Professor | Guohui Pan | Asia Growth Partners

Name	Guohui Pan
Contact Information	panguohui@im.ac.cn
Language ability	Chinese, English
Province	Beijing

Name

Guohui Pan

Contact Information

panguohui@im.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2008-09--2014-01 PhD: University of Chinese Academy of Sciences 2004-09--2008-07 Bachelor: China University of Mining and Technology (Beijing)
Work Experience	2022-01~Present - Institute of Microbiology, Chinese Academy of Sciences - Researcher 2019-08~2022-01 - Institute of Microbiology, Chinese Academy of Sciences - Project Researcher 2014-02~2019-08 - The Scripps Research Institute - Postdoctoral Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2008-09--2014-01 PhD: University of Chinese Academy of Sciences
2004-09--2008-07 Bachelor: China University of Mining and Technology (Beijing)

Work Experience

2022-01~Present - Institute of Microbiology, Chinese Academy of Sciences - Researcher
2019-08~2022-01 - Institute of Microbiology, Chinese Academy of Sciences - Project Researcher
2014-02~2019-08 - The Scripps Research Institute - Postdoctoral Researcher

Areas of Focus	Microbial natural product discovery, biosynthesis, and synthetic biology
Publications	Confirmation of the stereochemistry of spiroviolene, Yao Kong, Yuanning Liu, Kaibiao Wang, Tao Wang, Chen Wang, Ben Ai, Hongli Jia, Guohui Pan, Min Yin, Zhengren Xu, 2024 Cofactor-independent C–C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis, Jinmin Gao, Liyuan Li, Shijie Shen, Guomin Ai, Bin Wang, Fang Guo, Tongjian Yang, Hui Han, Zhengren Xu, Guohui Pan, Keqiang Fan, 2024 Discrete Acyltransferases and Thioesterases in Iso-Migrastatin and Lactimidomycin Biosynthesis, Andrew D Steele, Hui Jiang, Guohui Pan, Si-Kyu Lim, Edward Kalkreuter, Jianhua Ju, Thomas Kwong, Scott Rajski, Ben Shen, 2024 Tetracycline family natural products: discovery, biosynthesis and engineering, Haiyan Wang, Lijun Wang, Keqiang Fan, Guohui Pan, 2022 Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585, Zhang, Chaobo, Zhao, Youbao, Li, Zilong, Wang, Weishan, Huang, Ying, Pan, Guohui, Fan, Keqiang, 2022 (S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue-pigments indigoidine, 张志龙, 李鹏伟, 王敏, 张雁, 吴边, 陶勇, 潘国辉, 陈义华, 2022 Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus thermoglucosidasius, Wang, Junyang, Li, Zilong, Wang, Weishan, Pang, Shen, Yao, Yongpeng, Yuan, Fang, Wang, Huizhuan, Xu, Zhen, Pan, Guohui, Liu, Zihe, Chen, Yihua, Fan, Keqiang, 2022 The Richness and Diversity of Catalases in Bacteria, Yuan, Fang, Yin, Shouliang, Xu, Yang, Xiang, Lijun, Wang, Haiyan, Li, Zilong, Fan, Keqiang, Pan, Guohui, 2021 基于生物信息学分析从Streptomyces albofaciens JCM 4342中发现2，3-二羟基苯甲酸酯-L-丝氨酸脱水三聚体和二聚体天然产物, 王立军, 范可强, 王海燕, 胡会涛, 向丽军, 艾国民, 潘国辉, 2021 Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase, Meng, Song, Steele, Andrew D, Yan, Wei, Pan, Guohui, Kalkreuter, Edward, Liu, YuChen, Xu, Zhengren, Shen, Ben, 2021 基于生物信息学分析从Streptomyces albofaciens JCM 4342中发现2，3-二羟基苯甲酸酯-L-丝氨酸脱水三聚体和二聚体天然产物（英文）, 王立军, 范可强, 王海燕, 胡会涛, 向丽军, 艾国民, 潘国辉, 2021 A Versatile Transcription-Translation in One Approach for Activation of Cryptic Biosynthetic Gene Clusters, Zhang, Qian, Ren, JinWei, Wang, Weishan, Zhai, Jian, Yang, Jing, Liu, Ning, Huang, Ying, Chen, Yihua, Pan, Guohui, Fan, Keqiang, 2020 Targeting Bacterial Genomes for Natural Product Discovery, Kalkreuter, Edward, Pan, Guohui, Cepeda, Alexis J, Shen, Ben, 2020 The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research, McAlpine, James B, Chen, ShaoNong, Kutateladze, Andrei, MacMillan, John B, Appendino, Giovanni, Barison, Andersson, Beniddir, Mehdi A, Biavatti, Maique W, Bluml, Stefan, Boufridi, Asmaa, Butler, Mark S, Capon, Robert