Professor | Yongbin Chen | Asia Growth Partners

Name	Yongbin Chen
Contact Information	ybchen@mail.kiz.ac.cn
Language ability	Chinese, English
Province	Yunnan

Name

Yongbin Chen

Contact Information

ybchen@mail.kiz.ac.cn

Language ability

Chinese, English

Province

Yunnan

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2000-09--2005-07 PhD in Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences 1996-09--2000-07 Bachelor's in Science: Wuhan University
Work Experience	2012-05~Present - Kunming Institute of Zoology, Chinese Academy of Sciences - Researcher 2010-12~2012-05 - University of Texas Southwestern Medical Center - Instructor 2005-12~2010-11 - University of Texas Southwestern Medical Center - Postdoctoral Fellow
Awards	Lung Cancer Comprehensive Diagnosis and Treatment Technology Research and Clinical Application (2019): Second Prize, Provincial Level Ten Thousand Talents Program 'Leading Talents in Scientific and Technological Innovation' (2019): Ministerial Level Innovation and Application of Key Technologies for Tumor Bone Metastasis Mechanism and Diagnosis and Treatment (2019): Special Prize, Provincial Level Outstanding Reviewer of 'Biotechnology Bulletin' (2019): Other Yunnan Province Yunling Industrial Technology Leading Talent (2018): Provincial Level Innovation Talent Promotion Plan Young and Middle-aged Scientific and Technological Innovation Leading Talent (2016): National Level Seventh Yunnan Youth Science and Technology Award (2015): Provincial Level Excellent Youth Fund (2014): National Level Minimally Invasive Technology Research and Clinical Application of Spinal Metastatic Tumors (2014): First Prize, Provincial Level Yunnan Province Overseas High-level Talent (2013): Provincial Level Yunnan Province High-end Scientific and Technological Talent (2013): Provincial Level American Heart Association Grant (2010): National Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2000-09--2005-07 PhD in Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
1996-09--2000-07 Bachelor's in Science: Wuhan University

Work Experience

2012-05~Present - Kunming Institute of Zoology, Chinese Academy of Sciences - Researcher
2010-12~2012-05 - University of Texas Southwestern Medical Center - Instructor
2005-12~2010-11 - University of Texas Southwestern Medical Center - Postdoctoral Fellow

Awards

Lung Cancer Comprehensive Diagnosis and Treatment Technology Research and Clinical Application (2019): Second Prize, Provincial Level
Ten Thousand Talents Program 'Leading Talents in Scientific and Technological Innovation' (2019): Ministerial Level
Innovation and Application of Key Technologies for Tumor Bone Metastasis Mechanism and Diagnosis and Treatment (2019): Special Prize, Provincial Level
Outstanding Reviewer of 'Biotechnology Bulletin' (2019): Other
Yunnan Province Yunling Industrial Technology Leading Talent (2018): Provincial Level
Innovation Talent Promotion Plan Young and Middle-aged Scientific and Technological Innovation Leading Talent (2016): National Level
Seventh Yunnan Youth Science and Technology Award (2015): Provincial Level
Excellent Youth Fund (2014): National Level
Minimally Invasive Technology Research and Clinical Application of Spinal Metastatic Tumors (2014): First Prize, Provincial Level
Yunnan Province Overseas High-level Talent (2013): Provincial Level
Yunnan Province High-end Scientific and Technological Talent (2013): Provincial Level
American Heart Association Grant (2010): National Level

