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邵正萍
Medical School
浙江大学
浙江
Language: 中文, 英语
基因组不稳定性
Dna损伤
Dna修复
肿瘤发生
淋巴瘤
乳腺癌
活细胞成像
小鼠模型
生物信息学
Dna-Pkcs
Areas of Focus
- 基因组不稳定性
- DNA损伤与修复
- 肿瘤发生与发展
Work Experience
- 2022.05至今 - 浙江大学医学院 - 研究员
- 2019.09-2022.04 - 美国哥伦比亚大学医学院 - 副研究员
- 2014.12-2019.08 - 美国哥伦比亚大学医学院 - 博士后
- 2009.09-2011.09 - 美国德州大学西南医学中心 - 访问学者（联合培养博士生）
Academic Background & Achievements
- 2012.09-2014.06 临床医学（肿瘤学）博士: 浙江大学医学院
- 2007.09-2012.06 病理学与病理生理学博士: 浙江大学医学院
- 2003.09-2007.06 信息工程（光电系）学士: 浙江大学信息科学与工程学院
Publications
- DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis, Shao, Z, Flynn, RA, Crowe, JL, Zhu, Y, Liang, J, Jiang, W, Aryan, F, Aoude, P, Bertozzi, CR, Estes, VM et al., 2020
- Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo, Shao, Z, Lee, BJ, Rouleau-Turcotte, E, Langelier, MF, Lin, X, Estes, VM, Pascal, JM, and Zha, S., 2020
- Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination, Crowe JL, Shao Z, Wang XS, Wei PC, Jiang W, Lee BJ, Estes VM, Alt FW, Zha S., 2018
- DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice, Wang XS, Menolfi D, Wu-Baer F, Fangazio M, Meyer SN, Shao Z, Wang Y, Zhu Y, Lee BJ, Estes VM, Cupo OM, Gautier J, Pasqualucci L, Dalla-Favera R, Baer R, Zha S., 2021
- XRCC1 prevents toxic PARP1 trapping during DNA base excision repair, Demin AA, Hirota K, Tsuda M, Adamowicz M, Hailstone R, Brazina J, Gittens W, Kalasova I, Shao Z, Zha S, Sasanuma H, Hanzlikova H, Takeda S, Caldecott KW., 2021
- FATC Domain Deletion Compromises ATM Protein Stability, Blocks Lymphocyte Development, and Promotes Lymphomagenesis, Milanovic M, Shao Z, Estes VM, Wang XS, Menolfi D, Lin X, Lee BJ, Xu J, Cupo OM, Wang D, Zha S., 2021
- DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination, Crowe, JL, Wang, XS, Shao, Z, Lee, BJ, Estes, VM and Zha, S., 2020
- CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining, Wang XS, Zhao J, Wu-Baer F, Shao Z, Lee BJ, Cupo OM, Rabadan R, Gautier J, Baer R, Zha S., 2020
- Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination, Jiang W, Estes VM, Wang XS, Shao Z, Lee BJ, Lin X, Crowe JL, Zha S., 2019
- CtIP is essential for early B cell proliferation and development in mice, Liu X, Wang XS, Lee BJ, Wu-Baer FK, Lin X, Shao Z, Estes VM, Gautier J, Baer R, Zha S., 2019
- Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA, Menolfi D, Jiang W, Lee BJ, Moiseeva T, Shao Z, Estes V, Frattini MG, Bakkenist CJ, Zha S., 2018
