Professor | Yuexiang Wang | Asia Growth Partners

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Name	Yuexiang Wang
Contact Information	yxwang76@sinh.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Yuexiang Wang

Contact Information

yxwang76@sinh.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2001-09 to 2007-01 PhD: Fudan University Medical School 1994-09 to 1999-06 Pharmacology: Shanghai Medical University
Work Experience	2020-04 to Present - Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences - Researcher 2015-02 to 2020-03 - Shanghai Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine - Researcher 2014-11 to 2015-02 - Brigham and Women's Hospital, Harvard Medical School - Lecturer 2007-08 to 2014-10 - Brigham and Women's Hospital, Harvard Medical School - Postdoctoral Researcher/Senior Research Scientist 2007-07 to 2007-08 - Fudan University Medical School - Associate Professor 2004-07 to 2007-06 - Fudan University Medical School - Lecturer 1999-07 to 2004-06 - Fudan University Medical School - Assistant
Awards	Shanghai Medical Science and Technology Award, Second Prize (2021) American Association for Cancer Research – GlaxoSmithKline Outstanding Clinical Award (2014) Harvard Chinese Life Science Annual Distinguished Research Award, First Prize (2014) 9th National Youth Science and Technology Forum in Medicine and Health, First Prize (2006) Meiji Dairy Life Science Award, Excellence Award (2006) 2nd Shanghai Bank Basic Medical Science Award, Young and Middle-aged Group, First Prize (2003)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2001-09 to 2007-01 PhD: Fudan University Medical School
1994-09 to 1999-06 Pharmacology: Shanghai Medical University

Work Experience

2020-04 to Present - Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences - Researcher
2015-02 to 2020-03 - Shanghai Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine - Researcher
2014-11 to 2015-02 - Brigham and Women's Hospital, Harvard Medical School - Lecturer
2007-08 to 2014-10 - Brigham and Women's Hospital, Harvard Medical School - Postdoctoral Researcher/Senior Research Scientist
2007-07 to 2007-08 - Fudan University Medical School - Associate Professor
2004-07 to 2007-06 - Fudan University Medical School - Lecturer
1999-07 to 2004-06 - Fudan University Medical School - Assistant

Awards

Shanghai Medical Science and Technology Award, Second Prize (2021)
American Association for Cancer Research – GlaxoSmithKline Outstanding Clinical Award (2014)
Harvard Chinese Life Science Annual Distinguished Research Award, First Prize (2014)
9th National Youth Science and Technology Forum in Medicine and Health, First Prize (2006)
Meiji Dairy Life Science Award, Excellence Award (2006)
2nd Shanghai Bank Basic Medical Science Award, Young and Middle-aged Group, First Prize (2003)

