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Hang Yang
Life Science
University of Chinese Academy of Sciences
Hubei
Language: Chinese, English
Antimicrobial Resistance
Therapy
Bacteriophage
Host Immunity
Vector Vaccines
Microbiology
Infectious Diseases
Immunology
Pathogens
Biotechnology
Areas of Focus
- Antimicrobial resistance and therapy
- Bacteriophage and host immunity
- Bacteriophage vector vaccines
Work Experience
- 2021-10 to Present: Researcher at Wuhan Institute of Virology, Chinese Academy of Sciences
- 2018-04 to 2019-04: Visiting Scholar at University of Maryland, College Park
- 2018-01 to 2021-10: Young Researcher at Wuhan Institute of Virology, Chinese Academy of Sciences
- 2015-08 to 2017-12: Associate Researcher at Wuhan Institute of Virology, Chinese Academy of Sciences
- 2013-07 to 2015-08: Assistant Researcher at Wuhan Institute of Virology, Chinese Academy of Sciences
Academic Background & Achievements
- 2010-09 to 2013-06: Ph.D. from Wuhan Institute of Virology, Chinese Academy of Sciences
- 2007-09 to 2010-06: Master's from Huazhong Agricultural University
- 2003-09 to 2007-06: Bachelor's from Wuhan Polytechnic University
Publications
- Chrysin 7-O-β-D-glucuronide, a dual inhibitor of SARS-CoV-2 3CLpro and PLpro, for the prevention and treatment of COVID-19, Hang Yang, 2024
- Calcium-binding motif-mediated binding of redundant calcium offers a chimeolysin enhanced bactericidal activity and extended host range under physiological conditions, Hang Yang, 2023
- A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery, Hang Yang, 2023
- Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2, Hang Yang, 2022
- Effects of simeprevir on the replication of SARS-CoV-2 in vitro and in transgenic hACE2 mice, Hang Yang, 2022
- Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infection, Hang Yang, 2022
- Schaftoside inhibits 3CL^(pro)and PL^(pro)of SARS-CoV-2 virus and regulates immune response and inflammation of host cells for the treatment of COVID-19, Hang Yang, 2022
- Enriched Opportunistic Pathogens Revealed by Metagenomic Sequencing Hint Potential Linkages between Pharyngeal Microbiota and COVID-19, Hang Yang, 2021
- A Novel Acinetobacter baumannii Bacteriophage Endolysin LysAB54 With High Antibacterial Activity Against Multiple Gram-Negative Microbes, Hang Yang, 2021
- Internal cell-penetrating peptide-mediated internalization enables a chimeric lysin to target intracellular pathogens, Hang Yang, 2021
- Intrinsic Antimicrobial Peptide Facilitates a New Broad-Spectrum Lysin LysP53 to Kill Acinetobacter baumannii In Vitro and in a Mouse Burn Infection Model, Hang Yang, 2021
- Encapsulation and Delivery of Therapeutic Phages, Hang Yang, 2021
- Genetic Polymorphism Drives Susceptibility Between Bacteria and Bacteriophages, Hang Yang, 2021
- A Highly Active Chimeric Lysin with a Calcium-Enhanced Bactericidal Activity against Staphylococcus aureus In Vitro and In Vivo, Hang Yang, 2021
- Linker Editing of Pneumococcal Lysin ClyJ Conveys Improved Bactericidal Activity, Hang Yang, 2020
- Construction and characterization of a chimeric lysin ClyV with improved bactericidal activity against Streptococcus agalactiae in vitro and in vivo, Hang Yang, 2020
- Can bacteriophage endolysins be nebulised for inhalation delivery against Streptococcus pneumoniae?, Hang Yang, 2020
- A Choline-Recognizing Monomeric Lysin, ClyJ-3m, Shows Elevated Activity against Streptococcus pneumoniae, Hang Yang, 2020
- A Novel Double Core-Shell Bionanoparticle Formed by Ferritin and Baculoviral Polyhedrin, Hang Yang, 2019
- Construction of Lentivirus-Based Reference Material for RT-PCR Detection of Middle East Respiratory Syndrome Coronavirus and Its Application in External Quality Assessment, Hang Yang, 2019
