Professor | Shi-You Jiang | Asia Growth Partners

Name	Shi-You Jiang
Contact Information	jiangshiyou@mail.kib.ac.cn
Language ability	Chinese, English
Province	Yunnan

Name

Shi-You Jiang

Contact Information

jiangshiyou@mail.kib.ac.cn

Language ability

Chinese, English

Province

Yunnan

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Work Experience	2022-06 - Present - Kunming Institute of Botany, Chinese Academy of Sciences - Researcher, Research Group Leader, Introduced Outstanding Talent 2022-01 - 2022-06 - Wuhan University, School of Life Sciences - Research Assistant 2018-08 - 2022-05 - ShanghaiTech University, School of Life Science and Technology - Visiting Scholar 2016-04 - 2018-07 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Visiting Scholar 2016-02 - 2022-01 - Wuhan University, School of Life Sciences - Postdoctoral Researcher
Awards	2022 - Top Ten Original Research in Portal Hypertension and Liver Cirrhosis in China 2022 - Discover Glo Explorer Young Scientist Award by Chinese Society for Cell Biology 2022 - First Prize in the Fourth Scientific Image Competition at ShanghaiTech University 2022 - Second Prize in the Fourth Scientific Image Competition at ShanghaiTech University 2022 - Third Prize in the Fourth Scientific Image Competition at ShanghaiTech University 2017 - Excellent Microscope Image at Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences 2016 - Excellent Microscope Image at Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences 2013 - Third Prize in Microscopic Photography Competition by Chinese Society for Cell Biology 2013 - Olympus China Microscopic Image Competition

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Work Experience

2022-06 - Present - Kunming Institute of Botany, Chinese Academy of Sciences - Researcher, Research Group Leader, Introduced Outstanding Talent
2022-01 - 2022-06 - Wuhan University, School of Life Sciences - Research Assistant
2018-08 - 2022-05 - ShanghaiTech University, School of Life Science and Technology - Visiting Scholar
2016-04 - 2018-07 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Visiting Scholar
2016-02 - 2022-01 - Wuhan University, School of Life Sciences - Postdoctoral Researcher

Awards

2022 - Top Ten Original Research in Portal Hypertension and Liver Cirrhosis in China
2022 - Discover Glo Explorer Young Scientist Award by Chinese Society for Cell Biology
2022 - First Prize in the Fourth Scientific Image Competition at ShanghaiTech University
2022 - Second Prize in the Fourth Scientific Image Competition at ShanghaiTech University
2022 - Third Prize in the Fourth Scientific Image Competition at ShanghaiTech University
2017 - Excellent Microscope Image at Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
2016 - Excellent Microscope Image at Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
2013 - Third Prize in Microscopic Photography Competition by Chinese Society for Cell Biology
2013 - Olympus China Microscopic Image Competition

Areas of Focus	Cholesterol Metabolic Disease Pharmacology Non-Alcoholic Fatty Liver Disease Pharmacology
Publications	Discovery of Natural Potent HMG-CoA Reductase Degraders for Lowering Cholesterol, Xiao-Zheng Su, Lin-Fei Zhang, Kun Hu, Yang An, Qiao-Peng Zhang, Jian-Wei Tang, Bing-Chao Yan, Xing-Ren Li, Jie Cai, Xiao-Nian Li, Han-Dong Sun, Shi-You Jiang, Pema-Tenzin Puno, 2024 Discovery of an insulin-induced gene binding compound that ameliorates nonalcoholic steatohepatitis by inhibiting sterol regulatory element-binding protein-mediated lipogenesis, Shi-You Jiang, Xinglin Yang, Zimo Yang, JueWan Li, MengQiang Xu, YuXiu Qu, JingJie Tang, YunFeng Li, Liguo Wang, YiWen Shao, XinYuan Meng, Huili Hu, BaoLiang Song, Yu Rao, Wei Qi, 2022 Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol, Shi-You Jiang, Hui Li, JingJie Tang, Jie Wang, Jie Luo, Bing Liu, JinKai Wang, XiongJie Shi, HaiWei Cui, Jie Tang, Fan Yang, Wei Qi, WenWei Qiu, BaoLiang Song, 2018 Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase, Shi-You Jiang, JingJie Tang, Xiao Xu, Wei Qi, Suqian Wu, Chao Jiang, Jiaxu Hong, Jianjiang Xu, BaoLiang Song, Jie Luo, 2019 Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol, XingZi Li, Shi-You Jiang, GuoQiang Li, QianRu Jiang, JueWan Li, ChenChen Li, YuQin Han, BaoLiang Song, XinRan Ma, Wei Qi, WenWei Qiu, 2022 A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption, YingYu Zhang, ZhenYan Fu, Jian Wei, Wei Qi, Gulinaer Baituola, Jie Luo, YaJie Meng, ShuYuan Guo, Huiyong Yin, Shi-You Jiang, YunFeng Li, HongHua Miao, Yong Liu, Yan Wang, BoLiang Li, YiTong Ma, BaoLiang Song, 2018 A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation, Shi-You Jiang, Jiacheng Du, Qinghua Kong, Chaocui Li, Yan Li, Handong Sun, Jianxin Pu, Bingyu Mao, 2015 Interferon-Lambda3 (IFN-lambda 3) and Its Cognate Receptor Subunits in Tree Shrews (Tupaia belangeri): Genomic Sequence Retrieval, Molecular Identification and Expression Analysis, MingLi Li, WenWen Xu, YueDong Gao, Yan Guo, WenJu Wang, Chao Wang, Shi-You Jiang, Andrew Willden, JingFei Huang, HuaTang Zhang, 2013 Henryin, an ent-kaurane Diterpenoid, Inhibits Wnt Signaling through Interference with beta-Catenin/TCF4 Interaction in Colorectal Cancer Cells, Xingyao Li, Jianxin Pu, Shi-You Jiang, Jia Su, Lingmei Kong, Bingyu Mao, Handong Sun, Yan Li, 2013

