Professor | Lei Shi | Asia Growth Partners

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Name	Lei Shi
Contact Information	shilei@mail.kiz.ac.cn
Language ability	Chinese, English
Province	Yunnan

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Name

Lei Shi

Contact Information

shilei@mail.kiz.ac.cn

Language ability

Chinese, English

Province

Yunnan

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2007-09--2012-06 PhD: Kunming Institute of Zoology, Chinese Academy of Sciences 2003-09--2007-06 Bachelor: Southwest University
Work Experience	2020-10~Present - Kunming Institute of Zoology, Chinese Academy of Sciences - Researcher 2019-03~2020-10 - Salk Institute for Biological Studies, USA - Postdoctoral Researcher 2015-07~2019-02 - University of Michigan, Ann Arbor, USA - Postdoctoral Researcher 2012-07~2015-07 - Kunming Institute of Zoology, Chinese Academy of Sciences - Assistant Researcher 2007-09~2012-06 - Kunming Institute of Zoology, Chinese Academy of Sciences - PhD Student 2003-09~2007-06 - Southwest University - Bachelor Student

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2007-09--2012-06 PhD: Kunming Institute of Zoology, Chinese Academy of Sciences
2003-09--2007-06 Bachelor: Southwest University

Work Experience

2020-10~Present - Kunming Institute of Zoology, Chinese Academy of Sciences - Researcher
2019-03~2020-10 - Salk Institute for Biological Studies, USA - Postdoctoral Researcher
2015-07~2019-02 - University of Michigan, Ann Arbor, USA - Postdoctoral Researcher
2012-07~2015-07 - Kunming Institute of Zoology, Chinese Academy of Sciences - Assistant Researcher
2007-09~2012-06 - Kunming Institute of Zoology, Chinese Academy of Sciences - PhD Student
2003-09~2007-06 - Southwest University - Bachelor Student

Areas of Focus	Epigenetic regulatory mechanisms of nervous system evolution and development
Publications	In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche, NATURE COMMUNICATIONS, 2021 Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells, NATURE COMMUNICATIONS, 2021 Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80, NATURE COMMUNICATIONS, 2020 Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development, NATIONAL SCIENCE REVIEW: ENGLISH EDITION, 2019 Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion, NATURE COMMUNICATIONS, 2019 Generation of blastocyst-like structures from mouse embryonic and adult cell cultures, CELL, 2019 A transgenic monkey model for the study of human brain evolution, ZOOLOGICAL RESEARCH, 2019 Regional Selection of the Brain Size Regulating Gene CASC5 Provides New Insight into Human Brain Evolution, HUMAN GENETICS, 2017 Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution, MOLECULAR BIOLOGY AND EVOLUTION, 2016 Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages, SCIENTIFIC REPORTS, 2016 Estrogen regulation of microcephaly genes and evolution of brain sexual dimorphism in primates, BMC EVOLUTIONARY BIOLOGY, 2015 Human-Specific Hypomethylation of CENPJ, a Key Brain Size Regulator, MOLECULAR BIOLOGY AND EVOLUTION, 2014 Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population, WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2013 Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans, BMC BIOLOGY, 2013 Identification and functional characterization of a primate-specific E2F1 binding motif regulating MCPH1 expression, FEBS JOURNAL, 2012 MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene, GENE, 2012 Genetic association and identification of a functional SNP at GSK3 beta for schizophrenia susceptibility, SCHIZOPHRENIA RESEARCH, 2011

Areas of Focus

Epigenetic regulatory mechanisms of nervous system evolution and development

Publications

In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche, NATURE COMMUNICATIONS, 2021
Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells, NATURE COMMUNICATIONS, 2021
Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80, NATURE COMMUNICATIONS, 2020
Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development, NATIONAL SCIENCE REVIEW: ENGLISH EDITION, 2019
Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion, NATURE COMMUNICATIONS, 2019
Generation of blastocyst-like structures from mouse embryonic and adult cell cultures, CELL, 2019
A transgenic monkey model for the study of human brain evolution, ZOOLOGICAL RESEARCH, 2019
Regional Selection of the Brain Size Regulating Gene CASC5 Provides New Insight into Human Brain Evolution, HUMAN GENETICS, 2017
Comparative Methylome Analyses Identify Epigenetic Regulatory Loci of Human Brain Evolution, MOLECULAR BIOLOGY AND EVOLUTION, 2016
Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages, SCIENTIFIC REPORTS, 2016
Estrogen regulation of microcephaly genes and evolution of brain sexual dimorphism in primates, BMC EVOLUTIONARY BIOLOGY, 2015
Human-Specific Hypomethylation of CENPJ, a Key Brain Size Regulator, MOLECULAR BIOLOGY AND EVOLUTION, 2014
Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population, WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2013
Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans, BMC BIOLOGY, 2013
Identification and functional characterization of a primate-specific E2F1 binding motif regulating MCPH1 expression, FEBS JOURNAL, 2012
MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene, GENE, 2012
Genetic association and identification of a functional SNP at GSK3 beta for schizophrenia susceptibility, SCHIZOPHRENIA RESEARCH, 2011

Epigenetics Nervous System Evolution Development Regulation Mechanisms Neurobiology Genetics Research Biology

Yujun Hou - Tongji University

Fanglin Sun - Tongji University

Shi Jiejun - Tongji University

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