Upload Avatar (500 x 500)
Tian Yuqing
Life Science
University of Chinese Academy of Sciences
Beijing
Language: Chinese, English
Microbial
Secondary Metabolism
Synthesis
Regulation
Genetics
Biotechnology
Microbiology
Metabolic Engineering
Biosynthesis
Antibiotics
Areas of Focus
- Synthesis and Regulation of Microbial Secondary Metabolism
Work Experience
- 2007-05~Present - Institute of Microbiology, Chinese Academy of Sciences - Associate Researcher
- 2001-07~2003-12 - Department of Molecular Microbiology, John Innes Centre, UK - Visiting Scholar
- 1999-05~2001-02 - Beijing Genomics Institute - Collaborative Research
- 1996-11~2007-04 - Institute of Microbiology, Chinese Academy of Sciences - Assistant Researcher
- 1991-08~1996-10 - Institute of Microbiology, Chinese Academy of Sciences - Intern Researcher
Academic Background & Achievements
- 1994-09--1997-05 Master's Degree: Institute of Microbiology, Chinese Academy of Sciences
- 1987-09--1991-07 Bachelor's Degree: Peking University
Publications
- Reconstruction of a hybrid nucleoside antibiotic gene cluster based on scarless modification of large DNA fragment, Corresponding Author, 2017
- Activation and molecular mechanism of a cryptic oviedomycin biosynthetic gene cluster via the disruption of a global regulatory gene--adpA in Streptomyces ansochromogenes, Corresponding Author, 2017
- Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp, Third Author, 2016
- Genome engineering and direct cloning gene cluster via phage phiBT1 integrase-mediated site-specific recombination in Streptomyces, Third Author, 2015
- GouR, a TetR-family transcriptional regulator, coordinates the biosynthesis and export of gougerotin in Streptomyces graminearus, Second Author, 2014
- Assembly and features of secondary metabolite biosynthetic gene clusters in Streptomyces ansochromogenes, Corresponding Author, 2013
- Improvement of gougerotin and nikkomycin production by engineering their biosynthetic gene clusters, Fourth Author, 2013
- Importance and regulation of inositol biosynthesis during growth and differentiation of Streptomyces coelicolor, First Author, 2012
- Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties, Third Author, 2011
- SabR enhances nikkomycin production via regulating the transcriptional level of sanG, a pathway-specific regulatory gene in Streptomyces ansochromogenes, Fourth Author, 2011
- Characterization of EndoTT, a novel single-stranded DNA specific endonuclease from Thermoanaerobacter tengcongensis, Fourth Author, 2010
- Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production, Fifth Author, 2010
- SCO3900, co-transcripted with three downstream genes, is involved in the differentiation of Streptomyces coelicolor, Second Author, 2010
- The pleiotropic regulator AdpA-L directly controls the pathway-specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes, Fourth Author, 2009
- Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes, Fifth Author, 2009
- polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi subsp. asoensis, Third Author, 2009
- The tyrosine degradation gene hppD is transcriptionally activated by HpdA and repressed by HpdR in Streptomyces coelicolor, while hpdA is negatively autoregulated and repressed by HpdR, Fourth Author, 2007
- An unusual response regulator influences sporulation at early and late stages in Streptomyces coelicolor, First Author, 2007
- SanM catalyzes the formation of 4-pyridyl-2-oxo-4-hydroxyisovalerate in nikkomycin biosynthesis by interacting with SanN, Third Author, 2007
- SanT, a bidomain protein, is essential for nikkomycin biosynthesis of Streptomyces ansochromogenes, Second Author, 2007
- Identification and characterization of sawC, a whiA-like gene, essential for sporulation in Streptomyces ansochromogenes, Third Author, 2007
- SanJ, an ATP-dependent picolinate-CoA ligase, catalyzes the conversion of picolinate to picolinate-CoA during nikkomycin biosynthesis in S. ansochromogenes, Third Author, 2006
- A pathway-specific transcriptional regulatory gene for nikkomycin biosynthesis in Streptomyces ansochromogenes that also influences colony development, Second Author, 2005
- Lambda red-mediated genetic manipulation of antibiotic producing Streptomyces, Fourth Author, 2004
- A novel Streptomyces gene, samR, with different effects on differentiation of Streptomyces ansochromogenes and Streptomyces coelicolor, Second Author, 2002
- A Complete Sequence of the T. tengcongensis Genome, First Author, 2002
- The Streptomyces coelicolor sporulation-specific Sigma-WhiG form of RNA polymerase transcribes a gene encoding a ProX-like protein that is dispensable for sporulation, Third Author, 1998
