Areas of Focus
- Regulation of hematopoietic development
- Inflammatory response effects on blood regeneration and cellular aging
- Energy metabolism in the development of blood diseases
- Mechanisms of small molecule inhibitors in cancer immunotherapy
Work Experience
- 2017-2022 - Yale University School of Medicine, Postdoctoral Research
- 2022-present - Tongji University, Distinguished Research Fellow under the 'Young Hundred Talents Plan'
- 2023-present - Tongji University Affiliated Oriental Hospital, Distinguished Research Fellow
Academic Background & Achievements
- 2011 - Bachelor's Degree: Ocean University of China
- 2017 - PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- 2022 - Selected for Shanghai's 'Overseas High-Level Talent Introduction Plan'
Publications
- ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m(6)A modification-mediated RNA stability control, Gao Y*, Zimmer JT, Vasic R, Liu C, Gbyli R, Zheng SJ, Patel A, Liu W, Qi Z, Li Y, Nelakanti R, Song Y, Biancon G, Xiao AZ, Slavoff S, Kibbey RG, Flavell RA, Simon MD, Tebaldi T, Li HB, Halene S*, 2023
- In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2, Gbyli R, Song Y, Liu W, Gao Y, Biancon G, Chandhok NS, Wang X, Fu X, Patel A, Sundaram R, Tebaldi T, Mamillapalli P, Zeidan AM, Flavell RA, Prebet T, Bindra RS, Halene S*, 2022
- Transcriptome-wide quantification of double-stranded RNAs in live mouse tissues by dsRIP-Seq, Gao Y, Chen S, Halene S, Tebaldi T*, 2021
- m(6)A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development, Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA, Li HB, Tebaldi T, Halene S*, 2020
- The role of RNA epigenetic modification in normal and malignant hematopoiesis, Vasic R, Gao Y, Liu C, Halene S*, 2020
- Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, Gao Y, Zhang X, Zhang L, Cen J, Ni X, Liao X, Yang C, Li Y, Chen X, Zhang Z, Shu Y, Cheng X, Hay DC, Lai D, Pan G, Wei G, Hui L*, 2017
- Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes, Shi XL, Gao Y, Yan Y, Ma H, Sun L, Huang P, Ni X, Zhang L, Zhao X, Ren H, Hu D, Zhou Y, Tian F, Ji Y, Cheng X, Pan G, Ding YT, Hui L*, 2016
- Direct reprogramming of human fibroblasts to functional and expandable hepatocytes, Huang P, Zhang L, Gao Y, He Z, Yao D, Wu Z, Cen J, Chen X, Liu C, Hu Y, Lai D, Hu Z, Chen L, Zhang Y, Cheng X, Ma X, Pan G, Wang X, Hui L*, 2014
- 生物人工肝研究进展, 高义萌, 孙露露, 惠利健, 2016
- 细胞命运转变——癌化和转分化的研究, 高义萌, 惠利健, 2014
Awards
- 2014: Cell Press China Paper of the Year
- 2017: Top Ten Medical Advances in China
- 2018: First Prize, Shanghai Science and Technology Award (Ranked 4th)
- 2019: James Hudson Brown - Alexander B. Coxe Fellowship at Yale University School of Medicine
- 2021: ASH Scholar Award from the American Society of Hematology
