Professor | Shujia Zhu | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Shujia Zhu
Contact Information	shujiazhu@ion.ac.cn
Language ability	English, Chinese, French
Province	Shanghai

Upload Avatar (500 x 500)

Name

Shujia Zhu

Contact Information

shujiazhu@ion.ac.cn

Language ability

English, Chinese, French

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2009-09--2013-09 PhD: Université Pierre et Marie Curie (Paris VI) 2006-09--2009-06 Master's: East China Normal University 2002-09--2006-06 Bachelor's: Zhejiang University of Technology

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2009-09--2013-09 PhD: Université Pierre et Marie Curie (Paris VI)
2006-09--2009-06 Master's: East China Normal University
2002-09--2006-06 Bachelor's: Zhejiang University of Technology

Areas of Focus	Structure and function of synaptic proteins Molecular mechanisms and pathophysiology of autoimmune encephalitis Neuropharmacology based on structural and computational biology
Publications	Structural basis of ketamine action on human NMDA receptors, Zhang Y, Ye F, Zhang T, Lv S, Zhou L, Du D, Lin H, Guo F, Luo C#, Zhu S#, 2021 Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors, Wang H, Lv S, Stroebel D, Zhang J, Pan Y, Huang X, Zhang X, Paoletti P, Zhu S#, 2021 Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits, Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S#, 2023 Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors, Zhang J, Chang S, Xu P, Miao M, Wu H, Zhang Y, Zhang T, Wang H, Zhang J, Xie C, Song N, Luo C#, Zhang X#, Zhu S#, 2018 Mechanism of NMDA receptor inhibition and activation, Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E, 2016 Genetically encoding a light-switch in an ionotropic glutamate receptor reveals subunit-specific interfaces, Zhu S, Riou M, Yao A, Carvalho S, Rodriguez P, Bensaude O, Paoletti P#, Ye S#, 2014 Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain, Zhu S, Stroebel D, C.Andrea Y, Taly A, Paoletti P, 2013 Cryo-EM structure of human heptameric Pannexin 1 channel, Qu R, Dong L, Zhang J, Yu X#, Wang L#, Zhu S#, 2020 Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors, Zeng Y, Zheng Y, Zhang T, Ye F, Zhan L, Kou Z, Zhu S#, Gao Z#, 2022 NMDA receptors as therapeutic targets for depression treatment: Evidence from clinical to basic research, Lv S, Yao K, Zhang Y, Zhu S#, 2023 Mechanisms of PiT2-loop7 Missense Mutations Induced Pi Dyshomeostasis, Sun, H, Xu, X, Ma T, Cui J, Liu M, Xiong B. Zhu S#, Liu J#, 2022 Prediction of ligand modulation patterns on membrane receptors via lysine reactivity profiling, Zhou Y, Liu Z, Zhang J, Dou T, Chen J, Ge G, Zhu S#, Wang F#, 2019 Structure and symmetry inform gating principles of ionotropic glutamate receptors, Zhu S, Gouaux E, 2017 Controlling NMDA Receptor Subunit Composition Using Ectopic Retention Signals, Stroebel D, Carvalho S, Grand T, Zhu S, Paoletti P, 2014 Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines, Mony L, Zhu S, Carvalho S, Paoletti P, 2011 Allosteric modulators of NMDA receptors: multiple sites and mechanisms, Zhu S, Paoletti P, 2015

Areas of Focus

Structure and function of synaptic proteins
Molecular mechanisms and pathophysiology of autoimmune encephalitis
Neuropharmacology based on structural and computational biology

Publications

Structural basis of ketamine action on human NMDA receptors, Zhang Y*, Ye F*, Zhang T*, Lv S, Zhou L, Du D, Lin H, Guo F, Luo C#, Zhu S#, 2021
Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors, Wang H, Lv S, Stroebel D, Zhang J, Pan Y, Huang X, Zhang X, Paoletti P, Zhu S#, 2021
Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits, Zhang J*, Zhang M*, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S#, 2023
Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors, Zhang J*, Chang S*, Xu P*, Miao M, Wu H, Zhang Y, Zhang T, Wang H, Zhang J, Xie C, Song N, Luo C#, Zhang X#, Zhu S#, 2018
Mechanism of NMDA receptor inhibition and activation, Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E, 2016
Genetically encoding a light-switch in an ionotropic glutamate receptor reveals subunit-specific interfaces, Zhu S*, Riou M*, Yao A, Carvalho S, Rodriguez P, Bensaude O, Paoletti P#, Ye S#, 2014
Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain, Zhu S, Stroebel D, C.Andrea Y, Taly A, Paoletti P, 2013
Cryo-EM structure of human heptameric Pannexin 1 channel, Qu R*, Dong L*, Zhang J, Yu X#, Wang L#, Zhu S#, 2020
Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors, Zeng Y, Zheng Y, Zhang T, Ye F, Zhan L, Kou Z, Zhu S#, Gao Z#, 2022
NMDA receptors as therapeutic targets for depression treatment: Evidence from clinical to basic research, Lv S, Yao K, Zhang Y, Zhu S#, 2023
Mechanisms of PiT2-loop7 Missense Mutations Induced Pi Dyshomeostasis, Sun, H, Xu, X, Ma T, Cui J, Liu M, Xiong B. Zhu S#, Liu J#, 2022
Prediction of ligand modulation patterns on membrane receptors via lysine reactivity profiling, Zhou Y, Liu Z, Zhang J, Dou T, Chen J, Ge G, Zhu S#, Wang F#, 2019
Structure and symmetry inform gating principles of ionotropic glutamate receptors, Zhu S, Gouaux E, 2017
Controlling NMDA Receptor Subunit Composition Using Ectopic Retention Signals, Stroebel D, Carvalho S, Grand T, Zhu S, Paoletti P, 2014
Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines, Mony L, Zhu S, Carvalho S, Paoletti P, 2011
Allosteric modulators of NMDA receptors: multiple sites and mechanisms, Zhu S, Paoletti P, 2015

Synaptic Proteins Structure Function Autoimmune Encephalitis Molecular Mechanisms Pathophysiology Neuropharmacology Structural Biology Computational Biology Ligand-Gated Ion Channels

Xiaoou Zhang - Tongji University

Xiaobai Zhang - Tongji University

Liang Ge - Tsinghua University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us