Areas of Focus
- 天然免疫信号转导的生化机理
Work Experience
- 2012-02~现在 - 中国科学院上海生命科学院生物化学与分子生物学研究所 - 研究员
- 2009-01~2012-01 - 美国德州大学西南医学中心 - 讲师
- 2001-11~2008-12 - 美国德州大学西南医学中心 - 博士后
- 1995-09~2001-08 - 中科院上海生化所 - 博士生
- 1991-09~1995-07 - 武汉大学 - 学士生
Academic Background & Achievements
- 1995-09--2001-08 博士: 中科院上海生化所
- 1991-09--1995-07 学士: 武汉大学
Publications
- WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response, 侯法建, 2023
- FBXO38 regulates macrophage polarization to control the development of cancer and colitis, 侯法建, 2023
- Human STING Is Regulated by an Autoinhibitory Mechanism for Type I Interferon Production, 侯法建, 2022
- The Endoplasmic Reticulum ATP13A1 is Essential for MAVS-Mediated Antiviral Innate Immunity, 侯法建, 2022
- SARS-CoV-2 infection and the antiviral innate immune response, 侯法建, 2020
- TRAF 3 IP 3 mediates the recruitment of TRAF 3 to MAVS for antiviral innate immunity, 侯法建, 2019
- Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity, 侯法建, 2017
- Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling, 侯法建, 2017
- An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response, 侯法建, 2015
- A novel acetylation of beta-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation, 侯法建, 2011
- MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response, 侯法建, 2011
- The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity, 侯法建, 2008
- The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner, 侯法建, 2007
- Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion, 侯法建, 2005