Areas of Focus

Cholesterol Metabolic Disease Pharmacology
Non-Alcoholic Fatty Liver Disease Pharmacology

Publications

Discovery of Natural Potent HMG-CoA Reductase Degraders for Lowering Cholesterol, Xiao-Zheng Su, Lin-Fei Zhang, Kun Hu, Yang An, Qiao-Peng Zhang, Jian-Wei Tang, Bing-Chao Yan, Xing-Ren Li, Jie Cai, Xiao-Nian Li, Han-Dong Sun, Shi-You Jiang, Pema-Tenzin Puno, 2024
Discovery of an insulin-induced gene binding compound that ameliorates nonalcoholic steatohepatitis by inhibiting sterol regulatory element-binding protein-mediated lipogenesis, Shi-You Jiang, Xinglin Yang, Zimo Yang, JueWan Li, MengQiang Xu, YuXiu Qu, JingJie Tang, YunFeng Li, Liguo Wang, YiWen Shao, XinYuan Meng, Huili Hu, BaoLiang Song, Yu Rao, Wei Qi, 2022
Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol, Shi-You Jiang, Hui Li, JingJie Tang, Jie Wang, Jie Luo, Bing Liu, JinKai Wang, XiongJie Shi, HaiWei Cui, Jie Tang, Fan Yang, Wei Qi, WenWei Qiu, BaoLiang Song, 2018
Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase, Shi-You Jiang, JingJie Tang, Xiao Xu, Wei Qi, Suqian Wu, Chao Jiang, Jiaxu Hong, Jianjiang Xu, BaoLiang Song, Jie Luo, 2019
Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol, XingZi Li, Shi-You Jiang, GuoQiang Li, QianRu Jiang, JueWan Li, ChenChen Li, YuQin Han, BaoLiang Song, XinRan Ma, Wei Qi, WenWei Qiu, 2022
A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption, YingYu Zhang, ZhenYan Fu, Jian Wei, Wei Qi, Gulinaer Baituola, Jie Luo, YaJie Meng, ShuYuan Guo, Huiyong Yin, Shi-You Jiang, YunFeng Li, HongHua Miao, Yong Liu, Yan Wang, BoLiang Li, YiTong Ma, BaoLiang Song, 2018
A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation, Shi-You Jiang, Jiacheng Du, Qinghua Kong, Chaocui Li, Yan Li, Handong Sun, Jianxin Pu, Bingyu Mao, 2015
Interferon-Lambda3 (IFN-lambda 3) and Its Cognate Receptor Subunits in Tree Shrews (Tupaia belangeri): Genomic Sequence Retrieval, Molecular Identification and Expression Analysis, MingLi Li, WenWen Xu, YueDong Gao, Yan Guo, WenJu Wang, Chao Wang, Shi-You Jiang, Andrew Willden, JingFei Huang, HuaTang Zhang, 2013
Henryin, an ent-kaurane Diterpenoid, Inhibits Wnt Signaling through Interference with beta-Catenin/TCF4 Interaction in Colorectal Cancer Cells, Xingyao Li, Jianxin Pu, Shi-You Jiang, Jia Su, Lingmei Kong, Bingyu Mao, Handong Sun, Yan Li, 2013

Cholesterol Metabolism Disease Pharmacology Drug Development Atherosclerosis Cardiovascular Pathology Mechanism Research

Na Yang - Wuhan University

Wu Dongfang - Wuhan University

Jinsong Bian - Southern University of Science and Technology

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