Areas of Focus	Hypoxia adaptation mechanisms in high-altitude animals and non-model animals Tumorigenesis and tumor progression Stem cell pluripotency maintenance New drug screening for anti-tumor and stem cell function enhancement
Publications	LncRNA GSCAR promotes glioma stem cell maintenance via stabilizing SOX2 expression, Xiulin Jiang, Yong Zhang, Yixiao Yuan, Zhixian Jin, Haoqing Zhai, Baiyang Liu, Yao Li, Chun Zhang, Min Chen, Yulin Shi, Dongming Yan, Jun Pu, Yongbin Chen, Cuiping Yang, 2023 Hypoxia-induced GLT8D1 promotes glioma stem cell maintenance by inhibiting CD133 degradation through N-linked glycosylation, Yongbin Chen, 2022 MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling, Yongbin Chen, 2022 Gemin6 promotes c-Myc stabilization and non-small cell lung cancer progression via accelerating AURKB mRNA maturation, Yongbin Chen, 2022 A single mutation underlying phenotypic convergence for hypoxia adaptation on the Qinghai-Tibetan Plateau, Xu, Dongming, Yang, Cuiping, Shen, Qiushuo, Pan, Shengkai, Liu, Zhen, Zhang, Tongzuo, Zhou, Xin, Lei, Menglong, Chen, Peng, Yang, Hui, Zhang, Tao, Guo, Yuanting, Zhan, Xiangjiang, Chen, Yongbin, Shi, Peng, 2021 PirB functions as an intrinsic suppressor in hippocampal neural stem cells, Liu, Baiyang, Cheng, Wenjing, Cheng, Dating, Pu, Jun, Nie, Zhi, Xia, Cuifeng, Chen, Yongbin, Yang, Cuiping, 2021 miR-133b targets NCAPH to promote β-catenin degradation and reduce cancer stem cell maintenance in non-small cell lung cancer, Qiuxia Xiong, Liping Jiang, Kun Liu, Xiulin Jiang, Baiyang Liu, Yulin Shi, Dating Cheng, Yong Duan, Cuiping Yang, Yongbin Chen, 2021 Ivacaftor Inhibits Glioblastoma Stem Cell Maintenance and Tumor Progression, Liu, Kun, Pu, Jun, Nie, Zhi, Shi, Yulin, Jiang, Liping, Wu, Qisheng, Chen, Yongbin, Yang, Cuiping, 2021 Variation in the life history strategy underlies functional diversity of tumors, Li, Tao, Liu, Jialin, Feng, Jing, Liu, Zhenzhen, Liu, Sixue, Zhang, Minjie, Zhang, Yuezheng, Hou, Yali, Wu, Dafei, Li, Chunyan, Chen, Yongbin, Chen, Hua, Lu, Xuemei, 2021 RETSAT Mutation Selected for Hypoxia Adaptation Inhibits Tumor Growth, Jiang, Xiulin, He, Yaomei, Shen, Qiushuo, Duan, Lincan, Yuan, Yixiao, Tang, Lin, Shi, Yulin, Liu, Baiyang, Zhai, Haoqing, Shi, Peng, Yang, Cuiping, Chen, Yongbin, 2021 The role of m6A modification in the biological functions and diseases, Jiang, Xiulin, Liu, Baiyang, Nie, Zhi, Duan, Lincan, Xiong, Qiuxia, Jin, Zhixian, Yang, Cuiping, Chen, Yongbin, 2021 LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway, He, Yaomei, Jiang, Xiulin, Duan, Lincan, Xiong, Qiuxia, Yuan, Yixiao, Liu, Peishen, Jiang, Liping, Shen, Qiushuo, Zhao, Song, Yang, Cuiping, Chen, Yongbin, 2021 Hypoxia and cancer related pathology, Xiong, Qiuxia, Liu, Baiyang, Ding, Mingxia, Zhou, Jumin, Yang, Cuiping, Chen, Yongbin, 2020 Convergent genomic signatures of high-altitude adaptation among domestic mammals, DongDong Wu, CuiPing Yang, MingShan Wang, KunZhe Dong, DaWei Yan, ZiQian Hao, SongQing Fan, ShuZhou Chu, QiuShuo Shen, LiPing Jiang, Yan Li, Lin Zeng, HeQun Liu, HaiBing Xie, YunFei Ma, XiaoYan Kong, ShuLi Yang, XinXing Dong, Ali Esmailizadeh, David M Irwin, Xiao Xiao, Ming Li, Yang Dong, Wen Wang, Peng Shi, HaiPeng Li, YueHui Ma, Xiao Gou, YongBin Chen, YaPing Zhang, 2020 PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation, Xu, Peifang, Jiang, Liping, Yang, Yang, Wu, Mengge, Liu, Baiyang, Shi, Yulin, Shen, Qiushuo, Jiang, Xiulin, He, Yaomei, Cheng, Dating, Xiong, Qiuxia, Yang, Zuozhang, Duan, Lincan, Lin, Jie, Zhao, Song, Shi, Peng, Yang, Cuiping, Chen, Yongbin, 2020 Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling, Han, Yuhong, Wang, Bing, Cho, Yong Suk, Zhu, Jian, Wu, Jiang, Chen, Yongbin, Jiang, Jin, 2019 YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression, Shi, Yulin, Fan, Songqing, Wu, Mengge, Zuo, Zhixiang, Li, Xingyang, Jiang, Liping, Shen, Qiushuo, Xu, Peifang, Zeng, Lin, Zhou, Yongchun, Huang, Yunchao, Yang, Zuozhang, Zhou, Jumin, Gao, Jing, Zhou, Hu, Xu, Shuhua, Ji, Hongbin, Shi, Peng, Wu, DongDong, Yang, Cuiping, Chen, Yongbin, 2019 GRK5 functions as an oncogenic factor in non-small-cell lung cancer, Jiang LiPing, Fan SongQing, Xiong QiuXia, Zhou YongChun, Yang ZuoZhang, Li GaoFeng, Huang YunChao, Wu MengGe, Shen QiuShuo, Liu Kun, Yang CuiPing, Chen YongBin, 2018 Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes, CuiPing Yang, Xiaoyan Li, Yong Wu, Qiushuo Shen, Yong Zeng, Qiuxia Xiong, Mengping Wei, Chunhui Chen, Jiewei Liu, Yongxia Huo, Kaiqin Li, Gui Xue, YongGang Yao, Chen Zhang, Ming Li, Yongbin Chen, XiongJian Luo, 2018 Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma, Yao, Zhihong, Han, Lei, Chen, Yongbin, He, Fei, Sun, Bin, Kamar, Santosh, Zhang, Ya, Yang, Yihao, Wang, Cao, Yang, Zuozhang, 2018 NCAPH plays important roles in human colon cancer, Yin, Liang, Jiang, LiPing, Shen, QiuShuo, Xiong, QiuXia, Zhuo, Xiao, Zhang, LongLong, Yu, HaiJing, Guo, Xiang, Luo, Ying, Dong, Jian, Kong, QingPeng, Yang, CuiPing, Chen, YongBin, 2017 Establishment of basal cell carcinoma animal model in Chinese tree shrew (Tupaia belangeri chinensis)

