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施小山
Life Science
中国科学院大学
广东
Language: 中文, 英语
T细胞
抗肿瘤
免疫
质谱
技术
开发
应用
合成
免疫疗法
研究
Areas of Focus
- T细胞抗肿瘤免疫
- 新型质谱技术开发与应用
- 合成免疫学疗法开发
Work Experience
- 2021-06~现在 - 中国科学院深圳先进技术研究院 - 研究员
- 2016-04~2021-03 - 美国加州大学伯克利分校 - 博士后
- 2015-03~2016-03 - 中国科学院上海生命科学研究院 - 研究助理
- 2009-09~2015-02 - 中国科学院上海生物化学与细胞生物学研究所 - 理学博士
- 2005-09~2009-07 - 上海交通大学 - 理学学士
Academic Background & Achievements
- 2009-09--2015-02 理学博士: 中国科学院上海生物化学与细胞生物学研究所
- 2005-09--2009-07 理学学士: 上海交通大学
Publications
- Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy, SCIENCE ADVANCES, 2021
- Multiple Signaling Roles of CD3 and Its Application in CAR-T Cell Therapy, Cell, 2020
- ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer, JOURNAL OF CELL BIOLOGY, 2020
- The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment, ELIFE, 2020
- How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates, AUTOPHAGY, 2019
- FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates, MOLECULAR CELL, 2019
- Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017
- Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor, CELL RESEARCH, 2017
- Regulation of T cell signalling by membrane lipids, NATURE REVIEWS IMMUNOLOGY, 2016
- Acidic phospholipids govern the enhanced activation of IgG-B cell receptor, NATURE COMMUNICATIONS, 2015
- Lipid in T-cell receptor transmembrane signaling, PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2015
- Regulatory Mechanism of T-Cell Receptor Complex Phosphorylation, 2014, 2014
- Regulation of EGFR nanocluster formation by ionic protein-lipid interaction, CELL RESEARCH, 2014
- Ionic protein-lipid interaction at the plasma membrane: what can the charge do?, TRENDS IN BIOCHEMICAL SCIENCES, 2014
- Small ions, big functions, LIFE SCIENCES, 2013
- Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids, NATURE, 2013
- Small ions, big functions - Study on the mechanism of calcium ion regulation of T cell antigen receptor activation, CHINESE JOURNAL OF CELL BIOLOGY, 2013
- Structural basis for the recognition of Asef by adenomatous polyposis coli, CELL RESEARCH, 2012
- Structural and Functional Studies of T Cell Receptor, CHINESE JOURNAL OF CELL BIOLOGY, 2011
- Crystal structure of the armadillo repeat domain of adenomatous polyposis coli which reveals its inherent flexibility, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011
- Purification, crystallization and preliminary X-ray analysis of the DndE protein from Salmonella enterica serovar Cerro 87, which is involved in DNA phosphorothioation, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2011
Awards
- 2020: 中国生命科学十大进展
- 2020: 中国重要医学进展
- 2020: 细胞出版社中国年度论文
