Professor | Hui Xiao | Asia Growth Partners

Name	Hui Xiao
Contact Information	huixiao@ips.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Hui Xiao

Contact Information

huixiao@ips.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1994-09--1997-07 PhD in Molecular Genetics: Shanghai Institute of Plant Physiology, Chinese Academy of Sciences 1991-09--1994-07 Master's in Microbiology and Immunology: School of Life Sciences, Wuhan University 1987-09--1991-07 Bachelor's in Microbiology and Immunology: School of Life Sciences, Wuhan University
Awards	2017: Outstanding Doctoral Dissertation Supervisor, Chinese Academy of Sciences 2006: Best Young Scientist Award, Special Prize

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1994-09--1997-07 PhD in Molecular Genetics: Shanghai Institute of Plant Physiology, Chinese Academy of Sciences
1991-09--1994-07 Master's in Microbiology and Immunology: School of Life Sciences, Wuhan University
1987-09--1991-07 Bachelor's in Microbiology and Immunology: School of Life Sciences, Wuhan University

Awards

2017: Outstanding Doctoral Dissertation Supervisor, Chinese Academy of Sciences
2006: Best Young Scientist Award, Special Prize

Areas of Focus	Pattern Recognition Receptors Signaling and Regulation Mechanisms Molecular Mechanisms of Immune Response and Tolerance
Publications	Precision control of mTORC1 is crucial for the maintenance and IL-13 responsiveness of alveolar macrophages, Hu, Yanxiang, Wen, Jing, Zhang, Bei, Xiao, Hui, 2021 Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2 ' 3 '-Cyclic GMP-AMP and Cisplatin under Steady State and Inflammation, Chen, Xia, Wang, Li, Cao, Limin, Li, Tiantian, Li, Zhihong, Sun, Yumeng, Ding, Jinqiu, Zhou, Chun, Xie, Yadong, Yue, Nan, Nan, Jing, Jia, XinMing, Peng, Chao, Li, Huabin, Yang, Jinbo, Xiao, Hui, 2021 TSC1 Suppresses Macrophage Necroptosis for the Control of Infection by Fungal Pathogen Candida albicans, Xiao, Hui, 2021 Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity, Zhou, Chun, Chen, Xia, PlanellsCases, Rosa, Chu, Jiachen, Wang, Li, Cao, Limin, Li, Zhihong, LopezCayuqueo, Karen, I, Xie, Yadong, Ye, Shiwei, Wang, Xiang, Ullrich, Florian, Ma, Shixin, Fang, Yiyuan, Zhang, Xiaoming, Qian, Zhikang, Liang, Xiaozheng, Cai, ShiQing, Jiang, Zhengfan, Zhou, Dongming, Leng, Qibin, Xiao, Tsan S, Lan, Ke, Yang, Jinbo, Li, Huabin, Peng, Chao, Qiu, Zhaozhu, Jentsch, Thomas J, Xiao, Hui, 2020 Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer, Xie, Yadong, Zhao, Yifan, Shi, Lei, Li, Wei, Chen, Kun, Li, Min, Chen, Xia, Zhang, Haiwei, Li, Tiantian, MatsuzawaIshimoto, Yu, Yao, Xiaomin, Shao, Dianhui, Ke, Zunfu, Li, Jian, Chen, Yan, Zhang, Xiaoming, Cui, Jun, Cui, Shuzhong, Leng, Qibin, Cadwell, Ken, Li, Xiaoxia, Wei, Hong, Zhang, Haibing, Li, Huabin, Xiao, Hui, 