Professor | 陈可实 | 数字化转型顾问

Name	陈可实
Contact Information	chen_keshi@gibh.ac.cn
Language ability	中文, 英语
Province	广东

Name

陈可实

Contact Information

chen_keshi@gibh.ac.cn

Language ability

中文, 英语

Province

广东

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	2008-09--2013-07 博士: 中国科学院大学 2004-09--2008-07 学士: 中国科学技术大学
Work Experience	2023-01~现在 - 中国科学院广州生物医药与健康研究院 - 研究员 2017-01~2022-12 - 中国科学院广州生物医药与健康研究院 - 副研究员 2013-07~2016-12 - 中国科学院广州生物医药与健康研究院 - 助理研究员
Awards	中国科学院青年创新促进会优秀会员 (2022) 线粒体信号调控细胞命运研究一等奖 (2020) 干细胞多能性与重编程机理研究集体 (2017)

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

2008-09--2013-07 博士: 中国科学院大学
2004-09--2008-07 学士: 中国科学技术大学

Work Experience

2023-01~现在 - 中国科学院广州生物医药与健康研究院 - 研究员
2017-01~2022-12 - 中国科学院广州生物医药与健康研究院 - 副研究员
2013-07~2016-12 - 中国科学院广州生物医药与健康研究院 - 助理研究员

Awards

中国科学院青年创新促进会优秀会员 (2022)
线粒体信号调控细胞命运研究一等奖 (2020)
干细胞多能性与重编程机理研究集体 (2017)

Areas of Focus	基于表观遗传和代谢的多能干细胞命运调控研究
Publications	MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening, 通讯作者, 2022 Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation, 第2作者, 2022 Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade, 第2作者, 2020 Topology-dependent, bifurcated mitochondrial quality control under starvation, 第10作者, 2020 Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming, 第1作者, 2020 Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition, 第2作者, 2019 Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming, 第8作者, 2018 Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER-mitochondrial dynamics, 第8作者, 2018 BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming, 第4作者, 2017 Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction, 第2作者, 2017 Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming, 第2作者, 2016 Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming, 第2作者, 2016 Gadd45a is a heterochromatin relaxer that enhances iPS cell generation, 第1作者, 2016 Valproic Acid-Induced Hepatotoxicity in Alpers Syndrome Is Associated With Mitochondrial Permeability Transition Pore Opening-Dependent Apoptotic Sensitivity in an Induced Pluripotent Stem Cell Model, 第6作者, 2015 Tbx3 isoforms are involved in pluripotency maintaining through distinct regulation of Nanog transcriptional activity, 通讯作者, 2014 The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner, 第2作者, 2011 Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells, 第11作者, 2010

Areas of Focus

基于表观遗传和代谢的多能干细胞命运调控研究

Publications

MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening, 通讯作者, 2022
Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation, 第2作者, 2022
Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade, 第2作者, 2020
Topology-dependent, bifurcated mitochondrial quality control under starvation, 第10作者, 2020
Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming, 第1作者, 2020
Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition, 第2作者, 2019
Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming, 第8作者, 2018
Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER-mitochondrial dynamics, 第8作者, 2018
BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming, 第4作者, 2017
Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction, 第2作者, 2017
Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming, 第2作者, 2016
Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming, 第2作者, 2016
Gadd45a is a heterochromatin relaxer that enhances iPS cell generation, 第1作者, 2016
Valproic Acid-Induced Hepatotoxicity in Alpers Syndrome Is Associated With Mitochondrial Permeability Transition Pore Opening-Dependent Apoptotic Sensitivity in an Induced Pluripotent Stem Cell Model, 第6作者, 2015
Tbx3 isoforms are involved in pluripotency maintaining through distinct regulation of Nanog transcriptional activity, 通讯作者, 2014
The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner, 第2作者, 2011
Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells, 第11作者, 2010

表观遗传代谢多能干细胞细胞命运胚胎干细胞体细胞重编程线粒体代谢染色质重塑基因表达细胞信号

蒋德伟 - 中国科学院大学

Area of Focus
表观遗传 | 癌症 | 调控 | 代谢 | Dna损伤 | 应答 | 生物治疗 | 肿瘤 | 研究 | 治疗

李媛媛 - 中国科学院大学

陈帅 - 南京大学

Area of Focus
代谢 | 生理 | 疾病 | 糖尿病 | 心肌病 | 胰岛素抵抗 | 钙稳态 | 动物模型 | 药物开发 | 细胞信号

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