Areas of Focus
- Chemical Biology
- Proteomics
- Epigenetics
Work Experience
- 2019-01 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
- 2015-09 to 2019-01 - University of Chicago - Research Assistant
- 2012-11 to 2015-08 - University of Chicago - Postdoctoral Fellow
- 2010-08 to 2012-10 - Northwestern University - Postdoctoral Fellow
Academic Background & Achievements
- 2004-09 to 2010-06 Ph.D. in Science: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 2000-09 to 2004-06 B.Sc. in Science: Tongji University
Publications
- HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation, Huang He, 2023
- Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization, Huang He, 2023
- A Ru(ii)-catalyzed C–H activation and annulation cascade for the construction of highly coumarin-fused benzo[a]quinolizin-4-ones and pyridin-2-ones, Huang He, 2023
- Lactylome suggests novel mechanisms of metabolic adaptation in hepatocellular carcinoma, Huang He, 2023
- Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial, Huang He, 2022
- HBO1 catalyzes lysine benzoylation in mammalian cells, Huang He, 2022
- Quantitative Proteomics Analysis Expands the Roles of Lysine β-Hydroxybutyrylation Pathway in Response to Environmental β-Hydroxybutyrate, Huang He, 2022
- The regulatory enzymes and protein substrates for the lysine beta-hydroxybutyrylation pathway, Huang He, 2021
- Metabolic regulation of gene expression by histone lactylation, Huang He, 2019
- Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway, Huang He, 2018
- p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis, Huang He, 2018
- Lysine benzoylation is a histone mark regulated by SIRT2, Huang He, 2018
- Quantitative Crotonylome Analysis Expands the Roles of p300 in the Regulation of Lysine Crotonylation Pathway, Huang He, 2018
- Structure of p300 in complex with acyl-CoA variants, Huang He, 2017
- 2-Hydroxyisobutyrylation on histone H4K8 is regulated by glucose homeostasis in Saccharomyces cerevisiae., Huang He, 2017
- TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions, Huang He, 2016
- Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain, Huang He, 2016
- Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters, Huang He, 2016
- Metabolic Regulation of Gene Expression by Histone Lysine-X modification, Huang He, 2016
- Structure-Based Design of Bacterial Nitric Oxide Synthase Inhibitors, Huang He, 2015
- Quantitative Proteomic Analysis of Histone Modifications, Huang He, 2015
- Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation, Huang He, 2015
- SnapShot: Histone Modifications, Huang He, 2014
- Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5, Huang He, 2014
- Silverman RB. Potent and Selective Double-headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma., Huang He, 2014
- Structural and biological characterization of NOS inhibitors with antimicrobial properties, Huang He, 2014
- Arylazanyl pyrazolone derivatives as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of amyotrophic lateral sclerosis., Huang He, 2013
- Structure-guided Design of Selective Inhibitors of Neuronal Nitric Oxide Synthase, Huang He, 2013
- Selective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics Simulations, Huang He, 2012
- Recent advances in the gold-catalyzed additions to C–C multiple bonds, Huang He, 2011
- Iron deprivation caused by a novel iron chelator thiosemicarbazone-24 suppresses hepatocellular carcinoma in vitro and in vivo., Huang He, 2011
- PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo, Huang He, 2011
- Synthesis of 4-Aryl-2(5H)-furanones by Gold(I)-Catalyzed Intramolecular Annulation, Huang He, 2011
- Iron Deprivation Suppresses Hepatocellular Carcinoma Growth in Experimental Studies, Huang He, 2011
- A Series of alpha-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase II alpha Catalytic Activity, Huang He, 2010
- PH006, a novel and highly potent Src kinase inhibitor, suppresses tumor growth and metastasis in vitro and in vivo., Huang He, 2010
- Total Synthesis of Cytosporone B, Huang He, 2010
- Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase, Huang He, 2010
- A class of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase II alpha catalytic activity, Huang He, 2010
- Metal-Free Synthesis of 2-Substituted (N, O, C) Benzothiazoles via an Intramolecular C-S Bond Formation, Huang He, 2010
- Ligand-free iron/copper cocatalyzed N-arylations of aryl halides with amines under microwave irradiation, Huang He, 2010
- 新型Src激酶抑制剂PH006的抗肿瘤作用研究, Huang He, 2009
- A Simple and Efficient Copper-Catalyzed Tandem Synthesis of Quinoline-2-carboxylates at Room Temperature, Huang He, 2009
- Discovering novel quercetin-3-O-amino acid-esters as a new class of Src tyrosine kinase inhibitors, Huang He, 2009
- 缩氨基硫脲类新化合物TSC的抗肿瘤作用及其分子机制研究, Huang He, 2009
- A Simple and Convenient
Awards
- Outstanding Youth Science and Technology Innovation Talent (2022): Institute Level
- Pujiang Talent of Shanghai (2019): Provincial Level
- Excellent Award of the President of the Chinese Academy of Sciences (2010): Institute Level
- Outstanding Graduate of Shanghai Higher Education Institutions (2010): Provincial Level
- Eli Lilly Asia Outstanding Thesis Award (2010): First Prize
- Best Paper Award at the First Chinese Medicine Macau Forum (2009): Other
- Outstanding Poster Award at the 6th World Chinese Drug Chemistry Conference (2008): Other