Areas of Focus	Molecular mechanisms of gastrointestinal stromal tumor progression Molecular mechanisms of KRAS mutant cancers (pancreatic cancer, lung cancer, etc.) Integration of multi-omics big data analysis and artificial intelligence Development of novel diagnostic reagents and anti-tumor drugs
Publications	Genome-wide CRISPR screens identify PKMYT1 as a therapeutic target in pancreatic ductal adenocarcinoma, Simin Wang, Yangjie Xiong, Yuxiang Luo, Yanying Shen, Fengrui Zhang, Haoqi Lan, Yuzhi Pang, Xiaofang Wang, Xiaoqi Li, Xufen Zheng, Xiaojing Lu, Xiaoxiao Liu, Yumei Cheng, Tanwen Wu, Yue Dong, Yuan Lu, Jiujie Cui, Xiaona Jia, Sheng Yang, Liwei Wang, Yuexiang Wang, 2024 Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway, Xufen Zheng, Luo, Yuxiang, Yangjie Xiong, Xiaoxiao Liu, Chunling Zeng, Xiaojing Lu, Xiaofang Wang, Yumei Cheng, Simin Wang, Haoqi Lan, Kai Wang, Zhonghui Weng, Wenbo Bi, Xinxin Gan, Xiaona Jia, Linhui Wang, Yuexiang Wang, 2023 Activity of Anlotinib in the Second-Line Therapy of Metastatic Gastrointestinal Stromal Tumors: A Prospective, Multicenter, In Vitro Study, Zhou, Yongjian, Zeng, Chunling, Sun, Xiaofeng, Zhang, Jun, Qu, Hongyan, Zhang, Xinhua, Zhou, Ye, Liu, Zimin, Wu, Xiaojun, Wu, Xin, Jiao, Xuelong, Shen, Lin, Zhou, Yanbing, Wang, Yuexiang, Li, Jian, 2023 Cullin-9/p53 mediates HNRNPC degradation to inhibit erastin-induced ferroptosis and is blocked by MDM2 inhibition in colorectal cancer, Lv, Yang, Tang, Wentao, Zhang, Zhiyuan, Lin, Qi, Luo, Yuxiang, Zheng, Peng, Li, Ke, Jia, Xiaona, Pang, Yuzhi, Ji, Meiling, Feng, Qingyang, He, Guodong, Wang, Yuexiang, Xu, Jianmin, 2022 Integrated Screens Identify CDK1 as a Therapeutic Target in Advanced Gastrointestinal Stromal Tumors, Lu, Xiaojing, Pang, Yuzhi, Cao, Hui, Liu, Xiaoxiao, Tu, Lin, Shen, Yanying, Jia, Xiaona, Lee, JenChieh, Wang, Yuexiang, 2021 Advances in Targeted Therapy and Immunotherapy for Pancreatic Cancer, Liu, Xiaoxiao, Li, Zhang, Wang, Yuexiang, 2021 E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer, Li, Ke, Zheng, Xufen, Tang, Hua, Zang, Yuansheng, Zeng, Chunling, Liu, Xiaoxiao, Shen, Yanying, Pang, Yuzhi, Wang, Simin, Xie, Feifei, Lu, Xiaojing, Luo, Yuxiang, Li, Zhang, Bi, Wenbo, Jia, Xiaona, Huang, Tao, Wei, Rongqiang, Huang, Kenan, Chen, Zihao, Zhu, Qingchen, He, Yi, Zhang, Miaoying, Gu, Zhizhan, Xiao, Yichuan, Zhang, Xiaoyang, Fletcher, Jonathan A, Wang, Yuexiang, 2021 Oncogenic ERBB2 aberrations and KRAS mutations cooperate to promote pancreatic ductal adenocarcinoma progression, Li, Zhang, Shao, Chenghao, Liu, Xiaoxiao, Lu, Xiaojing, Jia, Xiaona, Zheng, Xufen, Wang, Simin, Zhu, Li, Li, Ke, Pang, Yuzhi, Xie, Feifei, Lu, Yuan, Wang, Yuexiang, 2020 Spectrum of activity of dasatinib against mutant KIT kinases associated with drug-sensitive and drug-resistant gastrointestinal stromal