATURE REVIEWS IMMUNOLOGY, 2016 Acidic phospholipids govern the enhanced activation of IgG-B cell receptor, NATURE COMMUNICATIONS, 2015 Lipid in T-cell receptor transmembrane signaling, PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2015 Regulatory Mechanism of T-Cell Receptor Complex Phosphorylation, 2014, 2014 Regulation of EGFR nanocluster formation by ionic protein-lipid interaction, CELL RESEARCH, 2014 Ionic protein-lipid interaction at the plasma membrane: what can the charge do?, TRENDS IN BIOCHEMICAL SCIENCES, 2014 Small ions, big functions, LIFE SCIENCES, 2013 Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids, NATURE, 2013 Small ions, big functions - Study on the mechanism of calcium ion regulation of T cell antigen receptor activation, CHINESE JOURNAL OF CELL BIOLOGY, 2013 Structural basis for the recognition of Asef by adenomatous polyposis coli, CELL RESEARCH, 2012 Structural and Functional Studies of T Cell Receptor, CHINESE JOURNAL OF CELL BIOLOGY, 2011 Crystal structure of the armadillo repeat domain of adenomatous polyposis coli which reveals its inherent flexibility, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011 Purification, crystallization and preliminary X-ray analysis of the DndE protein from Salmonella enterica serovar Cerro 87, which is involved in DNA phosphorothioation, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2011

Areas of Focus

T细胞抗肿瘤免疫
新型质谱技术开发与应用
合成免疫学疗法开发

Publications

Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy, SCIENCE ADVANCES, 2021
Multiple Signaling Roles of CD3 and Its Application in CAR-T Cell Therapy, Cell, 2020
ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer, JOURNAL OF CELL BIOLOGY, 2020
The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment, ELIFE, 2020
How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates, AUTOPHAGY, 2019
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates, MOLECULAR CELL, 2019
Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017
Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor, CELL RESEARCH, 2017
Regulation of T cell signalling by membrane lipids, NATURE REVIEWS IMMUNOLOGY, 2016
Acidic phospholipids govern the enhanced activation of IgG-B cell receptor, NATURE COMMUNICATIONS, 2015
Lipid in T-cell receptor transmembrane signaling, PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2015
Regulatory Mechanism of T-Cell Receptor Complex Phosphorylation, 2014, 2014
Regulation of EGFR nanocluster formation by ionic protein-lipid interaction, CELL RESEARCH, 2014
Ionic protein-lipid interaction at the plasma membrane: what can the charge do?, TRENDS IN BIOCHEMICAL SCIENCES, 2014
Small ions, big functions, LIFE SCIENCES, 2013
Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids, NATURE, 2013
Small ions, big functions - Study on the mechanism of calcium ion regulation of T cell antigen receptor activation, CHINESE JOURNAL OF CELL BIOLOGY, 2013
Structural basis for the recognition of Asef by adenomatous polyposis coli, CELL RESEARCH, 2012
Structural and Functional Studies of T Cell Receptor, CHINESE JOURNAL OF CELL BIOLOGY, 2011
Crystal structure of the armadillo repeat domain of adenomatous polyposis coli which reveals its inherent flexibility, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011
Purification, crystallization and preliminary X-ray analysis of the DndE protein from Salmonella enterica serovar Cerro 87, which is involved in DNA phosphorothioation, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2011

T细胞抗肿瘤免疫质谱技术开发应用合成免疫疗法研究

娄继忠 - 中国科学院大学

Area of Focus
肿瘤 | 免疫 | 识别 | 调控 | T细胞 | 功能 | 改造 | 力免疫学 | 信号 | 传导

朱明昭 - 中国科学院大学

娄继忠 - 中国科学院大学

Area of Focus
肿瘤 | 免疫 | 调控 | T细胞 | 力免疫学 | 信号传导 | 单分子 | 生物物理学 | 分子动力学 | 模拟

View All

Personal Information

Academic Information

Research

联系我们

还未创建账户?

Personal Information

Academic Information

Research

联系我们