Areas of Focus

Hypoxia adaptation mechanisms in high-altitude animals and non-model animals
Tumorigenesis and tumor progression
Stem cell pluripotency maintenance
New drug screening for anti-tumor and stem cell function enhancement

Publications

LncRNA GSCAR promotes glioma stem cell maintenance via stabilizing SOX2 expression, Xiulin Jiang, Yong Zhang, Yixiao Yuan, Zhixian Jin, Haoqing Zhai, Baiyang Liu, Yao Li, Chun Zhang, Min Chen, Yulin Shi, Dongming Yan, Jun Pu, Yongbin Chen, Cuiping Yang, 2023
Hypoxia-induced GLT8D1 promotes glioma stem cell maintenance by inhibiting CD133 degradation through N-linked glycosylation, Yongbin Chen, 2022
MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling, Yongbin Chen, 2022
Gemin6 promotes c-Myc stabilization and non-small cell lung cancer progression via accelerating AURKB mRNA maturation, Yongbin Chen, 2022
A single mutation underlying phenotypic convergence for hypoxia adaptation on the Qinghai-Tibetan Plateau, Xu, Dongming, Yang, Cuiping, Shen, Qiushuo, Pan, Shengkai, Liu, Zhen, Zhang, Tongzuo, Zhou, Xin, Lei, Menglong, Chen, Peng, Yang, Hui, Zhang, Tao, Guo, Yuanting, Zhan, Xiangjiang, Chen, Yongbin, Shi, Peng, 2021
PirB functions as an intrinsic suppressor in hippocampal neural stem cells, Liu, Baiyang, Cheng, Wenjing, Cheng, Dating, Pu, Jun, Nie, Zhi, Xia, Cuifeng, Chen, Yongbin, Yang, Cuiping, 2021
miR-133b targets NCAPH to promote β-catenin degradation and reduce cancer stem cell maintenance in non-small cell lung cancer, Qiuxia Xiong, Liping Jiang, Kun Liu, Xiulin Jiang, Baiyang Liu, Yulin Shi, Dating Cheng, Yong Duan, Cuiping Yang, Yongbin Chen, 2021
Ivacaftor Inhibits Glioblastoma Stem Cell Maintenance and Tumor Progression, Liu, Kun, Pu, Jun, Nie, Zhi, Shi, Yulin, Jiang, Liping, Wu, Qisheng, Chen, Yongbin, Yang, Cuiping, 2021
Variation in the life history strategy underlies functional diversity of tumors, Li, Tao, Liu, Jialin, Feng, Jing, Liu, Zhenzhen, Liu, Sixue, Zhang, Minjie, Zhang, Yuezheng, Hou, Yali, Wu, Dafei, Li, Chunyan, Chen, Yongbin, Chen, Hua, Lu, Xuemei, 2021
RETSAT Mutation Selected for Hypoxia Adaptation Inhibits Tumor Growth, Jiang, Xiulin, He, Yaomei, Shen, Qiushuo, Duan, Lincan, Yuan, Yixiao, Tang, Lin, Shi, Yulin, Liu, Baiyang, Zhai, Haoqing, Shi, Peng, Yang, Cuiping, Chen, Yongbin, 2021
The role of m6A modification in the biological functions and diseases, Jiang, Xiulin, Liu, Baiyang, Nie, Zhi, Duan, Lincan, Xiong, Qiuxia, Jin, Zhixian, Yang, Cuiping, Chen, Yongbin, 2021
LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway, He, Yaomei, Jiang, Xiulin, Duan, Lincan, Xiong, Qiuxia, Yuan, Yixiao, Liu, Peishen, Jiang, Liping, Shen, Qiushuo, Zhao, Song, Yang, Cuiping, Chen, Yongbin, 2021
