Professor | 竺淑佳 | 数字化转型顾问

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Name	竺淑佳
Contact Information	shujiazhu@ion.ac.cn
Language ability	英语, 中文, 法语
Province	上海

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Name

竺淑佳

Contact Information

shujiazhu@ion.ac.cn

Language ability

英语, 中文, 法语

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2009-09--2013-09 博士: 法国巴黎第六大学 2006-09--2009-06 硕士: 华东师范大学 2002-09--2006-06 本科: 浙江工业大学

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

2009-09--2013-09 博士: 法国巴黎第六大学
2006-09--2009-06 硕士: 华东师范大学
2002-09--2006-06 本科: 浙江工业大学

Areas of Focus	突触蛋白的结构与功能自身免疫性脑炎的分子机制及病理生理学研究基于结构与计算生物学的神经药理学
Publications	Structural basis of ketamine action on human NMDA receptors, Zhang Y, Ye F, Zhang T, Lv S, Zhou L, Du D, Lin H, Guo F, Luo C#, Zhu S#, 2021 Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors, Wang H, Lv S, Stroebel D, Zhang J, Pan Y, Huang X, Zhang X, Paoletti P, Zhu S#, 2021 Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits, Zhang J, Zhang M, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S#, 2023 Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors, Zhang J, Chang S, Xu P, Miao M, Wu H, Zhang Y, Zhang T, Wang H, Zhang J, Xie C, Song N, Luo C#, Zhang X#, Zhu S#, 2018 Mechanism of NMDA receptor inhibition and activation, Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E, 2016 Genetically encoding a light-switch in an ionotropic glutamate receptor reveals subunit-specific interfaces, Zhu S, Riou M, Yao A, Carvalho S, Rodriguez P, Bensaude O, Paoletti P#, Ye S#, 2014 Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain, Zhu S, Stroebel D, C.Andrea Y, Taly A, Paoletti P, 2013 Cryo-EM structure of human heptameric Pannexin 1 channel, Qu R, Dong L, Zhang J, Yu X#, Wang L#, Zhu S#, 2020 Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors, Zeng Y, Zheng Y, Zhang T, Ye F, Zhan L, Kou Z, Zhu S#, Gao Z#, 2022 NMDA receptors as therapeutic targets for depression treatment: Evidence from clinical to basic research, Lv S, Yao K, Zhang Y, Zhu S#, 2023 Mechanisms of PiT2-loop7 Missense Mutations Induced Pi Dyshomeostasis, Sun, H, Xu, X, Ma T, Cui J, Liu M, Xiong B. Zhu S#, Liu J#, 2022 Prediction of ligand modulation patterns on membrane receptors via lysine reactivity profiling, Zhou Y, Liu Z, Zhang J, Dou T, Chen J, Ge G, Zhu S#, Wang F#, 2019 Structure and symmetry inform gating principles of ionotropic glutamate receptors, Zhu S, Gouaux E, 2017 Controlling NMDA Receptor Subunit Composition Using Ectopic Retention Signals, Stroebel D, Carvalho S, Grand T, Zhu S, Paoletti P, 2014 Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines, Mony L, Zhu S, Carvalho S, Paoletti P, 2011 Allosteric modulators of NMDA receptors: multiple sites and mechanisms, Zhu S, Paoletti P, 2015

Areas of Focus

突触蛋白的结构与功能
自身免疫性脑炎的分子机制及病理生理学研究
基于结构与计算生物学的神经药理学

Publications

Structural basis of ketamine action on human NMDA receptors, Zhang Y*, Ye F*, Zhang T*, Lv S, Zhou L, Du D, Lin H, Guo F, Luo C#, Zhu S#, 2021
Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors, Wang H, Lv S, Stroebel D, Zhang J, Pan Y, Huang X, Zhang X, Paoletti P, Zhu S#, 2021
Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits, Zhang J*, Zhang M*, Wang Q, Wen H, Liu Z, Wang F, Wang Y, Yao F, Song N, Kou Z, Li Y, Guo F, Zhu S#, 2023
Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors, Zhang J*, Chang S*, Xu P*, Miao M, Wu H, Zhang Y, Zhang T, Wang H, Zhang J, Xie C, Song N, Luo C#, Zhang X#, Zhu S#, 2018
Mechanism of NMDA receptor inhibition and activation, Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E, 2016
Genetically encoding a light-switch in an ionotropic glutamate receptor reveals subunit-specific interfaces, Zhu S*, Riou M*, Yao A, Carvalho S, Rodriguez P, Bensaude O, Paoletti P#, Ye S#, 2014
Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain, Zhu S, Stroebel D, C.Andrea Y, Taly A, Paoletti P, 2013
Cryo-EM structure of human heptameric Pannexin 1 channel, Qu R*, Dong L*, Zhang J, Yu X#, Wang L#, Zhu S#, 2020
Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors, Zeng Y, Zheng Y, Zhang T, Ye F, Zhan L, Kou Z, Zhu S#, Gao Z#, 2022
NMDA receptors as therapeutic targets for depression treatment: Evidence from clinical to basic research, Lv S, Yao K, Zhang Y, Zhu S#, 2023
Mechanisms of PiT2-loop7 Missense Mutations Induced Pi Dyshomeostasis, Sun, H, Xu, X, Ma T, Cui J, Liu M, Xiong B. Zhu S#, Liu J#, 2022
Prediction of ligand modulation patterns on membrane receptors via lysine reactivity profiling, Zhou Y, Liu Z, Zhang J, Dou T, Chen J, Ge G, Zhu S#, Wang F#, 2019
Structure and symmetry inform gating principles of ionotropic glutamate receptors, Zhu S, Gouaux E, 2017
Controlling NMDA Receptor Subunit Composition Using Ectopic Retention Signals, Stroebel D, Carvalho S, Grand T, Zhu S, Paoletti P, 2014
Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines, Mony L, Zhu S, Carvalho S, Paoletti P, 2011
Allosteric modulators of NMDA receptors: multiple sites and mechanisms, Zhu S, Paoletti P, 2015

突触蛋白结构功能自身免疫性脑炎分子机制病理生理学神经药理学结构生物学计算生物学配体门控离子通道

林昶东 - 同济大学

Area of Focus
细胞粘附 | 信号传导 | 发展 | 感染 | 免疫 | 癌症 | 衰老 | 分子机制 | 病理生理学 | 治疗干预

孙方霖 - 同济大学

Area of Focus
表观遗传学 | 分子机制 | 调控 | 异染色质 | 结构 | 功能 | 干细胞 | 衰老 | 网络 | 研究

俞芳 - 上海师范大学

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