tumors, Zeng, Chunling, Zhu, Li, Jia, Xiaona, Pang, Yuzhi, Li, Zhang, Lu, Xiaojing, Xie, Feifei, Duan, Lili, Wang, Yuexiang, 2020 Oncogenic and drug-sensitive RET mutations in human epithelial ovarian cancer, Guan, Luyao, Li, Zhang, Xie, Feifei, Pang, Yuzhi, Zhang, Chenyun, Tang, Haosha, Zhang, Hao, Chen, Chun, Zhan, Yaying, Zhao, Ting, Jiang, Hongyuan, Jia, Xiaona, Wang, Yuexiang, Lu, Yuan, 2020 Mutational inactivation of mTORC1 repressor gene DEPDC5 in human gastrointestinal stromal tumors, Pang, Yuzhi, Xie, Feifei, Cao, Hui, Wang, Chunmeng, Zhu, Meijun, Liu, Xiaoxiao, Lu, Xiaojing, Huang, Tao, Shen, Yanying, Li, Ke, Jia, Xiaona, Li, Zhang, Zheng, Xufen, Wang, Simin, He, Yi, Wang, Linhui, Fletcher, Jonathan A, Wang, Yuexiang, 2019 KRAS and KIT gatekeeper mutations confer polyclonal primary imatinib resistance in GIST: Relevance of concomitant PI3K/AKT dysregulation, Serrano, César, Wang, Yuexiang, Mariño-Enríquez, Adrián, Lee, Jen-Chieh, Ravegnini, Gloria, Morgan, Jeffrey A, Bertagnolli, Monica M, Beadling, Carol, Demetri, George D, Corless, Christopher L, Heinrich, Michael C, Fletcher, Jonathan A, 2015 Cell cycle and dystrophin dysregulation in GIST, Wang, Yuexiang, Fletcher, Jonathan A, 2015 Dystrophin is a tumor suppressor in human cancers with myogenic programs, Wang, Yuexiang, MarinoEnriquez, Adrian, Bennett, Richard R, Zhu, Meijun, Shen, Yiping, Eilers, Grant, Lee, JenChieh, Henze, Joern, Fletcher, Benjamin S, Gu, Zhizhan, Fox, Edward A, Antonescu, Cristina R, Fletcher, Christopher D M, Guo, Xiangqian, Raut, Chandrajit P, Demetri, George D, van de Rijn, Matt, Ordog, Tamas, Kunkel, Louis M, Fletcher, Jonathan A, 2014 Bone morphogenetic protein-2 acts upstream of myocyte-specific enhancer factor 2a to control embryonic cardiac contractility, Wang, Yuexiang, Qian, Linxi, Liu, Dong, Yao, Lingling, Jiang, Qiu, Yu, Zhang, Gui, Yonghao, Zhong, Tao P, Song, Houyan, 2007 Myocyte-specific enhancer factor 2A is essential for zebrafish posterior somite development, Wang, Yuexiang, Qian, Linxi, Dong, Yongxin, Jiang, Qiu, Gui, Yonghao, Zhong, Tao P, Song, Houyan, 2006 Requirements of myocyte-specific enhancer factor 2A in zebrafish cardiac contractility, Wang, Yuexiang, Qian, Linxi, Yu, Zhang, Jiang, Qiu, Dong, Yongxin, Liu, Xuefei, Yang, Xinying, Zhong, TP, Song, Houyan, 2005 Wortmannin induces zebrafish cardia bifida through a mechanism independent of phosphoinositide 3-kinase and myosin light chain kinase, Wang, Yuexiang, Zhong, Tao, Qian, Linxi, Dong, Yongxin, Jiang, Qiu, Tan, Li, Song, Houyan, 2005 Developmental genetics of zebrafish cardiovascular systems, Wang, Yuexiang, Zhong, Tao, Song, Houyan, 2004 VEGF121 cDNA gene transfer and expression in Vitro, Wang, Yuexiang, Yang, Jian, Ma, Chungu, Yang Xinying, Song, Houyan, 2003 Molecular cloning, expression and characterization of recombinant human vascular endothelial growth factor 121, Wang, Yuexiang

