Areas of Focus
- 抗肿瘤药物
Work Experience
- 2022-11~现在 - 中国科学院上海药物研究所 - 研究员
- 2017-11~2022-10 - 中国科学院上海药物研究所 - 副研究员
- 2017-08~2017-10 - 中国科学院上海药物研究所 - 助理研究员
- 2015-07~2017-07 - 中国科学院上海药物研究所 - 博士后
- 2010-09~2015-06 - 中国药科大学 - 理学博士
- 2006-09~2010-06 - 中国药科大学 - 理学学士
Academic Background & Achievements
- 2010-09--2015-06 理学博士: 中国药科大学
- 2006-09--2010-06 理学学士: 中国药科大学
Publications
- Discovery, Optimization, and Evaluation of Novel Pyridin-2(1H)-one Analogues as Potent TRK Inhibitors for Cancer Treatment, Journal of Medicinal Chemistry, 2024
- Late-Stage Functionalization for the Divergent Synthesis of Podophyllotoxin Derivatives by Rhodium Catalysis, Chemistry - A European Journal, 2023
- Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors, Journal of Medicinal Chemistry, 2023
- 盘状结构域受体1（DDR1）激酶抑制剂的研究进展, 有机化学, 2022
- Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors, Journal of Medicinal Chemistry, 2022
- Discovery of Pyrazolo3,4-dpyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation, Journal of Medicinal Chemistry, 2022
- Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma, Journal of Medicinal Chemistry, 2021
- Design, synthesis and biological evaluation of pyrazolo3,4-dpyridazinone derivatives as covalent FGFR inhibitors, ACTA PHARMACEUTICA SINICA B, 2021
- Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors, ACS MEDICINAL CHEMISTRY LETTERS, 2021
Awards
- 赛诺菲-中国科学院上海生命科学研究院优秀青年人才奖励基金 (2020): 其他
- 上海市科技进步奖 (2020): 一等奖, 省级
- 上海市药学会药学科技奖 (2019): 一等奖, 省级
- 创新人才推进计划重点领域创新团队 (2018): 部委级
