1994-09--1997-05 Master's Degree: Institute of Microbiology, Chinese Academy of Sciences
1987-09--1991-07 Bachelor's Degree: Peking University
2007-05~Present - Institute of Microbiology, Chinese Academy of Sciences - Associate Researcher
2001-07~2003-12 - Department of Molecular Microbiology, John Innes Centre, UK - Visiting Scholar
1999-05~2001-02 - Beijing Genomics Institute - Collaborative Research
1996-11~2007-04 - Institute of Microbiology, Chinese Academy of Sciences - Assistant Researcher
1991-08~1996-10 - Institute of Microbiology, Chinese Academy of Sciences - Intern Researcher
Research
Synthesis and Regulation of Microbial Secondary Metabolism
Reconstruction of a hybrid nucleoside antibiotic gene cluster based on scarless modification of large DNA fragment, Corresponding Author, 2017
Activation and molecular mechanism of a cryptic oviedomycin biosynthetic gene cluster via the disruption of a global regulatory gene--adpA in Streptomyces ansochromogenes, Corresponding Author, 2017
Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp, Third Author, 2016
Genome engineering and direct cloning gene cluster via phage phiBT1 integrase-mediated site-specific recombination in Streptomyces, Third Author, 2015
GouR, a TetR-family transcriptional regulator, coordinates the biosynthesis and export of gougerotin in Streptomyces graminearus, Second Author, 2014
Assembly and features of secondary metabolite biosynthetic gene clusters in Streptomyces ansochromogenes, Corresponding Author, 2013
Improvement of gougerotin and nikkomycin production by engineering their biosynthetic gene clusters, Fourth Author, 2013
Importance and regulation of inositol biosynthesis during growth and differentiation of Streptomyces coelicolor, First Author, 2012
Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties, Third Author, 2011
SabR enhances nikkomycin production via regulating the transcriptional level of sanG, a pathway-specific regulatory gene in Streptomyces ansochromogenes, Fourth Author, 2011
Characterization of EndoTT, a novel single-stranded DNA specific endonuclease from Thermoanaerobacter tengcongensis, Fourth Author, 2010
Cloning, reassembling and integration of the entire nikkomycin biosynthetic gene cluster into Streptomyces ansochromogenes lead to an improved nikkomycin production, Fifth Author, 2010
SCO3900, co-transcripted with three downstream genes, is involved in the differentiation of Streptomyces coelicolor, Second Author, 2010
The pleiotropic regulator AdpA-L directly controls the pathway-specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes, Fourth Author, 2009
Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes, Fifth Author, 2009
polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi subsp. asoensis, Third Author, 2009
The tyrosine degradation gene hppD is transcriptionally activated by HpdA and repressed by HpdR in Streptomyces coelicolor, while hpdA is negatively autoregulated and repressed by HpdR, Fourth Author, 2007
An unusual response regulator influences sporulation at early and late stages in Streptomyces coelicolor, First Author, 2007
SanM catalyzes the formation of 4-pyridyl-2-oxo-4-hydroxyisovalerate in nikkomycin biosynthesis by interacting with SanN, Third Author, 2007
SanT, a bidomain protein, is essential for nikkomycin biosynthesis of Streptomyces ansochromogenes, Second Author, 2007
Identification and characterization of sawC, a whiA-like gene, essential for sporulation in Streptomyces ansochromogenes, Third Author, 2007
SanJ, an ATP-dependent picolinate-CoA ligase, catalyzes the conversion of picolinate to picolinate-CoA during nikkomycin biosynthesis in S. ansochromogenes, Third Author, 2006
A pathway-specific transcriptional regulatory gene for nikkomycin biosynthesis in Streptomyces ansochromogenes that also influences colony development, Second Author, 2005
A novel Streptomyces gene, samR, with different effects on differentiation of Streptomyces ansochromogenes and Streptomyces coelicolor, Second Author, 2002
A Complete Sequence of the T. tengcongensis Genome, First Author, 2002
The Streptomyces coelicolor sporulation-specific Sigma-WhiG form of RNA polymerase transcribes a gene encoding a ProX-like protein that is dispensable for sporulation, Third Author, 1998
