Professor | Feilong Meng | Asia Growth Partners

Name	Feilong Meng
Contact Information	Feilong.Meng@SIBCB.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Feilong Meng

Contact Information

Feilong.Meng@SIBCB.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2003-09--2007-07 Ph.D.: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences 1999-09--2003-06 Bachelor's: Nankai University
Work Experience	2015/10-Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher, Doctoral Supervisor, Research Group Leader 2009/11-2015/09 - Harvard Medical School/Boston Children's Hospital/Howard Hughes Medical Institute - Postdoctoral Fellow
Awards	2016: National Natural Science Foundation of China Excellent Young Scientists Fund 2016: 12th Batch of Youth **** Program by the Organization Department of the CPC Central Committee 2015: Harvard Medical School Chinese Scholars Life Sciences Research Annual Award 2014-15: Lymphoma Research Foundation Postdoctoral Fellowship 2011-13: American Cancer Society Postdoctoral Fellowship 2009: President's Award of the Chinese Academy of Sciences 2002: Chinese Academy of Sciences Scholarship 2001: Nankai University School of Life Sciences - Dupont Scholarship

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2003-09--2007-07 Ph.D.: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
1999-09--2003-06 Bachelor's: Nankai University

Work Experience

2015/10-Present - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher, Doctoral Supervisor, Research Group Leader
2009/11-2015/09 - Harvard Medical School/Boston Children's Hospital/Howard Hughes Medical Institute - Postdoctoral Fellow

Awards

2016: National Natural Science Foundation of China Excellent Young Scientists Fund
2016: 12th Batch of Youth **** Program by the Organization Department of the CPC Central Committee
2015: Harvard Medical School Chinese Scholars Life Sciences Research Annual Award
2014-15: Lymphoma Research Foundation Postdoctoral Fellowship
2011-13: American Cancer Society Postdoctoral Fellowship
2009: President's Award of the Chinese Academy of Sciences
2002: Chinese Academy of Sciences Scholarship
2001: Nankai University School of Life Sciences - Dupont Scholarship

Areas of Focus	Mechanisms of immune system diversification and tumor suppression Role of super-enhancers, convergent transcription, and long non-coding RNA in DNA deamination and immune system diversification
Publications	The Mechanism of Class Switch Recombination, Meng FL, Alt FW, Tian M, 2014 Mechanisms of programmed DNA lesions and genomic instability in the immune system, Alt FW, Zhang Y, Meng FL, Guo C, Schwer B, 2013 Convergent Transcription At Intragenic Super-Enhancers Targets AID-initiated Genomic Instability, Meng FL, Du Z, Federation A, Hu J, Wang Q, Kieffer-Kwon KR, Meyers RM, Amor C, Wasserman CR, Neuberg D, Casellas R, Nussenzweig M, Bradner JE#, Liu XS#, Alt FW#, 2014 The RNA Exosome Targets Activation Induced Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates, Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW, 2011 A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1, Ba Z, Meng FL, Gostissa M, Huang PY, Ke Q, Wang Z, Dao MN, Fujiwara Y, Rajewsky K, Zhang B, and Alt FW, 2015 Sua5p is required for telomere recombination in Saccharomyces cerevisiae, Meng FL, Chen XF, Hu Y, Tang HB, Dang W and Zhou JQ, 2010 Sua5p a Single-stranded Telomeric DNA Binding Protein Facilitates Telomere Replication, Meng FL, Hu Y, Shen N, Tong XJ, Wang J, Ding J and Zhou JQ, 2009 Candida albicans, a distinctive fungal model for cellular aging study, Fu XH, Meng FL, Hu Y, Zhou JQ, 2008 AID Recognizes Structured DNA for Class Switch Recombination, Qiao Q, Wang L, Meng FL, Hwang JK, Alt FW and Wu H, 2017 Phosphatidylinositol 3-kinase delta blockade increases genomic instability in B cells, Compagno M, Wang Q, Pighi C, Cheong TC, Meng FL, Poggio T, Yeap LS, Karaca E, Blasco RB, Langellotto F, Ambrogio C, Voena C, Wiestner A, Kasar SN, Brown JR, Sun J, Wu CJ, Gostissa M, Alt FW and Chiarle R, 2017 Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching, Dong J, Panchakshari RA, Zhang T, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho YJ, Du Z, Robbiani DF, Meng F, Gostissa M, Nussenzweig MC, Manis JP, Alt FW, 2015 Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes, Hu J, Zhang Y, Zhao L, Frock RL, Du Z, Meyers RM, Meng FL, Schatz DG, Alt FW, 2015 Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes, Yeap LS, Hwang JK*, Du Z, Meyers RM, Meng FL, Jakubauskaite A, Liu M, Mani V, Neuberg D, Kepler TB, Wang JH and Alt FW, 2015 Telomere Recombination Preferentially Occurs at Short Telomeres in Telomerase-Null Type II Survivors, Fu XH, Duan YM, Liu YT, Cai C, Meng FL, Zhou JQ, 2014 Telomerase-null survivor screening identifies novel telomere recombination regulators, Hu Y, Tang HB, Liu NN, Tong XJ, Dang W, Duan YM, Fu XH, Zhang Y, Peng J, Meng FL, Zhou JQ, 2013 SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation, Zhou BO, Wang SS, Xu LX, Meng FL, Xuan YJ, Duan YM, Wang JY, Hu H, Dong X, Ding J, Zhou JQ, 2010 Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae, Chen, XF, Meng, FL, and Zhou, JQ, 2009 Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo, Yang CP, Chen YB, Meng FL, Zhou JQ, 2006

