Areas of Focus
- Development of human nervous system using brain and optic nerve organoids
- Mechanisms and treatments of neurological diseases using organoids
- Brain and optic nerve tumor research using organoids
Work Experience
- 2010-2013 - Postdoctoral Researcher at Weill Medical College of Cornell University, USA
- 2014-2018 - Postdoctoral Researcher at Institute of Molecular Biotechnology, Austrian Academy of Sciences
- 2019-present - Distinguished Researcher at Tongji University, School of Life Sciences and Technology
Academic Background & Achievements
- 2004 - Bachelor's and Master's degrees from China Pharmaceutical University
- 2009 - PhD from University of Freiburg, Germany, under Melitta Schachner
- Published as first and corresponding author in prestigious journals
Publications
- RGCC balances self-renewal and neuronal differentiation of neural stem cells in the developing mammalian neocortex, Guo Z, Chen M, Chao Y, Cai C, Liu L, Zhao L, Li L, Bai QR, Xu Y, Niu W, Shi L, Bi Y, Ren D, Yuan F, Shi S, Zeng Q, Han K, Shi Y, Bian S, He G, 2021
- Maternal sevoflurane exposure induces temporary defects in interkinetic nuclear migration of radial glial progenitors in the fetal cerebral cortex through the Notch signalling pathway, Jiang M, Tang T, Liang X, Li J, Qiu Y, Liu S, Bian S, Xie Y, Fang F, Cang J, 2021
- PAUPAR and PAX6 sequentially regulate human embryonic stem cell cortical differentiation, Xu Y, Xi J, Wang G, Guo Z, Sun Q, Lu C, Ma L, Wu Y, Jia W, Zhu S, Guo X, Bian S, Kang J, 2021
- Application of fused organoid models to study human brain development and neural disorders, Chen A, Guo Z, Fang L, Bian S, 2020
- Genetically engineered cerebral organoids model formation of brain tumors, Bian S, Repic M, Guo Z, Kavirayani A, Burkard T, Bagley J, Krauditsch C, Knoblich JA, 2018
- Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex, Miao N, Bian S, Lee T, Mubarak T, Huang S, Wen Z, Hussain G, Sun T, 2018
- Fused cerebral organoids model interactions between brain regions, Bagley JA, Reumann D, Bian S, Lévi-Strauss J, Knoblich JA, 2017
- Self-organized developmental patterning and differentiation in cerebral organoids, Renner M, Lancaster MA, Bian S, Choi H, Ku T, Peer A, Chung K, Knoblich JA, 2017