Areas of Focus

Molecular mechanisms of gastrointestinal stromal tumor progression
Molecular mechanisms of KRAS mutant cancers (pancreatic cancer, lung cancer, etc.)
Integration of multi-omics big data analysis and artificial intelligence
Development of novel diagnostic reagents and anti-tumor drugs

Publications

Genome-wide CRISPR screens identify PKMYT1 as a therapeutic target in pancreatic ductal adenocarcinoma, Simin Wang, Yangjie Xiong, Yuxiang Luo, Yanying Shen, Fengrui Zhang, Haoqi Lan, Yuzhi Pang, Xiaofang Wang, Xiaoqi Li, Xufen Zheng, Xiaojing Lu, Xiaoxiao Liu, Yumei Cheng, Tanwen Wu, Yue Dong, Yuan Lu, Jiujie Cui, Xiaona Jia, Sheng Yang, Liwei Wang, Yuexiang Wang, 2024
Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway, Xufen Zheng, Luo, Yuxiang, Yangjie Xiong, Xiaoxiao Liu, Chunling Zeng, Xiaojing Lu, Xiaofang Wang, Yumei Cheng, Simin Wang, Haoqi Lan, Kai Wang, Zhonghui Weng, Wenbo Bi, Xinxin Gan, Xiaona Jia, Linhui Wang, Yuexiang Wang, 2023
Activity of Anlotinib in the Second-Line Therapy of Metastatic Gastrointestinal Stromal Tumors: A Prospective, Multicenter, In Vitro Study, Zhou, Yongjian, Zeng, Chunling, Sun, Xiaofeng, Zhang, Jun, Qu, Hongyan, Zhang, Xinhua, Zhou, Ye, Liu, Zimin, Wu, Xiaojun, Wu, Xin, Jiao, Xuelong, Shen, Lin, Zhou, Yanbing, Wang, Yuexiang, Li, Jian, 2023
Cullin-9/p53 mediates HNRNPC degradation to inhibit erastin-induced ferroptosis and is blocked by MDM2 inhibition in colorectal cancer, Lv, Yang, Tang, Wentao, Zhang, Zhiyuan, Lin, Qi, Luo, Yuxiang, Zheng, Peng, Li, Ke, Jia, Xiaona, Pang, Yuzhi, Ji, Meiling, Feng, Qingyang, He, Guodong, Wang, Yuexiang, Xu, Jianmin, 2022
Integrated Screens Identify CDK1 as a Therapeutic Target in Advanced Gastrointestinal Stromal Tumors, Lu, Xiaojing, Pang, Yuzhi, Cao, Hui, Liu, Xiaoxiao, Tu, Lin, Shen, Yanying, Jia, Xiaona, Lee, JenChieh, Wang, Yuexiang, 2021
Advances in Targeted Therapy and Immunotherapy for Pancreatic Cancer, Liu, Xiaoxiao, Li, Zhang, Wang, Yuexiang, 2021
E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer, Li, Ke, Zheng, Xufen, Tang, Hua, Zang, Yuansheng, Zeng, Chunling, Liu, Xiaoxiao, Shen, Yanying, Pang, Yuzhi, Wang, Simin, Xie, Feifei, Lu, Xiaojing, Luo, Yuxiang, Li, Zhang, Bi, Wenbo, Jia, Xiaona, Huang, Tao, Wei, Rongqiang, Huang, Kenan, Chen, Zihao, Zhu, Qingchen, He, Yi, Zhang, Miaoying, Gu, Zhizhan, Xiao, Yichuan, Zhang, Xiaoyang, Fletcher, Jonathan A, Wang, Yuexiang, 2021
Oncogenic ERBB2 aberrations and KRAS mutations cooperate to promote pancreatic ductal adenocarcinoma progression, Li, Zhang, Shao, Chenghao, Liu, Xiaoxiao, Lu, Xiaojing, Jia, Xiaona, Zheng, Xufen, Wang, Simin, Zhu, Li, Li, Ke, Pang, Yuzhi, Xie, Feifei, Lu, Yuan, Wang, Yuexiang, 2020
Spectrum of activity of dasatinib against mutant KIT kinases associated with drug-sensitive and drug-resistant gastrointestinal stromal tumors, Zeng, Chunling, Zhu, Li, Jia, Xiaona, Pang, Yuzhi, Li, Zhang, Lu, Xiaojing, Xie, Feifei, Duan, Lili, Wang, Yuexiang, 2020
