Professor | Fajian Hou | Asia Growth Partners

Name	Fajian Hou
Contact Information	fhou@sibcb.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Fajian Hou

Contact Information

fhou@sibcb.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1995-09--2001-08 PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences 1991-09--1995-07 Bachelor's: Wuhan University
Work Experience	2012-02~Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher 2009-01~2012-01 - University of Texas Southwestern Medical Center - Lecturer 2001-11~2008-12 - University of Texas Southwestern Medical Center - Postdoctoral Fellow 1995-09~2001-08 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - PhD Student 1991-09~1995-07 - Wuhan University - Bachelor's Student

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1995-09--2001-08 PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
1991-09--1995-07 Bachelor's: Wuhan University

Work Experience

2012-02~Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher
2009-01~2012-01 - University of Texas Southwestern Medical Center - Lecturer
2001-11~2008-12 - University of Texas Southwestern Medical Center - Postdoctoral Fellow
1995-09~2001-08 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - PhD Student
1991-09~1995-07 - Wuhan University - Bachelor's Student

Areas of Focus	Biochemical Mechanisms of Innate Immune Signal Transduction
Publications	WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response, Fajian Hou, 2023 FBXO38 regulates macrophage polarization to control the development of cancer and colitis, Fajian Hou, 2023 Human STING Is Regulated by an Autoinhibitory Mechanism for Type I Interferon Production, Fajian Hou, 2022 The Endoplasmic Reticulum ATP13A1 is Essential for MAVS-Mediated Antiviral Innate Immunity, Fajian Hou, 2022 SARS-CoV-2 infection and the antiviral innate immune response, Fajian Hou, 2020 TRAF 3 IP 3 mediates the recruitment of TRAF 3 to MAVS for antiviral innate immunity, Fajian Hou, 2019 Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity, Fajian Hou, 2017 Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling, Fajian Hou, 2017 An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response, Fajian Hou, 2015 A novel acetylation of beta-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation, Fajian Hou, 2011 MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response, Fajian Hou, 2011 The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity, Fajian Hou, 2008 The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner, Fajian Hou, 2007 Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion, Fajian Hou, 2005

Areas of Focus

Biochemical Mechanisms of Innate Immune Signal Transduction

Publications

WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response, Fajian Hou, 2023
FBXO38 regulates macrophage polarization to control the development of cancer and colitis, Fajian Hou, 2023
Human STING Is Regulated by an Autoinhibitory Mechanism for Type I Interferon Production, Fajian Hou, 2022
The Endoplasmic Reticulum ATP13A1 is Essential for MAVS-Mediated Antiviral Innate Immunity, Fajian Hou, 2022
SARS-CoV-2 infection and the antiviral innate immune response, Fajian Hou, 2020
TRAF 3 IP 3 mediates the recruitment of TRAF 3 to MAVS for antiviral innate immunity, Fajian Hou, 2019
Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity, Fajian Hou, 2017
Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling, Fajian Hou, 2017
An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response, Fajian Hou, 2015
A novel acetylation of beta-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation, Fajian Hou, 2011
MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response, Fajian Hou, 2011
The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity, Fajian Hou, 2008
The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner, Fajian Hou, 2007
Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion, Fajian Hou, 2005

Innate Immunity Signal Transduction Biochemistry Immune Response Molecular Biology Cell Biology Interferon Mavs Antiviral Macrophage Polarization

Lian Huan - Wuhan University

Hongbing Shu - Wuhan University

Weiwei Luo - University of Chinese Academy of Sciences

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