Areas of Focus
- Computational Protein Design
- Green Chemistry
- Biochemical Engineering
Work Experience
- 2017-12~2024-03 - Chinese Academy of Sciences, Institute of Microbiology - Deputy Director
- 2014-12~Present - Chinese Academy of Sciences, Institute of Microbiology - Researcher
- 2012-10~2014-11 - University of Groningen - Research Group Leader, Chief Biologist
- 2010-11~2012-09 - University of Groningen - Postdoctoral Researcher
Academic Background & Achievements
- 2006-09--2010-10 PhD: University of Groningen
- 2004-09--2006-07 Master's: University of Groningen
- 2000-09--2004-07 Bachelor's: Peking University
Publications
- A Label-Free and Continuous Fluorescence Detection for L-DOPA Decarboxylase Activity Based on Supramolecular Tandem Assay, Wu Bian, 2023
- Computational enzyme redesign: large jumps in function, Wu Bian, 2022
- Creating an Unusual Glycine-Rich Motif in a Peptide Amidase Leads to Versatile Protein C-Terminal Traceless Functionalization, Wu Bian, 2022
- Traceless enzymatic protein synthesis without ligation sites constraint, Wu Bian, 2022
- Photobiocatalytic Cascades for Acylating N-Heterocycles with Natural Amino Acids via the 2-Keto Acids, Wu Bian, 2022
- Recent advances in biocatalysis of nitrogen-containing heterocycles, Wu Bian, 2022
- (S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue-pigments indigoidine., Wu Bian, 2022
- Computational Redesign of a PETase for Plastic Biodegradation under Ambient Condition by the GRAPE Strategy, Wu Bian, 2021
- 从药物多肽到蛋白质全合成：酶促拼接的方法原理与前沿应用, Wu Bian, 2021
- Development of a versatile and efficient C-N lyase platform for asymmetric hydroamination via computational enzyme redesign, Wu Bian, 2021
- Construction of an Alternative NAD(+) De Novo Biosynthesis Pathway, Wu Bian, 2021
- Characterization and efficient production of a thermostable, halostable and organic solvent-stable cellulase from an oil reservoir, Wu Bian, 2020
- Bioretrosynthesis of Functionalized N ‐Heterocycles from Glucose via One‐Pot Tandem Collaborations of Designed Microbes, Wu Bian, 2020
- Improving the System Performance of the Asymmetric Biosynthesis of D-Pantoic Acid by Using Artificially Self-Assembled Enzymes in Escherichia coli, Wu Bian, 2020
- Reductase of Mutanobactin Synthetase Triggers Sequential C-C Macrocyclization, C-S Bond Formation, and C-C Bond Cleavage, Wu Bian, 2020
- Molecular dynamics investigations of structural and functional changes in Bcl-2 induced by the novel antagonist BDA-366, Wu Bian, 2019
- 合成微生物组：当“合成生物学”遇见“微生物组学”, Wu Bian, 2019
- 蛋白质工程：从定向进化到计算设计, Wu Bian, 2019
- Biochemical and structural characterization of a highly active branched-chain amino acid aminotransferase from Pseudomonas sp. for efficient biosynthesis of chiral amino acids, Wu Bian, 2019
- Molecular dynamics investigations of structural and functional changes in Bcl-2 induced by the novel antagonist BDA-366, Wu Bian, 2019
- Biochemical and structural characterization of a highly active branched-chain amino acid aminotransferase from Pseudomonas sp. for efficient biosynthesis of chiral amino acid., Wu Bian, 2019
- Thermostability improvement of the glucose oxidase from Aspergillus niger for efficient gluconic acid production via computational design, Wu Bian, 2019
- Enzymatic clickable functionalization of peptides via computationally engineered peptide amidase, Wu Bian, 2018
- 符合工程化需求的生物元件设计, Wu Bian, 2018
- Enzymatic clickable functionalization of peptides via computationally engineered peptide amidase, Wu Bian, 2018
- Engineering improved thermostability of the GH11 xylanase from Neocallimastix patriciarum via computational library design, Wu Bian, 2018
- Computational redesign of enzymes for regio- and enantioselective hydroamination, Wu Bian, 2018
- Molecular dynamics investigations of structural and functional changes in Bcl-2 induced by the novel antagonist BDA-366., Wu Bian, 2018
- 计算机辅助蛋白结构预测及酶的计算设计研究进展, Wu Bian, 2017
- Regio- and Stereospecific O-Glycosylation of Phenolic Compounds Catalyzed by a Fungal Glycosyltransferase from Mucor hiemalis, Wu Bian, 2017
- Versatile Peptide C-Terminal Functionalization via a Computationally Engineered Peptide Amidase, Wu Bian, 2016
- Engineering a Diverse Ligase Toolbox for Peptide Segment Condensation, Wu Bian, 2016
- Peptiligase, an Enzyme for Efficient Chemoenzymatic Peptide Synthesis and Cyclization in Water, Wu Bian, 2016
- Enzymatic Network for Production of Ether Amines From Alcohols, Wu Bian, 2016
- Peptide synthesis in neat organic solvents with novel thermostable proteases, Wu Bian, 2015
- One-Step C-Terminal Deprotection and Activation of Peptides with Peptide Amidase from Stenotrophomonas maltophilia in Neat Organic Solvent, Wu Bian, 2014
- Structural Investigations into the Stereochemistry and Activity of a Phenylalanine-2,3-aminomutase from Taxus chinensis, Wu Bian, 2014
- Azobenzene Photoswitches for Staudinger-Bertozzi Ligation, Wu Bian, 2013
- Priming ammonia lyases and aminomutases for industrial and therapeutic applications, Wu Bian, 2013
- Proteolysin, a Novel Highly Thermostable and Cosolvent-Compatible Protease from the Thermophilic Bacterium Coprothermobacter proteolyticus, Wu Bian, 2013
- Redesign of a Phenylalanine Aminomutase into a Phenylalanine Ammonia Lyase, Wu Bian, 2013
- Biochemical Properties and Crystal Structure of a β-Phenylalanine Aminotransferase from Variovorax paradoxus, Wu Bian, 2013
- Mechanism-Inspired Engineering of Phenylalanine Aminomutase for Enhanced ss-Regioselective Asymmetric Amination of Cinnamates, Wu Bian, 2012
- C-N lyases catalyzing addition of ammonia, amines and amides to C=C and C=O bonds, Wu Bian, 2012
- Preparation of β-phenylalanine using phenylalanine aminomutase, Wu Bian, 2012
- Aminomutases: mechanistic aspects, biotechnological applications and future perspectives, Wu Bian, 2011
- Engineering of an enantioselective tyrosine aminomutase by mutation of a single active site residue in phenylalanine aminomutase, Wu Bian, 2010
- Efficient Tandem Biocatalytic Process for the Kinetic Resolution of Aromatic beta-Amino Acids, Wu Bian, 2010
- Enantiomerically pure beta-phenylalanine analogues from alpha-beta-phenylalanine mixtures in a single reactive extraction step, Wu Bian, 2010
- Phenylalanine Aminomutase-Catalyzed Addition of Ammonia to Substituted Cinnamic Acids: a Route to Enantiopure alpha- and beta-Amino Acids, Wu Bian, 2009
- Enzymatic Synthesis of Enantiopure alpha- and beta-Amino Acids by Phenylalanine Aminomutase-Catalysed Amination of Cinnamic Acid Derivatives, Wu Bian, 2009
Awards
- Hebei Provincial Science and Technology Progress Award (2022): First Prize
