Areas of Focus
- Virology
- Virus Replication Mechanisms
- Virus-Host Interactions
- Viral Pathogenesis
- Antiviral Drugs and Vaccines
- Cell Biology
- JAK-STAT Signaling Pathway
- Inflammatory Response
Work Experience
- 2023-09 to Present - Wuhan Institute of Virology, Chinese Academy of Sciences - Full Professor
- 2021-09 to 2023-08 - Wuhan Institute of Virology, Chinese Academy of Sciences - Special-term Professor
- 2017-08 to 2021-09 - Wuhan Institute of Virology, Chinese Academy of Sciences - Associate Professor
- 2015-07 to 2017-07 - Wuhan Institute of Virology, Chinese Academy of Sciences - Assistant Professor
Academic Background & Achievements
- 2008-09 to 2015-06 PhD in Science: Wuhan Institute of Virology, Chinese Academy of Sciences
Publications
- Developing nucleoside tailoring strategies against SARS-CoV-2 via ribonuclease targeting chimera, Other (Collaborative Author), 2024
- Pathogenesis and virulence of Heartland virus, Corresponding Author, 2024
- Host factor MxA restricts Dabie bandavirus infection by targeting the viral NP protein to inhibit NP-RdRp interaction and ribonucleoprotein activity, Corresponding Author, 2023
- SFTS bunyavirus NSs protein sequestrates mTOR into inclusion bodies and deregulates mTOR-ULK1 signaling, provoking pro-viral autophagy, Corresponding Author, 2023
- A new cellular interactome of SARS-CoV-2 nucleocapsid protein and its biological implications, Corresponding Author, 2023
- Interactome profiling of Crimean-Congo hemorrhagic fever virus glycoproteins, Corresponding Author, 2023
- Editorial: Severe fever with thrombocytopenia syndrome, Corresponding Author, 2023
- SARS-CoV-2 NSP13 interacts with host IRF3, blocking antiviral immune responses, Corresponding Author, 2023
- Transcriptome profiling highlights regulated biological processes and type III interferon antiviral responses upon Crimean-Congo hemorrhagic fever virus infection, Corresponding Author, 2023
- Animal Model of Severe Fever With Thrombocytopenia Syndrome Virus Infection, Corresponding Author, 2022
- Antitumor efficacy of CRISPR/Cas9-engineered ICP6 mutant herpes simplex viruses in a mouse xenograft model for lung adenocarcinoma, Corresponding Author, 2022
- Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies, Fourth Author, 2021
- Immune evasion of SARS-CoV-2 from interferon antiviral system, Corresponding Author, 2021
- Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signaling, Corresponding Author, 2021
- Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies, Corresponding Author, 2021
- Non-structural Proteins of Severe Fever With Thrombocytopenia Syndrome Virus Suppress RNA Synthesis in a Transcriptionally Active cDNA-Derived Viral RNA Synthesis System, Third Author, 2021
- Recent Advances in Bunyavirus Reverse Genetics Research: Systems Development, Applications, and Future Perspectives, Corresponding Author, 2021
- Next-Generation Sequencing and Proteomics of Cerebrospinal Fluid From COVID-19 Patients With Neurological Manifestations, Tenth Author, 2021
- SARS-CoV-2 nsp1: Bioinformatics, Potential Structural and Functional Features, and Implications for Drug/Vaccine Designs, Corresponding Author, 2020
- The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action, Corresponding Author, 2020
- Combinatorial Minigenome Systems for Emerging Banyangviruses Reveal Viral Reassortment Potential and Importance of a Protruding Nucleotide in Genome 'Panhandle' for Promoter Activity and Reassortment, Corresponding Author, 2020
- Guertu virus NSs protein disrupts host defense by blocking antiviral interferon induction and action, Corresponding Author, 2020
- Host restriction of emerging high-pathogenic bunyaviruses via MOV10 by targeting viral nucleoprotein and blocking ribonucleoprotein assembly, Corresponding Author, 2020
- A RIG-I–like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination, Second Author, 2020
- A RIG-I–like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination, Corresponding Author, 2020
- Interferon-gamma-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1, First Author, 2019
- 疫苗具有“万能”效应？, Second Author, 2019
- Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1, Corresponding Author, 2019
- Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1, Corresponding Author, 2019
- The Major Hurdle for Effective Baculovirus Transduction into Mammalian Cells Is Passing Early Endosomes, Third Author, 2019
- Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo, First Author, 2018
- The roles of ebolavirus glycoproteins in viral pathogenesis, First Author, 2017
- Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase–IRF3 transcription factor interaction and signaling required for interferon induction, First Author, 2017
- A novel glycoprotein D-specific monoclonal antibody neutralizes herpes simplex virus, Seventh Author, 2017
- Disruption of Type I Interferon Signaling by the Nonstructural Protein of Severe Fever with Thrombocytopenia Syndrome Virus via the Hijacking of STAT2 and STAT1 into Inclusion Bodies, First Author, 2015
- 搭建流行病探测网络, Second Author, 2014
- Viral suppression of innate immunity via spatial isolation of TBK1/IKK epsilon from mitochondrial antiviral platform, First Author, 2014
Awards
- Outstanding Paper 2022 (2023): Other
- Outstanding Young Scientific Research Backbone of Wuhan Institute of Virology, Chinese Academy of Sciences (2020): Institute
- Member of Youth Innovation Promotion Association, Chinese Academy of Sciences (2019): Ministry Level
- Outstanding Young Scientific Research Backbone of Wuhan Institute of Virology, Chinese Academy of Sciences (2019): Institute
- Outstanding Young Backbone of State Key Laboratory of Virology (2017): Other
- Hubei Province Excellent Doctoral Dissertation Award (2017): Other
- Hubei Province Excellent Natural Science Paper Award (2016): Other
- Outstanding Graduate of Beijing Universities (2015): Institute
- Outstanding Graduate of Chinese Academy of Sciences (2015): Other
- President's Award of Chinese Academy of Sciences (2015): Other
