2014-05~Present - Institute of Zoology, Chinese Academy of Sciences - Researcher
2009-08~2014-01 - Massachusetts Institute of Technology - Postdoctoral Researcher
2003-09~2009-07 - University of Washington - Ph.D. Student
2001-09~2003-05 - University of Miami - M.Sc. Student
1997-09~2001-07 - Xiamen University - B.Sc. Student
Research
Gene Engineering Technology Epigenetic Modification Technology Development and Application
Heterologous survey of 130 DNA transposons in human cells highlights their functional divergence and expands the genome engineering toolbox, 10th Author, 2024
Unlocking CAR T cell potential: Inosine-induced stemness and enhanced potency., 2nd Author, 2024
Evolutionary mining and functional characterization of TnpB nucleases identify efficient miniature genome editors, 11th Author, 2023
Characterisation of X chromosome status of human extended pluripotent stem cells, 2nd Author, 2023
Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells, 3rd Author, 2022
Genetically Encoded Double-Stranded DNA-Based Nanostructure Folded by a Covalently Bivalent CRISPR/dCas System, 10th Author, 2022
Loss of circSRY reduces H2AX level in germ cells and impairs mouse spermatogenesis, 2nd Author, 2022
Small-molecule compounds boost genome-editing efficiency of cytosine base editor, 13th Author, 2021
Mutant B2M-HLA-E and B2M-HLA-G fusion proteins protects universal chimeric antigen receptor-modified T cells from allogeneic NK cell-mediated lysis, 8th Author, 2021
Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors, 16th Author, 2021
Response to 'Reproducibility of CRISPR Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation', 2nd Author, 2021
Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation, 9th Author, 2020
Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathway, 7th Author, 2020
Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development, 16th Author, 2020
Recent advances of genome editing and related technologies in China, 2nd Author, 2020
Recent advances in CRISPR research, 3rd Author, 2020
Engineering T Cells Using CRISPR/Cas9 for Cancer Therapy, 1st Author, 2020
TGF-beta inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors, 9th Author, 2020
Gene-edited babies: What went wrong and what could go wrong, 1st Author, 2019
5'capped and 3'polyA-tailed sgRNAs enhance the efficiency of CRISPR-Cas9 system, 6th Author, 2019
基因编辑技术照亮治癌之路, 2nd Author, 2019
Bacteria-free minicircle DNA system to generate integration-free CAR-T cells, 7th Author, 2019
In vitro transcribed sgRNA causes cell death by inducing interferon release, 6th Author, 2019
Argonaute proteins from human gastrointestinal bacteria catalyze DNA-guided cleavage of single- and double-stranded DNA at 37 degrees C, 11th Author, 2019
Editing porcine IGF2 regulatory element improved meat production in Chinese Bama pigs, 8th Author, 2018
5'capped and 3'polyA-tailed sgRNAs enhance the efficiency of CRISPR-Cas9 system, 6th Author, 2018
Temperature Effect on CRISPR-Cas9 Mediated Genome Editing, 5th Author, 2017
Editing base in mouse model, 1st Author, 2017
Erratum to: Questions about NgAgo, 14th Author, 2017
CRISPR-Cas9-Mediated Multiplex Gene Editing in CAR-T Cells, 10th Author, 2017
Delivery of Cas9 protein into mouse zygotes through a series of electroporation dramatically increased the efficiency of model creation, 10th Author, 2016
Casilio: A Versatile CRISPR-Cas9-Pumilio Hybrid for Gene Regulation and Genomic Labeling, 8th Author, 2016
NgAgo: An Exciting New Tool for Genome Editing, 1st Author, 2016
Questions about NgAgo, 13th Author, 2016
Molecular Criteria for Defining the Naive Human Pluripotent State, 8th Author, 2016
CRISPR-Cas9 Application in Mouse Model Creation and Transcription Regulation, 1st Author, 2016
基于CRISPR-Cas9新型基因编辑技术研究, 1st Author, 2016
Generating Mouse Models Using CRISPR-Cas9-Mediated Genome Editing, 8th Author, 2016
Questions About NgAgo, 14th Author, 2016
靶向核酸酶介导基因编辑技术的发展, 2nd Author, 2015
CRISPR-Cas9-mediated genome editing and guide RNA design, 4th Author, 2015
Targeting Hepatitis B Virus cccDNA by CRISPR/Cas9 Nuclease Efficiently Inhibits Viral Replication, 3rd Author, 2015
Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease, 10th Author, 2015
Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency, 3rd Author, 2014
Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells, 3rd Author, 2014
