2000-04--2001-09 Postdoctoral Research: National Institute of Agrobiological Resources, Japan
1994-10--2000-03 PhD: Tottori University, Japan
1988-09--1992-06 Bachelor's Degree: Shandong Institute of Building Materials Industry
2006-11~Present - Institute of Microbiology, Chinese Academy of Sciences - Researcher
2001-11~2006-10 - Faculty of Science, Hokkaido University, Japan - Special Researcher
2000-04~2001-09 - National Institute of Agrobiological Resources, Japan - Postdoctoral Research
1992-08~1994-08 - Inner Mongolia Building Materials Bureau - Technician
Chinese Preventive Medicine Association Science and Technology Award (2017): First Prize, National Level, 2016
Research
Pathogen Infection Mechanism Research Anti-Infective Drug Development
Glycan-Modified Peptides for Dual Inhibition of Human Immunodeficiency Virus Entry into Dendritic Cells and T Cells., Journal of Medicinal Chemistry, 2024
Improving Anti-HIV activity and pharmacokinetics of enfuvirtide (T20) by modification with oligomannose., European Journal of Medicinal Chemistry, 2024
Design, synthesis, and biological evaluation of covalent inhibitors targeting influenza virus hemagglutinin., Journal of Chinese Pharmaceutical Sciences, 2024
When the approaching threat is uncertain: Dynamics of defensive motivation and attention in trait anxiety, PSYCHOPHYSIOLOGY, 2022
Structure-based design of 5 '-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors, RSC ADVANCES, 2021
Zanamivir-Cholesterol Conjugate: A Long-Acting Neuraminidase Inhibitor with Potent Efficacy against Drug-Resistant Influenza Viruses, Journal of Medicinal Chemistry, 2021
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease, NATURE COMMUNICATIONS, 2020
Polyethylene Glycol 40-Modified Peptide with High Therapeutic Efficacy in Simian-Human Immunodeficiency Virus-Acutely Infected Rhesus Monkeys, JOURNAL OF VIROLOGY, 2020
Chemical modification and fluorescence labeling of Escherichia coli cell wall peptidoglycan, 微生物学报, 2020
Construction of glycan-functionalized nanoparticles and its application in the detection of sialic acid-binding protein, 中国农业大学学报, 2019
Long-Acting HIV-1 Fusion Inhibitory Peptides and their Mechanisms of Action, VIRUSES-BASEL, 2019
Detection of glycan-binding proteins using glycan-functionalized quantum dots and gold nanoparticles, JOURNAL OF CARBOHYDRATE CHEMISTRY, 2018
Detection and differentiation of influenza viruses with glycan-functionalized gold nanoparticles, BIOSENSORS AND BIOELECTRONICS, 2017
CASCIRE Surveillance Network and Work on Avian Influenza Viruses, SCIENCE CHINA-LIFE SCIENCES, 2017
Synthesis and biological evaluation of neoglycosphingolipids, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017
Synthesis of Sialic Acids, Their Derivatives, and Analogs by Using a Whole-Cell Catalyst, CHEMISTRY-A EUROPEAN JOURNAL, 2017
Enfuvirtide-PEG conjugate: A potent HIV fusion inhibitor with improved pharmacokinetic properties, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016
Resistance to Mutant Group 2 Influenza Virus Neuraminidases of an Oseltamivir-Zanamivir Hybrid Inhibitor, JOURNAL OF VIROLOGY, 2016
Structure-based tetravalent zanamivir with potent inhibitory activity against drug-resistant influenza viruses, JOURNAL OF MEDICINAL CHEMISTRY, 2016
Glycosylated Enfuvirtide: A Long-Lasting Glycopeptide with Potent Anti-HIV Activity, JOURNAL OF MEDICINAL CHEMISTRY, 2015
Biosynthesis of the Carbamoylated D-Gulosamine Moiety of Streptothricins: Involvement of a Guanidino-N-glycosyltransferase and an N-Acetyl-D-gulosamine Deacetylase, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015
Inhibition of influenza virus infection with chitosan-sialyloligosaccharides ionic complex, CARBOHYDRATE POLYMERS, 2014
Analysis of Influenza Virus Receptor Specificity Using Glycan-Functionalized Gold Nanoparticles, ACS NANO, 2014
Glycopeptide Synthesis on an Ionic Liquid Support, ORGANIC LETTERS, 2014
Glycosynthase with Broad Substrate Specificity - an Efficient Biocatalyst for the Construction of Oligosaccharide Library, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2013
A Highly Sensitive, Dual-Readout Assay Based on Gold Nanoparticles for Organophosphorus and Carbamate Pesticides, ANALYTICAL CHEMISTRY, 2012
Synthesis and Assessment of Globotriose-Chitosan Conjugate, a Novel Inhibitor of Shiga Toxins Produced by Escherichia coli, JOURNAL OF MEDICINAL CHEMISTRY, 2012
Carbohydrate-Functionalized Chitosan Fiber for Influenza Virus Capture, BIOMACROMOLECULES, 2011
Design and synthesis of novel cell wall inhibitors of Mycobacterium tuberculosis GlmM and GlmU, CARBOHYDRATE RESEARCH, 2011
Preparation of glyco-quantum dots for microbial detection, 中国农业大学学报, 2011
Chemoenzymatic syntheses of sialyl Lewis X-chitosan conjugate as potential anti-inflammatory agent, CARBOHYDRATE POLYMERS, 2011
Synthesis of galabiose-chitosan conjugate as potent inhibitor of streptococcus suis adhesion, BIOMACROMOLECULES, 2010
The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2010
Preparation of sialyloligosaccharide-chitosan polymer and its adsorption to avian influenza virus, 中国兽医科学, 2008
Glycosidation promoted by a reusable solid superacid in supercritical carbon dioxide, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006