Areas of Focus

Mechanisms of immune system diversification and tumor suppression
Role of super-enhancers, convergent transcription, and long non-coding RNA in DNA deamination and immune system diversification

Publications

The Mechanism of Class Switch Recombination, Meng FL, Alt FW, Tian M, 2014
Mechanisms of programmed DNA lesions and genomic instability in the immune system, Alt FW, Zhang Y, Meng FL, Guo C, Schwer B, 2013
Convergent Transcription At Intragenic Super-Enhancers Targets AID-initiated Genomic Instability, Meng FL*, Du Z*, Federation A*, Hu J, Wang Q, Kieffer-Kwon KR, Meyers RM, Amor C, Wasserman CR, Neuberg D, Casellas R, Nussenzweig M, Bradner JE#, Liu XS#, Alt FW#, 2014
The RNA Exosome Targets Activation Induced Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates, Basu U*, Meng FL*, Keim C*, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW, 2011
A Rapid Embryonic Stem Cell–Based Mouse Model for B-cell Lymphomas Driven by Epstein–Barr Virus Protein LMP1, Ba Z*, Meng FL*, Gostissa M*, Huang PY, Ke Q, Wang Z, Dao MN, Fujiwara Y, Rajewsky K, Zhang B, and Alt FW, 2015
Sua5p is required for telomere recombination in Saccharomyces cerevisiae, Meng FL, Chen XF, Hu Y, Tang HB, Dang W and Zhou JQ, 2010
Sua5p a Single-stranded Telomeric DNA Binding Protein Facilitates Telomere Replication, Meng FL, Hu Y, Shen N, Tong XJ, Wang J, Ding J and Zhou JQ, 2009
Candida albicans, a distinctive fungal model for cellular aging study, Fu XH*, Meng FL*, Hu Y, Zhou JQ, 2008
AID Recognizes Structured DNA for Class Switch Recombination, Qiao Q, Wang L, Meng FL, Hwang JK, Alt FW and Wu H, 2017
Phosphatidylinositol 3-kinase delta blockade increases genomic instability in B cells, Compagno M, Wang Q, Pighi C, Cheong TC, Meng FL, Poggio T, Yeap LS, Karaca E, Blasco RB, Langellotto F, Ambrogio C, Voena C, Wiestner A, Kasar SN, Brown JR, Sun J, Wu CJ, Gostissa M, Alt FW and Chiarle R, 2017
Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching, Dong J, Panchakshari RA, Zhang T, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho YJ, Du Z, Robbiani DF, Meng F, Gostissa M, Nussenzweig MC, Manis JP, Alt FW, 2015
Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes, Hu J, Zhang Y, Zhao L, Frock RL, Du Z, Meyers RM, Meng FL, Schatz DG, Alt FW, 2015
Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes, Yeap LS*, Hwang JK*, Du Z, Meyers RM, Meng FL, Jakubauskaite A, Liu M, Mani V, Neuberg D, Kepler TB, Wang JH and Alt FW, 2015
Telomere Recombination Preferentially Occurs at Short Telomeres in Telomerase-Null Type II Survivors, Fu XH, Duan YM, Liu YT, Cai C, Meng FL, Zhou JQ, 2014
Telomerase-null survivor screening identifies novel telomere recombination regulators, Hu Y, Tang HB, Liu NN, Tong XJ, Dang W, Duan YM, Fu XH, Zhang Y, Peng J, Meng FL, Zhou JQ, 2013
SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation, Zhou BO, Wang SS, Xu LX, Meng FL, Xuan YJ, Duan YM, Wang JY, Hu H, Dong X, Ding J, Zhou JQ, 2010
Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae, Chen, XF, Meng, FL, and Zhou, JQ, 2009
Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo, Yang CP, Chen YB, Meng FL, Zhou JQ, 2006

Immune System Diversification Tumor Suppression Super-Enhancers Convergent Transcription Long Non-Coding Rna Dna Deamination B Cells Genomic Instability Dna Damage

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