Professor | Lei Zhang | Asia Growth Partners

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Name	Lei Zhang
Contact Information	zhangl@fjirsm.ac.cn
Language ability	Chinese, English
Province	Fujian

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Name

Lei Zhang

Contact Information

zhangl@fjirsm.ac.cn

Language ability

Chinese, English

Province

Fujian

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2000-09 to 2007-01: Ph.D. from Huazhong Agricultural University 1996-09 to 2000-06: Bachelor's degree from Huazhong Agricultural University 2010: Awarded Outstanding Postdoctoral Researcher at Wuhan University
Work Experience	2023-06 to Present: Doctoral Supervisor at Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences 2019-12 to Present: Researcher at Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences 2019-07 to Present: Master's Supervisor at University of Chinese Academy of Sciences 2017-09 to 2018-09: Visiting Scholar at St. John's University, USA 2014-12 to 2019-12: Associate Researcher at Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences 2012-02 to 2014-12: Assistant Researcher at Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences 2010-09 to 2011-10: Research Assistant at Xiamen University 2007-08 to 2010-09: Postdoctoral Researcher/Lecturer at Wuhan University
Awards	First Prize for Excellent Academic Papers in Natural Science, Fujian Province (2022)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2000-09 to 2007-01: Ph.D. from Huazhong Agricultural University
1996-09 to 2000-06: Bachelor's degree from Huazhong Agricultural University
2010: Awarded Outstanding Postdoctoral Researcher at Wuhan University

Work Experience

2023-06 to Present: Doctoral Supervisor at Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
2019-12 to Present: Researcher at Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
2019-07 to Present: Master's Supervisor at University of Chinese Academy of Sciences
2017-09 to 2018-09: Visiting Scholar at St. John's University, USA
2014-12 to 2019-12: Associate Researcher at Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
2012-02 to 2014-12: Assistant Researcher at Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
2010-09 to 2011-10: Research Assistant at Xiamen University
2007-08 to 2010-09: Postdoctoral Researcher/Lecturer at Wuhan University

Awards

First Prize for Excellent Academic Papers in Natural Science, Fujian Province (2022)

Areas of Focus	Biochemistry and Molecular Biology Biomedical Materials Microbiology Pharmacy
Publications	The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts, Corresponding Author, 2024 A Serum-Stable supramolecular drug carrier for chemotherapeutics fabricated by a Peptide-Photosensitizer conjugate, 10th Author, 2023 A multi-functional nano-system combining PI3K-110α/β inhibitor overcomes P-glycoprotein mediated MDR and improves anti-cancer efficiency, Corresponding Author, 2023 CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells, Corresponding Author, 2022 Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers, First Author, 2022 Ribociclib Inhibits P-gp-Mediated Multidrug Resistance in Human Epidermoid Carcinoma Cells, First Author, 2022 Albumin-based nanoparticles combined with photodynamic therapy enhance the antitumor activity of curcumin derivative C086, Corresponding Author, 2021 Mechanisms of thrombosis and research progress on targeted antithrombotic drugs, First Author, 2021 Recent progress in antitumor functions of the intracellular antibodies, Corresponding Author, 2020 A strategy for enhanced tumor targeting of photodynamic therapy based on Escherichia coli-driven drug delivery system, Not mentioned, 2020 Plasminogen activator inhibitor (PAI) trap3, an exocellular peptide inhibitor of PAI-1, attenuates the rearrangement of F-actin and migration of cancer cells, Corresponding Author, 2020 The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer, First Author, 2020 Research Progress of Structure Based Antitumor Drug Design, First Author, 2020 Naftifine enhances photodynamic therapy against Staphylococcus aureus by inhibiting staphyloxanthin expression, 6th Author, 2020 Tetrandrine Interaction with ABCB1 Reverses Multidrug Resistance in Cancer Cells Through Competition with Anti-Cancer Drugs Followed by Downregulation of ABCB1 Expression, 8th Author, 2019 Properties and applications of nanoparticle/microparticle conveyors with adjuvant characteristics suitable for oral vaccination, Not mentioned, 2018 Controlled and targeted release of antigens by intelligent shell for improving applicability of oral vaccines, First Author, 2016 非均相高效催化剂在餐厨废油转化生物柴油中的应用, Corresponding Author, 2016 Chemical Synthesis, Versatile Structures and Functions of Tailorable Adjuvants for Optimizing Oral Vaccination, First Author, 2016 A Versatile Monoclonal Antibody Specific Against Human DAB2IP., 6th Author, 2015 Using inositol as a biocompatible ligand for efficient transgene expression, First Author, 2015 Inositol based non-viral vectors for transgene expression in human cervical carcinoma and hepatoma cell lines, Corresponding Author, 2014 Binary gene vectors based on hyperbranched poly( L-lactide-co-polyglycerol) and polyethylenimine for prolonged transgene expression via co-assembly with DNA into fiber core-shell triplexes, Corresponding Author, 2013 Hyperbranched amphiphilic polymer with folate mediated targeting property, First Author, 2010 PEI grafted hyperbranched polymers with polyglycerol as a core for gene delivery, First Author, 2010 Heparin-modified PEI encapsulated in thermosensitive hydrogels for efficient gene delivery and expression, 2nd Author, 2009 The copper-resistant bacterium ACU isolated from the rhizosphere of Eichhornia crassipes (Mart.) increased the endurance of Potamogeton crispus L. to copper toxicity, Not mentioned, 2008 Fusion of the genes for AHL-lactonase and S-layer protein in Bacillus thuringiensis increases its ability to inhibit soft rot caused by Erwinia carotovora, First Author, 2007 Physiological responses induced by copper bioaccumulation in Eichhornia crassipes (Mart.), 2nd Author, 2007