J, Choi, Young H, Coppage, David, Crews, Phillip, Crimmins, Michael T, Csete, Marie, Dewapriya, Pradeep, Egan, Joseph M, Garson, Mary J, GentaJouve, Gregory, Gerwick, William H, Gross, Harald, Harper, Mary Kay, Hermanto, Precilia, Hook, James M, Hunter, Luke, Jeannerat, Damien, Ji, NaiYun, Johnson, Tyler A, Kingston, David G I, Koshino, Hiroyuki, Lee, HsiauWei, Lewin, Guy, Li, Jie, Linington, Roger G, Liu, Miaomiao, McPhail, Kerry L, Molinski, Tadeusz F, Moore, Bradley S, Nam, JooWon, Neupane, Ram P, Niemitz, Matthias, Nuzillard, JeanMarc, Oberlies, Nicholas H, Ocampos, Fernanda M M, Pan, Guohui, Quinn, Ronald J, Reddy, D Sai, Renault, JeanHugues, RiveraChavez, Jose, Robien, Wolfgang, Saunders, Carla M, Schmidt, Thomas J, Seger, Christoph, Shen, Ben, Steinbeck, Christoph, , 2019 P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities, Kwong, Thomas, Ma, Ming, Pan, Guohui, Hindra, Yang, Dong, Yang, Chunying, Lohman, Jeremy R, Rudolf, Jeffrey D, Cleveland, John L, Shen, Ben, 2018 Discovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial Origin, Xu, Zhengren, Pan, Guohui, Zhou, Hao, Shen, Ben, 2018 Engineered jadomycin analogues with altered sugar moieties revealing JadS as a substrate flexible O-glycosyltransferase, Li, Liyuan, Pan, Guohui, Zhu, Xifen, Fan, Keqiang, Gao, Wubin, Ai, Guomin, Ren, Jinwei, Shi, Mingxin, Olano, Carlos, Salas, Jose A, Yang, Keqian, 2017 Discovery of the leinamycin family of natural products by mining actinobacterial genomes, Pan, Guohui, Xu, Zhengren, Guo, Zhikai, Hindra, Ma, Ming, Yang, Dong, Zhou, Hao, Gansemans, Yannick, Zhu, Xiangcheng, Huang, Yong, Zhao, LiXing, Jiang, Yi, Cheng, Jinhua, Van Nieuwerburgh, Filip, Suh, JooWon, Duan, Yanwen, Shen, Ben, 2017 Structure and Function of a C-C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis, Pan, Guohui, Gao, Xiaoqin, Fan, Keqiang, Liu, Junlin, Meng, Bing, Gao, Jinmin, Wang, Bin, Zhang, Chaobo, Han, Hui, Ai, Guomin, Chen, Yihua, Wu, Dong, Liu, ZhiJie, Yang, Keqian, 2017 New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp CB01883, Guo, Zhikai, Pan, Guohui, Xu, Zhengren, Yang, Dong, Hindra, Zhu, Xiangcheng, Huang, Yong, Zhao, LiXing, Jiang, Yi, Duan, Yanwen, Shen, Ben, 2017 Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement, Huang, Yong, Yang, Dong, Pan, Guohui, Tang, GongLi, Shen, Ben, 2016 Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins, Zhang, Bo, Yang, Dong, Yan, Yijun, Pan, Guohui, Xiang, Wensheng, Shen, Ben, 2016 Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase-Polyketide Synthase Interface for Leinamycin Biosynthesis, Huang, Yong, Tang, GongLi, Pan, Guohui, Chang, ChinYuan, Shen, Ben, 2016 Minimum Information about a Biosynthetic Gene cluster, Medema, Marnix H, Kottmann, Renzo, Yilmaz, Pelin, Cummings, Matthew, Biggins, John B, Blin, Kai, de Bruijn, Irene, Chooi, Yit Heng, Claesen, Jan, Coates, R Cameron, CruzMorales, Pablo, Duddela, Srikanth, Duesterhus, Stephanie, Edwards, Daniel J, Fewer, David P, Garg, Neha, Geiger, Christoph, GomezEscribano, Juan Pablo, Greule, Anja, Hadjithomas, Michalis, Haines, Anthony S, Helfrich, Eric J N, Hillwig, Matthew L, Ishida, Keishi, Jones, Adam C, Jones, Carla S, Jungmann, Katrin, Kegler, Carsten, Kim, Hyun Uk, Koetter, Peter, Krug, Daniel, Masschelein, Joleen, Melnik, Alexey V, Mantovani, Simone M, Monroe, Emily A, Moore, Marcus, Moss, Nathan, Nuetzmann, HansWilhelm, Pan, Guohui, Pati, Amrita, Petras, Daniel, Reen, F Jerry, Rosconi, Federico, Rui, Zhe, Tian, Zhenhua, Tobias, Nicholas J, Tsunematsu, Yuta, Wiemann, Philipp, Wyckoff, Elizabeth, Yan, Xiaohui, Yim, Grace, Yu, Fengan, Xie, Yunchang, Aigle, Bertrand, Apel, Alexander K, Balibar, Carl J, Balskus, Emily P, BaronaGomez, Francisco, B

