Professor | Hualiang Jiang | Asia Growth Partners

Name	Hualiang Jiang
Contact Information	hljiang@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Hualiang Jiang

Contact Information

hljiang@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1992-09--1995-07 PhD in Medicinal Chemistry: Shanghai Institute of Materia Medica, Chinese Academy of Sciences 1989-09--1992-07 MSc in Physical Chemistry: East China Normal University 1983-09--1987-07 BSc in Organic Chemistry: Nanjing University
Work Experience	2014-02~2019-02 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Director, Researcher, Doctoral Supervisor 2004-12~2014-02 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Doctoral Supervisor, Deputy Director 2001-08~2002-02 - Hong Kong University of Science and Technology - Visiting Scholar, Department of Biochemistry 1999-07~1999-12 - Weizmann Institute of Science, Israel - Visiting Professor 1997-09~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Group Leader, Doctoral Supervisor 1997-02~1997-07 - Hong Kong University of Science and Technology - Visiting Scholar, Department of Chemistry 1995-07~1997-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher 1987-07~1989-09 - Changzhou Chemical Research Institute, Jiangsu Province - Assistant Researcher
Awards	National Advanced Individual in Fighting COVID-19 (2020): National Level Excellent Supervisor Award (2018): Institute Level National Class 1.1 New Drug HCl Androxane (2017): Second Prize, National Level Shanghai Graduate Excellent Achievement (Thesis) Supervisor Award (2016): City Level Shanghai Science and Technology Award (2015): First Prize, Ministry Level BHPB Supervisor Research Award (2014): Institute Level WuXi AppTec Life Chemistry Award (2010): First Prize, Other National Excellent Doctoral Dissertation Supervisor (2010): National Level Shanghai Natural Science Peony Award (2009): Ministry Level Procter & Gamble Excellent Supervisor Award (2009): Ministry Level National Excellent Doctoral Dissertation Supervisor Award (2009): National Level CAS Zhu Li Yuehua Excellent Teacher Award (2008): Ministry Level National Natural Science Second Prize (2007): Second Prize, National Level CAS Excellent Graduate Supervisor Award (2007): Ministry Level Ho Leung Ho Lee Foundation Science and Technology Award (2007): Other National Excellent Doctoral Dissertation Supervisor Award (2006): National Level Shanghai Science and Technology Progress Award (2003): Second Prize, Ministry Level 8th Shanghai Science and Technology Elite (2003): Ministry Level Shanghai Science and Technology Progress Award (2003): First Prize, Ministry Level 5th China Youth Science Award (2002): Ministry Level Shanghai New Long March Pioneer (1999): Provincial Level Shanghai Science and Technology Progress Award (1999): Third Prize, Ministry Level CAS Natural Science Award (1997): Second Prize, Ministry Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1992-09--1995-07 PhD in Medicinal Chemistry: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1989-09--1992-07 MSc in Physical Chemistry: East China Normal University
1983-09--1987-07 BSc in Organic Chemistry: Nanjing University

Work Experience

2014-02~2019-02 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Director, Researcher, Doctoral Supervisor
2004-12~2014-02 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Doctoral Supervisor, Deputy Director
2001-08~2002-02 - Hong Kong University of Science and Technology - Visiting Scholar, Department of Biochemistry
1999-07~1999-12 - Weizmann Institute of Science, Israel - Visiting Professor
1997-09~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Group Leader, Doctoral Supervisor
1997-02~1997-07 - Hong Kong University of Science and Technology - Visiting Scholar, Department of Chemistry
1995-07~1997-09 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher
1987-07~1989-09 - Changzhou Chemical Research Institute, Jiangsu Province - Assistant Researcher

