Upload Avatar (500 x 500)
Hui Tao
Medical School
Wuhan University
Hubei
Language: Chinese, English
Synthetic Biology
Gene Mining
Biosynthesis
Bioinformatics
Enzyme Engineering
Metabolic Pathways
High-Value Chemicals
Microbial Synthesis
Biocatalysis
Natural Product Derivatives
Areas of Focus
- Synthetic Biology of Active Natural Products
- Enzyme Catalysis Mechanisms and Engineering
Work Experience
- 2023.02 - Present: Wuhan University, School of Pharmaceutical Sciences, Professor, Doctoral Supervisor
- 2022.08 - 2023.02: University of Tokyo, Japan, Project Researcher, Collaborative Supervisor: Prof. Hiroaki Suga
- 2018.10 - 2022.08: University of Tokyo, Japan, JSPS Special Research Fellow, Collaborative Supervisor: Prof. Ikuro Abe
- 2017.02 - 2017.03: Washington University in St. Louis, USA, Visiting Student, Collaborative Supervisor: Prof. Yinjie Tang
- 2016.05 - 2016.10: Chalmers University of Technology, Sweden, Visiting Student, Collaborative Supervisor: Prof. Jens Nielsen
Academic Background & Achievements
- 2013.09 - 2018.06 PhD: Wuhan University, School of Pharmaceutical Sciences, Supervisors: Prof. Zixin Deng, Prof. Tiangang Liu
- 2009.09 - 2013.06 Bachelor: Wuhan University, School of Pharmaceutical Sciences, Supervisor: Prof. Tiangang Liu
Publications
- Discovery of non-squalene triterpenes, Hui Tao et al., 2022
- Stereoselectivity and substrate specificity of the Fe (II)/α-ketoglutarate-dependent oxygenase TqaL, Hui Tao et al., 2022
- Molecular insights into the unusually promiscuous and catalytically versatile Fe (II)/α-ketoglutarate-dependent oxygenase SptF, Hui Tao et al., 2022
- One polyketide synthase, two distinct products: trans-acting enzyme-controlled product divergence in calbistrin biosynthesis, Hui Tao et al., 2021
- Harnessing Fe(II)/α-ketoglutarate-dependent oxygenases for structural diversification of fungal meroterpenoids, Hui Tao et al., 2022
- Enzymology and biosynthesis of the orsellinic acid derived medicinal meroterpenoids, Hui Tao et al., 2021
- Oxidative modification of free-standing amino acids by Fe (II)/αKG-dependent oxygenases, Hui Tao et al., 2022
- Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton, Hui Tao et al., 2021
- Strategies for enhancing the yield of the potent insecticide spinosad in actinomycetes, Hui Tao et al., 2019
- Absolute quantification of proteins in the fatty acid biosynthetic pathway using protein standard absolute quantification, Hui Tao et al., 2016
- Metabolic engineering of microbes for branched-chain biodiesel production with low-temperature property, Hui Tao et al., 2015
- Rational engineering of the nonheme iron-and 2-oxoglutarate-dependent oxygenase SptF, Hui Tao et al., 2022
- Structural diversification of andiconin-derived natural products by α-ketoglutarate-dependent dioxygenases, Hui Tao et al., 2020
- Heterologous biosynthesis of spinosad: an omics-guided large polyketide synthase gene cluster reconstitution in streptomyces, Hui Tao et al.
- Production of taxadiene by engineering of mevalonate pathway in Escherichia coli and endophytic fungus Alternaria alternata TPF6, Hui Tao et al., 2017
Awards
- JSPS Special Research Fellow (2018)
- Wuhan University Medical Outstanding Contribution Award (2016)
- Wuhan University Graduate Academic Innovation Award (2016)
