Professor | Yuanyuan Li | Asia Growth Partners

Name	Yuanyuan Li
Contact Information	liyuanyuan@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Yuanyuan Li

Contact Information

liyuanyuan@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2004-09 to 2010-01 Ph.D. in Pharmacology: Shanghai Institute of Materia Medica, Chinese Academy of Sciences 2000-09 to 2004-06 B.Sc. in Pharmacy: Huazhong University of Science and Technology
Work Experience	2020-08 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Group Leader 2019-10 to 2020-06 - Baylor College of Medicine, USA - Postdoctoral Fellow 2012-09 to 2018-04 - Northeast Ohio Medical University, USA - Postdoctoral Fellow 2010-09 to 2012-08 - Johns Hopkins University, USA - Postdoctoral Fellow 2004-09 to 2010-01 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Ph.D. in Pharmacology 2000-09 to 2004-06 - Huazhong University of Science and Technology - B.Sc. in Pharmacy
Awards	Shanghai Pujiang Talent (2021): City-level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2004-09 to 2010-01 Ph.D. in Pharmacology: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
2000-09 to 2004-06 B.Sc. in Pharmacy: Huazhong University of Science and Technology

Work Experience

2020-08 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Group Leader
2019-10 to 2020-06 - Baylor College of Medicine, USA - Postdoctoral Fellow
2012-09 to 2018-04 - Northeast Ohio Medical University, USA - Postdoctoral Fellow
2010-09 to 2012-08 - Johns Hopkins University, USA - Postdoctoral Fellow
2004-09 to 2010-01 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Ph.D. in Pharmacology
2000-09 to 2004-06 - Huazhong University of Science and Technology - B.Sc. in Pharmacy

Awards

Shanghai Pujiang Talent (2021): City-level

Areas of Focus	Metabolic Diseases Non-alcoholic Fatty Liver Disease Liver Fibrosis
Publications	Charting new paradigms for CAR-T cell therapy beyond current Achilles heels, 11th Author, 2024 Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways, 11th Author, 2023 Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism, 1st Author, 2021 Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice, 6th Author, 2020 Hepatic forkhead box protein A3 regulates ApoA-I expression, cholesterol efflux and atherogenesis, 1st Author, 2019 Lipocalin-2 Protects Against Diet-Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes, 4th Author, 2019 Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR, 4th Author, 2018 Carboxylesterase 2 Prevents Liver Steatosis by Modulating Lipolysis, ER stress and Lipogenesis and is regulated by Hepatocyte Nuclear Factor 4 Alpha in Mice, 1st Author, 2016 Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4α and Protects Against Alcohol- and MCD diet-induced Liver Injury, 3rd Author, 2016 A Metabolic Stress-inducible miR-34a-HNF4α Pathway Regulates Lipid and Lipoprotein Metabolism, 4th Author, 2015 Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes, 7th Author, 2015 Increasing β-Cell Mass Requires Additional Stimulation for Adaptation to Secretory Demand, 3rd Author, 2014 Tsc2 Is a Molecular Checkpoint Controlling Osteoblast Development and Glucose Homeostasis, 5th Author, 2014 Hepatic Carboxylesterase 1 Is Induced by Glucose and Regulates Postprandial Glucose Levels, 4th Author, 2014 Hepatic Carboxylesterase 1 Is Essential for Both Normal and Farnesoid X Receptor-Controlled Lipid Homeostasis, 2nd Author, 2014 Design and Synthesis of 4-(2,4,5-Trifluorophenyl)butane-1,3-diamines as Dipeptidyl PeptidaseIV Inhibitors, 2nd Author, 2013 Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice, 5th Author, 2013 Novel Small-Molecule PGC-1 alpha Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice, 4th Author, 2013 Development of Novel Alkene Oxindole Derivatives AsOrally Efficacious AMP-Activated Protein Kinase Activators, 2nd Author, 2013 Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A, 3rd Author, 2013 Bile acid receptors in non-alcoholic fatty liver disease, 1st Author, 2013 Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice, 1st Author, 2013 8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models, 7th Author, 2010 Discovery of novel PTP1B inhibitors with antihyperglycemic activity, 3rd Author, 2010 High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice, 3rd Author, 2010 Synthesis of (S)-, (R)-, and (rac)-2-amino-3,3-bis(4-fluorophenyl)propanoic acids and an evaluation of the DPP IV inhibitory activity of Denagliptin diastereomers, 3rd Author, 2008

Areas of Focus

Metabolic Diseases
Non-alcoholic Fatty Liver Disease
Liver Fibrosis

Publications

Charting new paradigms for CAR-T cell therapy beyond current Achilles heels, 11th Author, 2024
Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways, 11th Author, 2023
Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism, 1st Author, 2021
Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice, 6th Author, 2020
Hepatic forkhead box protein A3 regulates ApoA-I expression, cholesterol efflux and atherogenesis, 1st Author, 2019
Lipocalin-2 Protects Against Diet-Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes, 4th Author, 2019
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR, 4th Author, 2018
Carboxylesterase 2 Prevents Liver Steatosis by Modulating Lipolysis, ER stress and Lipogenesis and is regulated by Hepatocyte Nuclear Factor 4 Alpha in Mice, 1st Author, 2016
Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4α and Protects Against Alcohol- and MCD diet-induced Liver Injury, 3rd Author, 2016
A Metabolic Stress-inducible miR-34a-HNF4α Pathway Regulates Lipid and Lipoprotein Metabolism, 4th Author, 2015
Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes, 7th Author, 2015
Increasing β-Cell Mass Requires Additional Stimulation for Adaptation to Secretory Demand, 3rd Author, 2014
Tsc2 Is a Molecular Checkpoint Controlling Osteoblast Development and Glucose Homeostasis, 5th Author, 2014
Hepatic Carboxylesterase 1 Is Induced by Glucose and Regulates Postprandial Glucose Levels, 4th Author, 2014
Hepatic Carboxylesterase 1 Is Essential for Both Normal and Farnesoid X Receptor-Controlled Lipid Homeostasis, 2nd Author, 2014
Design and Synthesis of 4-(2,4,5-Trifluorophenyl)butane-1,3-diamines as Dipeptidyl PeptidaseIV Inhibitors, 2nd Author, 2013
Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice, 5th Author, 2013
Novel Small-Molecule PGC-1 alpha Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice, 4th Author, 2013
Development of Novel Alkene Oxindole Derivatives AsOrally Efficacious AMP-Activated Protein Kinase Activators, 2nd Author, 2013
Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A, 3rd Author, 2013
Bile acid receptors in non-alcoholic fatty liver disease, 1st Author, 2013
Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice, 1st Author, 2013
8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models, 7th Author, 2010
Discovery of novel PTP1B inhibitors with antihyperglycemic activity, 3rd Author, 2010
High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice, 3rd Author, 2010
Synthesis of (S)-, (R)-, and (rac)-2-amino-3,3-bis(4-fluorophenyl)propanoic acids and an evaluation of the DPP IV inhibitory activity of Denagliptin diastereomers, 3rd Author, 2008

Metabolic Diseases Non-Alcoholic Fatty Liver Disease Liver Fibrosis Pharmacology Liver Disease Metabolism Hepatology Cell Signaling Drug Development Biomedical Research

Songmei Liu - Wuhan University

Shijie Chen - University of Chinese Academy of Sciences

Yanfen Fang - University of Chinese Academy of Sciences

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