Professor | Shiyu Chen | Asia Growth Partners

Name	Shiyu Chen
Contact Information	chenshiyu@simm.ac.cn
Language ability	English, Chinese, German
Province	Shanghai

Name

Shiyu Chen

Contact Information

chenshiyu@simm.ac.cn

Language ability

English, Chinese, German

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2009-04--2014-12 PhD: Swiss Federal Institute of Technology Lausanne (EPFL) 2005-09--2008-06 Master's: Shanghai Institute of Materia Medica, Chinese Academy of Sciences 2001-09--2005-06 Bachelor's: Department of Chemistry, School of Chemistry and Chemical Engineering, Nanjing University
Work Experience	2020-04~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher 2015-01~2020-03 - Stanford University - Postdoctoral Researcher 2009-04~2014-12 - Swiss Federal Institute of Technology Lausanne (EPFL) - PhD 2005-09~2008-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Master's 2001-09~2005-06 - Nanjing University - Bachelor's
Awards	Chinese Academy of Sciences (2022): National Level Overseas Outstanding Youth (2022): National Level Pujiang Talent Program (2021): Provincial Level Swiss National Science Foundation - Advanced Postdoctoral Fellowship (2015): National Level Swiss National Science Foundation - SCNAT/SCS Award (2012): National Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2009-04--2014-12 PhD: Swiss Federal Institute of Technology Lausanne (EPFL)
2005-09--2008-06 Master's: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
2001-09--2005-06 Bachelor's: Department of Chemistry, School of Chemistry and Chemical Engineering, Nanjing University

Work Experience

2020-04~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
2015-01~2020-03 - Stanford University - Postdoctoral Researcher
2009-04~2014-12 - Swiss Federal Institute of Technology Lausanne (EPFL) - PhD
2005-09~2008-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Master's
2001-09~2005-06 - Nanjing University - Bachelor's

Awards

Chinese Academy of Sciences (2022): National Level
Overseas Outstanding Youth (2022): National Level
Pujiang Talent Program (2021): Provincial Level
Swiss National Science Foundation - Advanced Postdoctoral Fellowship (2015): National Level
Swiss National Science Foundation - SCNAT/SCS Award (2012): National Level

Areas of Focus	Microbiology and Biochemical Pharmacy
Publications	DNA encoded peptide library for SARS-CoV-2 3CL protease covalent inhibitor discovery and profiling, 6th Author, Corresponding Author, 2024 A phage display approach to identify highly selective covalent binders, 1st Author, 2021 Cyclic peptide drugs approved in the last two decades (2001-2021), 11th Author, 2021 Identification of highly selective covalent inhibitors by phage display, 1st Author, 2021 Synthetic and biological approaches to map the substrate specificities of proteases, 1st Author, 2019 Synthetic di-thiol containing amino acids for structurally shaping polypeptides and enhancing target-ligand binding interactions, 1st Author, 2014 Peptide Ligands Stabilized by Small Molecules, 1st Author, 2014 Phage Selection of Photoswitchable Peptide Ligands, 2nd Author, 2014 Tracking chemical reactions on the surface of filamentous phage using mass spectrometry, 1st Author, 2014 Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides, 11th Author, 2014 Pattern-Based Sensing of Peptides and Aminoglycosides with a Single Molecular Probe, 2nd Author, 2013 Bicyclic Peptide Ligands Pulled out of Cysteine-Rich Peptide Libraries, 1st Author, 2013 Improving Binding Affinity and Stability of Peptide Ligands by Substituting Glycines with D-Amino Acids, 1st Author, 2013 Bicyclic Peptides with Optimized Ring Size Inhibit Human Plasma Kallikrein and its Orthologues While Sparing Paralogous Proteases, 7th Author, 2012 Structurally Diverse Cyclisation Linkers Impose Different Backbone Conformations in Bicyclic Peptides, 1st Author, 2012 Bicyclic Peptide Inhibitor Reveals Large Contact Interface with a Protease Target, 3rd Author, 2012 Bicyclization and Tethering to Albumin Yields Long-Acting Peptide Antagonists, 4th Author, 2012 Microwave-assisted efficient copper-promoted N-arylation of Amines with arylboronic acids, 1st Author, 2008

Areas of Focus

Microbiology and Biochemical Pharmacy

Publications

DNA encoded peptide library for SARS-CoV-2 3CL protease covalent inhibitor discovery and profiling, 6th Author, Corresponding Author, 2024
A phage display approach to identify highly selective covalent binders, 1st Author, 2021
Cyclic peptide drugs approved in the last two decades (2001-2021), 11th Author, 2021
Identification of highly selective covalent inhibitors by phage display, 1st Author, 2021
Synthetic and biological approaches to map the substrate specificities of proteases, 1st Author, 2019
Synthetic di-thiol containing amino acids for structurally shaping polypeptides and enhancing target-ligand binding interactions, 1st Author, 2014
Peptide Ligands Stabilized by Small Molecules, 1st Author, 2014
Phage Selection of Photoswitchable Peptide Ligands, 2nd Author, 2014
Tracking chemical reactions on the surface of filamentous phage using mass spectrometry, 1st Author, 2014
Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides, 11th Author, 2014
Pattern-Based Sensing of Peptides and Aminoglycosides with a Single Molecular Probe, 2nd Author, 2013
Bicyclic Peptide Ligands Pulled out of Cysteine-Rich Peptide Libraries, 1st Author, 2013
Improving Binding Affinity and Stability of Peptide Ligands by Substituting Glycines with D-Amino Acids, 1st Author, 2013
Bicyclic Peptides with Optimized Ring Size Inhibit Human Plasma Kallikrein and its Orthologues While Sparing Paralogous Proteases, 7th Author, 2012
Structurally Diverse Cyclisation Linkers Impose Different Backbone Conformations in Bicyclic Peptides, 1st Author, 2012
Bicyclic Peptide Inhibitor Reveals Large Contact Interface with a Protease Target, 3rd Author, 2012
Bicyclization and Tethering to Albumin Yields Long-Acting Peptide Antagonists, 4th Author, 2012
Microwave-assisted efficient copper-promoted N-arylation of Amines with arylboronic acids, 1st Author, 2008

Microbiology Biochemical Pharmacy Drug Discovery Peptide Ligands Covalent Inhibitors Phage Display Protease Inhibitors Chemical Biology Synthetic Biology Biopharmaceuticals

Huanqin Dai - University of Chinese Academy of Sciences

Wang Luoyi - University of Chinese Academy of Sciences

Rui Gong - University of Chinese Academy of Sciences

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