Professor | 侯法建 | 数字化转型顾问

Name	侯法建
Contact Information	fhou@sibcb.ac.cn
Language ability	中文, 英语
Province	上海

Name

侯法建

Contact Information

fhou@sibcb.ac.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	1995-09--2001-08 博士: 中科院上海生化所 1991-09--1995-07 学士: 武汉大学
Work Experience	2012-02~现在 - 中国科学院上海生命科学院生物化学与分子生物学研究所 - 研究员 2009-01~2012-01 - 美国德州大学西南医学中心 - 讲师 2001-11~2008-12 - 美国德州大学西南医学中心 - 博士后 1995-09~2001-08 - 中科院上海生化所 - 博士生 1991-09~1995-07 - 武汉大学 - 学士生

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

1995-09--2001-08 博士: 中科院上海生化所
1991-09--1995-07 学士: 武汉大学

Work Experience

2012-02~现在 - 中国科学院上海生命科学院生物化学与分子生物学研究所 - 研究员
2009-01~2012-01 - 美国德州大学西南医学中心 - 讲师
2001-11~2008-12 - 美国德州大学西南医学中心 - 博士后
1995-09~2001-08 - 中科院上海生化所 - 博士生
1991-09~1995-07 - 武汉大学 - 学士生

Areas of Focus	天然免疫信号转导的生化机理
Publications	WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response, 侯法建, 2023 FBXO38 regulates macrophage polarization to control the development of cancer and colitis, 侯法建, 2023 Human STING Is Regulated by an Autoinhibitory Mechanism for Type I Interferon Production, 侯法建, 2022 The Endoplasmic Reticulum ATP13A1 is Essential for MAVS-Mediated Antiviral Innate Immunity, 侯法建, 2022 SARS-CoV-2 infection and the antiviral innate immune response, 侯法建, 2020 TRAF 3 IP 3 mediates the recruitment of TRAF 3 to MAVS for antiviral innate immunity, 侯法建, 2019 Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity, 侯法建, 2017 Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling, 侯法建, 2017 An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response, 侯法建, 2015 A novel acetylation of beta-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation, 侯法建, 2011 MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response, 侯法建, 2011 The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity, 侯法建, 2008 The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner, 侯法建, 2007 Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion, 侯法建, 2005

Areas of Focus

天然免疫信号转导的生化机理

Publications

WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response, 侯法建, 2023
FBXO38 regulates macrophage polarization to control the development of cancer and colitis, 侯法建, 2023
Human STING Is Regulated by an Autoinhibitory Mechanism for Type I Interferon Production, 侯法建, 2022
The Endoplasmic Reticulum ATP13A1 is Essential for MAVS-Mediated Antiviral Innate Immunity, 侯法建, 2022
SARS-CoV-2 infection and the antiviral innate immune response, 侯法建, 2020
TRAF 3 IP 3 mediates the recruitment of TRAF 3 to MAVS for antiviral innate immunity, 侯法建, 2019
Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity, 侯法建, 2017
Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling, 侯法建, 2017
An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response, 侯法建, 2015
A novel acetylation of beta-tubulin by San modulates microtubule polymerization via down-regulating tubulin incorporation, 侯法建, 2011
MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response, 侯法建, 2011
The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity, 侯法建, 2008
The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner, 侯法建, 2007
Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion, 侯法建, 2005

天然免疫信号转导生物化学免疫反应分子生物学细胞生物学干扰素 Mavs 抗病毒巨噬细胞极化

舒红兵 - 武汉大学

龚克 - 武汉大学

丁健 - 中国科学院大学

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