Areas of Focus
- Drug Quality Control
- Chromatographic Methodology
- Crystal Form Characterization
- Drug-Drug Cocrystal Screening
- Drug Degradation Kinetics and Thermodynamics
- Physicochemical Parameters of Druggability
Work Experience
- 1999-09 to Present - Shanghai Institute of Materia Medica - Researcher, Group Leader
- 1997-01 to 1999-04 - Xiamen University, Department of Biology - Postdoctoral Researcher
Publications
- Effects of aqueous extracts and volatile oils prepared from Huaxiang Anshen decoction on p-chlorophenylalanine-induced insomnia mice, 6th Author, 2024
- Separation and structural characterization of unknown impurity in vancomycin by two-dimensional preparative liquid chromatography, LC-MS and NMR, 5th Author, Corresponding Author, 2023
- Investigation of atropisomeric transformation of a novel PDE4 inhibitor with tetrahydroisoquinoline-based amide group and its primary study of binding to HSA, 7th Author, Corresponding Author, 2022
- \"Two-birds-one-stone\" colon-targeted nanomedicine treats ulcerative colitis via remodeling immune microenvironment and anti-fibrosis, 9th Author, 2022
- Discovery of CECR2 Bromodomain Inhibitors with High Selectivities over BPTF Bromodomain, 8th Author, 2022
- Study on the stability and hydrolysis kinetics of genotoxic impurities methanesulfonates, 6th Author, 2021
- Intrinsic stability study of L-alpha-glycerylphosphorylcholine with HPLC method development and validation, 5th Author, Corresponding Author, 2020
- Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases, 9th Author, Corresponding Author, 2020
- Bioluminescence imaging of carbon monoxide in living cells based on a selective deiodination reaction, 4th Author, 2020
- Determination of dissociation constant and oil-water partition coefficient of pregabalin by micro-potentiometric titration, 5th Author, 2020
- A Comprehensive Multilocus Sequence Typing Scheme for Identification and Genotyping of Staphylococcus Strains, 9th Author, Corresponding Author, 2019
- Characterization of drug-drug salt forms of metformin and aspirin with improved physicochemical properties, 5th Author, Corresponding Author, 2019
- Trace determination of mutagenic alkyl toluenesulfonate impurities via derivatization headspace-GC/MS in an active pharmaceutical ingredient of a candidate drug, 5th Author, Corresponding Author, 2018
- Advances on genotoxic impurities of sulfonate esters in pharmaceuticals, 5th Author, 2018
- Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species, 15th Author, 2018
- Crystal structures and physicochemical properties of amisulpride polymorphs, 2nd Author, Corresponding Author, 2017
- Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity, Not mentioned, 2017
- Application of capillary electrophoresis-frontal analysis for comparative evaluation of the binding interaction of captopril with human serum albumin in the absence and presence of hydrochlorothiazide, 4th Author, Corresponding Author, 2015
- Characterization of interactions between methoxatin disodium salt and human serum albumin by pressure-assisted capillary electrophoresis/frontal analysis and circular dichroism spectroscopy, 2nd Author, Corresponding Author, 2015
- Determination of pKavalues of a triptolide derivative and its impurities by pressure-assisted capillary electrophoresis, 3rd Author, Corresponding Author, 2014
- 反相离子对高效液相色谱法检查盐酸伊立替康（CPT-11）有关物质, 4th Author, 2013
- Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate, 9th Author, 2013
- Application of Phase Optimized Liquid Chromatography for Related Substances Detection in New Drug Candidate of Tripterygiumforrestii Derivative, 4th Author, 2011
- 创新候选药物晶型的质量控制研究策略探讨, 1st Author, 2011
- Application of Phase Optimized Liquid Chromatography for Related Substances Detection in New Drug Candidate of Tripterygiumforrestii Derivative, 4th Author, Corresponding Author, 2011
- Application of phase optimized liquid chromatography to oligopeptide separations, 5th Author, Corresponding Author, 2010
- 固定相优化液相色谱技术应用进展, 1st Author, 2010
- Study on Hydrolysis Reaction of Novel Camptothecin Derivative(L-P) Using Capillary Zone Electrophoresis, 4th Author, 2009
- Application of headspace solid phase microextraction for study of noncovalent interaction of borneol with human serum albumin, 2nd Author, Corresponding Author, 2009
- 药物中石油醚残留量的气相色谱检测方法学探讨, 3rd Author, 2008
- Investigating noncovalent interactions of rutin-serum albumin by capillary electrophoresis-frontal analysis, 3rd Author, Corresponding Author, 2008
- 胶束电动毛细管电泳法测定三七药材中人参皂苷Rgl，Re和Rbl的含量, 2nd Author, 2007
- Development and validation of a sensitive liquid chromatography-tandem mass spectrometry method for the determination of paeoniflorin in rat brain and its application to pharmacokinetic study, 8th Author, Corresponding Author, 2007
- 高效液相色谱法测定扎那米韦有关物质, 2nd Author, 2006
- 顶空固相微萃取-气相色谱法测定粉尘螨舌下滴剂中丙酮的残留量, 2nd Author, 2006
- 右旋糖酐铁注射液中右旋糖酐铁峰位相对分子质量的测定, 2nd Author, 2005
- 中英两国药典关于右旋糖酐铁注射液铁吸收度的考察方法比较, 1st Author, 2004
- 粉尘螨滴剂中硫柳汞限度的比色检查, 4th Author, 2004
- 基于电迁移率差异而分离的新型聚焦电泳技术, 4th Author, 1997
