Areas of Focus
- 病原感染机制研究
- 抗感染药物研发
Work Experience
- 2006-11~现在 - 中国科学院微生物研究所 - 研究员
- 2001-11~2006-10 - 日本北海道大学理学部 - 特聘研究员
- 2000-04~2001-09 - 日本农林水产省农业生物资源研究所 - 博士后研究
- 1992-08~1994-08 - 内蒙古建材局 - 技术员
Academic Background & Achievements
- 2000-04--2001-09 博士后研究: 日本农林水产省农业生物资源研究所
- 1994-10--2000-03 博士学位: 日本鸟取大学
- 1988-09--1992-06 学士: 山东建筑材料工业学院
Publications
- Glycan-Modified Peptides for Dual Inhibition of Human Immunodeficiency Virus Entry into Dendritic Cells and T Cells., Journal of Medicinal Chemistry, 2024
- Improving Anti-HIV activity and pharmacokinetics of enfuvirtide (T20) by modification with oligomannose., European Journal of Medicinal Chemistry, 2024
- Design, synthesis, and biological evaluation of covalent inhibitors targeting influenza virus hemagglutinin., Journal of Chinese Pharmaceutical Sciences, 2024
- When the approaching threat is uncertain: Dynamics of defensive motivation and attention in trait anxiety, PSYCHOPHYSIOLOGY, 2022
- Structure-based design of 5 '-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors, RSC ADVANCES, 2021
- Zanamivir-Cholesterol Conjugate: A Long-Acting Neuraminidase Inhibitor with Potent Efficacy against Drug-Resistant Influenza Viruses, Journal of Medicinal Chemistry, 2021
- Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease, NATURE COMMUNICATIONS, 2020
- Polyethylene Glycol 40-Modified Peptide with High Therapeutic Efficacy in Simian-Human Immunodeficiency Virus-Acutely Infected Rhesus Monkeys, JOURNAL OF VIROLOGY, 2020
- Chemical modification and fluorescence labeling of Escherichia coli cell wall peptidoglycan, 微生物学报, 2020
- Construction of glycan-functionalized nanoparticles and its application in the detection of sialic acid-binding protein, 中国农业大学学报, 2019
- Long-Acting HIV-1 Fusion Inhibitory Peptides and their Mechanisms of Action, VIRUSES-BASEL, 2019
- Glycoconjugate synthesis using chemoselective ligation. Org. Biomol. Chem., Organic & Biomolecular Chemistry, 0201
Awards
- 中华预防医学会科学技术奖 (2017): 一等奖, 国家级, 2016