- ClyJ Is a Novel Pneumococcal Chimeric Lysin with a Cysteine- and Histidine-Dependent Amidohydrolase/Peptidase Catalytic Domain, Hang Yang, 2019
- Effects of a Chimeric Lysin against Planktonic and Sessile Enterococcus faecalis Hint at Potential Application in Endodontic Therapy, Hang Yang, 2018
- Staphylococcus aureus virulence attenuation and immune clearance mediated by a phage lysin‐derived protein, Hang Yang, 2018
- Parallel susceptibility testing of bacteria through culture-quantitative pcr in 96-well plates, Hang Yang, 2018
- Activity of the Chimeric Lysin ClyR against Common Gram-Positive Oral Microbes and Its Anticaries Efficacy in Rat Models, Hang Yang, 2018
- Activity of the chimeric lysin clyr against common gram-positive oral microbes and its anticaries efficacy in rat models, Hang Yang, 2018
- Effects of a Chimeric Lysin against Planktonic and Sessile Enterococcus faecalis Hint at Potential Application in Endodontic Therapy, Hang Yang, 2018
- Accurate Detection of Methicillin-Resistant Staphylococcus aureus in Mixtures by Use of Single-Bacterium Duplex Droplet Digital PCR, Hang Yang, 2017
- Rapid and selective detection of E. coli O157:H7 combining phagomagnetic separation with enzymatic colorimetry, Hang Yang, 2017
- Combining phagomagnetic separation with immunoassay for specific, fast and sensitive detection of Staphylococcus aureus, Hang Yang, 2017
- A novel chimeric lysin with robust antibacterial activity against planktonic and biofilm methicillin-resistant Staphylococcus aureus, Hang Yang, 2017
- Comparison between a chimeric lysin ClyH and other enzymes for extracting DNA to detect methicillin resistant Staphylococcus aureus by quantitative PCR, Hang Yang, 2016
- Antibiofilm Activities of a Novel Chimeolysin against Streptococcus mutans under Physiological and Cariogenic Conditions, Hang Yang, 2016
- Sensitive and rapid detection of staphylococcus aureus in milk via cell binding domain of lysin, Hang Yang, 2016
- Sensitive and rapid detection of staphylococcus aureus in milk via cell binding domain of lysin, Hang Yang, 2016
- Rapid detection of viral antibodies based on multifunctional Staphylococcus aureus nanobioprobes, Hang Yang, 2016
- Rapid and sensitive detection of hiv-1 p24 antigen by immunomagnetic separation coupled with catalytic fluorescent immunoassay, Hang Yang, 2016
- Anti-biofilm activities of a novel chimeolysin against S. mutans in physiological and cariogenic conditions, Hang Yang, 2016
- Molecular dissection of phage lysin PlySs2: integrity of the catalytic and cell wall binding domains is essential for its broad lytic activity, Hang Yang, 2015
- Research progress in lysin therapy, Hang Yang, 2015
- Study of the interactions between endolysin and bacterial peptidoglycan on S. aureus by dynamic force spectroscopy, Hang Yang, 2015
- Molecular dissection of phage lysin PlySs2: integrity of the catalytic and cell wall binding domains is essential for its broad lytic activity, Hang Yang, 2015
- Construction of a chimeric lysin Ply187N-V12C with extended lytic activity against staphylococci and streptococci, Hang Yang, 2015
- Isolation and complete genome sequence of a novel virulent mycobacteriophage, CASbig, Hang Yang, 2015
- Aspartate inhibits Staphylococcus aureus biofilm formation, Hang Yang, 2015
- Antibacterial Activity of a Novel
Awards
- Wuhan Youth Science and Technology Morning Light Program (2016)
- Wuhan Yellow Crane Talent (Science and Technology) Program (2016)
- Third Prize at the Fourth Youth Scientist Forum of the Institute of Hydrobiology, Chinese Academy of Sciences (2013)
- Hubei Province Excellent Master's Thesis (2012)
- Paul Biotechnology Award for Outstanding Student (2012)
