2004-09--2006-07 Master's: University of Groningen
2000-09--2004-07 Bachelor's: Peking University
2017-12~2024-03 - Chinese Academy of Sciences, Institute of Microbiology - Deputy Director
2014-12~Present - Chinese Academy of Sciences, Institute of Microbiology - Researcher
2012-10~2014-11 - University of Groningen - Research Group Leader, Chief Biologist
2010-11~2012-09 - University of Groningen - Postdoctoral Researcher
Hebei Provincial Science and Technology Progress Award (2022): First Prize
Research
Computational Protein Design Green Chemistry Biochemical Engineering
A Label-Free and Continuous Fluorescence Detection for L-DOPA Decarboxylase Activity Based on Supramolecular Tandem Assay, Wu Bian, 2023
Computational enzyme redesign: large jumps in function, Wu Bian, 2022
Creating an Unusual Glycine-Rich Motif in a Peptide Amidase Leads to Versatile Protein C-Terminal Traceless Functionalization, Wu Bian, 2022
Traceless enzymatic protein synthesis without ligation sites constraint, Wu Bian, 2022
Photobiocatalytic Cascades for Acylating N-Heterocycles with Natural Amino Acids via the 2-Keto Acids, Wu Bian, 2022
Recent advances in biocatalysis of nitrogen-containing heterocycles, Wu Bian, 2022
(S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue-pigments indigoidine., Wu Bian, 2022
Computational Redesign of a PETase for Plastic Biodegradation under Ambient Condition by the GRAPE Strategy, Wu Bian, 2021
从药物多肽到蛋白质全合成：酶促拼接的方法原理与前沿应用, Wu Bian, 2021
Development of a versatile and efficient C-N lyase platform for asymmetric hydroamination via computational enzyme redesign, Wu Bian, 2021
Construction of an Alternative NAD(+) De Novo Biosynthesis Pathway, Wu Bian, 2021
Characterization and efficient production of a thermostable, halostable and organic solvent-stable cellulase from an oil reservoir, Wu Bian, 2020
Bioretrosynthesis of Functionalized N ‐Heterocycles from Glucose via One‐Pot Tandem Collaborations of Designed Microbes, Wu Bian, 2020
Improving the System Performance of the Asymmetric Biosynthesis of D-Pantoic Acid by Using Artificially Self-Assembled Enzymes in Escherichia coli, Wu Bian, 2020
Reductase of Mutanobactin Synthetase Triggers Sequential C-C Macrocyclization, C-S Bond Formation, and C-C Bond Cleavage, Wu Bian, 2020
Molecular dynamics investigations of structural and functional changes in Bcl-2 induced by the novel antagonist BDA-366, Wu Bian, 2019
合成微生物组：当“合成生物学”遇见“微生物组学”, Wu Bian, 2019
蛋白质工程：从定向进化到计算设计, Wu Bian, 2019
Biochemical and structural characterization of a highly active branched-chain amino acid aminotransferase from Pseudomonas sp. for efficient biosynthesis of chiral amino acids, Wu Bian, 2019
Molecular dynamics investigations of structural and functional changes in Bcl-2 induced by the novel antagonist BDA-366, Wu Bian, 2019
Biochemical and structural characterization of a highly active branched-chain amino acid aminotransferase from Pseudomonas sp. for efficient biosynthesis of chiral amino acid., Wu Bian, 2019
Thermostability improvement of the glucose oxidase from Aspergillus niger for efficient gluconic acid production via computational design, Wu Bian, 2019
Enzymatic clickable functionalization of peptides via computationally engineered peptide amidase, Wu Bian, 2018
符合工程化需求的生物元件设计, Wu Bian, 2018
Enzymatic clickable functionalization of peptides via computationally engineered peptide amidase, Wu Bian, 2018
Engineering improved thermostability of the GH11 xylanase from Neocallimastix patriciarum via computational library design, Wu Bian, 2018
Computational redesign of enzymes for regio- and enantioselective hydroamination, Wu Bian, 2018
Molecular dynamics investigations of structural and functional changes in Bcl-2 induced by the novel antagonist BDA-366., Wu Bian, 2018
计算机辅助蛋白结构预测及酶的计算设计研究进展, Wu Bian, 2017
Regio- and Stereospecific O-Glycosylation of Phenolic Compounds Catalyzed by a Fungal Glycosyltransferase from Mucor hiemalis, Wu Bian, 2017
Versatile Peptide C-Terminal Functionalization via a Computationally Engineered Peptide Amidase, Wu Bian, 2016
Engineering a Diverse Ligase Toolbox for Peptide Segment Condensation, Wu Bian, 2016
Peptiligase, an Enzyme for Efficient Chemoenzymatic Peptide Synthesis and Cyclization in Water, Wu Bian, 2016
Enzymatic Network for Production of Ether Amines From Alcohols, Wu Bian, 2016
Peptide synthesis in neat organic solvents with novel thermostable proteases, Wu Bian, 2015
One-Step C-Terminal Deprotection and Activation of Peptides with Peptide Amidase from Stenotrophomonas maltophilia in Neat Organic Solvent, Wu Bian, 2014
Structural Investigations into the Stereochemistry and Activity of a Phenylalanine-2,3-aminomutase from Taxus chinensis, Wu Bian, 2014
Azobenzene Photoswitches for Staudinger-Bertozzi Ligation, Wu Bian, 2013
Priming ammonia lyases and aminomutases for industrial and therapeutic applications, Wu Bian, 2013
Proteolysin, a Novel Highly Thermostable and Cosolvent-Compatible Protease from the Thermophilic Bacterium Coprothermobacter proteolyticus, Wu Bian, 2013
Redesign of a Phenylalanine Aminomutase into a Phenylalanine Ammonia Lyase, Wu Bian, 2013
Biochemical Properties and Crystal Structure of a β-Phenylalanine Aminotransferase from Variovorax paradoxus, Wu Bian, 2013
Mechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced ss-Regioselective Asymmetric Amination of Cinnamates, Wu Bian, 2012
C-N lyases catalyzing addition of ammonia, amines and amides to C=C and C=O bonds, Wu Bian, 2012
Preparation of β-phenylalanine using phenylalanine aminomutase, Wu Bian, 2012
Engineering of an enantioselective tyrosine aminomutase by mutation of a single active site residue in phenylalanine aminomutase, Wu Bian, 2010
Efficient Tandem Biocatalytic Process for the Kinetic Resolution of Aromatic beta-Amino Acids, Wu Bian, 2010
Enantiomerically pure beta-phenylalanine analogues from alpha-beta-phenylalanine mixtures in a single reactive extraction step, Wu Bian, 2010
Phenylalanine Aminomutase-Catalyzed Addition of Ammonia to Substituted Cinnamic Acids: a Route to Enantiopure alpha- and beta-Amino Acids, Wu Bian, 2009
Enzymatic Synthesis of Enantiopure alpha- and beta-Amino Acids by Phenylalanine Aminomutase-Catalysed Amination of Cinnamic Acid Derivatives, Wu Bian, 2009
Keywords
Protein DesignComputational BiologyEnzyme EngineeringBiocatalysisSynthetic BiologyGreen ChemistrySustainable ProcessesBiochemical PathwaysMetabolic EngineeringBiotechnology