Areas of Focus

Biochemistry and Molecular Biology
Biomedical Materials
Microbiology
Pharmacy

Publications

The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts, Corresponding Author, 2024
A Serum-Stable supramolecular drug carrier for chemotherapeutics fabricated by a Peptide-Photosensitizer conjugate, 10th Author, 2023
A multi-functional nano-system combining PI3K-110α/β inhibitor overcomes P-glycoprotein mediated MDR and improves anti-cancer efficiency, Corresponding Author, 2023
CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells, Corresponding Author, 2022
Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers, First Author, 2022
Ribociclib Inhibits P-gp-Mediated Multidrug Resistance in Human Epidermoid Carcinoma Cells, First Author, 2022
Albumin-based nanoparticles combined with photodynamic therapy enhance the antitumor activity of curcumin derivative C086, Corresponding Author, 2021
Mechanisms of thrombosis and research progress on targeted antithrombotic drugs, First Author, 2021
Recent progress in antitumor functions of the intracellular antibodies, Corresponding Author, 2020
A strategy for enhanced tumor targeting of photodynamic therapy based on Escherichia coli-driven drug delivery system, Not mentioned, 2020
Plasminogen activator inhibitor (PAI) trap3, an exocellular peptide inhibitor of PAI-1, attenuates the rearrangement of F-actin and migration of cancer cells, Corresponding Author, 2020
The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer, First Author, 2020
Research Progress of Structure Based Antitumor Drug Design, First Author, 2020
Naftifine enhances photodynamic therapy against Staphylococcus aureus by inhibiting staphyloxanthin expression, 6th Author, 2020
Tetrandrine Interaction with ABCB1 Reverses Multidrug Resistance in Cancer Cells Through Competition with Anti-Cancer Drugs Followed by Downregulation of ABCB1 Expression, 8th Author, 2019
Properties and applications of nanoparticle/microparticle conveyors with adjuvant characteristics suitable for oral vaccination, Not mentioned, 2018
Controlled and targeted release of antigens by intelligent shell for improving applicability of oral vaccines, First Author, 2016
非均相高效催化剂在餐厨废油转化生物柴油中的应用, Corresponding Author, 2016
Chemical Synthesis, Versatile Structures and Functions of Tailorable Adjuvants for Optimizing Oral Vaccination, First Author, 2016
A Versatile Monoclonal Antibody Specific Against Human DAB2IP., 6th Author, 2015
Using inositol as a biocompatible ligand for efficient transgene expression, First Author, 2015
Inositol based non-viral vectors for transgene expression in human cervical carcinoma and hepatoma cell lines, Corresponding Author, 2014
Binary gene vectors based on hyperbranched poly( L-lactide-co-polyglycerol) and polyethylenimine for prolonged transgene expression via co-assembly with DNA into fiber core-shell triplexes, Corresponding Author, 2013
Hyperbranched amphiphilic polymer with folate mediated targeting property, First Author, 2010
PEI grafted hyperbranched polymers with polyglycerol as a core for gene delivery, First Author, 2010
Heparin-modified PEI encapsulated in thermosensitive hydrogels for efficient gene delivery and expression, 2nd Author, 2009
The copper-resistant bacterium ACU isolated from the rhizosphere of Eichhornia crassipes (Mart.) increased the endurance of Potamogeton crispus L. to copper toxicity, Not mentioned, 2008
Fusion of the genes for AHL-lactonase and S-layer protein in Bacillus thuringiensis increases its ability to inhibit soft rot caused by Erwinia carotovora, First Author, 2007
Physiological responses induced by copper bioaccumulation in Eichhornia crassipes (Mart.), 2nd Author, 2007

Biochemistry Molecular Biology Biomedical Materials Microbiology Pharmacy Tumor Mechanisms Antitumor Drugs Oral Vaccines Protein Function Gene Regulation

Yihua Chen - University of Chinese Academy of Sciences

Yanfang Wang - Tongji University

Shaojun Dai - Shanghai Normal University

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