Areas of Focus
- Ion Channel Pharmacology and Drug Development
- Discovery and New Applications of Novel Ion Channels
- Viral Ion Channels
Work Experience
- 2020-08 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Deputy Director, Director of the Neuropsychiatric Disease Research Center
- 2016-10 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Group Leader
- 2013-10 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
- 2010-04 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher
- 2006-10 to 2010-03 - Johns Hopkins University School of Medicine - Postdoctoral
- 2003-09 to 2006-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - PhD Student
Academic Background & Achievements
- 2006-10 to 2010-03 Postdoctoral: Johns Hopkins University School of Medicine
- 2003-09 to 2006-06 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Publications
- Direct Identification of Complex Glycans via a Highly Sensitive Engineered Nanopore, Zhaobing Gao, 2024
- Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses, Zhaobing Gao, 2024
- Characterization of the role of TMEM175 in an in vitro lysosomal H+ fluxes model, Zhaobing Gao, 2023
- Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2, Zhaobing Gao, 2023
- Physiological and Pathological Functions of TRPM7 Channel and Its Small-molecule Modulators, Zhaobing Gao, 2023
- Ligand activation mechanisms of human KCNQ2 channel, Zhaobing Gao, 2023
- Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies, Zhaobing Gao, 2023
- Development of SV2A Ligands for Epilepsy Treatment: A Review of Levetiracetam, Brivaracetam, and Padsevonil, Zhaobing Gao, 2023
- Mapping the Acetylamino and Carboxyl Groups on Glycans by Engineered β-Hemolysin Nanopores, Zhaobing Gao, 2023
- Naphthylisoquinoline alkaloids, a new structural template inhibitor of Nav1.7 sodium channel, Zhaobing Gao, 2023
- Discovery of selective NaV1.8 inhibitors based on 5-chloro-2-(4,4-difluoroazepan-1-yl)-6-methyl nicotinamide scaffold for the treatment of pain, Zhaobing Gao, 2023
- Why is the SARS-CoV-2 Omicron variant milder?, Zhaobing Gao, 2022
- Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates, Zhaobing Gao, 2022
- SCN8A epileptic encephalopathy mutations display a gain-of-function phenotype and divergent sensitivity to antiepileptic drugs, Zhaobing Gao, 2022
- Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution, Zhaobing Gao, 2021
- SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, Zhaobing Gao, 2021
- Sanguinarine is an agonist of TRPA1 channel, Zhaobing Gao, 2021
- An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy, Zhaobing Gao, 2021
- Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate, Zhaobing Gao, 2021
- Identification of 2-substituted pyrrolo1,2-bpyridazine derivatives as new PARP-1 inhibitors, Zhaobing Gao, 2021
- CCT128930 is a novel and potent antagonist of TRPM7 channel, Zhaobing Gao, 2021
- Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core, Zhaobing Gao, 2020
- Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels, Zhaobing Gao, 2020
- Inhibitory effects of lappaconitine on the neuronal isoforms of voltage-gated sodium channels, Zhaobing Gao, 2019
- Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models, Zhaobing Gao, 2019
- A Small-Molecule Compound Selectively Activates K2P Channel TASK-3 by Acting at Two Distant Clusters of Residues, Zhaobing Gao, 2019
- Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity, Zhaobing Gao, 2019
- High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer’s disease mice, Zhaobing Gao, 2019
- 靶向TRPA1通道治疗有机磷导致的神经损伤, Zhaobing Gao, 2018
- A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel, Zhaobing Gao, 2018
- The synthesis and antistaphylococcal activity of N-sulfonaminoethyloxime derivatives of dehydroabietic acid, Zhaobing Gao, 2018
- Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate, Zhaobing Gao, 2018
- Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802, Zhaobing Gao, 2018
- CNV1014802 Rescues the Paroxysmal Extreme Pain Disorders Nav1.7 Mutants by Restoring Impaired Inactivation, Zhaobing Gao, 2017
- Label-free brainwide visualization of senile plaque using cryo-micro-optical sectioning tomography, Zhaobing Gao, 2017
- The synthesis and antistaphylococcal activity of dehydroabietic acid derivatives: modifications at C12 and C7, Zhaobing Gao, 2017
- Two novel C18-diterpenoid alkaloids, sinomontadine with an unprecedented seven-membered ring A and chloride-containing sinomontanine N from Aconitum sinomontanum, Zhaobing Gao, 2017
- Discovery of NAV1.7 Modulators from Marketed Drugs using High throuthput Automated Electrophysiological System Ionworks Barracuda, Zhaobing Gao, 2017
- TRPA1 channel mediates organophosphate-induced delayed neuropathy, Zhaobing Gao, 2017
- Voltage- to Ligand-Gated Switch in Voltage-Gated Potassium Channels, Zhaobing Gao, 2017
- MLKL forms cation channels, Zhaobing Gao, 2016
- Identification and Evaluation of Antiepileptic Activity of C-21 Steroidal Glycosides from the Roots of Cynanchum wilfordii, Zhaobing Gao, 2016
- Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy, Zhaobing Gao, 2016
- Computer-Aided Drug Discovery and Design Targeting Ion Channels, Zhaobing Gao, 2016
- Ion channels research in the post-genomic era, Zhaobing Gao, 2016
- Grafting voltage and pharmacological sensitivity in potassium channels, Zhaobing Gao, 2016
- Novel KCNQ2 channel activators discovered using fluorescence-based and automated patch-clamp-based high-throughput screening techniques, Zhaobing Gao
Awards
- Innovation Talent Promotion Plan Young and Middle-aged Science and Technology Innovation Leading Talent (2019)
- National Hundred, Thousand, and Ten Thousand Talent Project (2019)
- American Heart Association Postdoctoral Fellowship (2007)
