Areas of Focus
- Metabolic Diseases
- Non-alcoholic Fatty Liver Disease
- Liver Fibrosis
Work Experience
- 2020-08 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Group Leader
- 2019-10 to 2020-06 - Baylor College of Medicine, USA - Postdoctoral Fellow
- 2012-09 to 2018-04 - Northeast Ohio Medical University, USA - Postdoctoral Fellow
- 2010-09 to 2012-08 - Johns Hopkins University, USA - Postdoctoral Fellow
- 2004-09 to 2010-01 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Ph.D. in Pharmacology
- 2000-09 to 2004-06 - Huazhong University of Science and Technology - B.Sc. in Pharmacy
Academic Background & Achievements
- 2004-09 to 2010-01 Ph.D. in Pharmacology: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 2000-09 to 2004-06 B.Sc. in Pharmacy: Huazhong University of Science and Technology
Publications
- Charting new paradigms for CAR-T cell therapy beyond current Achilles heels, 11th Author, 2024
- Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways, 11th Author, 2023
- Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism, 1st Author, 2021
- Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice, 6th Author, 2020
- Hepatic forkhead box protein A3 regulates ApoA-I expression, cholesterol efflux and atherogenesis, 1st Author, 2019
- Lipocalin-2 Protects Against Diet-Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes, 4th Author, 2019
- Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR, 4th Author, 2018
- Carboxylesterase 2 Prevents Liver Steatosis by Modulating Lipolysis, ER stress and Lipogenesis and is regulated by Hepatocyte Nuclear Factor 4 Alpha in Mice, 1st Author, 2016
- Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4α and Protects Against Alcohol- and MCD diet-induced Liver Injury, 3rd Author, 2016
- A Metabolic Stress-inducible miR-34a-HNF4α Pathway Regulates Lipid and Lipoprotein Metabolism, 4th Author, 2015
- Mouse-Human Experimental Epigenetic Analysis Unmasks Dietary Targets and Genetic Liability for Diabetic Phenotypes, 7th Author, 2015
- Increasing β-Cell Mass Requires Additional Stimulation for Adaptation to Secretory Demand, 3rd Author, 2014
- Tsc2 Is a Molecular Checkpoint Controlling Osteoblast Development and Glucose Homeostasis, 5th Author, 2014
- Hepatic Carboxylesterase 1 Is Induced by Glucose and Regulates Postprandial Glucose Levels, 4th Author, 2014
- Hepatic Carboxylesterase 1 Is Essential for Both Normal and Farnesoid X Receptor-Controlled Lipid Homeostasis, 2nd Author, 2014
- Design and Synthesis of 4-(2,4,5-Trifluorophenyl)butane-1,3-diamines as Dipeptidyl PeptidaseIV Inhibitors, 2nd Author, 2013
- Novel Small-Molecule AMP-Activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice, 5th Author, 2013
- Novel Small-Molecule PGC-1 alpha Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice, 4th Author, 2013
- Development of Novel Alkene Oxindole Derivatives AsOrally Efficacious AMP-Activated Protein Kinase Activators, 2nd Author, 2013
- Pancreatic β-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A, 3rd Author, 2013
- Bile acid receptors in non-alcoholic fatty liver disease, 1st Author, 2013
- Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice, 1st Author, 2013
- 8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models, 7th Author, 2010
- Discovery of novel PTP1B inhibitors with antihyperglycemic activity, 3rd Author, 2010
- High-Throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound With Beneficial Effects on db/db Mice, 3rd Author, 2010
- Synthesis of (S)-, (R)-, and (rac)-2-amino-3,3-bis(4-fluorophenyl)propanoic acids and an evaluation of the DPP IV inhibitory activity of Denagliptin diastereomers, 3rd Author, 2008
Awards
- Shanghai Pujiang Talent (2021): City-level
