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Zhengping Shao
Medical School
Zhejiang University
Zhejiang
Language: Chinese, English
Genomic Instability
Dna Damage
Dna Repair
Tumorigenesis
Lymphoma
Breast Cancer
Live Cell Imaging
Mouse Models
Bioinformatics
Dna-Pkcs
Areas of Focus
- Genomic Instability
- DNA Damage and Repair
- Tumorigenesis and Development
Work Experience
- 2022.05-present - Zhejiang University School of Medicine - Researcher
- 2019.09-2022.04 - Columbia University Medical Center - Associate Researcher
- 2014.12-2019.08 - Columbia University Medical Center - Postdoctoral Researcher
- 2009.09-2011.09 - University of Texas Southwestern Medical Center - Visiting Scholar (Joint Ph.D. Student)
Academic Background & Achievements
- 2012.09-2014.06 Ph.D. in Clinical Medicine (Oncology): Zhejiang University School of Medicine
- 2007.09-2012.06 Ph.D. in Pathology and Pathophysiology: Zhejiang University School of Medicine
- 2003.09-2007.06 Bachelor's in Information Engineering (Optoelectronics): Zhejiang University School of Information Science and Engineering
Publications
- DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis, Shao, Z, Flynn, RA, Crowe, JL, Zhu, Y, Liang, J, Jiang, W, Aryan, F, Aoude, P, Bertozzi, CR, Estes, VM et al., 2020
- Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo, Shao, Z, Lee, BJ, Rouleau-Turcotte, E, Langelier, MF, Lin, X, Estes, VM, Pascal, JM, and Zha, S., 2020
- Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination, Crowe JL, Shao Z, Wang XS, Wei PC, Jiang W, Lee BJ, Estes VM, Alt FW, Zha S., 2018
- DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice, Wang XS, Menolfi D, Wu-Baer F, Fangazio M, Meyer SN, Shao Z, Wang Y, Zhu Y, Lee BJ, Estes VM, Cupo OM, Gautier J, Pasqualucci L, Dalla-Favera R, Baer R, Zha S., 2021
- XRCC1 prevents toxic PARP1 trapping during DNA base excision repair, Demin AA, Hirota K, Tsuda M, Adamowicz M, Hailstone R, Brazina J, Gittens W, Kalasova I, Shao Z, Zha S, Sasanuma H, Hanzlikova H, Takeda S, Caldecott KW., 2021
- FATC Domain Deletion Compromises ATM Protein Stability, Blocks Lymphocyte Development, and Promotes Lymphomagenesis, Milanovic M, Shao Z, Estes VM, Wang XS, Menolfi D, Lin X, Lee BJ, Xu J, Cupo OM, Wang D, Zha S., 2021
- DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination, Crowe, JL, Wang, XS, Shao, Z, Lee, BJ, Estes, VM and Zha, S., 2020
- CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining, Wang XS, Zhao J, Wu-Baer F, Shao Z, Lee BJ, Cupo OM, Rabadan R, Gautier J, Baer R, Zha S., 2020
- Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination, Jiang W, Estes VM, Wang XS, Shao Z, Lee BJ, Lin X, Crowe JL, Zha S., 2019
- CtIP is essential for early B cell proliferation and development in mice, Liu X, Wang XS, Lee BJ, Wu-Baer FK, Lin X, Shao Z, Estes VM, Gautier J, Baer R, Zha S., 2019
- Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA, Menolfi D, Jiang W, Lee BJ, Moiseeva T, Shao Z, Estes V, Frattini MG, Bakkenist CJ, Zha S., 2018