Oncogenic and drug-sensitive RET mutations in human epithelial ovarian cancer, Guan, Luyao, Li, Zhang, Xie, Feifei, Pang, Yuzhi, Zhang, Chenyun, Tang, Haosha, Zhang, Hao, Chen, Chun, Zhan, Yaying, Zhao, Ting, Jiang, Hongyuan, Jia, Xiaona, Wang, Yuexiang, Lu, Yuan, 2020
Mutational inactivation of mTORC1 repressor gene DEPDC5 in human gastrointestinal stromal tumors, Pang, Yuzhi, Xie, Feifei, Cao, Hui, Wang, Chunmeng, Zhu, Meijun, Liu, Xiaoxiao, Lu, Xiaojing, Huang, Tao, Shen, Yanying, Li, Ke, Jia, Xiaona, Li, Zhang, Zheng, Xufen, Wang, Simin, He, Yi, Wang, Linhui, Fletcher, Jonathan A, Wang, Yuexiang, 2019
KRAS and KIT gatekeeper mutations confer polyclonal primary imatinib resistance in GIST: Relevance of concomitant PI3K/AKT dysregulation, Serrano, César, Wang, Yuexiang, Mariño-Enríquez, Adrián, Lee, Jen-Chieh, Ravegnini, Gloria, Morgan, Jeffrey A, Bertagnolli, Monica M, Beadling, Carol, Demetri, George D, Corless, Christopher L, Heinrich, Michael C, Fletcher, Jonathan A, 2015
Cell cycle and dystrophin dysregulation in GIST, Wang, Yuexiang, Fletcher, Jonathan A, 2015
Dystrophin is a tumor suppressor in human cancers with myogenic programs, Wang, Yuexiang, MarinoEnriquez, Adrian, Bennett, Richard R, Zhu, Meijun, Shen, Yiping, Eilers, Grant, Lee, JenChieh, Henze, Joern, Fletcher, Benjamin S, Gu, Zhizhan, Fox, Edward A, Antonescu, Cristina R, Fletcher, Christopher D M, Guo, Xiangqian, Raut, Chandrajit P, Demetri, George D, van de Rijn, Matt, Ordog, Tamas, Kunkel, Louis M, Fletcher, Jonathan A, 2014
Bone morphogenetic protein-2 acts upstream of myocyte-specific enhancer factor 2a to control embryonic cardiac contractility, Wang, Yuexiang, Qian, Linxi, Liu, Dong, Yao, Lingling, Jiang, Qiu, Yu, Zhang, Gui, Yonghao, Zhong, Tao P, Song, Houyan, 2007
Myocyte-specific enhancer factor 2A is essential for zebrafish posterior somite development, Wang, Yuexiang, Qian, Linxi, Dong, Yongxin, Jiang, Qiu, Gui, Yonghao, Zhong, Tao P, Song, Houyan, 2006
Requirements of myocyte-specific enhancer factor 2A in zebrafish cardiac contractility, Wang, Yuexiang, Qian, Linxi, Yu, Zhang, Jiang, Qiu, Dong, Yongxin, Liu, Xuefei, Yang, Xinying, Zhong, TP, Song, Houyan, 2005
Wortmannin induces zebrafish cardia bifida through a mechanism independent of phosphoinositide 3-kinase and myosin light chain kinase, Wang, Yuexiang, Zhong, Tao, Qian, Linxi, Dong, Yongxin, Jiang, Qiu, Tan, Li, Song, Houyan, 2005
Developmental genetics of zebrafish cardiovascular systems, Wang, Yuexiang, Zhong, Tao, Song, Houyan, 2004
VEGF121 cDNA gene transfer and expression in Vitro, Wang, Yuexiang, Yang, Jian, Ma, Chungu, Yang Xinying, Song, Houyan, 2003
Molecular cloning, expression and characterization of recombinant human vascular endothelial growth factor 121, Wang, Yuexiang

Gastrointestinal Stromal Tumor Kras Mutant Cancer Pancreatic Cancer Lung Cancer Multi-Omics Big Data Analysis Artificial Intelligence Diagnostic Reagents Anti-Tumor Drugs Molecular Mechanisms

Chao Chen - Central South University

Zhuo Wang - Shanghai Jiao Tong University

Xin Li - University of Chinese Academy of Sciences

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