Awards

National Advanced Individual in Fighting COVID-19 (2020): National Level
Excellent Supervisor Award (2018): Institute Level
National Class 1.1 New Drug HCl Androxane (2017): Second Prize, National Level
Shanghai Graduate Excellent Achievement (Thesis) Supervisor Award (2016): City Level
Shanghai Science and Technology Award (2015): First Prize, Ministry Level
BHPB Supervisor Research Award (2014): Institute Level
WuXi AppTec Life Chemistry Award (2010): First Prize, Other
National Excellent Doctoral Dissertation Supervisor (2010): National Level
Shanghai Natural Science Peony Award (2009): Ministry Level
Procter & Gamble Excellent Supervisor Award (2009): Ministry Level
National Excellent Doctoral Dissertation Supervisor Award (2009): National Level
CAS Zhu Li Yuehua Excellent Teacher Award (2008): Ministry Level
National Natural Science Second Prize (2007): Second Prize, National Level
CAS Excellent Graduate Supervisor Award (2007): Ministry Level
Ho Leung Ho Lee Foundation Science and Technology Award (2007): Other
National Excellent Doctoral Dissertation Supervisor Award (2006): National Level
Shanghai Science and Technology Progress Award (2003): Second Prize, Ministry Level
8th Shanghai Science and Technology Elite (2003): Ministry Level
Shanghai Science and Technology Progress Award (2003): First Prize, Ministry Level
5th China Youth Science Award (2002): Ministry Level
Shanghai New Long March Pioneer (1999): Provincial Level
Shanghai Science and Technology Progress Award (1999): Third Prize, Ministry Level
CAS Natural Science Award (1997): Second Prize, Ministry Level

Areas of Focus	Drug Design Computational Biology Molecular Design
Publications	High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases, 13th Author, 2022 Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial, 18th Author, 2022 Structural basis of leukotriene B4 receptor 1 activation, 4th Author, 2022 A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors, 0th Author, 2022 Graph neural network approaches for drug-target interactions, 7th Author, 2022 An inductive graph neural network model for compound-protein interaction prediction based on a homogeneous graph, 7th Author, 2022 Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody, 22nd Author, 2022 Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2, 13th Author, 2022 Computational characterization of transducer recognition of β2 adrenergic receptor, 3rd Author, 2022 Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations, 9th Author, 2022 Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors, 15th Author, 2022 Why is the SARS-CoV-2 Omicron variant milder?, 7th Author, 2022 Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119, 10th Author, 2022 Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain, 11th Author, 2022 Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1), 12th Author, 2022 Blood-brain barrier penetration prediction enhanced by uncertainty estimation, 10th Author, 2022 Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model, 8th Author, 2022 BCL-2 inhibitor synergizes with PI3Kδ inhibitor and overcomes FLT3 inhibitor resistance in acute myeloid leukaemia, 8th Author, 2022 Drug target inference by mining transcriptional data using a novel graph convolutional network framework, 11th Author, 2022 Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer, 9th Author, 2022 Discovery of ARF1-targeting inhibitor demethylzeylasteral as a potential agent against breast cancer, 11th Author, 2022 Optimizing chemical reaction conditions using deep learning: a case study for the Suzuki-Miyaura cross-coupling reaction, 11th Author, 2020 Structural basis for activation of the growth hormone-releasing hormone receptor, 17th

Areas of Focus

Drug Design
Computational Biology
Molecular Design

Publications

High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases, 13th Author, 2022
Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial, 18th Author, 2022
Structural basis of leukotriene B4 receptor 1 activation, 4th Author, 2022
A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors, 0th Author, 2022
Graph neural network approaches for drug-target interactions, 7th Author, 2022
An inductive graph neural network model for compound-protein interaction prediction based on a homogeneous graph, 7th Author, 2022
Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody, 22nd Author, 2022
Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2, 13th Author, 2022
Computational characterization of transducer recognition of β2 adrenergic receptor, 3rd Author, 2022
Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations, 9th Author, 2022
Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors, 15th Author, 2022
Why is the SARS-CoV-2 Omicron variant milder?, 7th Author, 2022
Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119, 10th Author, 2022
Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain, 11th Author, 2022
Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1), 12th Author, 2022
Blood-brain barrier penetration prediction enhanced by uncertainty estimation, 10th Author, 2022
Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model, 8th Author, 2022
BCL-2 inhibitor synergizes with PI3Kδ inhibitor and overcomes FLT3 inhibitor resistance in acute myeloid leukaemia, 8th Author, 2022
Drug target inference by mining transcriptional data using a novel graph convolutional network framework, 11th Author, 2022
Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer, 9th Author, 2022
Discovery of ARF1-targeting inhibitor demethylzeylasteral as a potential agent against breast cancer, 11th Author, 2022
Optimizing chemical reaction conditions using deep learning: a case study for the Suzuki-Miyaura cross-coupling reaction, 11th Author, 2020
Structural basis for activation of the growth hormone-releasing hormone receptor, 17th

Drug Design Computational Biology Molecular Design Pharmacology Medicinal Chemistry Bioinformatics Structural Biology Chemical Biology Therapeutics Biochemistry

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