Areas of Focus
- Biosynthesis and Metabolic Regulation of Important Biologics
Work Experience
- 2005-11~Present - Institute of Microbiology, Chinese Academy of Sciences - Researcher, Doctoral Supervisor
- 2004-01~2005-09 - CNRS UPR9073, France - Postdoctoral Researcher
- 1989-08~2004-01 - First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine - Director of Molecular Biology Laboratory
Academic Background & Achievements
- 1999-09--2002-06 Ph.D. in Microbiology: Nankai University
- 1986-09--1989-06 M.Sc. in Microbiology: Nankai University
- 1982-09--1986-06 B.Sc. in Microbiology: Nankai University
Publications
- Model-guided metabolic rewiring to bypass pyruvate oxidation for pyruvate derivative synthesis by minimising carbon loss, Yun Zhang, Xueliang Wang, Christianah Odesanmi, Qitiao Hu, Dandan Li, Yuan Tang, Zhe Liu, Jie Mi, Shuwen Liu, Tingyi Wen, 2024
- Adaptive mechanisms of Bacillus to near space extreme environments, Aihua Deng, Tiantian Wang, Junyue Wang, Lai Li, Xueliang Wang, Li Liu, Tingyi Wen, 2023
- Multivariate modular metabolic engineering for enhanced l-methionine biosynthesis in Escherichia coli, Zhongcai Li, Qian Liu, Jiahui Sun, Jianjian Sun, Mingjie Li, Yun Zhang, Aihua Deng, Shuwen Liu, Tingyi Wen, 2023
- A Universal Method for Developing Autoinduction Expression Systems Using AHL-Mediated Quorum-Sensing Circuits, Lai Li, Aihua Deng, Shuwen Liu, Junyue Wang, Ruilin Shi, Tiantian Wang, Di Cui, Hua Bai, Yun Zhang, Tingyi Wen, 2022
- In silico-guided metabolic engineering of Bacillus subtilis for efficient biosynthesis of purine nucleosides by blocking the key backflow nodes, Aihua Deng, Qidi Qiu, Qinyun Sun, Zhenxiang Chen, Junyue Wang, Yu Zhang, Shuwen Liu, Tingyi Wen, 2022
- High-throughput sequencing unravels the cell heterogeneity of cerebrospinal fluid in the bacterial meningitis of children, Haihan Xiao, Haijuan Xiao, Yun Zhang, Lingyun Guo, Zhenzhen Dou, Linlin Liu, Wenya Feng, Bing Liu, Bing Hu, Tianming Chen, Gang Liu, Tingyi Wen, 2022
- Model-Guided Metabolic Rewiring for Gamma-Aminobutyric Acid and Butyrolactam Biosynthesis in Corynebacterium glutamicum ATCC13032, Yun Zhang, Jing Zhao, Xueliang Wang, Yuan Tang, Shuwen Liu, Tingyi Wen, 2022
- Zeolitic imidazolate framework-based nanoparticles for the cascade enhancement of cancer chemodynamic therapy by targeting glutamine metabolism, Hui Jian, Yun Zhang, Junyue Wang, Zhenxiang Chen, Tingyi Wen, 2022
- SHMT2 promotes cell viability and inhibits ROS-dependent, mitochondrial-mediated apoptosis via the intrinsic signaling pathway in bladder cancer cells, Yun Zhang, Zhe Liu, Xueliang Wang, Hui Jian, Xiaohai Han, Tingyi Wen, 2022
- Simultaneous Multiplex Genome Engineering via Accelerated Natural Transformation in Bacillus subtilis, Aihua Deng, Zhaopeng Sun, Tiantian Wang, Di Cui, Lai Li, Shuwen Liu, Fei Huang, Tingyi Wen, 2021
- Comparative Evaluation of Bandage Contact Lenses and Eye Patching after Bilateral Cataract Surgery, Dalan Jing, Aihua Deng, Hongmei Wang, Yilin Chou, Xiaodan Jiang, Zhenxiang Chen, Xuemin Li, Tingyi Wen, 2021
- Lysobacter oculi sp. nov., isolated from human Meibomian gland secretions, Hua Bai, Huibin Lv, Aihua Deng, Xiaodan Jiang, Xuemin Li, Tingyi Wen, 2020
- A seamless and iterative DNA assembly method named PS-Brick and its assisted metabolic engineering for threonine and 1-propanol production, Shuwen Liu, Haihan Xiao, Fangfang Zhang, Zheng Lu, Yun Zhang, Aihua Deng, Zhongcai Li, Cui Yang, Tingyi Wen, 2019
- Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Escherichia coli, Di Cui, Aihua Deng, Hua Bai, Zhao Yang, Yong Liang, Zhe Liub, Qidi Qiu, Laiyou Wang, Shuwen Liu, Yun Zhang, Yi Shi, Jianxun Qi, Tingyi Wen, 2019
- Reconstruction of TCA cycle in Corynebacterium glutamicum with a genome-scale metabolic network model for trans-4-hydroxyproline production, Yu Zhang, Yun Zhang, Xiuling Shang, Bo Wang, Qitiao Hu, Shuwen Liu, Tingyi Wen, 2019
