Professor | 李媛媛 | 数字化转型顾问

Name	李媛媛
Contact Information	liyuanyuan@simm.ac.cn
Language ability	中文, 英语
Province	上海

Name

李媛媛

Contact Information

liyuanyuan@simm.ac.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	2004-09至2010-01 药理学博士: 中国科学院上海药物研究所 2000-09至2004-06 药学学士: 华中科技大学
Work Experience	2020-08至今 - 中国科学院上海药物研究所 - 研究员，课题组长 2019-10至2020-06 - 美国贝勒医学院 - 博士后 2012-09至2018-04 - 美国东北俄亥俄医科大学 - 博士后 2010-09至2012-08 - 美国约翰霍普金斯大学 - 博士后 2004-09至2010-01 - 中国科学院上海药物研究所 - 药理学博士 2000-09至2004-06 - 华中科技大学 - 药学学士
Awards	上海浦江人才 (2021): 市地级

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

2004-09至2010-01 药理学博士: 中国科学院上海药物研究所
2000-09至2004-06 药学学士: 华中科技大学

Work Experience

2020-08至今 - 中国科学院上海药物研究所 - 研究员，课题组长
2019-10至2020-06 - 美国贝勒医学院 - 博士后
2012-09至2018-04 - 美国东北俄亥俄医科大学 - 博士后
2010-09至2012-08 - 美国约翰霍普金斯大学 - 博士后
2004-09至2010-01 - 中国科学院上海药物研究所 - 药理学博士
2000-09至2004-06 - 华中科技大学 - 药学学士

Awards

上海浦江人才 (2021): 市地级

Areas of Focus	代谢性疾病非酒精性脂肪肝肝纤维化
Publications	Charting new paradigms for CAR-T cell therapy beyond current Achilles heels, 第11作者, 2024 Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways, 第11作者, 2023 Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism, 第1作者, 2021 Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice, 第6作者, 2020 Hepatic forkhead box protein A3 regulates ApoA-I expression, cholesterol efflux and atherogenesis, 第1作者, 2019 Lipocalin-2 Protects Against Diet-Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes, 第4作者, 2019 Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR, 第4作者, 2018 Carboxylesterase 2 Prevents Liver Steatosis by Modulating Lipolysis, ER stress and Lipogenesis and is regulated by Hepatocyte Nuclear Factor 4 Alpha in Mice, 第1作者, 2016 Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4α and Protects Against Alcohol- and MCD diet-induced Liver Injury, 第3作者, 2016 A Metabolic Stress-inducible miR-34a-HNF4α Pathway Regulates Lipid and Lipoprotein Metabolism, 第4作者, 2015 Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes, 第7作者, 2015 Increasing β-Cell Mass Requires Additional Stimulation for Adaptation to Secretory Demand, 第3作者, 2014 Tsc2 Is a Molecular Checkpoint Controlling Osteoblast Development and Glucose Homeostasis, 第5作者, 2014 Hepatic Carboxylesterase 1 Is Induced by Glucose and Regulates Postprandial Glucose Levels, 第4作者, 2014 Hepatic Carboxylesterase 1 Is Essential for Both Normal and Farnesoid X Receptor-Controlled Lipid Homeostasis, 第2作者, 2014 Design and Synthesis of 4-(2,4,5-Trifluorophenyl)butane-1,3-diamines as Dipeptidyl PeptidaseIV Inhibitors, 第2作者, 2013 Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice, 第5作者, 2013 Novel Small-Molecule PGC-1 alpha Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice, 第4作者, 2013 Development of Novel Alkene Oxindole Derivatives AsOrally Efficacious AMP-Activated Protein Kinase Activators, 第2作者, 2013 Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A, 第3作者, 2013 Bile acid receptors in non-alcoholic fatty liver disease, 第1作者, 2013 Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice, 第1作者, 2013

Areas of Focus

代谢性疾病
非酒精性脂肪肝
肝纤维化

Publications

Charting new paradigms for CAR-T cell therapy beyond current Achilles heels, 第11作者, 2024
Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways, 第11作者, 2023
Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism, 第1作者, 2021
Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice, 第6作者, 2020
Hepatic forkhead box protein A3 regulates ApoA-I expression, cholesterol efflux and atherogenesis, 第1作者, 2019
Lipocalin-2 Protects Against Diet-Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes, 第4作者, 2019
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR, 第4作者, 2018
Carboxylesterase 2 Prevents Liver Steatosis by Modulating Lipolysis, ER stress and Lipogenesis and is regulated by Hepatocyte Nuclear Factor 4 Alpha in Mice, 第1作者, 2016
Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4α and Protects Against Alcohol- and MCD diet-induced Liver Injury, 第3作者, 2016
A Metabolic Stress-inducible miR-34a-HNF4α Pathway Regulates Lipid and Lipoprotein Metabolism, 第4作者, 2015
Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes, 第7作者, 2015
Increasing β-Cell Mass Requires Additional Stimulation for Adaptation to Secretory Demand, 第3作者, 2014
Tsc2 Is a Molecular Checkpoint Controlling Osteoblast Development and Glucose Homeostasis, 第5作者, 2014
Hepatic Carboxylesterase 1 Is Induced by Glucose and Regulates Postprandial Glucose Levels, 第4作者, 2014
Hepatic Carboxylesterase 1 Is Essential for Both Normal and Farnesoid X Receptor-Controlled Lipid Homeostasis, 第2作者, 2014
Design and Synthesis of 4-(2,4,5-Trifluorophenyl)butane-1,3-diamines as Dipeptidyl PeptidaseIV Inhibitors, 第2作者, 2013
Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice, 第5作者, 2013
Novel Small-Molecule PGC-1 alpha Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice, 第4作者, 2013
Development of Novel Alkene Oxindole Derivatives AsOrally Efficacious AMP-Activated Protein Kinase Activators, 第2作者, 2013
Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A, 第3作者, 2013
Bile acid receptors in non-alcoholic fatty liver disease, 第1作者, 2013
Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice, 第1作者, 2013

代谢性疾病非酒精性脂肪肝肝纤维化药理学肝病代谢肝脏病学细胞信号药物开发生物医学研究

宋保亮 - 武汉大学

邓文宏 - 武汉大学

Area of Focus
代谢 | 肿瘤学 | 药理学 | 胃肠病学 | 营养 | 体重控制 | 手术 | 并发症 | 药物反应 | 临床研究

陈可实 - 中国科学院大学

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