Areas of Focus
- 基于表观遗传和代谢的多能干细胞命运调控研究
Work Experience
- 2023-01~现在 - 中国科学院广州生物医药与健康研究院 - 研究员
- 2017-01~2022-12 - 中国科学院广州生物医药与健康研究院 - 副研究员
- 2013-07~2016-12 - 中国科学院广州生物医药与健康研究院 - 助理研究员
Academic Background & Achievements
- 2008-09--2013-07 博士: 中国科学院大学
- 2004-09--2008-07 学士: 中国科学技术大学
Publications
- MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening, 通讯作者, 2022
- Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation, 第2作者, 2022
- Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade, 第2作者, 2020
- Topology-dependent, bifurcated mitochondrial quality control under starvation, 第10作者, 2020
- Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming, 第1作者, 2020
- Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition, 第2作者, 2019
- Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming, 第8作者, 2018
- Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER-mitochondrial dynamics, 第8作者, 2018
- BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming, 第4作者, 2017
- Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction, 第2作者, 2017
- Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming, 第2作者, 2016
- Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming, 第2作者, 2016
- Gadd45a is a heterochromatin relaxer that enhances iPS cell generation, 第1作者, 2016
- Valproic Acid-Induced Hepatotoxicity in Alpers Syndrome Is Associated With Mitochondrial Permeability Transition Pore Opening-Dependent Apoptotic Sensitivity in an Induced Pluripotent Stem Cell Model, 第6作者, 2015
- Tbx3 isoforms are involved in pluripotency maintaining through distinct regulation of Nanog transcriptional activity, 通讯作者, 2014
- The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner, 第2作者, 2011
- Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells, 第11作者, 2010
Awards
- 中国科学院青年创新促进会优秀会员 (2022)
- 线粒体信号调控细胞命运研究一等奖 (2020)
- 干细胞多能性与重编程机理研究集体 (2017)
