Areas of Focus
- Medicinal Chemistry
- Chemical Biology
- Drug Design and Synthesis
Work Experience
- 2015-07 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
- 2014-11 to 2015-06 - University of California, San Francisco - Postdoctoral Fellow
- 2012-01 to 2014-11 - Salk Institute for Biological Studies - Postdoctoral Fellow
- 2010-11 to 2011-12 - Humboldt University of Berlin, Department of Chemistry - Postdoctoral Fellow, Humboldt Scholar
- 2008-09 to 2009-10 - University of Science and Technology of China, School of Chemistry and Materials Science - Associate Professor
Academic Background & Achievements
- 2003-09 to 2008-07 Ph.D.: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences
- 1999-09 to 2003-07 Bachelor's Degree in Chemistry: Wenzhou University
Publications
- Spatiotemporal and direct capturing global substrates of lysine-modifying enzymes in living cells., 10th Author, 2024
- Accelerating PROTACs Discovery through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry, 8th Author, 2024
- Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy, 10th Author, 2024
- Spatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors, 10th Author, 2023
- A heterobifunctional molecule recruits cereblon to an RNA scaffold and activates its PROTAC function, 9th Author, 2022
- Genetically Encoded Benzoyllysines Serve as Versatile Probe for Interrogating Histone Benzoylations and Interactions in Living Cells, 10th Author, 2021
- Light-induced efficient and residue-selective bioconjugation of native proteins via indazolone formation, 10th Author, 2021
- Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer, 10th Author, 2021
- Light-induced primary amines and o-nitrobenzyl alcohols cyclization as a versatile photoclick reaction for modular conjugation, 10th Author, 2020
- Genetically Encoded Residue-Selective Photo-Crosslinker to Capture Protein-Protein Interactions in Living Cells, 10th Author, 2019
Awards
- Shanghai Outstanding Young Talent (2020): Provincial Level
- Shanghai Science and Technology Rising Star (A Class) (2016): Provincial Level
- Pioneer Fund Postdoctoral Fellowship (The Salk Institute for Biological Studies) (2014): Institutional Level
- National Excellent Doctoral Dissertation (2010): Ministerial Level
- Alexander von Humboldt Research Fellowship (2009): Special
- Outstanding Doctoral Dissertation of the Chinese Academy of Sciences (2009): Institutional Level
- Special Prize of the President's Award of the Chinese Academy of Sciences (2008): Institutional Level
- Roche Creative Chemistry Award (Roche R&D Center, China) (2007): Special
