Areas of Focus
- Regulation of pluripotent stem cell fate based on epigenetics and metabolism
Work Experience
- 2023-01~Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
- 2017-01~2022-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher
- 2013-07~2016-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2008-09--2013-07 PhD: University of Chinese Academy of Sciences
- 2004-09--2008-07 Bachelor: University of Science and Technology of China
Publications
- MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening, Corresponding Author, 2022
- Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation, Second Author, 2022
- Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade, Second Author, 2020
- Topology-dependent, bifurcated mitochondrial quality control under starvation, Tenth Author, 2020
- Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming, First Author, 2020
- Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition, Second Author, 2019
- Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming, Eighth Author, 2018
- Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER-mitochondrial dynamics, Eighth Author, 2018
- BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming, Fourth Author, 2017
- Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction, Second Author, 2017
- Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming, Second Author, 2016
- Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming, Second Author, 2016
- Gadd45a is a heterochromatin relaxer that enhances iPS cell generation, First Author, 2016
- Valproic Acid-Induced Hepatotoxicity in Alpers Syndrome Is Associated With Mitochondrial Permeability Transition Pore Opening-Dependent Apoptotic Sensitivity in an Induced Pluripotent Stem Cell Model, Sixth Author, 2015
- Tbx3 isoforms are involved in pluripotency maintaining through distinct regulation of Nanog transcriptional activity, Corresponding Author, 2014
- The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner, Second Author, 2011
- Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells, Eleventh Author, 2010
Awards
- Outstanding Member of the Youth Innovation Promotion Association, Chinese Academy of Sciences (2022)
- First Prize for Research on Mitochondrial Signaling Regulation of Cell Fate (2020)
- Collective Research on Mechanisms of Stem Cell Pluripotency and Reprogramming (2017)
