Areas of Focus
- 代谢性疾病
- 非酒精性脂肪肝
- 肝纤维化
Work Experience
- 2020-08至今 - 中国科学院上海药物研究所 - 研究员，课题组长
- 2019-10至2020-06 - 美国贝勒医学院 - 博士后
- 2012-09至2018-04 - 美国东北俄亥俄医科大学 - 博士后
- 2010-09至2012-08 - 美国约翰霍普金斯大学 - 博士后
- 2004-09至2010-01 - 中国科学院上海药物研究所 - 药理学博士
- 2000-09至2004-06 - 华中科技大学 - 药学学士
Academic Background & Achievements
- 2004-09至2010-01 药理学博士: 中国科学院上海药物研究所
- 2000-09至2004-06 药学学士: 华中科技大学
Publications
- Charting new paradigms for CAR-T cell therapy beyond current Achilles heels, 第11作者, 2024
- Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways, 第11作者, 2023
- Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism, 第1作者, 2021
- Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice, 第6作者, 2020
- Hepatic forkhead box protein A3 regulates ApoA-I expression, cholesterol efflux and atherogenesis, 第1作者, 2019
- Lipocalin-2 Protects Against Diet-Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes, 第4作者, 2019
- Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR, 第4作者, 2018
- Carboxylesterase 2 Prevents Liver Steatosis by Modulating Lipolysis, ER stress and Lipogenesis and is regulated by Hepatocyte Nuclear Factor 4 Alpha in Mice, 第1作者, 2016
- Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4α and Protects Against Alcohol- and MCD diet-induced Liver Injury, 第3作者, 2016
- A Metabolic Stress-inducible miR-34a-HNF4α Pathway Regulates Lipid and Lipoprotein Metabolism, 第4作者, 2015
- Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes, 第7作者, 2015
- Increasing β-Cell Mass Requires Additional Stimulation for Adaptation to Secretory Demand, 第3作者, 2014
- Tsc2 Is a Molecular Checkpoint Controlling Osteoblast Development and Glucose Homeostasis, 第5作者, 2014
- Hepatic Carboxylesterase 1 Is Induced by Glucose and Regulates Postprandial Glucose Levels, 第4作者, 2014
- Hepatic Carboxylesterase 1 Is Essential for Both Normal and Farnesoid X Receptor-Controlled Lipid Homeostasis, 第2作者, 2014
- Design and Synthesis of 4-(2,4,5-Trifluorophenyl)butane-1,3-diamines as Dipeptidyl PeptidaseIV Inhibitors, 第2作者, 2013
- Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice, 第5作者, 2013
- Novel Small-Molecule PGC-1 alpha Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice, 第4作者, 2013
- Development of Novel Alkene Oxindole Derivatives AsOrally Efficacious AMP-Activated Protein Kinase Activators, 第2作者, 2013
- Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A, 第3作者, 2013
- Bile acid receptors in non-alcoholic fatty liver disease, 第1作者, 2013
- Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice, 第1作者, 2013
Awards
- 上海浦江人才 (2021): 市地级
