Areas of Focus
- CRISPR-based gene editing in hematopoietic stem cells for treating blood diseases such as thalassemia
- Signaling networks and epigenetic regulation in hematopoietic stem cell proliferation and differentiation
- Haploid embryonic stem cell combined with gene editing for studying multigenic genetic diseases
- Identification of new cancer immunotherapy targets through CRISPR library screening
Work Experience
- 2012-2015 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Postdoctoral Fellow, Associate Researcher
- 2015-2018 - Harvard Medical School - Postdoctoral Fellow
- 2018-present - East China Normal University, School of Life Sciences - Researcher, Doctoral Supervisor
Academic Background & Achievements
- 2002-2006 Bachelor's Degree: Wuhan University
- 2006-2012 PhD in Cell and Developmental Biology: Wuhan University
- First to demonstrate CRISPR-mediated genetic disease correction in animals
Publications
- Highly efficient therapeutic gene editing of human hematopoietic stem cells, Wu Y, Zeng J, Roscoe BP, Liu P, Yao Q, Lazzarrotto CR, Clement MK, Cole MA, Luk K, Baricordi C, Shen AH, Esrick EB, Manis JP, Dorfman DM, Williams DA, Biffi A, Brugnara C, Biasco L, Brendel C, Pinello L, Tsai SQ, Wolfe SA, Bauer DE, 2019
- An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities, Gehrke JM, Cervantes O, Clement MK, Wu Y, Zeng J, Bauer DE, Pinello L, Joung JK, 2018
- Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci, Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galacteros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, Zeng J, Kurita R, Nakamura Y, Yuan G-C, Lettre G, Bauer DE, Orkin SH, 2017
- Parthenogenetic haploid embryonic stem cells efficiently support mouse generation by oocyte injection, Zhong C, Xie Z, Yin Q, Dong R, Yang S, Wu Y, Yang L, Li J, 2016
- Spermatogenic Cell-Specific Gene Mutation in Mice via CRISPR-Cas9, Bai M, Liang D, Wang Y, Li Q, Wu Y, Li J, 2016
- CRISPR-Cas9-Mediated Genetic Screening in Mice with Haploid Embryonic Stem Cells Carrying a Guide RNA Library, Zhong C, Yin Q, Xie Z, Bai M, Dong R, Tang W, Xing Y, Zhang H, Yang S, Chen L, Bartolomei M, Ferguson-Smith A, Li D, Yang L, Wu Y, Li J, 2015
- Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate, Liu P, Dou X, Liu C, Wang L, Xing C, Peng G, Chen J, Yu F, Qiao Y, Song L, Wu Y, Yue C, Li J, Han JD, Tang K, Jing N, 2015
- Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells, Wu Y, Zhou H, Fan X, Zhang Y, Zhang M, Wang Y, Xie Z, Bai M, Yin Q, Liang D, Tang W, Liao J, Zhou C, Liu W, Zhu P, Guo H, Pan H, Wu C, Shi H, Wu L, Tang F, Li J, 2015
- Correction of a genetic disease in mouse via use of CRISPR-Cas9, Wu Y, Liang D, Wang Y, Bai M, Tang W, Bao S, Yan Z, Li D, Li J, 2013
- CPK3-phosphorylated RhoGDI1 is essential in the development of Arabidopsis seedlings and leaf epidermal cells, Wu Y, Zhao S, Tian H, He Y, Xiong W, Guo L, Wu Y, 2013
Awards
- 2017: Shanghai Science and Technology Award for Natural Sciences, First Prize - Research on the basis and application of oocyte-mediated cell reprogramming