2020 A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection, Wenjuan Wang, Zihou Deng, Hongyu Wu, Qun Zhao, Tiantian Li, Wencheng Zhu, Xiongjun Wang, Longhai Tang, Chengshu Wang, ShuZhong Cui, Hui Xiao, Jiangye Chen, 2019 TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis, Lei Shi, Xia Chen, Aiping Zang, Tiantian Li, Yanxiang Hu, Shixin Ma, Mengdie L, Huiyong Yin, Haikun Wang, Xiaoming Zhang, Bei Zhang, Qibin Leng, Jinbo Yang, Hui Xiao, 2019 Excessive CD11c(+)Tbet(+) B cells promote aberrant T-FH differentiation and affinity-based germinal center selection in lupus, Zhang, Wenqian, Zhang, Huihui, Liu, Shujun, Xia, Fucan, Kang, Zijian, Zhang, Yan, Liu, Yaoyang, Xiao, Hui, Chen, Lei, Huang, Chuanxin, Shen, Nan, Xu, Huji, Li, Fubin, 2019 The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis, Liu, Lulu, Wan, Xiaoling, Zhou, Peipei, Zhou, Xiaoyuan, Zhang, Wei, Hui, Xinhui, Yuan, Xiujie, Ding, Xiaodan, Zhu, Ruihong, Meng, Guangxun, Xiao, Hui, Ma, Feng, Huang, He, Song, Xianmin, Zhou, Bin, Xiong, Sidong, Zhang, Yan, 2018 MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation, Peipei Zhou, Xiaodan Ding, Xiaoling Wan, Lulu Liu, Xiujie Yuan, Wei Zhang, Xinhui Hui, Guangxun Meng, Hui Xiao, Bin Li, Jin Zhong, Fajian Hou, Lihwen Deng, Yan Zhang, 2018 Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance, Zhang, WuChang, Du, LinJuan, Zheng, XiaoJun, Chen, XiaoQing, Shi, Chaoji, Chen, BoYan, Sun, XueNan, Li, Chao, Zhang, YuYao, Liu, Yan, Xiao, Hui, Leng, Qibin, Jiang, Xinquan, Zhang, Zhiyuan, Sun, Shuyang, Duan, ShengZhong, 2018 NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection, Jianrong Wang, Nanhai He, Na Zhang, Dexian Quan, Shuo Zhang, Caroline Zhang, Ruth T Yu, Annette R Atkins, Ruihong Zhu, Chunhui Yang, Ying Cui, Christopher Liddle, Michael Downes, Hui Xiao, Ye Zheng, Johan Auwerx, Ronald M Evans, Qibin Leng, 2017 Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs, Ma, Shixin, Wan, Xiaoling, Deng, Zihou, Shi, Lei, Hao, Congfang, Zhou, Zhenyuan, Zhou, Chun, Fang, Yiyuan, Liu, Jinghua, Yang, Jing, Chen, Xia, Li, Tiantian, Zang, Aiping, Yin, Shigang, Li, Bin, Plumas, Joel, Chaperot, Laurence, Zhang, Xiaoming, Xu, Guoliang, Jiang, Lubin, Shen, Nan, Xiong, Sidong, Gao, Xiaoming, Zhang, Yan, Xiao, Hui, 2017 Wip1正调控TLR4信号介导I型干扰素的表达, 刘莹, 周纯, 刘晶华, 陈霞, 张文举, 肖晖, 2017 TLR signalling affects sperm mitochondrial function and motility via phosphatidylinositol 3-kinase and glycogen synthase