Professor | Xiaohua Chen | Asia Growth Partners

Name	Xiaohua Chen
Contact Information	xhchen@simm.ac.cn
Language ability	Chinese, English, German
Province	Shanghai

Name

Xiaohua Chen

Contact Information

xhchen@simm.ac.cn

Language ability

Chinese, English, German

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2003-09 to 2008-07 Ph.D.: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences 1999-09 to 2003-07 Bachelor's Degree in Chemistry: Wenzhou University
Work Experience	2015-07 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher 2014-11 to 2015-06 - University of California, San Francisco - Postdoctoral Fellow 2012-01 to 2014-11 - Salk Institute for Biological Studies - Postdoctoral Fellow 2010-11 to 2011-12 - Humboldt University of Berlin, Department of Chemistry - Postdoctoral Fellow, Humboldt Scholar 2008-09 to 2009-10 - University of Science and Technology of China, School of Chemistry and Materials Science - Associate Professor
Awards	Shanghai Outstanding Young Talent (2020): Provincial Level Shanghai Science and Technology Rising Star (A Class) (2016): Provincial Level Pioneer Fund Postdoctoral Fellowship (The Salk Institute for Biological Studies) (2014): Institutional Level National Excellent Doctoral Dissertation (2010): Ministerial Level Alexander von Humboldt Research Fellowship (2009): Special Outstanding Doctoral Dissertation of the Chinese Academy of Sciences (2009): Institutional Level Special Prize of the President's Award of the Chinese Academy of Sciences (2008): Institutional Level Roche Creative Chemistry Award (Roche R&D Center, China) (2007): Special

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2003-09 to 2008-07 Ph.D.: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences
1999-09 to 2003-07 Bachelor's Degree in Chemistry: Wenzhou University

Work Experience

2015-07 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
2014-11 to 2015-06 - University of California, San Francisco - Postdoctoral Fellow
2012-01 to 2014-11 - Salk Institute for Biological Studies - Postdoctoral Fellow
2010-11 to 2011-12 - Humboldt University of Berlin, Department of Chemistry - Postdoctoral Fellow, Humboldt Scholar
2008-09 to 2009-10 - University of Science and Technology of China, School of Chemistry and Materials Science - Associate Professor

Awards

Shanghai Outstanding Young Talent (2020): Provincial Level
Shanghai Science and Technology Rising Star (A Class) (2016): Provincial Level
Pioneer Fund Postdoctoral Fellowship (The Salk Institute for Biological Studies) (2014): Institutional Level
National Excellent Doctoral Dissertation (2010): Ministerial Level
Alexander von Humboldt Research Fellowship (2009): Special
Outstanding Doctoral Dissertation of the Chinese Academy of Sciences (2009): Institutional Level
Special Prize of the President's Award of the Chinese Academy of Sciences (2008): Institutional Level
Roche Creative Chemistry Award (Roche R&D Center, China) (2007): Special

Areas of Focus	Medicinal Chemistry Chemical Biology Drug Design and Synthesis
Publications	Spatiotemporal and direct capturing global substrates of lysine-modifying enzymes in living cells., 10th Author, 2024 Accelerating PROTACs Discovery through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry, 8th Author, 2024 Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy, 10th Author, 2024 Spatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors, 10th Author, 2023 A heterobifunctional molecule recruits cereblon to an RNA scaffold and activates its PROTAC function, 9th Author, 2022 Genetically Encoded Benzoyllysines Serve as Versatile Probe for Interrogating Histone Benzoylations and Interactions in Living Cells, 10th Author, 2021 Light-induced efficient and residue-selective bioconjugation of native proteins via indazolone formation, 10th Author, 2021 Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer, 10th Author, 2021 Light-induced primary amines and o-nitrobenzyl alcohols cyclization as a versatile photoclick reaction for modular conjugation, 10th Author, 2020 Genetically Encoded Residue-Selective Photo-Crosslinker to Capture Protein-Protein Interactions in Living Cells, 10th Author, 2019

Areas of Focus

Medicinal Chemistry
Chemical Biology
Drug Design and Synthesis

Publications

Spatiotemporal and direct capturing global substrates of lysine-modifying enzymes in living cells., 10th Author, 2024
Accelerating PROTACs Discovery through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry, 8th Author, 2024
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy, 10th Author, 2024
Spatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors, 10th Author, 2023
A heterobifunctional molecule recruits cereblon to an RNA scaffold and activates its PROTAC function, 9th Author, 2022
Genetically Encoded Benzoyllysines Serve as Versatile Probe for Interrogating Histone Benzoylations and Interactions in Living Cells, 10th Author, 2021
Light-induced efficient and residue-selective bioconjugation of native proteins via indazolone formation, 10th Author, 2021
Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer, 10th Author, 2021
Light-induced primary amines and o-nitrobenzyl alcohols cyclization as a versatile photoclick reaction for modular conjugation, 10th Author, 2020
Genetically Encoded Residue-Selective Photo-Crosslinker to Capture Protein-Protein Interactions in Living Cells, 10th Author, 2019

Drug Discovery Organic Synthesis Protein Interactions Enzyme Inhibition Molecular Design Pharmacology Bioconjugation Chemical Probes Therapeutics Biological Chemistry

Kui Hong - Wuhan University

Bingzheng Shen - Wuhan University

Xianghai Cai - University of Chinese Academy of Sciences

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