Professor | Dongxiang Liu | Asia Growth Partners

Name	Dongxiang Liu
Contact Information	liudongxiang@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Dongxiang Liu

Contact Information

liudongxiang@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1995-09--1998-07 Ph.D.: Shanghai Institute of Materia Medica, Chinese Academy of Sciences 1992-09--1995-08 Master's: Tongji University, Shanghai 1987-09--1992-08 Bachelor's: Tongji University, Shanghai
Work Experience	2005-06~2011-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Professor 2004-06~2005-05 - The Burnham Institute, California, U.S.A. - Research Assistant Professor 2002-01~2004-05 - University of Illinois at Urbana-Champaign - Research Scientist 1998-08~2001-12 - Thomas Jefferson University, Philadelphia, U.S.A - Postdoctor

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1995-09--1998-07 Ph.D.: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1992-09--1995-08 Master's: Tongji University, Shanghai
1987-09--1992-08 Bachelor's: Tongji University, Shanghai

Work Experience

2005-06~2011-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Professor
2004-06~2005-05 - The Burnham Institute, California, U.S.A. - Research Assistant Professor
2002-01~2004-05 - University of Illinois at Urbana-Champaign - Research Scientist
1998-08~2001-12 - Thomas Jefferson University, Philadelphia, U.S.A - Postdoctor

Areas of Focus	Protein Chemistry Drug Design Cancer Neurodegenerative Diseases Diabetes
Publications	LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter, Dongxiang Liu, 2023 A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate, Dongxiang Liu, 2022 Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors, Dongxiang Liu, 2021 Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1 H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5, Dongxiang Liu, 2020 Structural basis for the interaction of diapause hormone with its receptor in the silkworm, Bombyx mori, Dongxiang Liu, 2018 Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase, Dongxiang Liu, 2016 Crystal Structures of SIRT3 Revealed that the a2-a3 Loop and a3-Helix Affect the Interaction of Long-Chain Acyl Lysine, Dongxiang Liu, 2016 Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol, Dongxiang Liu, 2015 Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-1,2,4triazolo3,4-b1,3,4thiadiazole, Dongxiang Liu, 2014 Integration and Oligomerization of Bax Protein in Lipid Bilayers Characterized by Single Molecule Fluorescence Study, Dongxiang Liu, 2014 Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: Binding mode, inhibitory mechanism and biological action, Dongxiang Liu, 2013 Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate, Dongxiang Liu, 2013 Computational screening for active compounds targeting protein sequences: methodology and experimental validation., Dongxiang Liu, 2011 Dual role of Zn 2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1, Dongxiang Liu, 2010 Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as beta-Amyloid Peptide Aggregation Inhibitors, Dongxiang Liu, 2010 An enzyme-linked immunosorbent assay to compare the affinity of chemical compounds for beta-amyloid peptide as a monomer, Dongxiang Liu, 2010 A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide, Dongxiang Liu, 2009 A conserved hydrophobic core at Bcl-x(L) mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein, Dongxiang Liu, 2009 Structure assembly of Bcl-xL through a5-a5 and b6-b6 interhelix interactions in lipid membranes, Dongxiang Liu, 2009 Bcl-x(L) forms two distinct homodimers at non-ionic detergents: Implications in the dimerization of Bcl-2 family proteins, Dongxiang Liu, 2008 A new assay based on fluorescence resonance energy transfer to determine the binding affinity of BCl-x(L) inhibitors, Dongxiang Liu, 2008

Areas of Focus

Protein Chemistry
Drug Design
Cancer
Neurodegenerative Diseases
Diabetes

Publications

LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter, Dongxiang Liu, 2023
A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate, Dongxiang Liu, 2022
Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors, Dongxiang Liu, 2021
Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1 H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5, Dongxiang Liu, 2020
Structural basis for the interaction of diapause hormone with its receptor in the silkworm, Bombyx mori, Dongxiang Liu, 2018
Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase, Dongxiang Liu, 2016
Crystal Structures of SIRT3 Revealed that the a2-a3 Loop and a3-Helix Affect the Interaction of Long-Chain Acyl Lysine, Dongxiang Liu, 2016
Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol, Dongxiang Liu, 2015
Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-1,2,4triazolo3,4-b1,3,4thiadiazole, Dongxiang Liu, 2014
Integration and Oligomerization of Bax Protein in Lipid Bilayers Characterized by Single Molecule Fluorescence Study, Dongxiang Liu, 2014
Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: Binding mode, inhibitory mechanism and biological action, Dongxiang Liu, 2013
Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate, Dongxiang Liu, 2013
Computational screening for active compounds targeting protein sequences: methodology and experimental validation., Dongxiang Liu, 2011
Dual role of Zn 2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1, Dongxiang Liu, 2010
Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as beta-Amyloid Peptide Aggregation Inhibitors, Dongxiang Liu, 2010
An enzyme-linked immunosorbent assay to compare the affinity of chemical compounds for beta-amyloid peptide as a monomer, Dongxiang Liu, 2010
A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide, Dongxiang Liu, 2009
A conserved hydrophobic core at Bcl-x(L) mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein, Dongxiang Liu, 2009
Structure assembly of Bcl-xL through a5-a5 and b6-b6 interhelix interactions in lipid membranes, Dongxiang Liu, 2009
Bcl-x(L) forms two distinct homodimers at non-ionic detergents: Implications in the dimerization of Bcl-2 family proteins, Dongxiang Liu, 2008
A new assay based on fluorescence resonance energy transfer to determine the binding affinity of BCl-x(L) inhibitors, Dongxiang Liu, 2008

Protein Chemistry Drug Design Cancer Neurodegenerative Diseases Diabetes Molecular Inhibitors Sirt1 Bcl-Xl Bax Tbid

Hao Chen - Southern University of Science and Technology

Rui Chen - Wuhan University

Zhang Zhijiang - Wuhan University

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