- Efficient CRISPR–Cas9 mediated multiplex genome editing in yeasts, Laiyou Wang, Aihua Deng, Yun Zhang, Shuwen Liu, Yong Liang, Hua Bai, Di Cui, Qidi Qiu, Xiuling Shang, Zhao Yang, Xiuping He, Tingyi Wen, 2018
- Pathogens in the Meibomian Gland and Conjunctival Sac: Microbiome of Normal Subjects and Patients with Meibomian Gland Dysfunction, Xiaodan Jiang, Aihua Deng, Jiarui Yang, Hua Bai, Zhao Yang, Jie Wu, Huibin Lv, Xuemin Li, Tingyi Wen, 2018
- A RecET-assisted CRISPR-Cas9 genome editing in Corynebacterium glutamicum, Bo Wang, Qitiao Hu, Yu Zhang, Ruilin Shi, Xin Chai, Zhe Liu, Xiuling Shang, Yun Zhang, Tingyi Wen, 2018
- Bacterial Genome Editing via a Designed Toxin−Antitoxin Cassette, Jie Wu, Aihua Deng, Qinyun Sun, Hua Bai, Zhaopeng Sun, Xiuling Shang, Yun Zhang, Qian Liu, Yong Liang, Shuwen Liu, Yongsheng Che, Tingyi Wen, 2018
- Reprogramming one-carbon metabolic pathways to decouple l-serine catabolism from cell growth in Corynebacterium glutamicum, Yun Zhang, Xiuling Shang, Shujuan Lai, Yu Zhang, Qitiao Hu, Xin Chai, Bo Wang, Shuwen Liu, Tingyi Wen, 2018
- Native promoters of Corynebacterium glutamicum and its application in l-lysine production, Xiuling Shang, Xin Chai, Xuemei Lu, Yuan Li, Yun Zhang, Guoqiang Wang, Chen Zhang, Shuwen Liu, Yu Zhang, Jiyin Ma, Tingyi Wen, 2018
- A Novel Tool for Microbial Genome Editing Using the Restriction-Modification System, Hua Bai, Aihua Deng, Shuwen Liu, Di Cui, Qidi Qiu, Laiyou Wang, Zhao Yang, Jie Wu, Xiuling Shang, Yun Zhang, Tingyi Wen, 2018
- The KMT1A-GATA3-STAT3 circuit is a novel self-renewal signaling of human bladder cancer stem cells, Zhao Yang, Luyun He, Kaisu Lin, Yun Zhang, Aihua Deng, Yong Liang, Chong Li, Tingyi Wen, 2017
- A new genome-scale metabolic model of Corynebacterium glutamicum and its application, Yu Zhang, Jingyi Cai, Xiuling Shang, Bo Wang, Shuwen Liu, Xin Chai, Tianwei Tan, Yun Zhang, Tingyi Wen, 2017
- A novel pyruvate kinase and its application in lactic acid production under oxygen deprivation in Corynebacterium glutamicum, Xin Chai, Xiuling Shang, Yu Zhang, Shuwen Liu, Yong Liang, Yun Zhang, Tingyi Wen, 2016
- In vitro assembly of the bacterial actin protein MamK from ‘Candidatus Magnetobacterium casensis’ in the phylum Nitrospirae, Aihua Deng, Wei Lin, Nana Shi, Jie Wu, Zhaopeng Sun, Qinyun Sun, Hua Bai, Yongxin Pan, Tingyi Wen, 2016
- YjeH Is a Novel Exporter of l-Methionine and Branched-Chain Amino Acids in Escherichia coli, Qian Liu, Yong Liang, Yun Zhang, Xiuling Shang, Shuwen Liu, Jifu Wen, Tingyi Wen, 2015
- A high efficiency recombineering system with PCR-based ssDNA in Bacillus subtilis mediated by the native phage recombinase GP35, Zhaopeng Sun, Aihua Deng, Ting Hu, Jie Wu, Qinyun Sun, Hua Bai, Guoqiang Zhang, Tingyi Wen, 2015
- Secretory expression, functional characterization and molecular genetic analysis of a novel halo-solvent-tolerant protease from Bacillus gibsonii, Aihua Deng, Guoqiang Zhang, Nana Shi, Jie Wu, Fuping Lu, Tingyi Wen, 2014
- Characterization and Molecular Mechanism of AroP as an Aromatic Amino Acid and Histidine Transporter in Corynebacterium glutamicum, Xiuling Shang, Yun Zhang, Guoqiang Zhang, Xin Chai, Aihua Deng, Yong Liang, Tingyi Wen
Awards
- 2015: Key Technology and Industrial Application of Lysine and Threonine Industrial Production Strain Transformation, Chinese Academy of Sciences Science and Technology Promotion Development Award, Second Prize for Scientific Contribution
- 2016: Construction of L-Threonine, L-Serine, and L-Methionine Genetically Engineered Bacteria and Optimization of Fermentation Conditions, Yinchuan City Industry-University-Research Cooperation Award
- 2015: Zhu Li Yuehua Excellent Teacher Award, Chinese Academy of Sciences
- 2013: Excellent Graduate Student Supervisor Award, Chinese Academy of Sciences
