Areas of Focus
- Protein Chemistry
- Drug Design
- Cancer
- Neurodegenerative Diseases
- Diabetes
Work Experience
- 2005-06~2011-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Professor
- 2004-06~2005-05 - The Burnham Institute, California, U.S.A. - Research Assistant Professor
- 2002-01~2004-05 - University of Illinois at Urbana-Champaign - Research Scientist
- 1998-08~2001-12 - Thomas Jefferson University, Philadelphia, U.S.A - Postdoctor
Academic Background & Achievements
- 1995-09--1998-07 Ph.D.: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 1992-09--1995-08 Master's: Tongji University, Shanghai
- 1987-09--1992-08 Bachelor's: Tongji University, Shanghai
Publications
- LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter, Dongxiang Liu, 2023
- A Novel Mechanism for SIRT1 Activators That Does Not Rely on the Chemical Moiety Immediately C-Terminal to the Acetyl-Lysine of the Substrate, Dongxiang Liu, 2022
- Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors, Dongxiang Liu, 2021
- Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1 H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5, Dongxiang Liu, 2020
- Structural basis for the interaction of diapause hormone with its receptor in the silkworm, Bombyx mori, Dongxiang Liu, 2018
- Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase, Dongxiang Liu, 2016
- Crystal Structures of SIRT3 Revealed that the a2-a3 Loop and a3-Helix Affect the Interaction of Long-Chain Acyl Lysine, Dongxiang Liu, 2016
- Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol, Dongxiang Liu, 2015
- Structure-activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-1,2,4triazolo3,4-b1,3,4thiadiazole, Dongxiang Liu, 2014
- Integration and Oligomerization of Bax Protein in Lipid Bilayers Characterized by Single Molecule Fluorescence Study, Dongxiang Liu, 2014
- Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: Binding mode, inhibitory mechanism and biological action, Dongxiang Liu, 2013
- Discovery and Mechanism Study of SIRT1 Activators that Promote the Deacetylation of Fluorophore-Labeled Substrate, Dongxiang Liu, 2013
- Computational screening for active compounds targeting protein sequences: methodology and experimental validation., Dongxiang Liu, 2011
- Dual role of Zn 2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1, Dongxiang Liu, 2010
- Structural Optimization and Biological Evaluation of Substituted Bisphenol A Derivatives as beta-Amyloid Peptide Aggregation Inhibitors, Dongxiang Liu, 2010
- An enzyme-linked immunosorbent assay to compare the affinity of chemical compounds for beta-amyloid peptide as a monomer, Dongxiang Liu, 2010
- A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide, Dongxiang Liu, 2009
- A conserved hydrophobic core at Bcl-x(L) mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein, Dongxiang Liu, 2009
- Structure assembly of Bcl-xL through a5-a5 and b6-b6 interhelix interactions in lipid membranes, Dongxiang Liu, 2009
- Bcl-x(L) forms two distinct homodimers at non-ionic detergents: Implications in the dimerization of Bcl-2 family proteins, Dongxiang Liu, 2008
- A new assay based on fluorescence resonance energy transfer to determine the binding affinity of BCl-x(L) inhibitors, Dongxiang Liu, 2008