Areas of Focus

Microbial natural product discovery, biosynthesis, and synthetic biology

Publications

Confirmation of the stereochemistry of spiroviolene, Yao Kong, Yuanning Liu, Kaibiao Wang, Tao Wang, Chen Wang, Ben Ai, Hongli Jia, Guohui Pan, Min Yin, Zhengren Xu, 2024
Cofactor-independent C–C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis, Jinmin Gao, Liyuan Li, Shijie Shen, Guomin Ai, Bin Wang, Fang Guo, Tongjian Yang, Hui Han, Zhengren Xu, Guohui Pan, Keqiang Fan, 2024
Discrete Acyltransferases and Thioesterases in Iso-Migrastatin and Lactimidomycin Biosynthesis, Andrew D Steele, Hui Jiang, Guohui Pan, Si-Kyu Lim, Edward Kalkreuter, Jianhua Ju, Thomas Kwong, Scott Rajski, Ben Shen, 2024
Tetracycline family natural products: discovery, biosynthesis and engineering, Haiyan Wang, Lijun Wang, Keqiang Fan, Guohui Pan, 2022
Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585, Zhang, Chaobo, Zhao, Youbao, Li, Zilong, Wang, Weishan, Huang, Ying, Pan, Guohui, Fan, Keqiang, 2022
(S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue-pigments indigoidine, 张志龙, 李鹏伟, 王敏, 张雁, 吴边, 陶勇, 潘国辉, 陈义华, 2022
Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus thermoglucosidasius, Wang, Junyang, Li, Zilong, Wang, Weishan, Pang, Shen, Yao, Yongpeng, Yuan, Fang, Wang, Huizhuan, Xu, Zhen, Pan, Guohui, Liu, Zihe, Chen, Yihua, Fan, Keqiang, 2022
The Richness and Diversity of Catalases in Bacteria, Yuan, Fang, Yin, Shouliang, Xu, Yang, Xiang, Lijun, Wang, Haiyan, Li, Zilong, Fan, Keqiang, Pan, Guohui, 2021
基于生物信息学分析从Streptomyces albofaciens JCM 4342中发现2，3-二羟基苯甲酸酯-L-丝氨酸脱水三聚体和二聚体天然产物, 王立军, 范可强, 王海燕, 胡会涛, 向丽军, 艾国民, 潘国辉, 2021
Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase, Meng, Song, Steele, Andrew D, Yan, Wei, Pan, Guohui, Kalkreuter, Edward, Liu, YuChen, Xu, Zhengren, Shen, Ben, 2021
基于生物信息学分析从Streptomyces albofaciens JCM 4342中发现2，3-二羟基苯甲酸酯-L-丝氨酸脱水三聚体和二聚体天然产物（英文）, 王立军, 范可强, 王海燕, 胡会涛, 向丽军, 艾国民, 潘国辉, 2021
A Versatile Transcription-Translation in One Approach for Activation of Cryptic Biosynthetic Gene Clusters, Zhang, Qian, Ren, JinWei, Wang, Weishan, Zhai, Jian, Yang, Jing, Liu, Ning, Huang, Ying, Chen, Yihua, Pan, Guohui, Fan, Keqiang, 2020
Targeting Bacterial Genomes for Natural Product Discovery, Kalkreuter, Edward, Pan, Guohui, Cepeda, Alexis J, Shen, Ben, 2020
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research, McAlpine, James B, Chen, ShaoNong, Kutateladze, Andrei, MacMillan, John B, Appendino, Giovanni, Barison, Andersson, Beniddir, Mehdi A, Biavatti, Maique W, Bluml, Stefan, Boufridi, Asmaa, Butler, Mark S, Capon, Robert J, Choi, Young H, Coppage, David, Crews, Phillip, Crimmins, Michael T, Csete, Marie, Dewapriya, Pradeep, Egan, Joseph M, Garson, Mary J, GentaJouve, Gregory, Gerwick, William H, Gross, Harald, Harper, Mary Kay, Hermanto, Precilia, Hook, James M, Hunter, Luke, Jeannerat, Damien, Ji, NaiYun, Johnson, Tyler A, Kingston, David G I, Koshino, Hiroyuki, Lee, HsiauWei, Lewin, Guy, Li, Jie, Linington, Roger G, Liu, Miaomiao, McPhail, Kerry L, Molinski, Tadeusz F, Moore, Bradley S, Nam, JooWon, Neupane, Ram P, Niemitz, Matthias, Nuzillard, JeanMarc, Oberlies, Nicholas H, Ocampos, Fernanda M M, Pan, Guohui, Quinn, Ronald J, Reddy, D Sai, Renault, JeanHugues, RiveraChavez, Jose, Robien, Wolfgang, Saunders, Carla M, Schmidt, Thomas J, Seger, Christoph, Shen, Ben, Steinbeck, Christoph, , 2019
