Areas of Focus
- 药物质量控制
- 色谱方法学
- 晶型表征
- 药-药共晶筛选
- 药物降解动力学与热力学机制
- 成药性理化参数
Work Experience
- 1999-09 至今 - 上海药物研究所 - 研究员，课题组长
- 1997-01 至 1999-04 - 厦门大学生物学系 - 博士后
Publications
- Effects of aqueous extracts and volatile oils prepared from Huaxiang Anshen decoction on p-chlorophenylalanine-induced insomnia mice, 第6作者, 2024
- Separation and structural characterization of unknown impurity in vancomycin by two-dimensional preparative liquid chromatography, LC-MS and NMR, 第5作者，通讯作者, 2023
- Investigation of atropisomeric transformation of a novel PDE4 inhibitor with tetrahydroisoquinoline-based amide group and its primary study of binding to HSA, 第7作者，通讯作者, 2022
- \"Two-birds-one-stone\" colon-targeted nanomedicine treats ulcerative colitis via remodeling immune microenvironment and anti-fibrosis, 第9作者, 2022
- Discovery of CECR2 Bromodomain Inhibitors with High Selectivities over BPTF Bromodomain, 第8作者, 2022
- 基因毒性杂质甲磺酸酯稳定性及水解反应动力学研究, 第6作者, 2021
- Intrinsic stability study of L-alpha-glycerylphosphorylcholine with HPLC method development and validation, 第5作者，通讯作者, 2020
- Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases, 第9作者，通讯作者, 2020
- Bioluminescence imaging of carbon monoxide in living cells based on a selective deiodination reaction, 第4作者, 2020
- 微量电位滴定法测定普瑞巴林的解离常数和油水分配系数, 第5作者, 2020
- A Comprehensive Multilocus Sequence Typing Scheme for Identification and Genotyping of Staphylococcus Strains, 第9作者，通讯作者, 2019
- Characterization of drug-drug salt forms of metformin and aspirin with improved physicochemical properties, 第5作者，通讯作者, 2019
- Trace determination of mutagenic alkyl toluenesulfonate impurities via derivatization headspace-GC/MS in an active pharmaceutical ingredient of a candidate drug, 第5作者，通讯作者, 2018
- 药物中磺酸酯类基因毒性杂质研究进展, 第5作者, 2018
- Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species, 第15作者, 2018
- Crystal structures and physicochemical properties of amisulpride polymorphs, 第2