kinase-3α, Xingxing Zhu, Dongyan Shi, Xiaoqian Li, Weijuan Gong, Fengjiao Wu, Xuejiang Guo, Hui Xiao, Lixin Liu, Hong Zhou, 2016 Fibroblast Growth Factor 21 Improves Hepatic Insulin Sensitivity by Inhibiting Mammalian Target of Rapamycin Complex 1 in Mice, Gong, Qi, Hu, Zhimin, Zhang, Feifei, Cui, Aoyuan, Chen, Xin, Jiang, Haoyang, Gao, Jing, Chen, Xuqing, Han, Yamei, Liang, Qingning, Ye, Dewei, Shi, Lei, Chin, Y Eugene, Wang, Yu, Xiao, Hui, Guo, Feifan, Liu, Yong, Zang, Mengwei, Xu, Aimin, Li, Yu, 2016 Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy, Javed Numan, Xue Guang, Lu Ailing, Xing Yue, Iwakura Yoichiro, Xiao Hui, Lecoeur Herv, Spth Gerald F, Meng Guangxun, 2016 逆转录病毒感染小鼠原代巨噬细胞方法研究, 肖晖, 2016 Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal T(H)17 responses, Deng, Zihou, Ma, Shixin, Zhou, Hao, Zang, Aiping, Fang, Yiyuan, Li, Tiantian, Shi, Huanjing, Liu, Mei, Du, Min, Taylor, Patricia R, Zhu, Helen He, Chen, Jiangye, Meng, Guangxun, Li, Fubin, Chen, Changbin, Zhang, Yan, Jia, XinMing, Lin, Xin, Zhang, Xiaoming, Pearlman, Eric, Li, Xiaoxia, Feng, GenSheng, Xiao, Hui, 2015 MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response, James, Sharmy J, Jiao, Huipeng, Teh, HongYing, Takahashi, Hirotaka, Png, Chin Wen, Phoon, Meng Chee, Suzuki, Youichi, Sawasaki, Tatsuy, Xiao, Hui, Chow, Vincent T K, Yamamoto, Naoki, Reynolds, Joseph M, Flavell, Richard A, Dong, Chen, Zhang, Yongliang, 2015 Casein Kinase II Controls TBK1/IRF3 Activation in IFN Response against Viral Infection, Sharmy J James, Yu Xiang, Jinghua Liu, Ke Lan, Yadong Xie, Jin Zhong, Min Du, Xia Chen, Bing Sun, Chuanping Yuan, Mingzhou Chen, Hui Xiao, Yongliang Zhang, 2015 骨髓来源巨噬细胞中有效地敲除floxed基因的新方案, 何丽, 熊思东, 肖晖, 2015 mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines, He, Li, Zang, Aiping, Du, Min, Ma, Dapeng, Yuan, Chuanping, Zhou, Chun, Mu, Jing, Shi, Huanjing, Li, Dapeng, Huang, Xulin, Deng, Qiang, Xiao, Jianhua, Yan, Huimin, Hui, Lijian, Lan, Ke, Xiong, Sidong, Li, Xiaoxia, Huang, Zhong, Xiao, Hui, 2015 Non-Classical MHC I-E negatively regulates macrophage activation and Th17 cells in NOD mice, 肖晖, 2015 Kaposi's Sarcoma-Associated Herpesvirus-Encoded Replication and Transcription Activator Impairs Innate Immunity via Ubiquitin-Mediated Degradation of Myeloid Differentiation Factor 88, Zhao, Qinglan, Liang, Deguang, Sun, Rui, Jia, Baosen, Xia, Tian, Xiao, Hui, Lan, Ke, 2015 The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90, Wang, Chenhui, Wu, Ling, Bulek, Katarzyna, Martin, Bradley N, Zepp, Jarod A, Kang, Zizhen, Liu, Caini, Herjan, Tomasz, Misra, Saurav, Carman, Julie A, Gao, Ji, Dongre