P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities, Kwong, Thomas, Ma, Ming, Pan, Guohui, Hindra, Yang, Dong, Yang, Chunying, Lohman, Jeremy R, Rudolf, Jeffrey D, Cleveland, John L, Shen, Ben, 2018
Discovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial Origin, Xu, Zhengren, Pan, Guohui, Zhou, Hao, Shen, Ben, 2018
Engineered jadomycin analogues with altered sugar moieties revealing JadS as a substrate flexible O-glycosyltransferase, Li, Liyuan, Pan, Guohui, Zhu, Xifen, Fan, Keqiang, Gao, Wubin, Ai, Guomin, Ren, Jinwei, Shi, Mingxin, Olano, Carlos, Salas, Jose A, Yang, Keqian, 2017
Discovery of the leinamycin family of natural products by mining actinobacterial genomes, Pan, Guohui, Xu, Zhengren, Guo, Zhikai, Hindra, Ma, Ming, Yang, Dong, Zhou, Hao, Gansemans, Yannick, Zhu, Xiangcheng, Huang, Yong, Zhao, LiXing, Jiang, Yi, Cheng, Jinhua, Van Nieuwerburgh, Filip, Suh, JooWon, Duan, Yanwen, Shen, Ben, 2017
Structure and Function of a C-C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis, Pan, Guohui, Gao, Xiaoqin, Fan, Keqiang, Liu, Junlin, Meng, Bing, Gao, Jinmin, Wang, Bin, Zhang, Chaobo, Han, Hui, Ai, Guomin, Chen, Yihua, Wu, Dong, Liu, ZhiJie, Yang, Keqian, 2017
New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp CB01883, Guo, Zhikai, Pan, Guohui, Xu, Zhengren, Yang, Dong, Hindra, Zhu, Xiangcheng, Huang, Yong, Zhao, LiXing, Jiang, Yi, Duan, Yanwen, Shen, Ben, 2017
Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement, Huang, Yong, Yang, Dong, Pan, Guohui, Tang, GongLi, Shen, Ben, 2016
Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins, Zhang, Bo, Yang, Dong, Yan, Yijun, Pan, Guohui, Xiang, Wensheng, Shen, Ben, 2016
Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase-Polyketide Synthase Interface for Leinamycin Biosynthesis, Huang, Yong, Tang, GongLi, Pan, Guohui, Chang, ChinYuan, Shen, Ben, 2016
Minimum Information about a Biosynthetic Gene cluster, Medema, Marnix H, Kottmann, Renzo, Yilmaz, Pelin, Cummings, Matthew, Biggins, John B, Blin, Kai, de Bruijn, Irene, Chooi, Yit Heng, Claesen, Jan, Coates, R Cameron, CruzMorales, Pablo, Duddela, Srikanth, Duesterhus, Stephanie, Edwards, Daniel J, Fewer, David P, Garg, Neha, Geiger, Christoph, GomezEscribano, Juan Pablo, Greule, Anja, Hadjithomas, Michalis, Haines, Anthony S, Helfrich, Eric J N, Hillwig, Matthew L, Ishida, Keishi, Jones, Adam C, Jones, Carla S, Jungmann, Katrin, Kegler, Carsten, Kim, Hyun Uk, Koetter, Peter, Krug, Daniel, Masschelein, Joleen, Melnik, Alexey V, Mantovani, Simone M, Monroe, Emily A, Moore, Marcus, Moss, Nathan, Nuetzmann, HansWilhelm, Pan, Guohui, Pati, Amrita, Petras, Daniel, Reen, F Jerry, Rosconi, Federico, Rui, Zhe, Tian, Zhenhua, Tobias, Nicholas J, Tsunematsu, Yuta, Wiemann, Philipp, Wyckoff, Elizabeth, Yan, Xiaohui, Yim, Grace, Yu, Fengan, Xie, Yunchang, Aigle, Bertrand, Apel, Alexander K, Balibar, Carl J, Balskus, Emily P, BaronaGomez, Francisco, B

Microbial Natural Products Discovery Biosynthesis Synthetic Biology Genomics Biocatalysis Metabolic Engineering Biotechnology Pharmacology

Hui Tao - Wuhan University

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