2010-09--2015-06 Ph.D. in Science: China Pharmaceutical University
2006-09--2010-06 Bachelor's in Science: China Pharmaceutical University
2022-11~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
2017-11~2022-10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher
2017-08~2017-10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher
2015-07~2017-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Researcher
2010-09~2015-06 - China Pharmaceutical University - Ph.D. in Science
2006-09~2010-06 - China Pharmaceutical University - Bachelor's in Science
Sanofi-Youth Talent Award of Shanghai Institute of Life Sciences, Chinese Academy of Sciences (2020): Other
Shanghai Science and Technology Progress Award (2020): First Prize, Provincial Level
Shanghai Pharmaceutical Association Pharmaceutical Science and Technology Award (2019): First Prize, Provincial Level
Innovation Talent Promotion Plan Key Field Innovation Team (2018): Ministerial Level
Research
Antitumor Drugs
Discovery, Optimization, and Evaluation of Novel Pyridin-2(1H)-one Analogues as Potent TRK Inhibitors for Cancer Treatment, Journal of Medicinal Chemistry, 2024
Late-Stage Functionalization for the Divergent Synthesis of Podophyllotoxin Derivatives by Rhodium Catalysis, Chemistry - A European Journal, 2023
Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors, Journal of Medicinal Chemistry, 2023
Research Progress of Discoid Domain Receptor 1(DDR1) Inhibitors, 有机化学, 2022
Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors, Journal of Medicinal Chemistry, 2022
Discovery of Pyrazolo3,4-dpyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation, Journal of Medicinal Chemistry, 2022
Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma, Journal of Medicinal Chemistry, 2021
Design, synthesis and biological evaluation of pyrazolo3,4-dpyridazinone derivatives as covalent FGFR inhibitors, ACTA PHARMACEUTICA SINICA B, 2021
Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors, ACS MEDICINAL CHEMISTRY LETTERS, 2021
Cp*Rh(III)-Catalyzed C-H 3,3-Difluoroallylation of Indoles and N-Iodosuccinimide-Mediated Cyclization for the Synthesis of Fluorinated 3,4-Dihydropyrimido-1,6-a-indol-1(2H)-one Derivatives, 有机化学, 2020
Supramolecular Drug-Drug Complex Vesicles Enable Sequential Drug Release for Enhanced Combination Therapy, ACS APPLIED MATERIALS & INTERFACES, 2020
Sulfoximines-Assisted Rh(III)-Catalyzed C-H Activation and Intramolecular Annulation for the Synthesis of Fused Isochromeno-1,2-Benzothiazines Scaffolds under Room Temperature, MOLECULES, 2020
Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1 H -Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5, MOLECULES, 2020
Ruthenium-Catalyzed C-H Activations for the Synthesis of Indole Derivatives, CATALYSTS, 2020
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease, SCIENCE, 2020
Rhodium(III)-Catalyzed C-H Alkenylation: Access to Maleimide-Decorated Tryptophan and Tryptophan-Containing Peptides, ORGANIC LETTERS, 2020
Discovery and Development of a Series of Pyrazolo3,4-dpyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design, Journal of Medicinal Chemistry, 2019
Rh(III)-Catalyzed Annulation of Boc-Protected Benzamides with Diazo Compounds: Approach to Isocoumarins, MOLECULES, 2019
Rh(III)-Catalyzed Hydroarylation of Alkyne MIDA Boronates via C-H Activation of Indole Derivatives, Journal of Organic Chemistry, 2019
A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo, ACTA PHARMACOLOGICA SINICA, 2019
Cp*Rh(III)-Catalyzed C-H Bond Difluorovinylation of Indoles with alpha,alpha-Difluorovinyl Tosylate, Journal of Organic Chemistry, 2019
Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies, Journal of Medicinal Chemistry, 2019
Rapid access to difluoroalkylated pyrrolobenzodiazepines via a Pd-catalyzed C-H difluoroalkylation/cyclization cascade reaction, ORGANIC CHEMISTRY FRONTIERS, 2019
Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer, Journal of Medicinal Chemistry, 2017
Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position, ADVANCED SYNTHESIS & CATALYSIS, 2017
Pd(II)-catalyzed direct functionalization of C-H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes, ORGANIC CHEMISTRY FRONTIERS, 2016
Palladium-Catalyzed C2-Acylation of Indoles with alpha-Diketones Assisted by the Removable N-(2-Pyrimidyl) Group, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2015
Design, Synthesis, and Biological Evaluation of NovelImidazo1,2- a pyridine Derivatives as Potentc-Met Inhibitors, ACS MEDICINAL CHEMISTRY LETTERS, 2015
A simple copper-catalyzed two-step one-pot synthesis of indolo1,2- a quinazoline, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2014
An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K-4Fe(CN)(6), CHEMICAL COMMUNICATIONS, 2012
