Professor | Keshi Chen | Asia Growth Partners

Name	Keshi Chen
Contact Information	chen_keshi@gibh.ac.cn
Language ability	Chinese, English
Province	Guangdong

Name

Keshi Chen

Contact Information

chen_keshi@gibh.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2008-09--2013-07 PhD: University of Chinese Academy of Sciences 2004-09--2008-07 Bachelor: University of Science and Technology of China
Work Experience	2023-01~Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher 2017-01~2022-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher 2013-07~2016-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Assistant Researcher
Awards	Outstanding Member of the Youth Innovation Promotion Association, Chinese Academy of Sciences (2022) First Prize for Research on Mitochondrial Signaling Regulation of Cell Fate (2020) Collective Research on Mechanisms of Stem Cell Pluripotency and Reprogramming (2017)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2008-09--2013-07 PhD: University of Chinese Academy of Sciences
2004-09--2008-07 Bachelor: University of Science and Technology of China

Work Experience

2023-01~Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
2017-01~2022-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher
2013-07~2016-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Assistant Researcher

Awards

Outstanding Member of the Youth Innovation Promotion Association, Chinese Academy of Sciences (2022)
First Prize for Research on Mitochondrial Signaling Regulation of Cell Fate (2020)
Collective Research on Mechanisms of Stem Cell Pluripotency and Reprogramming (2017)

Areas of Focus	Regulation of pluripotent stem cell fate based on epigenetics and metabolism
Publications	MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening, Corresponding Author, 2022 Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation, Second Author, 2022 Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade, Second Author, 2020 Topology-dependent, bifurcated mitochondrial quality control under starvation, Tenth Author, 2020 Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming, First Author, 2020 Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition, Second Author, 2019 Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming, Eighth Author, 2018 Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER-mitochondrial dynamics, Eighth Author, 2018 BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming, Fourth Author, 2017 Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction, Second Author, 2017 Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming, Second Author, 2016 Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming, Second Author, 2016 Gadd45a is a heterochromatin relaxer that enhances iPS cell generation, First Author, 2016 Valproic Acid-Induced Hepatotoxicity in Alpers Syndrome Is Associated With Mitochondrial Permeability Transition Pore Opening-Dependent Apoptotic Sensitivity in an Induced Pluripotent Stem Cell Model, Sixth Author, 2015 Tbx3 isoforms are involved in pluripotency maintaining through distinct regulation of Nanog transcriptional activity, Corresponding Author, 2014 The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner, Second Author, 2011 Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells, Eleventh Author, 2010

Areas of Focus

Regulation of pluripotent stem cell fate based on epigenetics and metabolism

Publications

MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening, Corresponding Author, 2022
Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation, Second Author, 2022
Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade, Second Author, 2020
Topology-dependent, bifurcated mitochondrial quality control under starvation, Tenth Author, 2020
Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming, First Author, 2020
Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition, Second Author, 2019
Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming, Eighth Author, 2018
Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER-mitochondrial dynamics, Eighth Author, 2018
BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming, Fourth Author, 2017
Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction, Second Author, 2017
Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming, Second Author, 2016
Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming, Second Author, 2016
Gadd45a is a heterochromatin relaxer that enhances iPS cell generation, First Author, 2016
Valproic Acid-Induced Hepatotoxicity in Alpers Syndrome Is Associated With Mitochondrial Permeability Transition Pore Opening-Dependent Apoptotic Sensitivity in an Induced Pluripotent Stem Cell Model, Sixth Author, 2015
Tbx3 isoforms are involved in pluripotency maintaining through distinct regulation of Nanog transcriptional activity, Corresponding Author, 2014
The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner, Second Author, 2011
Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells, Eleventh Author, 2010

Epigenetics Metabolism Pluripotent Stem Cells Cell Fate Embryonic Stem Cells Somatic Cell Reprogramming Mitochondrial Metabolism Chromatin Remodeling Gene Expression Cellular Signaling

Jianwei Jiao - University of Chinese Academy of Sciences

Jiekai Chen - University of Chinese Academy of Sciences

Lin Guo - University of Chinese Academy of Sciences

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