Hypoxia and cancer related pathology, Xiong, Qiuxia, Liu, Baiyang, Ding, Mingxia, Zhou, Jumin, Yang, Cuiping, Chen, Yongbin, 2020
Convergent genomic signatures of high-altitude adaptation among domestic mammals, DongDong Wu, CuiPing Yang, MingShan Wang, KunZhe Dong, DaWei Yan, ZiQian Hao, SongQing Fan, ShuZhou Chu, QiuShuo Shen, LiPing Jiang, Yan Li, Lin Zeng, HeQun Liu, HaiBing Xie, YunFei Ma, XiaoYan Kong, ShuLi Yang, XinXing Dong, Ali Esmailizadeh, David M Irwin, Xiao Xiao, Ming Li, Yang Dong, Wen Wang, Peng Shi, HaiPeng Li, YueHui Ma, Xiao Gou, YongBin Chen, YaPing Zhang, 2020
PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation, Xu, Peifang, Jiang, Liping, Yang, Yang, Wu, Mengge, Liu, Baiyang, Shi, Yulin, Shen, Qiushuo, Jiang, Xiulin, He, Yaomei, Cheng, Dating, Xiong, Qiuxia, Yang, Zuozhang, Duan, Lincan, Lin, Jie, Zhao, Song, Shi, Peng, Yang, Cuiping, Chen, Yongbin, 2020
Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling, Han, Yuhong, Wang, Bing, Cho, Yong Suk, Zhu, Jian, Wu, Jiang, Chen, Yongbin, Jiang, Jin, 2019
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression, Shi, Yulin, Fan, Songqing, Wu, Mengge, Zuo, Zhixiang, Li, Xingyang, Jiang, Liping, Shen, Qiushuo, Xu, Peifang, Zeng, Lin, Zhou, Yongchun, Huang, Yunchao, Yang, Zuozhang, Zhou, Jumin, Gao, Jing, Zhou, Hu, Xu, Shuhua, Ji, Hongbin, Shi, Peng, Wu, DongDong, Yang, Cuiping, Chen, Yongbin, 2019
GRK5 functions as an oncogenic factor in non-small-cell lung cancer, Jiang LiPing, Fan SongQing, Xiong QiuXia, Zhou YongChun, Yang ZuoZhang, Li GaoFeng, Huang YunChao, Wu MengGe, Shen QiuShuo, Liu Kun, Yang CuiPing, Chen YongBin, 2018
Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes, CuiPing Yang, Xiaoyan Li, Yong Wu, Qiushuo Shen, Yong Zeng, Qiuxia Xiong, Mengping Wei, Chunhui Chen, Jiewei Liu, Yongxia Huo, Kaiqin Li, Gui Xue, YongGang Yao, Chen Zhang, Ming Li, Yongbin Chen, XiongJian Luo, 2018
Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma, Yao, Zhihong, Han, Lei, Chen, Yongbin, He, Fei, Sun, Bin, Kamar, Santosh, Zhang, Ya, Yang, Yihao, Wang, Cao, Yang, Zuozhang, 2018
NCAPH plays important roles in human colon cancer, Yin, Liang, Jiang, LiPing, Shen, QiuShuo, Xiong, QiuXia, Zhuo, Xiao, Zhang, LongLong, Yu, HaiJing, Guo, Xiang, Luo, Ying, Dong, Jian, Kong, QingPeng, Yang, CuiPing, Chen, YongBin, 2017
Establishment of basal cell carcinoma animal model in Chinese tree shrew (Tupaia belangeri chinensis)

Hypoxia High-Altitude Tumorigenesis Tumor Progression Stem Cells Pluripotency Drug Screening Anti-Tumor Gene Expression Evolutionary Biology

Yu Chen Xia - Wuhan University

Jingtao Guo - University of Chinese Academy of Sciences

Dongyuan Ma - University of Chinese Academy of Sciences

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