Areas of Focus

Pattern Recognition Receptors Signaling and Regulation Mechanisms
Molecular Mechanisms of Immune Response and Tolerance

Publications

Precision control of mTORC1 is crucial for the maintenance and IL-13 responsiveness of alveolar macrophages, Hu, Yanxiang, Wen, Jing, Zhang, Bei, Xiao, Hui, 2021
Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2 ' 3 '-Cyclic GMP-AMP and Cisplatin under Steady State and Inflammation, Chen, Xia, Wang, Li, Cao, Limin, Li, Tiantian, Li, Zhihong, Sun, Yumeng, Ding, Jinqiu, Zhou, Chun, Xie, Yadong, Yue, Nan, Nan, Jing, Jia, XinMing, Peng, Chao, Li, Huabin, Yang, Jinbo, Xiao, Hui, 2021
TSC1 Suppresses Macrophage Necroptosis for the Control of Infection by Fungal Pathogen Candida albicans, Xiao, Hui, 2021
Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity, Zhou, Chun, Chen, Xia, PlanellsCases, Rosa, Chu, Jiachen, Wang, Li, Cao, Limin, Li, Zhihong, LopezCayuqueo, Karen, I, Xie, Yadong, Ye, Shiwei, Wang, Xiang, Ullrich, Florian, Ma, Shixin, Fang, Yiyuan, Zhang, Xiaoming, Qian, Zhikang, Liang, Xiaozheng, Cai, ShiQing, Jiang, Zhengfan, Zhou, Dongming, Leng, Qibin, Xiao, Tsan S, Lan, Ke, Yang, Jinbo, Li, Huabin, Peng, Chao, Qiu, Zhaozhu, Jentsch, Thomas J, Xiao, Hui, 2020
Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer, Xie, Yadong, Zhao, Yifan, Shi, Lei, Li, Wei, Chen, Kun, Li, Min, Chen, Xia, Zhang, Haiwei, Li, Tiantian, MatsuzawaIshimoto, Yu, Yao, Xiaomin, Shao, Dianhui, Ke, Zunfu, Li, Jian, Chen, Yan, Zhang, Xiaoming, Cui, Jun, Cui, Shuzhong, Leng, Qibin, Cadwell, Ken, Li, Xiaoxia, Wei, Hong, Zhang, Haibing, Li, Huabin, Xiao, Hui, 2020
A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection, Wenjuan Wang, Zihou Deng, Hongyu Wu, Qun Zhao, Tiantian Li, Wencheng Zhu, Xiongjun Wang, Longhai Tang, Chengshu Wang, ShuZhong Cui, Hui Xiao, Jiangye Chen, 2019
TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis, Lei Shi, Xia Chen, Aiping Zang, Tiantian Li, Yanxiang Hu, Shixin Ma, Mengdie L, Huiyong Yin, Haikun Wang, Xiaoming Zhang, Bei Zhang, Qibin Leng, Jinbo Yang, Hui Xiao, 2019
Excessive CD11c(+)Tbet(+) B cells promote aberrant T-FH differentiation and affinity-based germinal center selection in lupus, Zhang, Wenqian, Zhang, Huihui, Liu, Shujun, Xia, Fucan, Kang, Zijian, Zhang, Yan, Liu, Yaoyang, Xiao, Hui, Chen, Lei, Huang, Chuanxin, Shen, Nan, Xu, Huji, Li, Fubin, 2019
The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis, Liu, Lulu, Wan, Xiaoling, Zhou, Peipei, Zhou, Xiaoyuan, Zhang, Wei, Hui, Xinhui, Yuan, Xiujie, Ding, Xiaodan, Zhu, Ruihong, Meng, Guangxun, Xiao, Hui, Ma, Feng, Huang, He, Song, Xianmin, Zhou, Bin, Xiong, Sidong, Zhang, Yan, 2018
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation, Peipei Zhou, Xiaodan Ding, Xiaoling Wan, Lulu Liu, Xiujie Yuan, Wei Zhang, Xinhui Hui, Guangxun Meng, Hui Xiao, Bin Li, Jin Zhong, Fajian Hou, Lihwen Deng, Yan Zhang, 2018
Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance, Zhang, WuChang, Du, LinJuan, Zheng, XiaoJun, Chen, XiaoQing, Shi, Chaoji, Chen, BoYan, Sun, XueNan, Li, Chao, Zhang, YuYao, Liu, Yan, Xiao, Hui, Leng, Qibin, Jiang, Xinquan, Zhang, Zhiyuan, Sun, Shuyang, Duan, ShengZhong, 2018
NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection, Jianrong Wang, Nanhai He, Na Zhang, Dexian Quan, Shuo Zhang, Caroline Zhang, Ruth T Yu, Annette R Atkins, Ruihong Zhu, Chunhui Yang, Ying Cui, Christopher Liddle, Michael Downes, Hui Xiao, Ye Zheng, Johan Auwerx, Ronald M Evans, Qibin Leng, 2017
Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs, Ma, Shixin, Wan, Xiaoling, Deng, Zihou, Shi, Lei, Hao, Congfang, Zhou, Zhenyuan, Zhou, Chun, Fang, Yiyuan, Liu, Jinghua, Yang, Jing, Chen, Xia, Li, Tiantian, Zang, Aiping, Yin, Shigang, Li, Bin, Plumas, Joel, Chaperot, Laurence, Zhang, Xiaoming, Xu, Guoliang, Jiang, Lubin, Shen, Nan, Xiong, Sidong, Gao, Xiaoming, Zhang, Yan, Xiao, Hui, 2017
Wip1正调控TLR4信号介导I型干扰素的表达, 刘莹, 周纯, 刘晶华, 陈霞, 张文举, 肖晖, 2017
TLR signalling affects sperm mitochondrial function and motility via phosphatidylinositol 3-kinase and glycogen synthase kinase-3α, Xingxing Zhu, Dongyan Shi, Xiaoqian Li, Weijuan Gong, Fengjiao Wu, Xuejiang Guo, Hui Xiao, Lixin Liu, Hong Zhou, 2016
Fibroblast Growth Factor 21 Improves Hepatic Insulin Sensitivity by Inhibiting Mammalian Target of Rapamycin Complex 1 in Mice, Gong, Qi, Hu, Zhimin, Zhang, Feifei, Cui, Aoyuan, Chen, Xin, Jiang, Haoyang, Gao, Jing, Chen, Xuqing, Han, Yamei, Liang, Qingning, Ye, Dewei, Shi, Lei, Chin, Y Eugene, Wang, Yu, Xiao, Hui, Guo, Feifan, Liu, Yong, Zang, Mengwei, Xu, Aimin, Li, Yu, 2016
Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy, Javed Numan, Xue Guang, Lu Ailing, Xing Yue, Iwakura Yoichiro, Xiao Hui, Lecoeur Herv, Spth Gerald F, Meng Guangxun, 2016
逆转录病毒感染小鼠原代巨噬细胞方法研究, 肖晖, 2016
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal T(H)17 responses, Deng, Zihou, Ma, Shixin, Zhou, Hao, Zang, Aiping, Fang, Yiyuan, Li, Tiantian, Shi, Huanjing, Liu, Mei, Du, Min, Taylor, Patricia R, Zhu, Helen He, Chen, Jiangye, Meng, Guangxun, Li, Fubin, Chen, Changbin, Zhang, Yan, Jia, XinMing, Lin, Xin, Zhang, Xiaoming, Pearlman, Eric, Li, Xiaoxia, Feng, GenSheng, Xiao, Hui, 2015
MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response, James, Sharmy J, Jiao, Huipeng, Teh, HongYing, Takahashi, Hirotaka, Png, Chin Wen, Phoon, Meng Chee, Suzuki, Youichi, Sawasaki, Tatsuy, Xiao, Hui, Chow, Vincent T K, Yamamoto, Naoki, Reynolds, Joseph M, Flavell, Richard A, Dong, Chen, Zhang, Yongliang, 2015
Casein Kinase II Controls TBK1/IRF3 Activation in IFN Response against Viral Infection, Sharmy J James, Yu Xiang, Jinghua Liu, Ke Lan, Yadong Xie, Jin Zhong, Min Du, Xia Chen, Bing Sun, Chuanping Yuan, Mingzhou Chen, Hui Xiao, Yongliang Zhang, 2015
骨髓来源巨噬细胞中有效地敲除floxed基因的新方案, 何丽, 熊思东, 肖晖, 2015
mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines, He, Li, Zang, Aiping, Du, Min, Ma, Dapeng, Yuan, Chuanping, Zhou, Chun, Mu, Jing, Shi, Huanjing, Li, Dapeng, Huang, Xulin, Deng, Qiang, Xiao, Jianhua, Yan, Huimin, Hui, Lijian, Lan, Ke, Xiong, Sidong, Li, Xiaoxia, Huang, Zhong, Xiao, Hui, 2015
Non-Classical MHC I-E negatively regulates macrophage activation and Th17 cells in NOD mice, 肖晖, 2015
Kaposi's Sarcoma-Associated Herpesvirus-Encoded Replication and Transcription Activator Impairs Innate Immunity via Ubiquitin-Mediated Degradation of Myeloid Differentiation Factor 88, Zhao, Qinglan, Liang, Deguang, Sun, Rui, Jia, Baosen, Xia, Tian, Xiao, Hui, Lan, Ke, 2015
The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90, Wang, Chenhui, Wu, Ling, Bulek, Katarzyna, Martin, Bradley N, Zepp, Jarod A, Kang, Zizhen, Liu, Caini, Herjan, Tomasz, Misra, Saurav, Carman, Julie A, Gao, Ji, Dongre

Tlr Clr Rlr Cgas Sting Immune Response Host Defense Inflammation Immune Regulation T Cell Differentiation

Hui Xiao - University of Chinese Academy of Sciences

Qian Youcun - University of Chinese Academy of Sciences

Lianpan Dai - University of Chinese Academy of Sciences

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