Areas of Focus
- Microbiology and Biochemical Pharmacy
Work Experience
- 2020-04~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
- 2015-01~2020-03 - Stanford University - Postdoctoral Researcher
- 2009-04~2014-12 - Swiss Federal Institute of Technology Lausanne (EPFL) - PhD
- 2005-09~2008-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Master's
- 2001-09~2005-06 - Nanjing University - Bachelor's
Academic Background & Achievements
- 2009-04--2014-12 PhD: Swiss Federal Institute of Technology Lausanne (EPFL)
- 2005-09--2008-06 Master's: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 2001-09--2005-06 Bachelor's: Department of Chemistry, School of Chemistry and Chemical Engineering, Nanjing University
Publications
- DNA encoded peptide library for SARS-CoV-2 3CL protease covalent inhibitor discovery and profiling, 6th Author, Corresponding Author, 2024
- A phage display approach to identify highly selective covalent binders, 1st Author, 2021
- Cyclic peptide drugs approved in the last two decades (2001-2021), 11th Author, 2021
- Identification of highly selective covalent inhibitors by phage display, 1st Author, 2021
- Synthetic and biological approaches to map the substrate specificities of proteases, 1st Author, 2019
- Synthetic di-thiol containing amino acids for structurally shaping polypeptides and enhancing target-ligand binding interactions, 1st Author, 2014
- Peptide Ligands Stabilized by Small Molecules, 1st Author, 2014
- Phage Selection of Photoswitchable Peptide Ligands, 2nd Author, 2014
- Tracking chemical reactions on the surface of filamentous phage using mass spectrometry, 1st Author, 2014
- Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides, 11th Author, 2014
- Pattern-Based Sensing of Peptides and Aminoglycosides with a Single Molecular Probe, 2nd Author, 2013
- Bicyclic Peptide Ligands Pulled out of Cysteine-Rich Peptide Libraries, 1st Author, 2013
- Improving Binding Affinity and Stability of Peptide Ligands by Substituting Glycines with D-Amino Acids, 1st Author, 2013
- Bicyclic Peptides with Optimized Ring Size Inhibit Human Plasma Kallikrein and its Orthologues While Sparing Paralogous Proteases, 7th Author, 2012
- Structurally Diverse Cyclisation Linkers Impose Different Backbone Conformations in Bicyclic Peptides, 1st Author, 2012
- Bicyclic Peptide Inhibitor Reveals Large Contact Interface with a Protease Target, 3rd Author, 2012
- Bicyclization and Tethering to Albumin Yields Long-Acting Peptide Antagonists, 4th Author, 2012
- Microwave-assisted efficient copper-promoted N-arylation of Amines with arylboronic acids, 1st Author, 2008
Awards
- Chinese Academy of Sciences (2022): National Level
- Overseas Outstanding Youth (2022): National Level
- Pujiang Talent Program (2021): Provincial Level
- Swiss National Science Foundation - Advanced Postdoctoral Fellowship (2015): National Level
- Swiss National Science Foundation - SCNAT/SCS Award (2012): National Level
