Areas of Focus
- Antitumor Drugs
Work Experience
- 2022-11~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
- 2017-11~2022-10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher
- 2017-08~2017-10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher
- 2015-07~2017-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Researcher
- 2010-09~2015-06 - China Pharmaceutical University - Ph.D. in Science
- 2006-09~2010-06 - China Pharmaceutical University - Bachelor's in Science
Academic Background & Achievements
- 2010-09--2015-06 Ph.D. in Science: China Pharmaceutical University
- 2006-09--2010-06 Bachelor's in Science: China Pharmaceutical University
Publications
- Discovery, Optimization, and Evaluation of Novel Pyridin-2(1H)-one Analogues as Potent TRK Inhibitors for Cancer Treatment, Journal of Medicinal Chemistry, 2024
- Late-Stage Functionalization for the Divergent Synthesis of Podophyllotoxin Derivatives by Rhodium Catalysis, Chemistry - A European Journal, 2023
- Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors, Journal of Medicinal Chemistry, 2023
- Research Progress of Discoid Domain Receptor 1(DDR1) Inhibitors, 有机化学, 2022
- Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors, Journal of Medicinal Chemistry, 2022
- Discovery of Pyrazolo3,4-dpyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation, Journal of Medicinal Chemistry, 2022
- Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma, Journal of Medicinal Chemistry, 2021
- Design, synthesis and biological evaluation of pyrazolo3,4-dpyridazinone derivatives as covalent FGFR inhibitors, ACTA PHARMACEUTICA SINICA B, 2021
- Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors, ACS MEDICINAL CHEMISTRY LETTERS, 2021
- Cp*Rh(III)-Catalyzed C-H 3,3-Difluoroallylation of Indoles and N-Iodosuccinimide-Mediated Cyclization for the Synthesis of Fluorinated 3,4-Dihydropyrimido-1,6-a-indol-1(2H)-one Derivatives, 有机化学, 2020
- Supramolecular Drug-Drug Complex Vesicles Enable Sequential Drug Release for Enhanced Combination Therapy, ACS APPLIED MATERIALS & INTERFACES, 2020
- Sulfoximines-Assisted Rh(III)-Catalyzed C-H Activation and Intramolecular Annulation for the Synthesis of Fused Isochromeno-1,2-Benzothiazines Scaffolds under Room Temperature, MOLECULES, 2020
- Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1 H -Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5, MOLECULES, 2020
- Ruthenium-Catalyzed C-H Activations for the Synthesis of Indole Derivatives, CATALYSTS, 2020
- Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease, SCIENCE, 2020
- Rhodium(III)-Catalyzed C-H Alkenylation: Access to Maleimide-Decorated Tryptophan and Tryptophan-Containing Peptides, ORGANIC LETTERS, 2020
- Discovery and Development of a Series of Pyrazolo3,4-dpyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design, Journal of Medicinal Chemistry, 2019
- Rh(III)-Catalyzed Annulation of Boc-Protected Benzamides with Diazo Compounds: Approach to Isocoumarins, MOLECULES, 2019
- Rh(III)-Catalyzed Hydroarylation of Alkyne MIDA Boronates via C-H Activation of Indole Derivatives, Journal of Organic Chemistry, 2019
- A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo, ACTA PHARMACOLOGICA SINICA, 2019
- Cp*Rh(III)-Catalyzed C-H Bond Difluorovinylation of Indoles with alpha,alpha-Difluorovinyl Tosylate, Journal of Organic Chemistry, 2019
- Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies, Journal of Medicinal Chemistry, 2019
- Rapid access to difluoroalkylated pyrrolobenzodiazepines via a Pd-catalyzed C-H difluoroalkylation/cyclization cascade reaction, ORGANIC CHEMISTRY FRONTIERS, 2019
- Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer, Journal of Medicinal Chemistry, 2017
- Cp*Rh(III)-Catalyzed Directed C-H Methylation and Arylation of Quinoline N-Oxides at the C-8 Position, ADVANCED SYNTHESIS & CATALYSIS, 2017
- Pd(II)-catalyzed direct functionalization of C-H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes, ORGANIC CHEMISTRY FRONTIERS, 2016
- Palladium-Catalyzed C2-Acylation of Indoles with alpha-Diketones Assisted by the Removable N-(2-Pyrimidyl) Group, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2015
- Design, Synthesis, and Biological Evaluation of NovelImidazo1,2- a pyridine Derivatives as Potentc-Met Inhibitors, ACS MEDICINAL CHEMISTRY LETTERS, 2015
- A simple copper-catalyzed two-step one-pot synthesis of indolo1,2- a quinazoline, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2014
- An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K-4Fe(CN)(6), CHEMICAL COMMUNICATIONS, 2012
Awards
- Sanofi-Youth Talent Award of Shanghai Institute of Life Sciences, Chinese Academy of Sciences (2020): Other
- Shanghai Science and Technology Progress Award (2020): First Prize, Provincial Level
- Shanghai Pharmaceutical Association Pharmaceutical Science and Technology Award (2019): First Prize, Provincial Level
- Innovation Talent Promotion Plan Key Field Innovation Team (2018): Ministerial Level
