Professor | Wu Yuxuan | Asia Growth Partners

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Name	Wu Yuxuan
Language ability	Chinese, English
Province	Shanghai

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Name

Wu Yuxuan

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	East China Normal University
Faculty	Life Sciences
Academic Background & Achievements	2002-2006 Bachelor's Degree: Wuhan University 2006-2012 PhD: Wuhan University, Cell and Developmental Biology First to demonstrate CRISPR-mediated genetic disease correction in animals
Work Experience	2012-2015 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Postdoctoral Fellow, Associate Researcher 2015-2018 - Harvard Medical School - Postdoctoral Fellow 2018-present - East China Normal University, School of Life Sciences - Researcher, Doctoral Supervisor
Awards	2017: Shanghai Science and Technology Award, First Prize - Research on the basis and application of oocyte-mediated cell reprogramming

University/Lab Affiliation and Title

East China Normal University

Faculty

Life Sciences

Academic Background & Achievements

2002-2006 Bachelor's Degree: Wuhan University
2006-2012 PhD: Wuhan University, Cell and Developmental Biology
First to demonstrate CRISPR-mediated genetic disease correction in animals

Work Experience

2012-2015 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Postdoctoral Fellow, Associate Researcher
2015-2018 - Harvard Medical School - Postdoctoral Fellow
2018-present - East China Normal University, School of Life Sciences - Researcher, Doctoral Supervisor

Awards

2017: Shanghai Science and Technology Award, First Prize - Research on the basis and application of oocyte-mediated cell reprogramming

Areas of Focus	CRISPR-based gene editing in hematopoietic stem cells for treating blood disorders such as thalassemia Signaling networks and epigenetic regulation in hematopoietic stem cell proliferation and differentiation Haploid embryonic stem cells combined with gene editing for studying multigenic diseases Identification of new cancer immunotherapy targets using CRISPR library screening
Publications	Highly efficient therapeutic gene editing of human hematopoietic stem cells, Wu Y, Zeng J, Roscoe BP, Liu P, Yao Q, Lazzarrotto CR, Clement MK, Cole MA, Luk K, Baricordi C, Shen AH, Esrick EB, Manis JP, Dorfman DM, Williams DA, Biffi A, Brugnara C, Biasco L, Brendel C, Pinello L, Tsai SQ, Wolfe SA, Bauer DE, 2019 An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities, Gehrke JM, Cervantes O, Clement MK, Wu Y, Zeng J, Bauer DE, Pinello L, Joung JK, 2018 Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci, Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galacteros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, Zeng J, Kurita R, Nakamura Y, Yuan G-C, Lettre G, Bauer DE, Orkin SH, 2017 Parthenogenetic haploid embryonic stem cells efficiently support mouse generation by oocyte injection, Zhong C, Xie Z, Yin Q, Dong R, Yang S, Wu Y, Yang L, Li J, 2016 Spermatogenic Cell-Specific Gene Mutation in Mice via CRISPR-Cas9, Bai M, Liang D, Wang Y, Li Q, Wu Y, Li J, 2016 CRISPR-Cas9-Mediated Genetic Screening in Mice with Haploid Embryonic Stem Cells Carrying a Guide RNA Library, Zhong C, Yin Q, Xie Z, Bai M, Dong R, Tang W, Xing Y, Zhang H, Yang S, Chen L, Bartolomei M, Ferguson-Smith A, Li D, Yang L, Wu Y, Li J, 2015 Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate, Liu P, Dou X, Liu C, Wang L, Xing C, Peng G, Chen J, Yu F, Qiao Y, Song L, Wu Y, Yue C, Li J, Han JD, Tang K, Jing N, 2015 Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells, Wu Y, Zhou H, Fan X, Zhang Y, Zhang M, Wang Y, Xie Z, Bai M, Yin Q, Liang D, Tang W, Liao J, Zhou C, Liu W, Zhu P, Guo H, Pan H, Wu C, Shi H, Wu L, Tang F, Li J, 2015 Correction of a genetic disease in mouse via use of CRISPR-Cas9, Wu Y, Liang D, Wang Y, Bai M, Tang W, Bao S, Yan Z, Li D, Li J, 2013 CPK3-phosphorylated RhoGDI1 is essential in the development of Arabidopsis seedlings and leaf epidermal cells, Wu Y, Zhao S, Tian H, He Y, Xiong W, Guo L, Wu Y, 2013

Areas of Focus

CRISPR-based gene editing in hematopoietic stem cells for treating blood disorders such as thalassemia
Signaling networks and epigenetic regulation in hematopoietic stem cell proliferation and differentiation
Haploid embryonic stem cells combined with gene editing for studying multigenic diseases
Identification of new cancer immunotherapy targets using CRISPR library screening

Publications

Highly efficient therapeutic gene editing of human hematopoietic stem cells, Wu Y, Zeng J, Roscoe BP, Liu P, Yao Q, Lazzarrotto CR, Clement MK, Cole MA, Luk K, Baricordi C, Shen AH, Esrick EB, Manis JP, Dorfman DM, Williams DA, Biffi A, Brugnara C, Biasco L, Brendel C, Pinello L, Tsai SQ, Wolfe SA, Bauer DE, 2019
An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities, Gehrke JM, Cervantes O, Clement MK, Wu Y, Zeng J, Bauer DE, Pinello L, Joung JK, 2018
Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci, Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galacteros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, Zeng J, Kurita R, Nakamura Y, Yuan G-C, Lettre G, Bauer DE, Orkin SH, 2017
Parthenogenetic haploid embryonic stem cells efficiently support mouse generation by oocyte injection, Zhong C, Xie Z, Yin Q, Dong R, Yang S, Wu Y, Yang L, Li J, 2016
Spermatogenic Cell-Specific Gene Mutation in Mice via CRISPR-Cas9, Bai M, Liang D, Wang Y, Li Q, Wu Y, Li J, 2016
CRISPR-Cas9-Mediated Genetic Screening in Mice with Haploid Embryonic Stem Cells Carrying a Guide RNA Library, Zhong C, Yin Q, Xie Z, Bai M, Dong R, Tang W, Xing Y, Zhang H, Yang S, Chen L, Bartolomei M, Ferguson-Smith A, Li D, Yang L, Wu Y, Li J, 2015
Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate, Liu P, Dou X, Liu C, Wang L, Xing C, Peng G, Chen J, Yu F, Qiao Y, Song L, Wu Y, Yue C, Li J, Han JD, Tang K, Jing N, 2015
Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells, Wu Y, Zhou H, Fan X, Zhang Y, Zhang M, Wang Y, Xie Z, Bai M, Yin Q, Liang D, Tang W, Liao J, Zhou C, Liu W, Zhu P, Guo H, Pan H, Wu C, Shi H, Wu L, Tang F, Li J, 2015
Correction of a genetic disease in mouse via use of CRISPR-Cas9, Wu Y, Liang D, Wang Y, Bai M, Tang W, Bao S, Yan Z, Li D, Li J, 2013
CPK3-phosphorylated RhoGDI1 is essential in the development of Arabidopsis seedlings and leaf epidermal cells, Wu Y, Zhao S, Tian H, He Y, Xiong W, Guo L, Wu Y, 2013

Crispr Gene Editing Hematopoietic Stem Cells Thalassemia Blood Disorders Signaling Networks Epigenetic Regulation Haploid Embryonic Stem Cells Multigenic Diseases Cancer Immunotherapy

Yimeng Gao - Tongji University

Wu Yuxuan - East China Normal University

Guohui Chuai - Tongji University

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