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Lei Zhang
Life Science
University of Chinese Academy of Sciences
Fujian
Language: Chinese, English
Biochemistry
Molecular Biology
Biomedical Materials
Microbiology
Pharmacy
Tumor Mechanisms
Antitumor Drugs
Oral Vaccines
Protein Function
Gene Regulation
Areas of Focus
- Biochemistry and Molecular Biology
- Biomedical Materials
- Microbiology
- Pharmacy
Work Experience
- 2023-06 to Present: Doctoral Supervisor at Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
- 2019-12 to Present: Researcher at Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
- 2019-07 to Present: Master's Supervisor at University of Chinese Academy of Sciences
- 2017-09 to 2018-09: Visiting Scholar at St. John's University, USA
- 2014-12 to 2019-12: Associate Researcher at Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
- 2012-02 to 2014-12: Assistant Researcher at Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
- 2010-09 to 2011-10: Research Assistant at Xiamen University
- 2007-08 to 2010-09: Postdoctoral Researcher/Lecturer at Wuhan University
Academic Background & Achievements
- 2000-09 to 2007-01: Ph.D. from Huazhong Agricultural University
- 1996-09 to 2000-06: Bachelor's degree from Huazhong Agricultural University
- 2010: Awarded Outstanding Postdoctoral Researcher at Wuhan University
Publications
- The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts, Corresponding Author, 2024
- A Serum-Stable supramolecular drug carrier for chemotherapeutics fabricated by a Peptide-Photosensitizer conjugate, 10th Author, 2023
- A multi-functional nano-system combining PI3K-110α/β inhibitor overcomes P-glycoprotein mediated MDR and improves anti-cancer efficiency, Corresponding Author, 2023
- CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells, Corresponding Author, 2022
- Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers, First Author, 2022
- Ribociclib Inhibits P-gp-Mediated Multidrug Resistance in Human Epidermoid Carcinoma Cells, First Author, 2022
- Albumin-based nanoparticles combined with photodynamic therapy enhance the antitumor activity of curcumin derivative C086, Corresponding Author, 2021
- Mechanisms of thrombosis and research progress on targeted antithrombotic drugs, First Author, 2021
- Recent progress in antitumor functions of the intracellular antibodies, Corresponding Author, 2020
- A strategy for enhanced tumor targeting of photodynamic therapy based on Escherichia coli-driven drug delivery system, Not mentioned, 2020
- Plasminogen activator inhibitor (PAI) trap3, an exocellular peptide inhibitor of PAI-1, attenuates the rearrangement of F-actin and migration of cancer cells, Corresponding Author, 2020
- The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer, First Author, 2020
- Research Progress of Structure Based Antitumor Drug Design, First Author, 2020
- Naftifine enhances photodynamic therapy against Staphylococcus aureus by inhibiting staphyloxanthin expression, 6th Author, 2020
- Tetrandrine Interaction with ABCB1 Reverses Multidrug Resistance in Cancer Cells Through Competition with Anti-Cancer Drugs Followed by Downregulation of ABCB1 Expression, 8th Author, 2019
- Properties and applications of nanoparticle/microparticle conveyors with adjuvant characteristics suitable for oral vaccination, Not mentioned, 2018
- Controlled and targeted release of antigens by intelligent shell for improving applicability of oral vaccines, First Author, 2016
- 非均相高效催化剂在餐厨废油转化生物柴油中的应用, Corresponding Author, 2016
- Chemical Synthesis, Versatile Structures and Functions of Tailorable Adjuvants for Optimizing Oral Vaccination, First Author, 2016
- A Versatile Monoclonal Antibody Specific Against Human DAB2IP., 6th Author, 2015
- Using inositol as a biocompatible ligand for efficient transgene expression, First Author, 2015
- Inositol based non-viral vectors for transgene expression in human cervical carcinoma and hepatoma cell lines, Corresponding Author, 2014
- Binary gene vectors based on hyperbranched poly( L-lactide-co-polyglycerol) and polyethylenimine for prolonged transgene expression via co-assembly with DNA into fiber core-shell triplexes, Corresponding Author, 2013
- Hyperbranched amphiphilic polymer with folate mediated targeting property, First Author, 2010
- PEI grafted hyperbranched polymers with polyglycerol as a core for gene delivery, First Author, 2010
- Heparin-modified PEI encapsulated in thermosensitive hydrogels for efficient gene delivery and expression, 2nd Author, 2009
- The copper-resistant bacterium ACU isolated from the rhizosphere of Eichhornia crassipes (Mart.) increased the endurance of Potamogeton crispus L. to copper toxicity, Not mentioned, 2008
- Fusion of the genes for AHL-lactonase and S-layer protein in Bacillus thuringiensis increases its ability to inhibit soft rot caused by Erwinia carotovora, First Author, 2007
- Physiological responses induced by copper bioaccumulation in Eichhornia crassipes (Mart.), 2nd Author, 2007
Awards
- First Prize for Excellent Academic Papers in Natural Science, Fujian Province (2022)
